International Journal of Breast Cancer最新文献

{"title":"Breast Cancer Screening Using a Modified Inertial Projective Algorithms for Split Feasibility Problems.","authors":"Pennipat Nabheerong,&nbsp;Warissara Kiththiworaphongkich,&nbsp;Watcharaporn Cholamjiak","doi":"10.1155/2023/2060375","DOIUrl":"https://doi.org/10.1155/2023/2060375","url":null,"abstract":"<p><p>To detect breast cancer in mammography screening practice, we modify the inertial relaxed CQ algorithm with Mann's iteration for solving split feasibility problems in real Hilbert spaces to apply in an extreme learning machine as an optimizer. Weak convergence of the proposed algorithm is proved under certain mild conditions. Moreover, we present the advantage of our algorithm by comparing it with existing machine learning methods. The highest performance value of 85.03% accuracy, 82.56% precision, 87.65% recall, and 85.03% F1-score show that our algorithm performs better than the other machine learning models.</p>","PeriodicalId":46159,"journal":{"name":"International Journal of Breast Cancer","volume":"2023 ","pages":"2060375"},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10360927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent Toxoplasmosis among Breast Cancer Patients in Jahrom, South of Iran.","authors":"Marzeieh Haghbin,&nbsp;Salar Maani,&nbsp;Mohammad Aref Bagherzadeh,&nbsp;Ahmadreza Bazmjoo,&nbsp;Heshmatollah Shakeri,&nbsp;Ali Taghipour,&nbsp;Shahab Falahi,&nbsp;Azra Kenarkoohi,&nbsp;Milad Badri,&nbsp;Amir Abdoli","doi":"10.1155/2023/4792260","DOIUrl":"https://doi.org/10.1155/2023/4792260","url":null,"abstract":"<p><strong>Objective: </strong>Reactivation of latent toxoplasmosis is the main cause of severe infection among immunocompromised patients, including patients with cancer. Hence, this study is aimed at screening the status of <i>Toxoplasma gondii</i> infection among breast cancer patients by serological and molecular methods and determining their associated risk factors in Jahrom County, Fars Province, south of Iran.</p><p><strong>Methods: </strong>One hundred and seven women with breast cancer (aged 34 to 80 years) were screened for anti-<i>T. gondii</i> antibodies (IgG and IgM) during 2019-2020. A questionnaire regarding demographic factors was filled out by participants. Molecular detection was performed by polymerase chain reaction (PCR) using the primer pair targeting the repetitive element (RE) gene of <i>T. gondii</i>. The risk factors and demographic data were analyzed by SPSS software (ver. 20, Chicago, IL, USA) using the Chi-squared test.</p><p><strong>Results: </strong>Anti-<i>T. gondii</i> IgG was detected in 45.8% (49/107) of the patients, which indicates latent infection, but anti-<i>T. gondii</i> IgM and PCR were negative in all samples. Demographic factors revealed a statistically significant increased <i>T. gondii</i> seropositivity among nonmenopause cancer patients (<i>P</i> < 0.0005), patients without previous breast cancer (<i>P</i> = 0.0001), and human epidermal growth factor receptor 2- (<i>HER2-</i>) negative patients (<i>P</i> = 0.00002). As such, patients with a history of previous abortions and who were at stages II, III, and IIII of cancer had higher seropositivity rates than patients without a history of previous abortions or who were at stage I cancer, but the statistical analysis was not significant. We did not find a statistically significant association between <i>T. gondii</i> seropositivity and other risk factors of toxoplasmosis (e.g., education level, type of water source, washing raw fruits and vegetables, consumption of raw or undercooked meat, and contact with soil, cats, and domestic animal).</p><p><strong>Conclusion: </strong>A high seroprevalence rate of latent <i>T. gondii</i> infection was detected among patients with breast cancer; hence, these patients may be at high risk for reactivation of latent infection. Screening of <i>T. gondii</i> infection is recommended to detect active infection among patients with malignancies.</p>","PeriodicalId":46159,"journal":{"name":"International Journal of Breast Cancer","volume":"2023 ","pages":"4792260"},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9899701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep Inferior Epigastric Perforator Flap for Immediate Breast Reconstruction following Mastectomy in Breast Cancer Patients: An Initial Experience in Vietnam.","authors":"Xuan Hau Nguyen,&nbsp;Viet Dung Pham Thi,&nbsp;Xuan Hien Nguyen,&nbsp;Thi Dung Vu,&nbsp;Hop Nhan Nguyen,&nbsp;Quang Dao Pham,&nbsp;Van Ty Ngo","doi":"10.1155/2023/5964040","DOIUrl":"https://doi.org/10.1155/2023/5964040","url":null,"abstract":"<p><strong>Background: </strong>Breast reconstruction in breast cancer patients is an optional surgery that improves the quality of life while preserving the efficacy of chemotherapy and radiotherapy. Deep inferior epigastric perforator (DIEP) flap is a new but reliable and safe technique for autologous breast reconstruction. After mastectomy, immediate reconstruction is the preferred method because of its aesthetic result and convenience. This study is aimed at summarizing our experience in DIEP flap for immediate breast reconstruction.</p><p><strong>Methods: </strong>A prospective study was performed on 30 breast cancer patients who underwent intermediate breast reconstruction for DIEP flap after mastectomy from June 2019 to June 2021 in Hanoi Medical University Hospital. Clinicopathology characteristics, tumor stage, treatment, and complications were evaluated.</p><p><strong>Result: </strong>The mean age of patients was 44.9 (range: 29-73 years). 86.7% of patients were in stages I and II. Five patients (16.7%) received neoadjuvant chemotherapy. 20 patients (66.7%) underwent nipple-sparing mastectomy (NSM) procedures. The mean operating time was 341 minutes. The mean time to receive chemotherapy was 34.68 days. The mean number of perforators was 1.30. The overall flap success rate was 90%. Twelve patients (40%) experienced complications. Four patients (13.3%) returned to the operating room due to venous congestions. Two patients (6.67%) had complete flap loss. Other complication: fat necrosis (6.7%), seroma (13.3%), partial flap loss (3.3%), abdominal wound dehiscence (6.7%), pneumonia (3.3%), and pulmonary embolism (6.7%). After one-month postoperation, 88.9% of patients were satisfied with their breasts, and 74.07% were satisfied with the operation.</p><p><strong>Conclusion: </strong>DIEP flap is a new but reliable and safe technique for autologous breast reconstruction. Though patients opting for breast reconstruction still have a low risk of complication and reconstruction failure, this procedure should be used more frequently in appropriate patients to improve their quality of life.</p>","PeriodicalId":46159,"journal":{"name":"International Journal of Breast Cancer","volume":"2023 ","pages":"5964040"},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10554208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Galangin-Loaded Gold Nanoparticles: Molecular Mechanisms of Antiangiogenesis Properties in Breast Cancer.","authors":"Malik H Qaddoori,&nbsp;Hanady S Al-Shmgani","doi":"10.1155/2023/3251211","DOIUrl":"https://doi.org/10.1155/2023/3251211","url":null,"abstract":"<p><p>Angiogenesis is important for tissue during normal physiological processes as well as in a number of diseases, including cancer. Drug resistance is one of the largest difficulties to antiangiogenesis therapy. Due to their lower cytotoxicity and stronger pharmacological advantage, phytochemical anticancer medications have a number of advantages over chemical chemotherapeutic drugs. In the current study, the effectiveness of AuNPs, AuNPs-GAL, and free galangin as an antiangiogenesis agent was evaluated. Different physicochemical and molecular approaches have been used including the characterization, cytotoxicity, scratch wound healing assay, and gene expression of <i>VEGF</i> and <i>ERKI</i> in MCF-7 and MDA-MB-231 human breast cancer cell line. Results obtained from MTT assay show cell growth reduction in a time- and dose-dependent aspect; also, in comparison to individual treatment, a synergistic impact was indicated. CAM assay results demonstrated galangin-gold nanoparticle capacity to suppress angiogenesis in chick embryo. Additionally, altering <i>VEGF</i> and <i>ERKI</i> gene expression was recorded. Taken together, all the results can conclude that galangin-conjugated gold nanoparticles can be a promising antiangiogenesis supplemental drug in breast cancer treatment.</p>","PeriodicalId":46159,"journal":{"name":"International Journal of Breast Cancer","volume":"2023 ","pages":"3251211"},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10789219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Oxidative Stress Parameters and Hematological Indices in Breast Cancer Patients.","authors":"Hiva Danesh,&nbsp;Nasrin Ziamajidi,&nbsp;Seyed Alireza Mesbah-Namin,&nbsp;Nahid Nafisi,&nbsp;Roghayeh Abbasalipourkabir","doi":"10.1155/2022/1459410","DOIUrl":"https://doi.org/10.1155/2022/1459410","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is one of the leading causes of death in women worldwide. This causes an increase in free radicals, resulting in oxidative stress. The aim of this study was to determine the effect of breast cancer on oxidative stress and its relationship with hematological indices.</p><p><strong>Methods: </strong>This case-control study included 43 women with breast cancer and 37 age-matched healthy controls. Oxidative stress and its correlation with hematological profiles over seven months were evaluated. Finally, the data were compared between the two groups using the <i>t</i>-test and Pearson's test, and the results were analyzed using the SPSS 24 software.</p><p><strong>Results: </strong>The results revealed that patients with breast cancer had significantly increased hemoglobin (HB), hematocrit (HCT), mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) levels compared with healthy subjects (<i>p</i> < 0.05). In addition, oxidative stress parameters, such as superoxide dismutase (SOD), catalase (CAT), total oxidant status (TOS), and total antioxidant capacity (TAC), were significantly elevated. Glutathione peroxidase (GPX) and malondialdehyde (MDA) were significantly lower in patients with breast cancer than in the control group (<i>p</i> < 0.05). Statistical significance in hematological indices showed a positive or negative correlation with oxidative stress parameters.</p><p><strong>Conclusion: </strong>Women with breast cancer showed a deranged complete blood count (CBC) pattern compared to healthy individuals.</p>","PeriodicalId":46159,"journal":{"name":"International Journal of Breast Cancer","volume":"2022 ","pages":"1459410"},"PeriodicalIF":1.9,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33501924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost and Clinical Benefits Associated with Oncotype DX® Test in Patients with Early-Stage HR+/HER2- Node-Negative Breast Cancer in the Netherlands.","authors":"Felix E de Jongh,&nbsp;Reva Efe,&nbsp;Kirsten H Herrmann,&nbsp;Jelle A Spoorendonk","doi":"10.1155/2022/5909724","DOIUrl":"https://doi.org/10.1155/2022/5909724","url":null,"abstract":"<p><strong>Objectives: </strong>Patients with early-stage HR+/HER2- N0 breast cancer may receive adjuvant chemotherapy in combination with surgery. However, chemotherapy does not always lead to improved survival and incurs high healthcare costs and increased adverse events. To support decision-making regarding adjuvant chemotherapy, genomic profile testing performed with tests such as the Oncotype DX® test can help healthcare practitioners decide whether chemotherapy provides any benefit to these patients. As such, a cost-consequence model was developed with the aim to estimate the economic impact of using different gene expression tests or no testing, in patients with node-negative early-stage breast cancer.</p><p><strong>Methods: </strong>A cost-consequence model was developed to estimate the economic impact of three different scenarios in the Dutch setting: (1) Oncotype DX® test, (2) MammaPrint®, and (3) and no genomic profile testing. The model included chemotherapy costs, administration costs, short- and long-term adverse event costs, productivity loss, genomic profiling testing costs, cost of cancer recurrence, and hospitalization costs.</p><p><strong>Results: </strong>A treatment paradigm with Oncotype DX resulted in average savings per patient of €6,768 vs. a paradigm with MammaPrint and €13,125 vs. a paradigm with no genomic testing. Furthermore, due to less patients receiving adjuvant chemotherapy through better targeting by the Oncotype DX test, fewer adverse events, sick days, practice visits, and hospitalizations were required compared to MammaPrint and no genomic profiling.</p><p><strong>Conclusions: </strong>Testing with Oncotype DX test in Dutch clinical practice in patients with early-stage breast cancer proved to be cost-saving versus MammaPrint and no genomic profiling tests. Introducing the Oncotype DX test to the Dutch setting will likely reduce the economic resources that are required.</p>","PeriodicalId":46159,"journal":{"name":"International Journal of Breast Cancer","volume":"2022 ","pages":"5909724"},"PeriodicalIF":1.9,"publicationDate":"2022-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33545808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and Prognostic Role of Serum Omentin and NGAL Levels in Egyptian Breast Cancer Patients.","authors":"Al-Shimaa Mahmoud Abas,&nbsp;Mohamed H Sherif,&nbsp;Sara A Elmoneam Farag","doi":"10.1155/2022/5971981","DOIUrl":"https://doi.org/10.1155/2022/5971981","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer (BC) is globally the main cause of cancer-related deaths in women. Tumor biomarkers have significant role in diagnosis and predicting the prognosis and decide the specific therapy to each patient.</p><p><strong>Aim: </strong>In this study, we investigated whether omentin and NGAL levels were altered in patients with breast cancer and the relationship between these markers and their clinicopathological parameters. <i>Subjects and Methods</i>. This study included 120 patients with breast cancer and 30 healthy individuals served as controls. We measured the serum level of omentin and NGAL by ELISA technique.</p><p><strong>Results: </strong>Our results showed that there were statistically significant differences in serum omentin and NGAL levels between two groups. Also, in breast cancer patients, there was significant difference between omentin level, the same results with NGAL level and patient's age, tumor size, lymph node, and metastasis. No significant relationship was found between omentin level and tumor grade, ER, PR, and HER2. The cutoff value for the prediction of breast cancer was determined at >113.2 ng/ml for omentin and >145.3 ng/ml for NGAL with a sensitivity of 91.7% and 100%, specificity of 100% and 80%, positive predictive value of 100% and 90.9%, negative predictive value of 85.7% and 100%, and accuracy of 94.4% and 93.3%, respectively. In conclusion, serum omentin and NGAL can be used as strong diagnostic markers for breast cancer.</p>","PeriodicalId":46159,"journal":{"name":"International Journal of Breast Cancer","volume":"2022 ","pages":"5971981"},"PeriodicalIF":1.9,"publicationDate":"2022-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33486210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Tumor Infiltrating Lymphocytes Densities and Ki67 Index on Residual Breast Cancer Burden following Neoadjuvant Chemotherapy.","authors":"Aya Elmahs,&nbsp;Ghada Mohamed,&nbsp;Mostafa Salem,&nbsp;Dina Omar,&nbsp;Amany Mohamed Helal,&nbsp;Nahed Soliman","doi":"10.1155/2022/2597889","DOIUrl":"https://doi.org/10.1155/2022/2597889","url":null,"abstract":"<p><p>To avoid unnecessary neoadjuvant chemotherapy in case anticipating a poor therapy response, it is essential to find the pathological parameters that would predict pathological complete response or at least a decrease in tumor burden following neoadjuvant chemotherapy. The purpose of this study is to investigate the hypothesis that tumor infiltrating lymphocytes can predict the efficacy of neoadjuvant chemotherapy and to find the Ki67 cutoff value that best predicts the benefit of chemotherapy. 153 cases of breast cancer were chosen, based on their molecular subtype: triple negative subtype (77) and luminal, HER2-ve subtype (76). Histopathological assessment of pretherapy core biopsies was conducted to assess variable pathological parameters including TILs rates with the aid of immunohistochemical staining for CD20 and CD3. Moreover, core biopsies were stained for Ki67, and the findings were compared to the residual cancer burden following neoadjuvant chemotherapy. On analyzing and contrasting the two groups, a significant association between molecular subtype and pathological complete response was confirmed, while tumor-infiltrating lymphocytes in either group had no effect on therapy response. We used receiver operating characteristic curve analysis to determine that a cutoff of 36% for Ki67 is the most accurate value to predict complete therapy response.</p>","PeriodicalId":46159,"journal":{"name":"International Journal of Breast Cancer","volume":"2022 ","pages":"2597889"},"PeriodicalIF":1.9,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33476104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Educational Intervention on Knowledge, Attitude, and Practice of Women towards Breast Cancer Screening","authors":"T. Rakhshani, Maryam Dada, Seyyed Mansour Kashfi, A. Kamyab, A. K. Jeihooni","doi":"10.1155/2022/5697739","DOIUrl":"https://doi.org/10.1155/2022/5697739","url":null,"abstract":"Background Early identification of breast cancer may result in earlier treatment and a lower mortality rate. This fact has resulted in the development of screening programs to detect breast cancer in its early stages; thus, the current study sought to investigate the influence of educational intervention on knowledge, attitude, and practice about breast cancer screening in Izeh, Khozestan Province, Iran. Materials and Methods This experiment was carried out on the women of Izeh city in 2019. This study included 120 women who were randomized into the experimental and control groups at random (60 in the experimental and 60 in the control groups). Before and two months after the intervention, data were collected using a researcher-created questionnaire by the control and education groups. The intervention program for the intervention group included eight educational sessions over the course of two months. The SPSS 20 statistical program was used to examine the data, as well as the paired t-test, independent t-test, and Chi-square. Results There was no significant difference between the experimental and control groups' mean scores of knowledge, attitude, and practice prior to the educational intervention, but a significant difference was observed after the intervention, with the experimental group obtaining significantly higher mean scores of knowledge, attitude, and practice (P = 0.05). Conclusion In the present study, the educational intervention on the knowledge, attitude, and practice towards breast cancer screening led to the increased scores of the experimental group compared to control group.","PeriodicalId":46159,"journal":{"name":"International Journal of Breast Cancer","volume":"15 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88882616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of Frozen Section in Carcinoma Breast: Systematic Review","authors":"M. Rana, A. P. S. Rana, Uttam Sharma, T. S. Barwal, Aklank Jain","doi":"10.1155/2022/4958580","DOIUrl":"https://doi.org/10.1155/2022/4958580","url":null,"abstract":"Background The frozen section (FS) has been a good technique in surgical management of breast lesions since many years. But complete agreement and cooperation have not been achieved everywhere among surgeons and pathologists especially in the developing countries. FS undergoes continuous criticism due to various shortcomings but continued to be evaluated especially in developing countries. Objectives This review was conducted to synthesize information on the use of frozen section in carcinoma breast. Data Sources. The MEDLINE database for frozen section since its origin and its implication in recent breast surgery techniques was studied. Study Eligibility Criteria. Sixty-five articles were reviewed with complete analysis on FS in both benign and malignant breast lesions. Study Appraisal and Synthesis Methods. The analysis of frozen section was done as a diagnostic tool in breast lesions, margin status in breast conservative surgery in carcinoma breast, and sentinel lymph node and use of immunohistochemistry for sentinel lymph node FS. Results It was analysed that the FS gives accurate results in margin status analysis, decreasing rerecurrence. Conclusion The accuracy of FSA, low recurrence rate, avoidance of reoperation, and good cosmesis are the key points of its use in breast conservative surgery. Its use in sentinel lymph node biopsy (SLNB) is equivocal. However, application of immunohistochemistry on frozen section of SLNB is an evolving trend in today's era.","PeriodicalId":46159,"journal":{"name":"International Journal of Breast Cancer","volume":"37 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74951392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}