MLTJ-Muscles Ligaments and Tendons Journal最新文献

CatWalk XT Gait Parameters Associated with Mouse Achilles Tendon Injury and Healing.

IF 0.5

MLTJ-Muscles Ligaments and Tendons Journal Pub Date : 2024-04-01 DOI: 10.32098/mltj.02.2024.19

Giulia Crosio, Emily R King, Alice H Huang

{"title":"CatWalk XT Gait Parameters Associated with Mouse Achilles Tendon Injury and Healing.","authors":"Giulia Crosio, Emily R King, Alice H Huang","doi":"10.32098/mltj.02.2024.19","DOIUrl":"https://doi.org/10.32098/mltj.02.2024.19","url":null,"abstract":"<p><p>Tendons are connective tissues with limited healing potential which results in permanently impaired function. Although direct mechanical testing of tendon remains the gold standard for functional analyses, this assay is terminal and tracking healing over time requires the use of many animals. An alternative method for quantifying tendon function is gait analysis, which is non-terminal and enables longitudinal tracking of the same animal. To date, commercial systems used to analyze gait are mostly applied to study neurobehavior, and applications for tendon research has been limited. Since these systems typically output many parameters, it is challenging to know which parameter is most relevant for a specific injury model. To address this challenge, we used a well-established rodent locomotion system (CatWalk XT) to measure longitudinal gait parameters in sham and Achilles tendon-injured mice (from PREOP to 56 days post-injury) and identified relevant and reproducible parameters specifically associated with Achilles tendon injury and healing. Micro computed tomography (micro-CT) and mechanical testing also confirmed persistent tendon impairment in the same animals at the terminal timepoint. Collectively, our results provide a useful reference and recommendation of CatWalk gait parameters and the control comparisons that both conserve the use of animals while maintaining high reproducibility standards for Achilles tendon injury studies.</p>","PeriodicalId":46318,"journal":{"name":"MLTJ-Muscles Ligaments and Tendons Journal","volume":"14 2","pages":"376-385"},"PeriodicalIF":0.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Straightforward Approach to Analyze Skeletal Muscle MRI in Limb-Girdle Muscular Dystrophy for Differential Diagnosis: A Systematic Review 一个简单的方法来分析骨骼肌MRI在四肢带状肌萎缩症的鉴别诊断:一个系统的回顾

MLTJ-Muscles Ligaments and Tendons Journal Pub Date : 2023-11-08 DOI: 10.3390/muscles2040029

Ryo Morishima, Benedikt Schoser

{"title":"A Straightforward Approach to Analyze Skeletal Muscle MRI in Limb-Girdle Muscular Dystrophy for Differential Diagnosis: A Systematic Review","authors":"Ryo Morishima, Benedikt Schoser","doi":"10.3390/muscles2040029","DOIUrl":"https://doi.org/10.3390/muscles2040029","url":null,"abstract":"Skeletal muscle MRI studies in limb-girdle muscular dystrophy (LGMD) have increased over the past decades, improving the utility of MRI as a differential diagnostic tool. Nevertheless, the relative rarity of individual genotypes limits the scope of what each study can address, making it challenging to obtain a comprehensive overview of the MRI image of this splintered group. Furthermore, MRI studies have varied in their methods for assessing fat infiltration, which is essential in skeletal muscle MRI evaluation. It stayed problematic and impeded attempts to integrate multiple studies to cover the core MRI features of a distinct LGMD. In this study, we conducted a systematic review of LGMD in adults published until April 2023; 935 references were screened in PubMed and EMBASE, searches of the gray literature, and additional records were added during the screening process. Finally, 39 studies were included in our final analysis. We attempted to quantitatively synthesize the MRI data sets from the 39 individual studies. Finally, we illustrated ideal and simple MRI muscle involvement patterns of six representative LGMD genotypes. Our summary synthesis reveals a distinct distribution pattern of affected muscles by LGMD genotypes, which may be helpful for a quick first-tier differential diagnosis guiding genetic diagnostics.","PeriodicalId":46318,"journal":{"name":"MLTJ-Muscles Ligaments and Tendons Journal","volume":"343 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135392334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Electromyographic Biofeedback in the Recovery of the Vastus Lateralis after Knee Injury: A Single-Group Case Study 肌电生物反馈在膝关节损伤后股外侧肌恢复中的疗效:单组病例研究

MLTJ-Muscles Ligaments and Tendons Journal Pub Date : 2023-11-07 DOI: 10.3390/muscles2040028

Verónica Morales-Sánchez, Rafael E. Reigal, Raul Antunes, Rui Matos, Antonio Hernández-Mendo, Diogo Monteiro

{"title":"Efficacy of Electromyographic Biofeedback in the Recovery of the Vastus Lateralis after Knee Injury: A Single-Group Case Study","authors":"Verónica Morales-Sánchez, Rafael E. Reigal, Raul Antunes, Rui Matos, Antonio Hernández-Mendo, Diogo Monteiro","doi":"10.3390/muscles2040028","DOIUrl":"https://doi.org/10.3390/muscles2040028","url":null,"abstract":"Electromyographic biofeedback (EMG-BF) is a technique that can contribute to the improvement of muscle tone and control in the rehabilitation process after injury. The aim of this research was to determine the effectiveness of EMG-BF in increasing the electromyographic activity of the vastus lateralis after knee injury. The sample consisted of four individuals who had undergone surgery or rehabilitation to resolve either a partial meniscal tear or a patellar tendon strain. The intervention consisted of a program of ten sessions of EMG-BF work. Twelve trials were performed in each session, in which participants were instructed to target the muscle tension produced by the vastus lateralis of the uninjured hemilateral limb. Of the twelve trials in each session, the first three and the last three were performed without feedback, and the intermediate six with feedback. The recording of muscle activity was performed using CY-351/2 Mioback equipment, which allowed the amplitude of the electromyographic signal to be evaluated. The results indicated that the sample analyzed reached greater amplitude during the biofeedback trials, both for the maximum (Z = −13.43, p < 0.001, Cohen’s d = 0.64, 95% CI (0.27, 1.01)) and mean (Z = −7.26, p < 0.001, Cohen’s d = 0.24, 95% CI (−0.12, 0.60)) values. The amplitude also increased throughout the ten sessions, both for the maximum (Z = −3.06, p < 0.01, Cohen’s d = 1.37, 95% CI (0.29, 2.45)) and mean (Z = −3.06, p < 0.01, Cohen’s d = 1.20, 95% CI (0.34, 2.08)) values. Thus, the results highlight the efficacy of this technique in improving muscle activity, suggesting that it is a useful therapeutic procedure in injury recovery.","PeriodicalId":46318,"journal":{"name":"MLTJ-Muscles Ligaments and Tendons Journal","volume":"1 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135432969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Correlation between Core Muscular Endurance, Body Composition, and Back Pain in Firefighters: An Observational Study 核心肌肉耐力、身体成分和消防员背部疼痛之间的相关性:一项观察性研究

MLTJ-Muscles Ligaments and Tendons Journal Pub Date : 2023-10-24 DOI: 10.3390/muscles2040027

Shelby Sanregret, Austin Alan Kohler, Andrew Ray Moore, Angelia Maleah Holland-Winkler

{"title":"The Correlation between Core Muscular Endurance, Body Composition, and Back Pain in Firefighters: An Observational Study","authors":"Shelby Sanregret, Austin Alan Kohler, Andrew Ray Moore, Angelia Maleah Holland-Winkler","doi":"10.3390/muscles2040027","DOIUrl":"https://doi.org/10.3390/muscles2040027","url":null,"abstract":"Firefighters are at a higher risk for experiencing back pain due to the nature of their job, but physical fitness may help to reduce this risk. Therefore, the primary purpose of this study was to determine if a correlation between subjective back pain severity and core muscular endurance exists in firefighters. A secondary purpose was to determine if age or body composition were correlated with back pain severity. This cross-sectional study was performed at a fire department during their Physical Fitness Assessment Program and included 72 male firefighters. Measures included weight, body fat percentage, maximal plank hold times for core muscular endurance, and the Oswestry Low Back Pain Disability Questionnaire. A Pearson product correlation analysis was performed between back pain score and each of the following variables: body fat percentage, BMI, age, and plank hold times. A second set of correlation coefficient analyses was performed between the same variables exclusively in subjects who reported back pain. This study found that, within this population of firefighters, there was no significant correlation between back pain and plank times or body composition variables, although there was a trend toward significant correlations between BMI and body fat percentage when only subjects with back pain were considered.","PeriodicalId":46318,"journal":{"name":"MLTJ-Muscles Ligaments and Tendons Journal","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135266178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances and Prospects in Understanding Vertebrate Cardiac Conduction System, Pacemaker Cell, and Cardiac Muscle Development: Toward Novel Biological Therapies 了解脊椎动物心脏传导系统、起搏器细胞和心肌发育的进展与展望:迈向新的生物疗法

MLTJ-Muscles Ligaments and Tendons Journal Pub Date : 2023-10-12 DOI: 10.3390/muscles2040026

Ridwan Opeyemi Bello, Shannon Frew, Yusra Siddiqui, Rashid Minhas

{"title":"Advances and Prospects in Understanding Vertebrate Cardiac Conduction System, Pacemaker Cell, and Cardiac Muscle Development: Toward Novel Biological Therapies","authors":"Ridwan Opeyemi Bello, Shannon Frew, Yusra Siddiqui, Rashid Minhas","doi":"10.3390/muscles2040026","DOIUrl":"https://doi.org/10.3390/muscles2040026","url":null,"abstract":"The heart is composed of muscle cells called cardiomyocytes, including a specialized population named pacemaker cells that form the cardiac conduction system (CCS), which is responsible for generating the action potential dictating heart contractions. Failure of the CCS system leads to cardiac arrhythmias, which require complicated therapies and often the surgical implantation of electrical pacemakers. However, recent research has focused on the development of novel therapies using biological pacemakers that aim to substitute electrical devices. While most signaling pathways and transcription factors involved in the development of the pacemaker cells are known, the upstream regulatory networks need to be predicted through computer-based databases, mathematical modeling, as well as the functional testing of the regulatory elements in vivo, indicating the need for further research. Here, we summarize the current knowledge about the vertebrate myocardial CCS system and the development of the pacemaker cells, as well as emphasize the areas of future research to clarify the regulation of muscle pacemaker cells and the ease of development of biological therapies.","PeriodicalId":46318,"journal":{"name":"MLTJ-Muscles Ligaments and Tendons Journal","volume":"249 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136013690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discrepancy of Beta-Hydroxybutyrate Measurements between a Blood Meter and GC-MS Methods in Healthy Humans 健康人血液计与气相色谱-质谱法测定β -羟基丁酸的差异

MLTJ-Muscles Ligaments and Tendons Journal Pub Date : 2023-09-27 DOI: 10.3390/muscles2040025

Angelia Maleah Holland-Winkler, Andrew R. Moore, Jenna K. Ansley, Noah A. Fritz, Ilya Bederman

{"title":"Discrepancy of Beta-Hydroxybutyrate Measurements between a Blood Meter and GC-MS Methods in Healthy Humans","authors":"Angelia Maleah Holland-Winkler, Andrew R. Moore, Jenna K. Ansley, Noah A. Fritz, Ilya Bederman","doi":"10.3390/muscles2040025","DOIUrl":"https://doi.org/10.3390/muscles2040025","url":null,"abstract":"Ketone salt (KS) supplementation induces temporary nutritional ketosis to achieve potential exercise performance and health benefits. Racemic KS includes both D/L isomers of β-hydroxybutyrate, yet commercially available measurement devices (i.e., blood meters) only measure the D variant. The aim of this study was to investigate the efficacy of a blood meter to measure serum β-hydroxybutyrate in comparison with gas chromatography–mass spectrometry (GC-MS) before and 30 min after consuming a placebo or racemic KS. In this triple-blinded cross-over study, 16 healthy adults were administered either a placebo or KS drink, and the circulating β-hydroxybutyrate concentration was measured at baseline (PRE) and 30 min following consumption (POST) using a blood ketone meter and by GC-MS. Compared to the placebo, both GC-MS and the blood meter obtained significantly greater β-hydroxybutyrate levels from PRE to POST time-points after consuming KS. Additionally, GC-MS results showed significantly higher levels of β-hydroxybutyrate with both the placebo and KS at PRE and POST time-points, as compared to the blood meter. These results indicate that (1) even in the absence of KS, the blood meter yields significantly lower β-hydroxybutyrate values than GC-MS, and (2) the inability of the blood meter to measure L-β-hydroxybutyrate values POST KS warrants the further development of publicly available ketone measurement apparatuses.","PeriodicalId":46318,"journal":{"name":"MLTJ-Muscles Ligaments and Tendons Journal","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135537108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Loop Diuretics and Sarcopenia: A Potential Association 袢利尿剂和肌肉减少症:潜在的关联

MLTJ-Muscles Ligaments and Tendons Journal Pub Date : 2023-09-22 DOI: 10.3390/muscles2040024

Nikolaos D. Karakousis, Petros N. Georgakopoulos

{"title":"Loop Diuretics and Sarcopenia: A Potential Association","authors":"Nikolaos D. Karakousis, Petros N. Georgakopoulos","doi":"10.3390/muscles2040024","DOIUrl":"https://doi.org/10.3390/muscles2040024","url":null,"abstract":"Background: Loop diuretics (LDs) are used to treat various health conditions including heart failure (HF), liver cirrhosis, and chronic kidney disease (CKD). Sarcopenia is a skeletal muscle health issue related to the depletion and decrease of muscle mass and strength, leading to adverse outcomes including frailty syndrome, functional decline, falls, hospitalizations, augmented length of hospital stay, and increased morbidity and mortality. Methods: This study investigated the probable association between LD use and sarcopenia via conducting a non-systematic review of the existing literature. Results: In subjects with non-dialysis-dependent chronic kidney disease (NDD-CKD), an augmented risk of sarcopenia is significantly associated with LD use. Interestingly, in patients with HF treated with LDs, thigh and arm circumferences were significantly small, which is indicative of skeletal muscle wasting. Additionally, in anorexic subjects who are more likely to be on diuretic medication, suffering also from cachexia, a higher prevalence of sarcopenia was demonstrated. In cirrhotic subjects, the treatment dosage of LDs was inversely correlated with the skeletal muscle area per year (ΔSMA). Nevertheless, in subjects with liver cirrhosis treated with LDs, who were divided into those with and those without muscle cramps, the presence of sarcopenia was similar. Conclusions: Further investigation is imperative to validate potential interplay between LDs and sarcopenia.","PeriodicalId":46318,"journal":{"name":"MLTJ-Muscles Ligaments and Tendons Journal","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136061317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Degradative Signaling in ATG7-Deficient Skeletal Muscle Following Cardiotoxin Injury 心脏毒素损伤后atg7缺陷骨骼肌中的降解信号

MLTJ-Muscles Ligaments and Tendons Journal Pub Date : 2023-09-15 DOI: 10.3390/muscles2030023

Fasih Ahmad Rahman, Troy Campbell, Darin Bloemberg, Sarah Chapman, Joe Quadrilatero

{"title":"Degradative Signaling in ATG7-Deficient Skeletal Muscle Following Cardiotoxin Injury","authors":"Fasih Ahmad Rahman, Troy Campbell, Darin Bloemberg, Sarah Chapman, Joe Quadrilatero","doi":"10.3390/muscles2030023","DOIUrl":"https://doi.org/10.3390/muscles2030023","url":null,"abstract":"Skeletal muscle is a complex tissue comprising multinucleated and post-mitotic cells (i.e., myofibers). Given this, skeletal muscle must maintain a fine balance between growth and degradative signals. A major system regulating the remodeling of skeletal muscle is autophagy, where cellular quality control is mediated by the degradation of damaged cellular components. The accumulation of damaged cellular material can result in elevated apoptotic signaling, which is particularly relevant in skeletal muscle given its post-mitotic nature. Luckily, skeletal muscle possesses the unique ability to regenerate in response to injury. It is unknown whether a relationship between autophagy and apoptotic signaling exists in injured skeletal muscle and how autophagy deficiency influences myofiber apoptosis and regeneration. In the present study, we demonstrate that an initial inducible muscle-specific autophagy deficiency does not alter apoptotic signaling following cardiotoxin injury. This finding is presumably due to the re-establishment of ATG7 levels following injury, which may be attributed to the contribution of a functional Atg7 gene from satellite cells. Furthermore, the re-expression of ATG7 resulted in virtually identical regenerative potential. Overall, our data demonstrate that catastrophic injury may “reset” muscle gene expression via the incorporation of nuclei from satellite cells.","PeriodicalId":46318,"journal":{"name":"MLTJ-Muscles Ligaments and Tendons Journal","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135438369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-Cultural Adaptation and Validation of the Italian Version of the Spine Functional Index 意大利语版脊柱功能索引的跨文化适应与验证

MLTJ-Muscles Ligaments and Tendons Journal Pub Date : 2023-09-01 DOI: 10.32098/mltj.03.2023.05

L. Pannuti, A. Marsocci, F. Curti, G. Maggi, B. Petrone, A. Peretti, E. Ruberti, F. Magnifica

引用次数: 0

Quality and Reliability of Trigger Finger YouTube Videos 触发手指YouTube视频的质量和可靠性

MLTJ-Muscles Ligaments and Tendons Journal Pub Date : 2023-09-01 DOI: 10.32098/mltj.03.2023.16

K. Uzel, M.K. Yilmaz, M. A. Çaçan, M. Artuc

引用次数: 0