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Infant Feeding Practices of HIV Positive Mothers and Its Association with Counseling and HIV Disclosure Status in Ethiopia: A Systematic Review and Meta-Analysis 埃塞俄比亚艾滋病毒阳性母亲的婴儿喂养实践及其与咨询和艾滋病毒披露状况的关系:系统回顾和荟萃分析
IF 1.7
AIDS Research and Treatment Pub Date : 2019-08-01 DOI: 10.1155/2019/3862098
Getaneh Mulualem Belay, Chalachew Adugna Wubneh
{"title":"Infant Feeding Practices of HIV Positive Mothers and Its Association with Counseling and HIV Disclosure Status in Ethiopia: A Systematic Review and Meta-Analysis","authors":"Getaneh Mulualem Belay, Chalachew Adugna Wubneh","doi":"10.1155/2019/3862098","DOIUrl":"https://doi.org/10.1155/2019/3862098","url":null,"abstract":"Introduction Breastfeeding is the ideal food source for all newborns globally. However, in the era of Human Immune Deficiency Virus (HIV) infection, feeding practice is a challenge due to mother-to-child HIV transmission. Therefore, this systematic review and meta-analysis aimed to estimate the national prevalence of exclusive breastfeeding and mixed feeding practices among HIV positive mothers and its association with counseling and HIV disclosure status to the spouse in Ethiopia. Methods We searched all available articles from the electronic databases including PubMed, EMBASE, Google Scholar, and the Web of Science. Moreover, reference lists of the included studies and the Ethiopian institutional research repositories were used. Searching of articles was limited to the studies conducted in Ethiopia and published in English language. We have included observational studies including cohort, cross-sectional, and case-control studies. The weighted inverse variance random effects model was used. The overall variations between studies were checked through heterogeneity test (I2). Subgroup analysis by region was conducted. To assess the quality of the study, the Joanna Briggs Institute (JBI) quality appraisal criteria were employed. Publication bias was checked with the funnel plot and Egger's regression test. Result A total of 18 studies with 4,844 participants were included in this study. The national pooled prevalence of exclusive breastfeeding and mixed feeding practices among HIV positive mothers were 63.43% (95% CI: 48.19, 78.68) and 23.11% (95% CI: 10.10, 36.13), respectively. In the subgroup analysis, the highest prevalence of exclusive breastfeeding practice was observed in Tigray (90.12%) and the lowest in Addis Ababa (41.92%). Counseling on feeding option with an odds ratio of 4.32 (95% CI: 2.75, 6.77) and HIV disclosure status to the spouse with an odds ratio of 6.05 (95% CI: 3.03, 12.06) were significantly associated with exclusive breast feedings practices. Conclusion Most mothers report exclusive breastfeeding, but there are still almost a quarter of mothers who mix feed. Counseling on feeding options and HIV disclosure status to the spouse should be improved.","PeriodicalId":46303,"journal":{"name":"AIDS Research and Treatment","volume":"2019 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/3862098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41418097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Factors Affecting Psychological Distress among People Living with HIV/AIDS at Selected Hospitals of North Shewa Zone, Amhara Region, Ethiopia 影响埃塞俄比亚阿姆哈拉地区北谢瓦区选定医院艾滋病毒/艾滋病感染者心理困扰的因素
IF 1.7
AIDS Research and Treatment Pub Date : 2019-07-22 DOI: 10.1155/2019/8329483
Elyas Admasu Basha, B. Derseh, Y. Haile, Gedion Tafere
{"title":"Factors Affecting Psychological Distress among People Living with HIV/AIDS at Selected Hospitals of North Shewa Zone, Amhara Region, Ethiopia","authors":"Elyas Admasu Basha, B. Derseh, Y. Haile, Gedion Tafere","doi":"10.1155/2019/8329483","DOIUrl":"https://doi.org/10.1155/2019/8329483","url":null,"abstract":"Background The new advances for the treatment of HIV infection using Highly Active Antiretroviral Therapy (HAART) have dramatically improved disease prognosis. However, they are living longer with a chronic condition that increases the risk for psychiatric and psychosocial problems. Various studies have linked HIV/AIDS with a number of psychological problems, depression being the most common. Moreover, studies have found that chronically ill people are at increased risk of psychological problems. Thus, this study aimed at assessing the level of psychological distress and its associated factors among people living with HIV/AIDS in selected Hospitals of North Sowa Zone of Amhara region, Ethiopia, 2017. Method Institution based cross-sectional study design with systematic random sampling method was used. Data was collected by structured interviewer-based Amharic version questionnaire. A total of 422 people living with HIV/AIDS were involved in the study from 1 to 30 May 2017. Data analysis was done with the help of a computer program (SPSS version 16.0). Binary logistic regression analysis was used for bivariate and multivariate analysis. The strength of the association was presented by odds ratio with a 95% confidence interval. Result The prevalence of psychological distress was 7.8% (95% CI: 5.25%, 10.39%). Being female (AOR = 3.02; 95% CI: 1.16, 7.82), illiterates (AOR = 3.91; 95% CI: 1.31, 6.45), participants who currently use alcohol (AOR = 2.70; 95% CI: 1.23, 5.88), respondents whose CD4 count is less than 500 cells/μl (AOR = 2.28; 95% CI: 1.02, 5.11), and participants who are considered stigmatized (AOR = 2.41; 95% CI: 1.11, 5.22) were positively associated with psychological distress. Conclusion The prevalence of psychological distress was low as compared to other studies conducted in Ethiopia. This may affect the quality of life of people living with HIV/AIDS and their families. Being female, illiteracy, alcohol use, and having lower CD4 count and perceived stigma increased the odds of psychological distress. Thus, concerned stakeholders should collaborate on the integration of HIV/AIDs treatment and mental health services.","PeriodicalId":46303,"journal":{"name":"AIDS Research and Treatment","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2019-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/8329483","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43461226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Facilitators to Accessibility of HIV/AIDS-Related Health Services among Transgender Women Living with HIV in Yogyakarta, Indonesia 印度尼西亚日惹感染艾滋病毒的跨性别妇女获得艾滋病毒/艾滋病相关保健服务的促进者
IF 1.7
AIDS Research and Treatment Pub Date : 2019-07-01 DOI: 10.1155/2019/6045726
N. Fauk, M. Merry, T. A. Siri, Fabiola Tazrina Tazir, M. Sigilipoe, Kristin Oktanita Tarigan, L. Mwanri
{"title":"Facilitators to Accessibility of HIV/AIDS-Related Health Services among Transgender Women Living with HIV in Yogyakarta, Indonesia","authors":"N. Fauk, M. Merry, T. A. Siri, Fabiola Tazrina Tazir, M. Sigilipoe, Kristin Oktanita Tarigan, L. Mwanri","doi":"10.1155/2019/6045726","DOIUrl":"https://doi.org/10.1155/2019/6045726","url":null,"abstract":"The study aimed to explore facilitators or enabling factors that enhance accessibility (defined as the opportunity to be able to use) to HIV/AIDS-related health services among HIV positive transgender women, also known as Waria in Yogyakarta, Indonesia. A qualitative study employing one-on-one in-depth interviews was conducted from December 2017 to February 2018. Participants were HIV positive Waria recruited using purposive and snowball sampling techniques. Data were analysed using the framework analysis for qualitative research. The findings showed that participants' knowledge of HIV/AIDS and the availability of HIV/AIDS-related health services were enablers to the services accessibility. Emotional support from fellow Waria displayed in various ways, such as kind and caring attention, attentive listening, and encouraging words, was an important social support that played a role in supporting Waria's accessibility to the services. HIV/AIDS-related health service information shared personally or jointly by fellow Waria and instrumental support including helping each other to collect antiretroviral (ARV) from hospitals or community health centres, contacting ambulance in emergency situations, accompanying each other to health service facilities, and helping those without the health insurance to receive free health services were also the social support enabling accessibility to the services among the study participants. Appraisal support such as providing constructive feedback and affirmation was another enabling factor to Waria's accessibility to the services. The findings indicate the needs to broadly disseminate information and educate Waria populations and their significant others about HIV/AIDS and related health services to raise their awareness of HIV/AIDS and acceptance of HIV/AIDS positive individuals. Educating and broadly disseminating this information in other settings in the country will also increase accessibility to the HIV/AIDS services among Waria, their families, and communities addressing the currently existing inequities in health. The findings also reinforce the importance of the establishment of Waria peer-support groups within Waria communities and the involvement of Waria in HIV/AIDS activities and programs, which may increase their awareness of HIV/AIDS, and accessibility to HIV/AIDS-related health services.","PeriodicalId":46303,"journal":{"name":"AIDS Research and Treatment","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/6045726","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48336476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
High Human Immunodeficiency Virus (HIV) Viral Load and Coinfection with Viral Hepatitis Are Associated with Liver Enzyme Abnormalities among HIV Seropositive Patients on Antiretroviral Therapy in the Lake Victoria Zone, Tanzania. 在坦桑尼亚维多利亚湖地区接受抗逆转录病毒治疗的HIV血清阳性患者中,高人类免疫缺陷病毒(HIV)病毒载量和病毒性肝炎合并感染与肝酶异常相关。
IF 1.7
AIDS Research and Treatment Pub Date : 2019-06-02 eCollection Date: 2019-01-01 DOI: 10.1155/2019/6375714
Shabani Iddi, Caroline A Minja, Vitus Silago, Asteria Benjamin, Jastine Mpesha, Shimba Henerico, Benson R Kidenya, Stephen E Mshana, Mariam M Mirambo
{"title":"High Human Immunodeficiency Virus (HIV) Viral Load and Coinfection with Viral Hepatitis Are Associated with Liver Enzyme Abnormalities among HIV Seropositive Patients on Antiretroviral Therapy in the Lake Victoria Zone, Tanzania.","authors":"Shabani Iddi,&nbsp;Caroline A Minja,&nbsp;Vitus Silago,&nbsp;Asteria Benjamin,&nbsp;Jastine Mpesha,&nbsp;Shimba Henerico,&nbsp;Benson R Kidenya,&nbsp;Stephen E Mshana,&nbsp;Mariam M Mirambo","doi":"10.1155/2019/6375714","DOIUrl":"https://doi.org/10.1155/2019/6375714","url":null,"abstract":"<p><strong>Background: </strong>Liver enzymes abnormalities have been found to be common among patients on antiretroviral treatment (ART). Apart from the effects of ART on these changes, other factors that can potentially contribute to the abnormal levels of these enzymes have been found to vary in different geographical locations. This study investigated factors associated with liver enzymes abnormalities among human immunodeficiency virus (HIV) infected individuals on ART from the Lake Victoria zone, Tanzania.</p><p><strong>Methods: </strong>A cross-sectional study involving a total of 230 sera from HIV seropositive patients from different regions of the Lake Victoria zone was carried out in July 2017. All samples with required variables/parameters such as age, sex, ART regimen, and residence were serially included in the study. Hepatitis B virus (HBV) and Hepatitis C virus (HCV) detection and liver enzymes assays (alanine transaminase (ALAT) and aspartate transaminase (ASAT)) were assessed following the standard procedures. Data were analyzed by using STATA version 13.</p><p><strong>Results: </strong>The median age of the study participants was 38 (interquartile range [IQR]:30-48) years. The overall prevalence of abnormal liver enzymes was 43.04% (99/230, 95% CI: 36.6-49.3). A total of 26.09% (60/230) had elevated ASAT while 23.9% (55/230) patients had elevated ALAT levels. ASAT levels were significantly high among patients with high HIV viral load (P= 0.002) while ALAT levels were significantly high among those coinfected with hepatitis C virus (P=0.017) and hepatitis B virus (P<0.001).</p><p><strong>Conclusion: </strong>A significant proportion of HIV seropositive individuals on ART have abnormal levels of liver enzymes, which is significantly associated with high HIV viral load and viral hepatitis. This calls for the need to emphasize screening of viral hepatitis and provision of appropriate management among HIV seropositive individuals in this setting.</p>","PeriodicalId":46303,"journal":{"name":"AIDS Research and Treatment","volume":"2019 ","pages":"6375714"},"PeriodicalIF":1.7,"publicationDate":"2019-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/6375714","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37392518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
The Incremental Cost of Delivering PrEP as a Bridge to ART for HIV Serodiscordant Couples in Public HIV Care Clinics in Kenya. 在肯尼亚公共艾滋病毒护理诊所为艾滋病毒血清不一致的夫妇提供PrEP作为抗逆转录病毒治疗的桥梁的增量成本
IF 1.7
AIDS Research and Treatment Pub Date : 2019-05-02 eCollection Date: 2019-01-01 DOI: 10.1155/2019/4170615
Elizabeth M Irungu, Monisha Sharma, Christopher Maronga, Nelly Mugo, Kenneth Ngure, Connie Celum, Ruanne V Barnabas, Jared Baeten, Renee Heffron
{"title":"The Incremental Cost of Delivering PrEP as a Bridge to ART for HIV Serodiscordant Couples in Public HIV Care Clinics in Kenya.","authors":"Elizabeth M Irungu,&nbsp;Monisha Sharma,&nbsp;Christopher Maronga,&nbsp;Nelly Mugo,&nbsp;Kenneth Ngure,&nbsp;Connie Celum,&nbsp;Ruanne V Barnabas,&nbsp;Jared Baeten,&nbsp;Renee Heffron","doi":"10.1155/2019/4170615","DOIUrl":"https://doi.org/10.1155/2019/4170615","url":null,"abstract":"<p><strong>Background: </strong>In 2016, the Kenyan Ministry of Health (MOH) released guidelines that recommend preexposure prophylaxis (PrEP) for persons with substantial ongoing HIV risk, including those in HIV serodiscordant partnerships. Estimates of the costs of delivering PrEP within Kenyan public health facilities are needed for planning for PrEP scale up.</p><p><strong>Methods: </strong>We estimated the incremental annual costs of providing PrEP to HIV uninfected partners as a time-limited \"bridge\" until the infected partner is virally suppressed on ART within HIV serodiscordant couples as part of routine clinic care in Thika, Kenya. Costs were collected from the Partners Demonstration Project, a prospective evaluation of integrated delivery of preexposure prophylaxis (PrEP) and antiretroviral therapy (ART) to high-risk HIV serodiscordant couples. We conducted time and motion studies to distinguish between activities related to research, routine clinical care, and PrEP delivery. Costs (2015 US dollars) were collected from the MOH perspective and divided into staff, transportation, equipment, supplies, buildings and overhead, and start-up.</p><p><strong>Results: </strong>PrEP related activities conducted during the screening, enrollment, and follow-up visits took an average of 13 minutes, 51 minutes, and 12 minutes, respectively. Assuming a staff structure of 3 counselors, 1 nurse, and 2 clinicians, we estimate that 3,178 couples can be screened, 1,444 couples offered PrEP and ART, and 6,138 couples followed up annually in an average HIV care clinic. Using costs incurred by the MOH for personnel, drug, and laboratory tests, we estimate that the incremental cost of offering PrEP to HIV uninfected partners within existing ART programs is $86.79 per couple per year. Personnel and PrEP medication made up the largest portion of the costs. We estimate that the total cost to Ministry of Health of delivering integrated PrEP and ART program in public health facilities is $250.19 per HIV serodiscordant couple per year.</p><p><strong>Conclusions: </strong>Time-limited provision of PrEP to the HIV uninfected partner within HIV serodiscordant couples can be an affordable delivery model implemented in HIV care programs in Kenya and similar settings. These costs can be used for budgetary planning and cost effectiveness analyses.</p>","PeriodicalId":46303,"journal":{"name":"AIDS Research and Treatment","volume":"2019 ","pages":"4170615"},"PeriodicalIF":1.7,"publicationDate":"2019-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/4170615","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37318205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Delayed Antiretroviral Therapy (ART) Initiation among Hospitalized Adults in a Resource-Limited Settings: A Challenge to the Global Target of ART for 90% of HIV-Infected Individuals. 在资源有限的环境中,住院成人的延迟抗逆转录病毒治疗(ART)启动:对90%HIV感染者的ART全球目标的挑战。
IF 1.7
AIDS Research and Treatment Pub Date : 2019-04-01 eCollection Date: 2019-01-01 DOI: 10.1155/2019/1832152
Prossie Merab Ingabire, Fred Semitala, Moses R Kamya, Damalie Nakanjako
{"title":"Delayed Antiretroviral Therapy (ART) Initiation among Hospitalized Adults in a Resource-Limited Settings: A Challenge to the Global Target of ART for 90% of HIV-Infected Individuals.","authors":"Prossie Merab Ingabire, Fred Semitala, Moses R Kamya, Damalie Nakanjako","doi":"10.1155/2019/1832152","DOIUrl":"10.1155/2019/1832152","url":null,"abstract":"<p><strong>Background: </strong>Combination antiretroviral therapy (cART) initiation in hospital settings, where individuals often present with undiagnosed, untreated, advanced HIV disease, is not well understood.</p><p><strong>Methods: </strong>A cross-sectional study was conducted to determine a period prevalence of cART initiation within two weeks of eligibility, as determined at hospitalization. Using a pretested and precoded data extraction tool, data on cART initiation status and reason for not initiating cART was collected. Phone calls were made to patients that had left the hospital by the end of the two-week period. Delayed cART initiation was defined as failure to initiate cART within two weeks. Sociodemographic characteristics, WHO clinical stage, CD4 count, cART initiation status, and reasons for delayed cART initiation were extracted and analyzed.</p><p><strong>Results: </strong>Overall, 386 HIV-infected adults were enrolled, of whom 289/386 (74.9%) had delayed cART initiation, 77/386 (19.9%) initiated cART, and 20/386 (5.2%) were lost-to-follow-up, within two weeks of cART eligibility. Of 289 with delayed ART initiation, 94 (32.5%) died within two weeks of cART eligibility. Patients with a CD4 cell count≥ 50 cells/<i>μ</i>l and who resided in ≥8 kilometers from the hospital were more likely to have delayed cART initiation [adjusted odds ratio (AOR) 2.34, 95% CI: 1.33-4.10, p value 0.003; and AOR 1.92, 95% CI: 1.09-3.40, p value 0.025; respectively].</p><p><strong>Conclusion: </strong>Up to 75% of hospitalized HIV-infected, cART-naïve, cART-eligible patients did not initiate cART and had a 33% pre-ART mortality rate within two weeks of eligibility for cART. Hospital based strategies to hasten cART initiation during hospitalization and electronic patient tracking systems could promote active linkage to HIV treatment programs, to prevent HIV/AIDS-associated mortality in resource-limited settings.</p>","PeriodicalId":46303,"journal":{"name":"AIDS Research and Treatment","volume":"2019 ","pages":"1832152"},"PeriodicalIF":1.7,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37216470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Consistent Condom Use and Associated Factors among HIV-Positive Clients on Antiretroviral Therapy in North West Ethiopian Health Center, 2016 GC. 埃塞俄比亚西北部卫生中心抗逆转录病毒治疗HIV阳性患者的避孕套使用情况及相关因素,2016 GC。
IF 1.7
AIDS Research and Treatment Pub Date : 2019-03-17 DOI: 10.1155/2019/7134908
Mohammed Seid Ali, Eleni Tesfaye Tegegne, Mekibib Kassa Tesemma, Kaleab Tesfaye Tegegne
{"title":"Consistent Condom Use and Associated Factors among HIV-Positive Clients on Antiretroviral Therapy in North West Ethiopian Health Center, 2016 GC.","authors":"Mohammed Seid Ali,&nbsp;Eleni Tesfaye Tegegne,&nbsp;Mekibib Kassa Tesemma,&nbsp;Kaleab Tesfaye Tegegne","doi":"10.1155/2019/7134908","DOIUrl":"10.1155/2019/7134908","url":null,"abstract":"<p><strong>Background: </strong>The burden of Human Immune Deficiency Virus or Acquired Immune Deficiency Syndrome is high in sub-Saharan countries including Ethiopia which have over two-thirds of the global HIV burden. Many would argue that consistent condom use is not most effective method for HIV prevention. Condoms offer protection against unwanted pregnancy and some sexually transmitted infections including Human Immune Deficiency Virus, when used correctly and consistently. Inconsistent use of condom by People Living with Human Immune Deficiency Virus or Acquired Immune Deficiency Syndrome on Antiretroviral Therapy will lead to further worsening the Human Immune Deficiency Virus infection epidemic and reinfection with new drug resistant viral strains.</p><p><strong>Objective: </strong>To assess magnitude of consistent condom use and associated factors among HIV-positive clients on Antiretroviral Therapy in North West Ethiopian health center, 2016 GC.</p><p><strong>Method: </strong>An institutional based cross-sectional study was conducted, from April 15 to June 10, 2016. A total of 358 patients on ART in Koladiba Health Center had participated in this research. Koladiba Health Center is the first health center in Ethiopia that is found in Debbie district, which is located in north Gondar Zone. Study participants were selected by simple random sampling technique. Data were collected by using pretested structured questionnaires and analyzed using SPSS version 22. Descriptive statistics was computed and binary and multiple logistic regressions were also conducted to examine the effect of selected independent variables on consistent condom use.</p><p><strong>Result: </strong>A total of 358 ART clients participated in the study with response rate of 90%. Among study participants, 138 (38.5%) were in the age category of 35-44 years. About 216 (60.3%) of the participants were female and 325 (90.8%) were Orthodox followers. Consistent condom use was reported by 130 (55.8%) sexually active study subjects. Respondents in rural residence (AOR=0.326, 95% CI: 0.109, 0.973) and sexual partner initiated condom use (AOR=0.031, 95% CI: 0.005, 0.186) were found to be the independent predictors of consistent condom use.</p><p><strong>Conclusion and recommendations: </strong>Consistent condom utilization among HIV clients on ART was low (55.8%). Place of residence and condom use initiation during sexual contact were significantly associated with consistent condom use. It is better to give more emphasis on health education and counseling service about consistent condom use for PLWHA who are on ART during follow-up especially for those who came from rural areas.</p>","PeriodicalId":46303,"journal":{"name":"AIDS Research and Treatment","volume":"2019 ","pages":"7134908"},"PeriodicalIF":1.7,"publicationDate":"2019-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/7134908","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37174036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 28
Corrigendum to "A Critical Review of the Evidence Concerning the HIV Latency Reversing Effect of Disulfiram, the Possible Explanations for Its Inability to Reduce the Size of the Latent Reservoir In Vivo, and the Caveats Associated with Its Use in Practice". “关于双硫仑逆转HIV潜伏期作用的证据的批判性回顾,其无法减少体内潜伏库大小的可能解释,以及与实际使用相关的注意事项”的更正。
IF 1.7
AIDS Research and Treatment Pub Date : 2019-03-13 eCollection Date: 2019-01-01 DOI: 10.1155/2019/4942573
Harry D J Knights
{"title":"Corrigendum to \"A Critical Review of the Evidence Concerning the HIV Latency Reversing Effect of Disulfiram, the Possible Explanations for Its Inability to Reduce the Size of the Latent Reservoir In Vivo, and the Caveats Associated with Its Use in Practice\".","authors":"Harry D J Knights","doi":"10.1155/2019/4942573","DOIUrl":"https://doi.org/10.1155/2019/4942573","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/2017/8239428.].</p>","PeriodicalId":46303,"journal":{"name":"AIDS Research and Treatment","volume":"2019 ","pages":"4942573"},"PeriodicalIF":1.7,"publicationDate":"2019-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/4942573","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37167998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Healthcare Workers' Perspectives on the Barriers to Providing HIV Services to Children in Sub-Saharan Africa. 保健工作者对向撒哈拉以南非洲儿童提供艾滋病毒服务的障碍的看法。
IF 1.7
AIDS Research and Treatment Pub Date : 2019-03-03 eCollection Date: 2019-01-01 DOI: 10.1155/2019/8056382
Chipo Mutambo, Khumbulani Hlongwana
{"title":"Healthcare Workers' Perspectives on the Barriers to Providing HIV Services to Children in Sub-Saharan Africa.","authors":"Chipo Mutambo,&nbsp;Khumbulani Hlongwana","doi":"10.1155/2019/8056382","DOIUrl":"https://doi.org/10.1155/2019/8056382","url":null,"abstract":"<p><strong>Background: </strong>In order to accelerate the HIV response to meet the UNAIDS 90-90-90 indicators for children, healthcare workers need to lead a scale-up of HIV services in primary healthcare settings. Such a scale-up will require investigation into existing barriers that prevent healthcare workers from effectively providing those services to children. Furthermore, if the identified barriers are not well understood, designing context-specific and effective public health response programmes may prove difficult.</p><p><strong>Objective: </strong>This study reviews the current literature pertaining to healthcare workers' perspectives on the barriers to providing HIV services to children in the primary care setting in Sub-Saharan Africa.</p><p><strong>Methods: </strong>English articles published between 2010 and April 2018 were searched in electronic databases including Sabinet, MEDLINE, PubMed, and Google Scholar. Key search words used during the search were \"healthcare workers' perspectives\" and \"barriers to providing HIV testing to children\" OR \"barriers to ART adherence AND children\" and \"barriers to HIV disclosure AND children.\" <i>Results</i>. There are various barriers to provider-initiated counselling and testing (PICT) of children and disclosure of HIV status to children, including the following: lack of child-friendly infrastructure at clinics; lack of consensus on legal age of consent for both HIV testing and disclosure; healthcare worker unfamiliarity with HIV testing and disclosure guidelines; lack of training in child psychology; and confusion around the healthcare worker's role, which most believed was only to provide health education and clinical services and to correct false information, but not to participate in disclosure. Additionally, primary caregivers were reported to be a barrier to care and treatment of children as they continue to refuse HIV testing for their children and delay disclosure.</p><p><strong>Conclusion: </strong>Training, mentoring, and providing healthcare workers with guidelines on how to provide child-focused HIV care have the potential to address the majority of the barriers to the provision of child-friendly HIV services to children. However, the need to educate primary caregivers on the importance of testing children and disclosing to them is equally important.</p>","PeriodicalId":46303,"journal":{"name":"AIDS Research and Treatment","volume":"2019 ","pages":"8056382"},"PeriodicalIF":1.7,"publicationDate":"2019-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/8056382","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37116018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Primary HIV Drug Resistance among Recently Infected Cases of HIV in North-West India. 印度西北部新近感染艾滋病毒病例的主要艾滋病毒耐药性。
IF 1.7
AIDS Research and Treatment Pub Date : 2019-02-27 eCollection Date: 2019-01-01 DOI: 10.1155/2019/1525646
C K Chauhan, P V M Lakshmi, V Sagar, A Sharma, S K Arora, R Kumar
{"title":"Primary HIV Drug Resistance among Recently Infected Cases of HIV in North-West India.","authors":"C K Chauhan,&nbsp;P V M Lakshmi,&nbsp;V Sagar,&nbsp;A Sharma,&nbsp;S K Arora,&nbsp;R Kumar","doi":"10.1155/2019/1525646","DOIUrl":"https://doi.org/10.1155/2019/1525646","url":null,"abstract":"<p><strong>Background: </strong>Antiretroviral treatment may lead to the emergence of HIV drug resistance, which can be transmitted. HIV primary drug resistance (PDR) is of great public health concern because it has the potential to compromise the efficacy of antiretroviral therapy (ART) at the population level.</p><p><strong>Objective: </strong>To estimate the level of primary drug resistance among recently infected cases of HIV in 6 ART centres of North-Western India from September 2014 to June 2016.</p><p><strong>Methods: </strong>The level of primary drug resistance was studied among 37 recently infected HIV cases identified by Limiting antigen (Lag) avidity assay based on modified Recent Infection Testing Algorithm (RITA). The reverse transcriptase region of HIV-1 <i>pol</i> gene (1-268 codons) was genotyped. The sequences were analyzed using the Calibrated Population Resistance (CPR) tool of Stanford University HIV drug resistance (DR) database to identify drug resistance.</p><p><strong>Results: </strong>Among 37 isolates studied, 6 (16.2%) samples showed primary drug resistance (PDR) against reverse transcriptase (RT) inhibitor. The proportion of primary drug resistance was 22.2% (2/9) among female sex workers, 14.3% (1/7) among men having sex with men, and 14.3% (3/21) among injecting drug users. Observed mutations were K219R, L74V, K219N, and Y181C. Injecting drug user (IDU) has showed resistance to either nucleoside/nucleotide reverse transcriptase inhibitors (NRTI) or nonnucleotide reverse transcriptase inhibitors (NNRTI).</p><p><strong>Conclusion: </strong>Resistance to either NRTI or NNRTI among the recently is a new challenge that needs to be addressed. The fact that both Y181C isolates are IDUs is important and represents 2/21 (~10%) NNRTI drug resistance. Surveillance for primary drug resistance (PDR) needs to be integrated into next generation of HIV surveillance as access to ART is increasing due to introduction of test and treat policy.</p>","PeriodicalId":46303,"journal":{"name":"AIDS Research and Treatment","volume":"2019 ","pages":"1525646"},"PeriodicalIF":1.7,"publicationDate":"2019-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/1525646","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37112145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
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