AIDS Research and Treatment最新文献_第10页

HIV Epidemic in Tanzania: The Possible Role of the Key Populations. 坦桑尼亚的艾滋病毒流行:关键人群可能发挥的作用。

IF 1.7

AIDS Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-08-17 DOI: 10.1155/2017/7089150

Bonaventura C T Mpondo, Daniel W Gunda, Semvua B Kilonzo

引用次数: 23

HIV Case Management Support Service Is Associated with Improved CD4 Counts of Patients Receiving Care at the Antiretroviral Clinic of Pantang Hospital, Ghana. 艾滋病毒病例管理支持服务与加纳潘唐医院抗逆转录病毒诊所接受治疗的患者CD4计数的改善有关。

IF 1.1

AIDS Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-09-20 DOI: 10.1155/2017/4697473

Bismark Sarfo, Naa Ashiley Vanderpuye, Abigail Addison, Peter Nyasulu

{"title":"HIV Case Management Support Service Is Associated with Improved CD4 Counts of Patients Receiving Care at the Antiretroviral Clinic of Pantang Hospital, Ghana.","authors":"Bismark Sarfo, Naa Ashiley Vanderpuye, Abigail Addison, Peter Nyasulu","doi":"10.1155/2017/4697473","DOIUrl":"10.1155/2017/4697473","url":null,"abstract":"Background: Factors associated with individual patient-level management of HIV have received minimal attention in sub-Saharan Africa. This study determined the association between support services and cluster of differentiation 4 (CD4) counts among HIV patients attending ART clinic in Ghana.Methodology: This was a cross-sectional study involving adults with HIV recruited between 1 August 2014 and 31 January 2015. Data on support services were obtained through a closed-ended personal interview while the CD4 counts data were collected from their medical records. Data were entered into EpiData and analyzed using Stata software.Results: Of the 201 patients who participated in the study, 67% (129/191) received case management support service. Counseling about how to prevent the spread of HIV (crude odds ratio (cOR) (95% confidence interval (CI)) (2.79 (1.17-6.68)), mental health services (0.2 (0.04-1.00)), and case management support service (2.80 (1.34-5.82))) was associated with improved CD4 counts of 350 cells/mm3 or more. After adjusting for counseling about how to prevent the spread of HIV and mental health services, case management support service was significantly associated with CD4 counts of 350 cells/mm3 or more (aOR = 2.36 (CI = 1.01-5.49)).Conclusion: Case management support service for HIV patients receiving ART improves their CD4 counts above 350 cells/mm3. Incorporating HIV case management services in ART regimen should be a priority in sub-Saharan Africa.","PeriodicalId":46303,"journal":{"name":"AIDS Research and Treatment","volume":"2017 ","pages":"4697473"},"PeriodicalIF":1.1,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35556245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HIV among Female Sex Workers in Five Cities in Burkina Faso: A Cross-Sectional Baseline Survey to Inform HIV/AIDS Programs. 布基纳法索五个城市女性性工作者的艾滋病毒感染情况:为艾滋病毒/艾滋病项目提供信息的横断面基线调查。

IF 1.7

AIDS Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-11-15 DOI: 10.1155/2017/9580548

Henri Gautier Ouedraogo, Odette Ky-Zerbo, Adama Baguiya, Ashley Grosso, Sara Goodman, Benoît Cesaire Samadoulougou, Marcel Lougue, Nongoba Sawadogo, Yves Traore, Nicolas Barro, Stefan Baral, Seni Kouanda

{"title":"HIV among Female Sex Workers in Five Cities in Burkina Faso: A Cross-Sectional Baseline Survey to Inform HIV/AIDS Programs.","authors":"Henri Gautier Ouedraogo, Odette Ky-Zerbo, Adama Baguiya, Ashley Grosso, Sara Goodman, Benoît Cesaire Samadoulougou, Marcel Lougue, Nongoba Sawadogo, Yves Traore, Nicolas Barro, Stefan Baral, Seni Kouanda","doi":"10.1155/2017/9580548","DOIUrl":"https://doi.org/10.1155/2017/9580548","url":null,"abstract":"Background: Female sex workers (FSWs) are considered a vulnerable population for HIV infection and a priority for HIV/AIDS response programs. This study aimed to determine HIV prevalence among FSWs in five cities in Burkina Faso.Methods: FSWs aged 18 and older were recruited using respondent driven sampling (RDS) in five cities (Ouagadougou, Bobo-Dioulasso, Koudougou, Ouahigouya, and Tenkodogo) in Burkina Faso from 2013 to 2014. HIV testing was performed using the HIV testing national algorithm. We conducted bivariate and multivariate logistic regression analysis to assess correlates of HIV in all cities combined (not RDS-adjusted).Results: Among Ouagadougou, Koudougou, and Ouahigouya FSWs, RDS-adjusted HIV prevalence was 13.5% (95% Confidence Interval [CI]: 9.6-18.7), 13.3% (95% CI: 7.6-22.4), and 13.0% (95% CI: 7.6-21.3), respectively, compared to 30.1% (95% CI: 25.5-35.1) among Bobo-Dioulasso FSWs. Factors associated with HIV infection were age (adjusted odds ratio [aOR] = 7.84 95% CI: 3.78-16.20), being married or cohabitating (aOR = 2.43, 95% CI: 1.31-4.49), and history of pregnancy (aOR = 5.24, 95% CI: 1.44-18.97).Conclusion: These results highlight the need to strengthen HIV prevention among FSWs, through behavior change strategies, and improve access to sexual and reproductive health services.","PeriodicalId":46303,"journal":{"name":"AIDS Research and Treatment","volume":"2017 ","pages":"9580548"},"PeriodicalIF":1.7,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/9580548","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35681965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Patient Experiences of Decentralized HIV Treatment and Care in Plateau State, North Central Nigeria: A Qualitative Study. 尼日利亚中北部高原州分散艾滋病毒治疗和护理的患者经验:一项定性研究。

IF 1.7

AIDS Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-02-26 DOI: 10.1155/2017/2838059

Grace O Kolawole, Hannah N Gilbert, Nancin Y Dadem, Becky L Genberg, Patricia A Agaba, Prosper Okonkwo, Oche O Agbaji, Norma C Ware

{"title":"Patient Experiences of Decentralized HIV Treatment and Care in Plateau State, North Central Nigeria: A Qualitative Study.","authors":"Grace O Kolawole, Hannah N Gilbert, Nancin Y Dadem, Becky L Genberg, Patricia A Agaba, Prosper Okonkwo, Oche O Agbaji, Norma C Ware","doi":"10.1155/2017/2838059","DOIUrl":"https://doi.org/10.1155/2017/2838059","url":null,"abstract":"Background. Decentralization of care and treatment for HIV infection in Africa makes services available in local health facilities. Decentralization has been associated with improved retention and comparable or superior treatment outcomes, but patient experiences are not well understood. Methods. We conducted a qualitative study of patient experiences in decentralized HIV care in Plateau State, north central Nigeria. Five decentralized care sites in the Plateau State Decentralization Initiative were purposefully selected. Ninety-three patients and 16 providers at these sites participated in individual interviews and focus groups. Data collection activities were audio-recorded and transcribed. Transcripts were inductively content analyzed to derive descriptive categories representing patient experiences of decentralized care. Results. Patient participants in this study experienced the transition to decentralized care as a series of \"trade-offs.\" Advantages cited included saving time and money on travel to clinic visits, avoiding dangers on the road, and the \"family-like atmosphere\" found in some decentralized clinics. Disadvantages were loss of access to ancillary services, reduced opportunities for interaction with providers, and increased risk of disclosure. Participants preferred decentralized services overall. Conclusion. Difficulty and cost of travel remain a fundamental barrier to accessing HIV care outside urban centers, suggesting increased availability of community-based services will be enthusiastically received.","PeriodicalId":46303,"journal":{"name":"AIDS Research and Treatment","volume":"2017 ","pages":"2838059"},"PeriodicalIF":1.7,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/2838059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34845602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Describing Point of Entry into Care and Being Lost to Program in a Cohort of HIV Positive Pregnant Women in a Large Urban Centre in Uganda. 描述乌干达一个大型城市中心的HIV阳性孕妇队列进入护理点和失去方案。

IF 1.7

AIDS Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-04-02 DOI: 10.1155/2017/3527563

Rachel Musomba, Frank Mubiru, Shadia Nakalema, Hope Mackline, Ivan Kalule, Agnes N Kiragga, Rosalind Parkes Ratanshi, Barbara Castelnuovo

{"title":"Describing Point of Entry into Care and Being Lost to Program in a Cohort of HIV Positive Pregnant Women in a Large Urban Centre in Uganda.","authors":"Rachel Musomba, Frank Mubiru, Shadia Nakalema, Hope Mackline, Ivan Kalule, Agnes N Kiragga, Rosalind Parkes Ratanshi, Barbara Castelnuovo","doi":"10.1155/2017/3527563","DOIUrl":"10.1155/2017/3527563","url":null,"abstract":"Introduction. We aim to describe the time of entry into care and factors associated with being lost to program (LTP) in pregnant women on Option B Plus in an integrated HIV and antenatal care (ANC) clinic in Uganda. Methods. We included all pregnant women enrolled into the integrated HIV-ANC clinic from January 2012 to 31st July 2014, while the follow up period extended up to October 30th 2015. LTP was defined as being out of care for ≥3 months. Results. Overall 856 women were included. Only 36.4% (86/236) of the women were enrolled in the first trimester. Overall 69 (8.1%) were LTP. In the multivariate analysis older women (HR: 0.80 per five-year increase, CI: 0.64-1.0, and P = 0.060) and women on ART at the time of pregnancy (0.58, CI: 0.34-0.98, and P = 0.040) were more likely not to be LTP. Among women already on ART at the time of pregnancy no factor was associated with LTP. Conclusion. Our results suggest the need for interventions to enhance prompt linkage of HIV positive women to HIV services for ART initiation and for increased retention particularly in young and ART naive women.","PeriodicalId":46303,"journal":{"name":"AIDS Research and Treatment","volume":"2017 ","pages":"3527563"},"PeriodicalIF":1.7,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/3527563","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34964592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Mortality and Its Predictors among HIV Infected Patients Taking Antiretroviral Treatment in Ethiopia: A Systematic Review. 埃塞俄比亚接受抗逆转录病毒治疗的艾滋病毒感染者死亡率及其预测因素:一项系统综述

IF 1.7

AIDS Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-10-30 DOI: 10.1155/2017/5415298

Mohammed Biset Ayalew

{"title":"Mortality and Its Predictors among HIV Infected Patients Taking Antiretroviral Treatment in Ethiopia: A Systematic Review.","authors":"Mohammed Biset Ayalew","doi":"10.1155/2017/5415298","DOIUrl":"https://doi.org/10.1155/2017/5415298","url":null,"abstract":"Background: Even though the benefit of antiretroviral therapy (ART) is well established, there is a regional variation in the extent of its benefit. The aim of this review is to highlight mortality and its predictors in Ethiopian adult HIV patients who were on ART.Methods: Relevant articles were searched on PubMed and Google Scholar databases. The search terms used in different combinations were predictor/determinant/factors, mortality/death/survival, HIV, ART/HAART, and Ethiopia.Result: 5-40.8% of the patients died during the follow-up period. More than half (50-68.8%) of the deaths occurred within 6 months of initiating ART. Advanced stage disease (stage III and stage IV), nonworking functional status (bedridden and ambulatory), low baseline CD4 count, low baseline hemoglobin level, TB coinfection, lower baseline weight, and poor treatment adherence were commonly identified as predictors of death in HIV patients.Conclusion: 5-40.8% of HIV patients in Ethiopia die in 2-5 years of initiating antiretroviral treatment. Most of the deaths in HIV patients occur early in the course of treatment. Special emphasis should be given for patients with advanced stage disease, nonworking functional status, low baseline CD4 count, low baseline hemoglobin level, TB coinfection, lower baseline weight, and poor treatment adherence.","PeriodicalId":46303,"journal":{"name":"AIDS Research and Treatment","volume":"2017 ","pages":"5415298"},"PeriodicalIF":1.7,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/5415298","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35228568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 53

Antiretroviral Treatment Adherence: Knowledge and Experiences among Adolescents and Young Adults in Soweto, South Africa. 抗逆转录病毒治疗依从性:南非索韦托青少年和年轻人的知识和经验。

IF 1.7

AIDS Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-03-20 DOI: 10.1155/2017/5192516

Stefanie Hornschuh, Janan Janine Dietrich, Celokuhle Tshabalala, Fatima Laher

{"title":"Antiretroviral Treatment Adherence: Knowledge and Experiences among Adolescents and Young Adults in Soweto, South Africa.","authors":"Stefanie Hornschuh, Janan Janine Dietrich, Celokuhle Tshabalala, Fatima Laher","doi":"10.1155/2017/5192516","DOIUrl":"https://doi.org/10.1155/2017/5192516","url":null,"abstract":"Human immunodeficiency virus (HIV) management of adolescents and young adults (AYAs) is particularly pertinent to sub-Saharan Africa, where the pediatric HIV burden is marked. Antiretroviral treatment (ART) adherence is a major challenge for AYAs. This qualitative study explored knowledge and experiences of adherence amongst AYAs attending treatment at the Perinatal HIV Research Unit (PHRU), Soweto, South Africa. Four focus group discussions (FGDs) and eight in-depth interviews (IDIs) were conducted with HIV-infected 15-25-year-old ART recipients. Transcripts were coded thematically. Participants (n = 26) were aged median 18.5 years, 59.1% female and 69.2% virally suppressed <400 cp/ml. Three main themes emerged during FGDs and IDIs: (i) correct knowledge about how to be adherent, benefits, and nonadherence consequences, (ii) social, personal, and medication-related barriers to adherence, and (iii) reminder, concealment, and motivational strategies to optimize adherence. Interventions to improve AYA adherence could focus on practical strategies, including status disclosure and medication concealment.","PeriodicalId":46303,"journal":{"name":"AIDS Research and Treatment","volume":"2017 ","pages":"5192516"},"PeriodicalIF":1.7,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/5192516","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34912139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Ritonavir-Boosted Darunavir Plus Two Nucleoside Reverse Transcriptase Inhibitors versus Other Regimens for Initial Antiretroviral Therapy for People with HIV Infection: A Systematic Review. 利托那韦加达鲁那韦加两种核苷类逆转录酶抑制剂与其他治疗方案对艾滋病病毒感染者的初始抗逆转录病毒疗法的比较：系统回顾。

IF 1.7

AIDS Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-09-26 DOI: 10.1155/2017/2345617

Tatevik Balayan, Hacsi Horvath, George W Rutherford

{"title":"Ritonavir-Boosted Darunavir Plus Two Nucleoside Reverse Transcriptase Inhibitors versus Other Regimens for Initial Antiretroviral Therapy for People with HIV Infection: A Systematic Review.","authors":"Tatevik Balayan, Hacsi Horvath, George W Rutherford","doi":"10.1155/2017/2345617","DOIUrl":"10.1155/2017/2345617","url":null,"abstract":"Background: Darunavir is a second-generation protease-inhibitor used with ritonavir (DRV/r) and two nucleoside reverse-transcriptase inhibitors as an option in first-line antiretroviral treatment (ART).Methods: We systematically reviewed randomized controlled trials (RCTs) of DRV/r versus other regimens in patients initiating ART. We searched five bibliographic databases and other key resources. We had no language limitations. We assessed bias risk with the Cochrane tool and used GRADE to assess evidence quality. We report findings in terms of risk ratio (RR) with 95% confidence intervals (CI).Findings: Three RCTs met inclusion criteria. In plasma viral load suppression, DRV/r outperformed ritonavir-boosted lopinavir at 48 weeks (RR 1.13, 95% CI 1.03-1.25), 96 weeks (RR 1.11, 95% CI 1.02-1.21), and 192 weeks (RR 1.20, 95% CI 1.07-1.35). DRV/r was similar to dolutegravir at 48 weeks (RR 0.96, 95% CI 0.87-1.06) but less effective at 96 weeks (RR 0.84, 95% CI 0.75-0.93). At 96 weeks, DRV/r underperformed raltegravir (RR 0.94, 95% CI 0.88-0.99) but was similar to ritonavir-boosted atazanavir (RR 1.02, 95% CI 0.96-1.09). Overall bias risk was moderate. Evidence quality was also moderate.Interpretation: Initial ART regimens using DRV/r should be considered in future World Health Organization guidelines.","PeriodicalId":46303,"journal":{"name":"AIDS Research and Treatment","volume":"2017 ","pages":"2345617"},"PeriodicalIF":1.7,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35503489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conceptualising the Factors Affecting Retention in Care of Patients on Antiretroviral Treatment in Kabwe District, Zambia, Using the Ecological Framework. 赞比亚卡布韦区抗逆转录病毒治疗患者护理中影响保留的因素的概念化，使用生态框架。

IF 1.7

AIDS Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-11-09 DOI: 10.1155/2017/7356362

Ferdinand C Mukumbang, Joyce Chali Mwale, Brian van Wyk

{"title":"Conceptualising the Factors Affecting Retention in Care of Patients on Antiretroviral Treatment in Kabwe District, Zambia, Using the Ecological Framework.","authors":"Ferdinand C Mukumbang, Joyce Chali Mwale, Brian van Wyk","doi":"10.1155/2017/7356362","DOIUrl":"10.1155/2017/7356362","url":null,"abstract":"Background: HIV remains a major public health challenge in Zambia. The roll-out of antiretroviral treatment (ART) has engendered new challenges in retention in care.Objective: To conceptualise the factors affecting retention in care of ART patients at three primary healthcare facilities using the ecological framework.Method: Qualitative data were collected through in-depth interviews with 45 ART patients and three focus group discussions with 20 healthcare providers from three primary healthcare facilities in Kabwe district, Zambia, and subjected to thematic content analysis.Results: Individual level barriers to retention in care included side effects, gaining weight, belief in faith healing, and use of herbal remedies and alcohol. Interpersonal barriers such as stigma and nondisclosure of HIV status were reported. At the institutional level, inadequate space in the clinic, long waiting times, long travel distances, and shortage of third-line drugs presented barriers to retention in care. Food shortages and patient mobility were reported as community barriers to retention in care.Conclusion: The ecological framework conceptualises the complex and dynamic factors affecting retention in ART care and highlights the need for multifaceted interventions that combine health education, disease management, and opportunities for income generation in a socially responsive and accountable environment.","PeriodicalId":46303,"journal":{"name":"AIDS Research and Treatment","volume":"2017 ","pages":"7356362"},"PeriodicalIF":1.7,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/7356362","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35664805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 44

Prevalence and Clinical Spectrum of Liver Disease in Nepalese HIV-Sero-Positive Patients Undergoing Antiretroviral Therapy: A Cross-Sectional Hospital Based Study. 尼泊尔接受抗逆转录病毒治疗的hiv血清阳性患者肝脏疾病的患病率和临床谱:一项基于医院的横断面研究

IF 1.7

AIDS Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-06-11 DOI: 10.1155/2017/3134790

Roshan Kumar Jha, Shiv Kumar Sah

{"title":"Prevalence and Clinical Spectrum of Liver Disease in Nepalese HIV-Sero-Positive Patients Undergoing Antiretroviral Therapy: A Cross-Sectional Hospital Based Study.","authors":"Roshan Kumar Jha, Shiv Kumar Sah","doi":"10.1155/2017/3134790","DOIUrl":"https://doi.org/10.1155/2017/3134790","url":null,"abstract":"Introduction: Liver enzyme abnormalities are common in HIV patients, and the prevalence varies across the nations. In Nepal, however, prevalence of liver enzyme disorder and the spectrum of these populations are lacking.Objective: The present study sheds light on prevalence and clinical spectrum of liver disease in Nepalese HIV-sero-positive patients.Methods: This cross-sectional study was conducted at OPD/ART, Clinic of Bir Hospital, NAMS. One hundred and forty-four HIV positive patients were enrolled consecutively and their clinical profiles of liver injury were investigated.Results: Of 144 recruited patients, liver enzyme injury was observed in 82 (56.9%). Majority 61 (42.4%) of these cases had hepatocellular type of liver injury. Opportunistic infections were reported in 18 cases, with 9 (6.2%) TB and 8 (5.6%) HCV. Test for significance of liver injury confirmed the absence of any tendency towards an association with coinfection, CD4 cells, ART regimen, and alcohol consumption (P > 0.05). However, gender significantly linked with liver injury as well as the pattern of liver injury (P < 0.05).Conclusion: The study revealed high rate of liver injury in a substantial proportion of HIV individuals, stressing that a regular clinic follow-up is necessary for the HIV individuals who are undergoing ART.","PeriodicalId":46303,"journal":{"name":"AIDS Research and Treatment","volume":"2017 ","pages":"3134790"},"PeriodicalIF":1.7,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/3134790","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35158939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2