Analytical and Bioanalytical Chemistry最新文献

{"title":"A comparative study of data-independent acquisition and data-dependent acquisition in liquid chromatography-mass spectrometry-based untargeted metabolomics analysis of Panax genus sample.","authors":"Yi Wu, Yang Wang","doi":"10.1007/s00216-025-05861-9","DOIUrl":"10.1007/s00216-025-05861-9","url":null,"abstract":"<p><p>Data-independent acquisition (DIA) and data-dependent acquisition (DDA) are frequently employed in the execution of tandem mass spectrometry (MS2) analyses. This study explored the application of DIA (MSe) and DDA (fast-DDA) in liquid chromatography-mass spectrometry (LC-MS)-based untargeted metabolomics using Panax genus samples. MSe provided comprehensive sample information, extracting more ion peaks with better peak shape and increased scan points compared to fast-DDA. Features from MSe data are four times more than those from fast-DDA data. Fast-DDA, however, delivered high-quality MS2 data, enhancing compound annotation via the GNPS web tool. Database matches with fast-DDA data were nearly 35 times greater than those using MSe data. Therefore, combining MSe and fast-DDA can improve data analysis and metabolite annotation. An improved workflow integrating DIA and DDA was proposed, requiring additional QC sample injections for DDA analysis but eliminating the need for sample reprocessing and re-analysis, thus saving time and resources. The established workflow was applied to the Panax genus samples analysis to confirm its applicability. This study offers a deeper understanding of DIA and DDA, guiding the selection of data acquisition strategies for LC-MS-based untargeted metabolomics.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":"3215-3228"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and characterization of chiral vitamin C using ion mobility and theoretical calculation.","authors":"Ying Zou, Manli Zhang, Dongdong Zhou, Chaoxian Chi, Fangling Wu, Chuan-Fan Ding","doi":"10.1007/s00216-025-05855-7","DOIUrl":"10.1007/s00216-025-05855-7","url":null,"abstract":"<p><p>Vitamin C (L-( +)-ascorbic acid, L-AA) is an essential micronutrient. Its diastereoisomer, D-(-)-isoascorbic acid (D-IAA), is only 5% as active as L-AA. Therefore, it is crucial to identify and characterize the diastereoisomers of ascorbic acid. In this work, a straightforward and direct method using ion mobility-mass spectrometry (IM-MS) was proposed to identify ascorbic acid isomers. Ternary complexes [L-AA + γ-CD + 2Cs-H]⁺ and [D-IAA + γ-CD + 2Cs-H]⁺, formed by non-covalent interaction of the isomer with the selective agent γ-CD and the metal ion Cs⁺, were separated in ion drift tubes with a resolution of R_p-p as high as 1.398. Meanwhile, comparisons with different CDs and metal ions revealed varying separation efficiencies. Theoretical calculations were conducted to determine the optimal conformations of [L-AA + γ-CD + 2Cs-H]⁺ and [D-IAA + γ-CD + 2Cs-H]⁺. Conformational analysis highlighted distinct structural differences at the molecular level, providing insight into the mobility separation mechanism of AA via the formation of ternary complexes with γ-CD and metal ions. Additionally, a quantitative analysis for the determination of chiral isomers was established with effective linearity and acceptable sensitivity. The method was successfully applied to assess L-AA/D-IAA content in pharmaceuticals and fruit samples.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":"3157-3168"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of cyclopiazonic acid in food samples by using molecularly imprinted polymers based on magnetic halloysite nanotubes.","authors":"Miriam Guadaño-Sánchez, Juan J López, Luis A Serrano, Laura Álvaro-Gómez, Lucas Pérez, Matilde Saura-Múzquiz, Javier L Urraca","doi":"10.1007/s00216-025-05854-8","DOIUrl":"10.1007/s00216-025-05854-8","url":null,"abstract":"<p><p>A fast, accurate, and simple method of molecularly imprinted solid-phase extraction from magnetic molecularly imprinted polymers (m-MISPE) has been developed for the determination of cyclopiazonic acid (CPA) in food samples. For the synthesis of the magnetic molecularly imprinted polymers, the core-shell method through microwave irradiation was employed. Firstly, as the core halloysite nanotubes were functionalized with magnetite nanoparticles. Then, the molecular imprinted polymer (MIP) shell was created around the halloysite nanotube cores by microwave induction. In the MIP synthesis for the template molecule, an analogous compound in structure to that of CPA has been used as a surrogate molecule to reduce the costs and toxicity produced by the toxin. Besides, washing and elution m-MISPE steps were optimized to eliminate the interferences. Cross-reactivity of the m-MISPE proposed method has been tested with different mycotoxins to determine the selectivity of the polymer towards CPA (imprinting factor (IF): MIP/NIP_CPA = 3,1; MIP/NIP_ZON = 2,2; MIP/NIP_AOH = 1,7; MIP/NIP_OCRA = 0,8). Finally, the m-MISPE method has been successfully applied to rice flour samples at three different concentration levels, 75, 120, and 200 μg/L, whose recoveries were 83, 97, and 93% and their RDS were 1, 2, and 2, respectively. The detection and quantification limits were 11.1 and 36.5 µg/kg respectively. This procedure is considered an easy and economical analytical way to determine CPA in food in routine laboratories of any food quality and is easy to implement versus the current methods in the determination of this mycotoxin.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":"3141-3156"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel chlorinated phospholipids-possible biomarkers of chlorine gas exposure.","authors":"Noora-Kaisa Rantanen, Nurhazlina Hamzah, Matti A Kjellberg, Solja Säde, Paula Vanninen, Hanna Hakulinen","doi":"10.1007/s00216-025-05864-6","DOIUrl":"10.1007/s00216-025-05864-6","url":null,"abstract":"<p><p>Biomarkers are needed to verify suspected exposure to chlorine gas in chemical attacks. Here, we aimed to expand upon the array of known biomarkers of chlorine gas exposure. 1-Palmitoyl- 2-oleoyl-sn-glycero- 3-phosphocholine (POPC), a phospholipid belonging to the phosphatidylcholine (PC) class, was chosen as the study material. The lipids were chlorinated using chlorine gas, followed by analysis for chlorinated PCs using liquid chromatography (LC) coupled with mass spectrometry (MS), using unit- (MS, MS/MS) and high-resolution (HRMS, MS/HRMS). By interpreting accurate masses, isotopic patterns, and fragmentation patterns, PC chlorohydrin, PC dichloride, the chlorinated PC with m/z 794.54611 (here denoted as PC A) and 10 novel chlorinated PCs were identified: four PCs chlorinated at the glycerol backbone and six chlorinated peroxy-diphospholipids. Similar experiments with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE) resulted in the formation of the corresponding chlorohydrin and dichloride, as well as five chlorinated phosphatidylethanolamines (PEs) with chlorine in the glycerol backbone. Surprisingly, no chlorinated forms of 1-palmitoyl-2-stearoyl-sn-glycero-3-phosphocholine (PSPC) were observed in similar experiments. In total, 15 novel chlorinated lipids were found. Furthermore, to determine the relevance of the novel lipids as biomarkers, a pig lung tissue sample was chlorinated in vitro. Two monomeric chlorinated PCs and two chlorinated peroxy-diphospholipids were identified from the chlorine-exposed lung sample, showing that the novel lipid compounds are potential biomarkers for chlorine gas exposure.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":"3285-3298"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative detection of rubella virus IgM antibodies using inductively coupled plasma mass spectrometry with elemental labeling: a new clinical application of mass spectrometry.","authors":"Haoran Li, Wencan Jiang, Gongwei Sun, Linfeng Sheng, Ruimin Ma, Guojun Zhang","doi":"10.1007/s00216-025-05873-5","DOIUrl":"10.1007/s00216-025-05873-5","url":null,"abstract":"<p><p>Rubella is a virus that can cause severe complications, such as congenital rubella syndrome, in pregnant women and newborns. Most clinical laboratories currently use qualitative methods to detect IgM antibodies; however, these have limitations in determining disease severity and progression. Thus, a quantitative IgM assay is required to enhance clinical diagnosis and treatment. Therefore, we employed the principle of the capture method for detecting rubella virus (RV) IgM. RV IgM was captured using anti-human IgM antibodies immobilized on magnetic beads, followed by adding Tm³⁺-labeled RV detection antigen, before performing inductively coupled plasma mass spectrometry (ICP-MS) analysis. The method demonstrated excellent linearity with a correlation coefficient (R²) of 0.9944 and a detection limit of 5 U/mL. Precision testing showed that the coefficients of variation (CV) for the low-concentration and high-concentration samples were 11.73% and 6.79%, respectively. Interference studies have shown that the bias from common interfering substances is less than 10%, and the method exhibits high specificity. The daily stability test results remained within 10%, while the recovery rate ranged from 95.25% to 102.43%. The reference interval for negative samples was less than 215.36 U/mL, and the kappa consistency test between our method and the electrochemiluminescence immunoassay method showed strong agreement, with a value of 0.86 (>0.75). In conclusion, we have successfully established a quantitative antibody detection method based on ICP-MS and stable element labeling. The method met the Clinical and Laboratory Standards Institute standards, confirming its clinical applicability as a reliable tool for detecting RV IgM.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":"3393-3403"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser-generated Pt/Ni nanocatalysts-carbon nanofibers enabling self-calibrated enzyme-free glucose detection at physiological pH.","authors":"Christoph Bruckschlegel, Vivien Fleischmann, Aladin Ullrich, Luc Girard, Pierre Bauduin, Antje J Baeumner, Nongnoot Wongkaew","doi":"10.1007/s00216-025-05869-1","DOIUrl":"10.1007/s00216-025-05869-1","url":null,"abstract":"<p><p>We propose a bimetallic alloy composed of Pt and Ni embedded within laser-induced carbon nanofibers (Pt/Ni-LCNFs) as an enzyme-free transducer for the detection of glucose under physiological pH. Laser exposure on electrospun polyimide nanofibers, embedded with Pt and Ni precursors, facilitated not only the formation of LCNFs but also the generation of Pt/Ni nanoparticles with a radius of approximately 2 nm and a distinctive crystalline structure. X-ray photoelectron spectroscopy revealed the oxidation states of the laser-generated Pt/Ni and confirmed the formation of the Pt/Ni alloy nanocatalysts. Additionally, small-angle X-ray scattering has shown that the graphitic structures of the LCNFs strongly depend on the metal salt concentrations and molar ratio. Pt/Ni-LCNFs were exploited as enzyme-free electrodes for glucose sensing at physiological pH. The presence of Pt in the alloy enabled a low potential (-0.9 V for 20 s) in situ generation of highly localized OH^- which facilitated glucose electrooxidation by Ni. Under optimized conditions, Pt/Ni-LCNFs achieved reliable glucose detection in physiological conditions (pH 7.4), with detection limit of 0.3 mM, linearity from 0.1 to 4 mM, and minimal interference from other electroactive species. Self-calibrated data acquisition strategy provided an excellent recovery rate (95 ± 10%) in diluted human serum. Furthermore, unlike enzyme-based sensors, the catalytic activity of Pt/Ni LCNFs was maintained after sterilization, highlighting their robustness and potential in biomedical applications and bioprocess monitoring.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":"3337-3351"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the molecular dynamics of wound healing: integrating spatially resolved lipidomics and temporally resolved proteomics.","authors":"Hongxia Bai, Alejandra Suarez Arnedo, Yining Liu, Tatiana Segura, David Muddiman","doi":"10.1007/s00216-025-05865-5","DOIUrl":"10.1007/s00216-025-05865-5","url":null,"abstract":"<p><p>Understanding the spatial-temporal molecular dynamics of wound healing is crucial for devising effective treatments. Three-dimensional mass spectrometry imaging (3D MSI) enables the comprehensive visualization of molecular distribution throughout skin layers, offering valuable insights into the wound healing process. However, traditional 3D MSI often faces challenges in maintaining data integrity and accurate image registration in the third dimension. To address this, we employed infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI), a hybrid ambient ionization technique capable of sequential imaging through consecutive ablation events for precise 3D image reconstruction. Herein, 3D IR-MALDESI MSI was used to compare the lipidome of fresh-frozen wound samples at three stages of wound healing (inflammation, proliferation, and remodeling) with the healthy skin of SKH- 1 mice. Supplementing this data with a refined LC-MS-based proteomics protocol on selected wound biopsies, our integrated approach deepens our understanding of the molecular intricacies inherent in tissue regeneration.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":"3299-3314"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mass spectrometry analysis of PM_2.5 in poultry farms and the cytotoxicity and metabolism perturbation of BEAS-2B cells.","authors":"Xia Liu, Lei Yan, Jia Wang, Clement Yaw Effah, Hanmin Lan, Lihua Ding, Yongjun Wu","doi":"10.1007/s00216-025-05871-7","DOIUrl":"10.1007/s00216-025-05871-7","url":null,"abstract":"<p><p>To evaluate the potential risks posed by farm-derived fine particulate matter (PM_2.5), we conducted a comprehensive analysis of PM_2.5 samples collected from chicken farms. Specifically, water-soluble ions, metal and metalloids, and volatile organic compounds (VOCs) were quantitatively determined via ion chromatography, inductively coupled plasma mass spectrometry (ICP-MS), and gas chromatography‒mass spectrometry (GC‒MS), respectively. Furthermore, the microbial composition was elucidated through 16S ribosomal RNA (rRNA) high-throughput sequencing and ribosomal DNA (rDNA)-internal transcribed spacer (ITS) analysis. The study revealed that the water-soluble ion profile of PM_2.5 was dominated by NO₃^-, NH₄⁺, and SO₄^2-, among others. Notably, aluminum, zinc, and manganese emerged as metals with relatively high concentrations. The primary VOCs identified were formic acid, acetic acid, and propionic acid. Microbiologically, Aspergillus and Faecalibacterium were the predominant genera detected. Upon exposure to PM_2.5, BEAS-2B cells exhibited marked morphological alterations and a decrease in cell viability. Additionally, a dose-dependent increase in intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels was observed, accompanied by a decrease in superoxide dismutase (SOD) activity. This oxidative stress was further corroborated by elevated levels of inflammatory cytokines, including IL-6, IL-8, and TNF-α. Our findings suggest that livestock-generated PM_2.5 significantly impacts cellular metabolism, particularly amino acid and nucleotide metabolism. Notably, PM_2.5 from these environments can elicit cellular oxidative stress and inflammatory responses, which, with prolonged exposure, may lead to adverse health outcomes in both animals and humans. Therefore, the physical, chemical, and microbial characteristics of PM_2.5 in poultry farms cannot be overlooked, emphasizing the critical need to improve the air quality within these facilities.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":"3371-3382"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A hemicyanine-based dual-responsive fluorescent sensor for the detection of lithium and cyanide ions: application in living cells.","authors":"Ziya Aydin, Mukaddes Keskinates, Esra Armagan, Bahar Yilmaz Altinok, Mevlut Bayrakci","doi":"10.1007/s00216-025-05852-w","DOIUrl":"10.1007/s00216-025-05852-w","url":null,"abstract":"<p><p>A hemicyanine-based colorimetric and fluorometric sensor, 2-(2-(2,3,5,6,8,9-hexahydrobenzo[b][1,4,7,10]tetraoxacyclododecin-12-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indol-1-ium iodide (MH-5), was developed and synthesized to detect Li⁺ and CN^- ions in DMSO-PBS buffer solution (10 mM, pH 7.25, v/v 1:9). MH-5 displayed a rapid and highly selective colorimetric response to both Li⁺ and CN^-, indicated by a distinct color change from pink to pale pink in the presence of Li⁺ and to colorless upon CN^- detection, without interference from other cations or anions. The interaction mechanisms of MH-5 with Li⁺ and CN^- ions were investigated using various analytical techniques, including ¹H NMR, ESI-MS, FT-IR spectroscopy, and Job's plot analysis. These studies suggest that CN^- is detected through nucleophilic addition to the indolium moiety of MH-5, while Li⁺ detection occurs via coordination with oxygen atoms in the crown ether structure. The fluorescence-based detection limits for Li⁺ and CN^- were determined to be 0.150 µM and 0.154 µM, respectively. Additionally, MH-5 was evaluated in living cells, demonstrating effective cell penetration and reliable detection of Li⁺ and CN^- ions for potential bio-imaging applications.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":"3127-3139"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functionalized magnetic covalent organic frameworks with refining tunable cores for highly selective adsorption of immunosuppressive drugs.","authors":"Jianhua Shi, Jin Huang, Jiang Qing, Youwei Chen, Taoyu Meng, Wenli Zhou, Zhou Xu, Maolong Chen, Li Wen, Ye Jiao, Yunhui Cheng, Libing Wang, Li Ding","doi":"10.1007/s00216-025-05877-1","DOIUrl":"10.1007/s00216-025-05877-1","url":null,"abstract":"<p><p>Immunosuppressant drugs (ISDs) are widely used in the treatment of organ rejection following human transplantation and in autoimmune diseases. Herein, this study demonstrates that carbonylated covalent organic frameworks (COFs) with pore-matching capabilities can serve as promising interference-resistant adsorbents for the rapid and efficient capture of ISDs (cyclosporin A (CsA), tacrolimus (FK-506), and rapamycin (RPM)) from complex whole blood matrices. Under optimized conditions, MCOF-2-COOH, with a pore size 1.5 times the diameter of the drug molecule, demonstrated superior ISDs adsorption performance, achieving an adsorption capacity of up to 84.95 mg g^-1 in 10 min. Instrumental characterization and theoretical calculations elucidated the potential adsorption matrix, revealing that the COF provides multiple forces, including hydrogen bonding, electrostatics, and π-π interactions, with the carboxyl site playing a crucial role. This study provides both a theoretical basis and experimental evidence for the use of COF materials in the selective adsorption of drugs from complex matrices, as well as a strategy for designing functionally customized COFs for drug therapy monitoring applications.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":"3447-3464"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}