Analytical and Bioanalytical Chemistry最新文献

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QuEChERS analytical approach for monitoring endocrine-disrupting chemicals in human urine. 用于监测人体尿液中内分泌干扰化学物质的QuEChERS分析方法。
IF 3.8 2区 化学
Analytical and Bioanalytical Chemistry Pub Date : 2025-09-24 DOI: 10.1007/s00216-025-06099-1
S Callejas-Martos, E Eljarrat
{"title":"QuEChERS analytical approach for monitoring endocrine-disrupting chemicals in human urine.","authors":"S Callejas-Martos, E Eljarrat","doi":"10.1007/s00216-025-06099-1","DOIUrl":"https://doi.org/10.1007/s00216-025-06099-1","url":null,"abstract":"<p><p>This study introduces an analytical method for the determination of endocrine-disrupting chemicals (EDCs) in human urine samples, employing QuEChERS as a clean-up step for the first time in this biological matrix. Sample preparation was rigorously optimized through the evaluation of sample and final dilution volumes, balancing the need to reduce matrix interference without sacrificing sensitivity. High-performance liquid chromatography coupled with a triple quadrupole-time-of-flight mass spectrometer (HPLC-QTOF) was employed, enabling the detection of 13 target analytes (five OPEs, five phthalates, and three parabens' metabolites). Chromatographic separation was achieved in 16 min, and mass spectrometry parameters were fine-tuned to maximize signal sensitivity. The method was validated by assessing parameters such as selectivity, linearity, precision, accuracy, and sensitivity. Linearity of response was demonstrated for all of the compounds (r<sup>2</sup> > 0.99), with method detection limits of 0.01-0.33 ng/mL and limits of quantification of 0.03-1.08 ng/mL. Accuracy ranged from 67 to 99% and inter- and intra-day precision were under 20%, for the majority of the analytes. The validated method was then applied to 39 human urine samples, confirming its reliability and practical utility for monitoring EDC exposure in urban populations. The highest concentrations were found in parabens, followed by phthalates and finally OPEs, with median values of 117, 43.5, and 25.4 ng/g of creatinine, respectively. The detection of all three EDC groups in 100% of the samples underscores the importance of this comprehensive analytical approach being capable of simultaneously assessing these contaminants in human biomonitoring studies.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantification of the amount of surface groups of aminated silica nano- and microparticles utilizing a fluorine tag and HR-CS-GFMAS. 利用氟标记和HR-CS-GFMAS定量胺化二氧化硅纳米和微粒表面基团的数量。
IF 3.8 2区 化学
Analytical and Bioanalytical Chemistry Pub Date : 2025-09-22 DOI: 10.1007/s00216-025-06107-4
Isabella Tavernaro, Fabian Simon, Lennart Gehrenkemper, Charlie Tobias, Ute Resch-Genger, Björn Meermann
{"title":"Quantification of the amount of surface groups of aminated silica nano- and microparticles utilizing a fluorine tag and HR-CS-GFMAS.","authors":"Isabella Tavernaro, Fabian Simon, Lennart Gehrenkemper, Charlie Tobias, Ute Resch-Genger, Björn Meermann","doi":"10.1007/s00216-025-06107-4","DOIUrl":"10.1007/s00216-025-06107-4","url":null,"abstract":"<p><p>The performance, bioavailability, and safe use of engineered nanomaterials (NMs) depends not only on properties such as size, shape, and surface area, but largely on surface chemistry. While many sizing methods have been established, there is still a lack of validated screening methods for determining NM surface functional groups (FGs). In this context, we present a fast and simple method for FG quantification using high resolution-continuum source-graphite furnace molecular absorption spectrometry (HR-CS-GFMAS) and assess its applicability for the surface analysis of representatively chosen aminated silica nanoparticles (NPs) and microparticles (MPs) in conjunction with amino FG labeling with a fluorine tag. For this proof-of-concept study, first surface amino FG screening of the silica NPs and MPs was done with a potentiometric back titration method, providing the total amount of protonatable surface FGs, and two optical assays relying on reporter dyes with sizes and spatial requirements, i.e., surface binding areas smaller or larger than that of the fluorine tag to estimate the maximum and reporter-accessible number of amino FGs. Subsequently, the surface amino FGs were labeled with the fluorine tag 4-(trifluoromethyl)benzoic acid (TFMB) and the amount of fluorine originating from the bound TFMB molecules was quantified by HR-CS-GFMAS in two common organic solvents, i.e., dimethyl sulfoxide (DMSO) or ethanol (EtOH) to assess possible interferences from organic matrices. Our study revealed limits of detection (LODs) and quantification (LOQs) for fluorine of 1.0 µg/L and 3.5 µg/L in EtOH and 1.5 µg/L and 5.0 µg/L in DMSO, respectively. Overall, a quick and simple method for analyzing surface FGs on NPs and MPs was presented utilizing broadly available fluorine tags and HR-CS-GFMAS for fluorine quantification, which can be applied, e.g., for homogeneity, stability, and aging studies of surface-modified particles. This could contribute to ease the understanding of property-safety relationships for surface-functionalized NMs.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrodeposition and transfer of silver micro-kohlrabies for stretchable surface-enhanced Raman scattering. 可拉伸表面增强拉曼散射的银微kohl狂犬病电沉积和转移。
IF 3.8 2区 化学
Analytical and Bioanalytical Chemistry Pub Date : 2025-09-20 DOI: 10.1007/s00216-025-06132-3
Limei Liu, Mingxi Zhang, Taimin Sun, Tingfeng Dai, Jianing Ding, Binghao Wang
{"title":"Electrodeposition and transfer of silver micro-kohlrabies for stretchable surface-enhanced Raman scattering.","authors":"Limei Liu, Mingxi Zhang, Taimin Sun, Tingfeng Dai, Jianing Ding, Binghao Wang","doi":"10.1007/s00216-025-06132-3","DOIUrl":"https://doi.org/10.1007/s00216-025-06132-3","url":null,"abstract":"<p><p>Stretchable surface-enhanced Raman scattering (SERS) substrates are pivotal for real-time chemical sensing on deformable surfaces but face challenges in maintaining sensitivity under mechanical strain. Here, we introduce a two-step electrodeposition and double-embedded transfer method to fabricate silver micro-kohlrabies (Ag MKs) on stretchable substrates. Ag microspheres are first electrodeposited on ITO/glass, followed by the growth of Ag nanodendrites at optimized voltage (1.3 V) and time (5 min), forming hierarchical micro-nano structures with abundant electromagnetic hotspots. A double-embedded transfer technique involving polyvinyl alcohol (PVA) and polydimethylsiloxane (PDMS) ensures robust integration of Ag MKs onto elastomeric substrates while preserving hotspot accessibility. The resulting substrate demonstrates high sensitivity with an enhancement factor of ~10<sup>7</sup>, uniformity, mechanical durability (50 stretch cycles at 50% strain), and stability (30-day storage). Practical application in thiram detection achieves a detection limit of 10<sup>-8</sup> M, highlighting its potential for on-site pesticide monitoring. This work advances stretchable SERS platforms by combining tunable nanostructure fabrication with reliable mechanical performance.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145090864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imaging and simulation study of electrokinetic supercharging in flow-gated capillary electrophoresis. 流动门控毛细管电泳中电动增压的成像与仿真研究。
IF 3.8 2区 化学
Analytical and Bioanalytical Chemistry Pub Date : 2025-09-20 DOI: 10.1007/s00216-025-06116-3
Ying Gong, Zhengyang Ye, Atena Tajaddodi, Maojun Gong
{"title":"Imaging and simulation study of electrokinetic supercharging in flow-gated capillary electrophoresis.","authors":"Ying Gong, Zhengyang Ye, Atena Tajaddodi, Maojun Gong","doi":"10.1007/s00216-025-06116-3","DOIUrl":"https://doi.org/10.1007/s00216-025-06116-3","url":null,"abstract":"<p><p>Electrokinetic supercharging (EKS), an efficient sample preconcentration technique, has demonstrated millionfold concentration enhancement. Despite extensive studies, the detailed behavior of associated ions during EKS remains insufficiently understood. This research aims to elucidate the underlying EKS mechanisms on a flow-gated capillary electrophoresis (CE) system by using the combination of fluorescence imaging, computer simulations, and comparative analysis of electropherograms under various pairs of leading/terminating electrolytes (LE/TE). Two distinct operational modes were evaluated to highlight procedural differences: simultaneous EKS and sequential EKS. In the simultaneous mode, transient isotachophoresis (tITP) was conducted concurrently with field-amplified sample injection (FASI). For effective operation, LE anions were included in background electrolyte (BGE), while the TE anionic plug was generated by FASI from TE anions included in the sample. In the sequential mode, FASI was performed first to inject and preconcentrate analytes along with LE anions present in the sample, and the preconcentrated LE plug then functioned as LE in the subsequent tITP stage. While sequential EKS generally yielded lower signal enhancement compared to the simultaneous approach, it offered improved operational control and reproducibility. Due to its greater robustness, sequential EKS was chosen for the determination of herbicide residues in cereal samples. This study offers detailed insights into ion dynamics under various EKS configurations and provides practical guidelines for selecting LE/TE compositions and optimizing buffer conditions in flow-gated CE systems.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145090872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of the differentiation of Sambucus nigra plant parts using a multi-target and suspect screening by LC-HRMS and ICP-OES. 利用LC-HRMS和ICP-OES多靶点筛选评价黑参植物部位的分化。
IF 3.8 2区 化学
Analytical and Bioanalytical Chemistry Pub Date : 2025-09-20 DOI: 10.1007/s00216-025-06112-7
M Häßler, K Wetzel, L Warnecke, T Niedenthal, L Montero, J F Ayala-Cabrera, O J Schmitz
{"title":"Assessment of the differentiation of Sambucus nigra plant parts using a multi-target and suspect screening by LC-HRMS and ICP-OES.","authors":"M Häßler, K Wetzel, L Warnecke, T Niedenthal, L Montero, J F Ayala-Cabrera, O J Schmitz","doi":"10.1007/s00216-025-06112-7","DOIUrl":"https://doi.org/10.1007/s00216-025-06112-7","url":null,"abstract":"<p><p>Traditional plant medicine is among the most popular and strongest growing forms of alternative medicine. Based on ancient healing practices, it still plays a significant role in the treatment of many medical conditions. Its impact significantly influenced the creation of therapeutic products by using medical herbs in a continuously growing market. Therefore, it is important to properly characterize and differentiate medical plant parts. In this work, a multi-target and suspect screening approach for the elemental composition as well as the organic compound profile of different plant parts of Sambucus nigra was assessed using inductively coupled plasma-optical emission spectroscopy (ICP-OES) and liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) to identify potential biomarkers and establish their correlations with the total phenolic content (TPC). For the elemental analysis, calcium and potassium were found as the main elements screened in the S. nigra plant parts, but with no correlation to the TPC content. In contrast, phosphorus showed a slight correlation with the TPC and significant correlations with concentrations of several phenolic compounds. Regarding the organic compound profile, 88 features were tentatively identified with high confidence (levels 1-3), some of them for the first time in S. nigra. These compounds are mainly associated with phenolic compounds such as flavonoids or cinnamic acid derivatives, among others. Moreover, 18 of these compounds were identified as potential biomarkers to differentiate between plant parts (i.e. rutin, quercetin, bergapten, etc.). These findings not only give insights into the characterization of S. nigra but might serve as a basis for evaluating individual substances as well as different plant parts regarding their potential hepatoprotective characteristics. The LC-HRMS method could serve as a basis for future analyses of medicinal plants, aiming for reduced analysis time, high separation performance (especially for phenolic compounds), and better result comparability.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145090839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasensitive detection of imidacloprid in fruits and vegetables using a lateral flow immunoassay based on highly luminescent Au nanoclusters. 基于高发光金纳米团簇的横向流动免疫法超灵敏检测水果和蔬菜中的吡虫啉。
IF 3.8 2区 化学
Analytical and Bioanalytical Chemistry Pub Date : 2025-09-20 DOI: 10.1007/s00216-025-06118-1
Weina Chai, Ziyue Cao, Haoyuan Tan, Xiao He, Jiangxue Dong, Hongyuan Yan, Ming Su
{"title":"Ultrasensitive detection of imidacloprid in fruits and vegetables using a lateral flow immunoassay based on highly luminescent Au nanoclusters.","authors":"Weina Chai, Ziyue Cao, Haoyuan Tan, Xiao He, Jiangxue Dong, Hongyuan Yan, Ming Su","doi":"10.1007/s00216-025-06118-1","DOIUrl":"https://doi.org/10.1007/s00216-025-06118-1","url":null,"abstract":"<p><p>In this work, a highly sensitive lateral flow immunoassay (LFIA) strip based on luminescent green-emitting gold nanoclusters (AuNCs) was developed for ultrasensitive and facile visual determination of imidacloprid (ICP). Specifically, the structurally ordered AuNCs system, constructed through 6-aza-2-thiothymine (ATT) as the coordinating ligand and L-arginine (Arg) as the guest molecule (denoted as Arg/ATT/AuNCs), exhibited enhanced and persistent fluorescent emission characteristics. Furthermore, the presence of unbound carboxyl moieties on the Arg/ATT/AuNCs complex facilitated the conjugation with biomolecules, thereby providing a functional indicator for the biosensor assembly. The developed strips operate on the principle of an indirect competitive assay and are capable of effectively detecting target samples in less than 12 min. Moreover, the sample only needs to undergo simple crushing and filtration. The assay provides qualitative results through visual inspection under a UV lamp and quantitative analysis via a portable fluorescence reader. The visual limit of detection (vLOD) was 7.5 ng/mL and the limit of detection (LOD) is 0.026 ng/mL. Additionally, the average recoveries of ICP from apples, oranges, cucumbers, and cabbages samples ranged from 78.0% to 104.8%, 82.0% to 99.1%, 94.0% to 99.1%, and 93.0% to 101.9%, respectively, with relative standard deviations less than 10%. Given its ultrasensitive luminescence performance, the AuNCs-LFIA strip offers great potential for rapid, sensitive, and cost-effective detection of analytes in food safety monitoring.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145090889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Celebrating successes and envisioning future innovations of PAT. 庆祝成功并展望PAT未来的创新。
IF 3.8 2区 化学
Analytical and Bioanalytical Chemistry Pub Date : 2025-09-19 DOI: 10.1007/s00216-025-06117-2
Tobias Eifert, Martin Gerlach, Katharina Dahlmann, Bernhard Lendl, Matthias Rädle, Martin Jäger
{"title":"Celebrating successes and envisioning future innovations of PAT.","authors":"Tobias Eifert, Martin Gerlach, Katharina Dahlmann, Bernhard Lendl, Matthias Rädle, Martin Jäger","doi":"10.1007/s00216-025-06117-2","DOIUrl":"https://doi.org/10.1007/s00216-025-06117-2","url":null,"abstract":"","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new GFP chromophore analogue for detection of viscosity and cysteine with AND logic-gate-based fluorescence readout. 一种新的GFP发色团模拟物,用于检测粘度和半胱氨酸与逻辑门为基础的荧光读出。
IF 3.8 2区 化学
Analytical and Bioanalytical Chemistry Pub Date : 2025-09-19 DOI: 10.1007/s00216-025-06113-6
Min Zhang, Jiajia Liu, Xinzhu Yuan, Yanli Wen, Chusen Huang
{"title":"A new GFP chromophore analogue for detection of viscosity and cysteine with AND logic-gate-based fluorescence readout.","authors":"Min Zhang, Jiajia Liu, Xinzhu Yuan, Yanli Wen, Chusen Huang","doi":"10.1007/s00216-025-06113-6","DOIUrl":"https://doi.org/10.1007/s00216-025-06113-6","url":null,"abstract":"<p><p>Due to the significant roles of cysteine and viscosity in living cells and related biological processes, the development of visualization tools for in situ detection is essential. Despite the fact that numerous fluorescent probes have been developed for real-time detection of cysteine or viscosity, there are still limited amounts of probes that could be used for dual detection of cysteine and viscosity, which will prevent deep insights into the biological roles of cysteine and viscosity in living cells, particularly their interrelationships. Herein, a new near-infrared (NIR) fluorescent probe (Cys-BTH) was designed and synthesized by conjugating thieno [3,2-b]thiophene-2,5-dicarbaldehyde to the green fluorescent protein (GFP) chromophore hydroxybenzylidene imidazolidinone (HBDI). Due to the intramolecular motion property and selective interaction of the carboxyl group, Cys-BTH exhibited \"AND\" logic-gate-based sensing performance in the presence of both Cys and high viscosity. Live-cell imaging assays further demonstrated the practical use of Cys-BTH in monitoring biological processes with overexpressed Cys and high viscosity.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Examining the effects of analytical replication on data quality in a non‑targeted analysis experiment. 更正:在非目标分析实验中检验分析复制对数据质量的影响。
IF 3.8 2区 化学
Analytical and Bioanalytical Chemistry Pub Date : 2025-09-16 DOI: 10.1007/s00216-025-06101-w
Troy M Ferland, Heather D Whitehead, Timothy J Buckley, Alex Chao, Jeffrey M Minucci, E Tyler Carr, Greg Janesch, Safia Rizwan, Nathaniel Charest, Antony J Williams, James P McCord, Jon R Sobus
{"title":"Correction to: Examining the effects of analytical replication on data quality in a non‑targeted analysis experiment.","authors":"Troy M Ferland, Heather D Whitehead, Timothy J Buckley, Alex Chao, Jeffrey M Minucci, E Tyler Carr, Greg Janesch, Safia Rizwan, Nathaniel Charest, Antony J Williams, James P McCord, Jon R Sobus","doi":"10.1007/s00216-025-06101-w","DOIUrl":"https://doi.org/10.1007/s00216-025-06101-w","url":null,"abstract":"","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145068814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ratiometric photoelectrochemical sensors: advances in food analysis and emerging applications. 比率光电化学传感器:食品分析的进展和新兴应用。
IF 3.8 2区 化学
Analytical and Bioanalytical Chemistry Pub Date : 2025-09-15 DOI: 10.1007/s00216-025-06102-9
Yuanqiang Hao, Jinting Sun, Peisheng Zhang, Rongjin Zeng, Maotian Xu, Shu Chen
{"title":"Ratiometric photoelectrochemical sensors: advances in food analysis and emerging applications.","authors":"Yuanqiang Hao, Jinting Sun, Peisheng Zhang, Rongjin Zeng, Maotian Xu, Shu Chen","doi":"10.1007/s00216-025-06102-9","DOIUrl":"https://doi.org/10.1007/s00216-025-06102-9","url":null,"abstract":"<p><p>Ratiometric photoelectrochemical (PEC) sensors have emerged as a compelling class of analytical tools, offering internal calibration, enhanced signal stability, and improved tolerance to environmental variability. These advantages are particularly relevant to the field of food analysis, where sample complexity often compromises the reliability of single-signal detection strategies. In recent years, diverse ratiometric PEC platforms have been developed. This review systematically categorizes ratiometric PEC sensors into five main types: wavelength-resolved, voltage-resolved, spatially resolved, dual-mode, and other emerging strategies involving polarity switching or stimulus-responsive interfaces. For each category, representative sensing mechanisms, photoelectrode architectures, and real-world applications-especially in the detection of food contaminants such as mycotoxins, antibiotics, and pesticide residues-are comprehensively discussed. Furthermore, key challenges and future directions are outlined. This review aims to provide a conceptual foundation and technical reference for advancing ratiometric PEC sensing technologies in food safety and beyond.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145068854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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