PROGRESS IN PEDIATRIC CARDIOLOGY最新文献

{"title":"Successful treatment of aortic root thrombus and neonatal myocardial infarction with systemic tissue plasminogen activator","authors":"Liza Hashim ,&nbsp;Theodore Millette ,&nbsp;Michael Shorofsky","doi":"10.1016/j.ppedcard.2025.101878","DOIUrl":"10.1016/j.ppedcard.2025.101878","url":null,"abstract":"<div><div>Neonatal myocardial infarction portends a grim prognosis, especially when severe left ventricular (LV) dysfunction is also seen. This report describes a 1-day-old with an uncomplicated prenatal course and delivery who presented with bacteremia and an aortic root thrombus, which led to left main coronary artery (LMCA) ischemia on day of life 1. He was treated with systemic tissue plasminogen activator with complete thrombus resolution, effectively restoring LMCA flow. With the addition of guideline-directed medical therapy, his LV function improved.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"79 ","pages":"Article 101878"},"PeriodicalIF":0.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145362089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis of outcomes of patent ductus arteriosus (PDA) stenting in a resource limited setting","authors":"K. Veena Bharati ,&nbsp;Avinash Anantharaj ,&nbsp;Nishad Plakkal ,&nbsp;Narayanan Parameswaran ,&nbsp;Satyen Parida ,&nbsp;Ajay Kumar Jha ,&nbsp;Chitra Rajeswari Thangaswamy ,&nbsp;Sreevathsa K.S. Prasad ,&nbsp;Hemachandran Munusamy ,&nbsp;Deepak Barathi ,&nbsp;Sundararaj Rajkumar ,&nbsp;Siddique Ahmed ,&nbsp;Raja Selvaraj ,&nbsp;Bhagwati Prasad Pant","doi":"10.1016/j.ppedcard.2025.101882","DOIUrl":"10.1016/j.ppedcard.2025.101882","url":null,"abstract":"<div><h3>Background</h3><div>Ductal stenting is a viable alternative to surgical shunts. Immediate outcomes of this procedure and the number of babies progressing to the final corrective surgery in developing countries need to be studied.</div></div><div><h3>Objectives</h3><div>To evaluate the immediate and late outcomes of PDA stenting in infants with critical congenital heart disease (CCHD) over the past 5 years in a single center.</div></div><div><h3>Methods</h3><div>Retrospective analysis of medical records and telephonic communication with parents.</div></div><div><h3>Results</h3><div>From January 2019 to March 2025, 22 infants underwent PDA stenting. Except for 2 (axillary access), the rest were done via femoral arterial access. Drug eluting stents were used in all except 1. The median age at stenting was 13 days, and median weight was 2.6 kg. TOF with pulmonary atresia was the most common indication, and median SpO2 off PGE1 was 65 %. The procedure was successful in 17 (77.2 %). There were 3 in-hospital deaths after a technically successful procedure. We were able to contact 12 patients (54.5 %). The median duration of palliation provided was 8 months. Reinterventions were not required for any baby. One child underwent Fontan-completion, while 5 underwent second stage surgery/definitive surgery. 2 were awaiting surgery. The interstage mortality between PDA stenting and the second stage or definitive surgery was 3/11 (27.2 %), and between 2nd and final stages was 2/8 (25 %). Currently, 7 are under follow-up and doing well.</div></div><div><h3>Conclusion</h3><div>In resource constrained settings, among infants who undergo PDA stenting for CCHD, roughly only half of those who were successfully discharged post-stenting successfully completed the full course of the proposed surgical correction, which is much lower in comparison to 85 % reported in Western literature.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"79 ","pages":"Article 101882"},"PeriodicalIF":0.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of nonelective removal of peripherally inserted central catheters in children with heart disease","authors":"Nayana Maria Gomes de Souza,&nbsp;Patrícia Linard Avelar,&nbsp;Karla Maria Carneiro Rolim,&nbsp;René Rodrigues Pereira,&nbsp;Candice Torres de Melo Bezerra Cavalcante","doi":"10.1016/j.ppedcard.2025.101868","DOIUrl":"10.1016/j.ppedcard.2025.101868","url":null,"abstract":"<div><h3>Background</h3><div>In the pediatric population with heart disease, evidence has assessed the risk factors for all types of access devices. However, there is little evidence to elucidate the predictive factors that cause major complications for nonelective removal of peripherally inserted central catheters (PICC) in this population.</div></div><div><h3>Objective</h3><div>The purpose of this study was to identify predictors of nonelective removal of PICC in a pediatric population hospitalized for heart disease.</div></div><div><h3>Methods</h3><div>This was a retrospective cohort study with a sample of 559 PICC lines inserted in 412 neonates, infants, toddlers, children, and adolescents admitted to the tertiary Pediatric Cardiology Unit of a public hospital in northeastern Brazil. We followed the children from insertion until the removal of the PICC. Bivariate analysis and logistic regression were conducted to identify predictors of nonelective removal.</div></div><div><h3>Results</h3><div>Among the variables investigated that maintained statistical significance for nonelective PICC catheter removal were selection of the external jugular vein, number of venipunctures, noncentral location of the catheter tip, and use of prostaglandin E1(PGE1). The previous central venous catheter insertion was determined as a protective factor for nonelective PICC removal.</div></div><div><h3>Conclusion</h3><div>External jugular vein selection for insertion, multiple venipuncture attempts, use of PGE1, and noncentral catheter tip position were associated with nonelective removal of the PICC catheter due to complications.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"79 ","pages":"Article 101868"},"PeriodicalIF":0.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective evaluation of pacemaker rate response in pediatric patients","authors":"Anthony G. Pompa ,&nbsp;William B. Orr ,&nbsp;Lisa Roelle ,&nbsp;Nathan Miller ,&nbsp;Jennifer N. Avari Silva","doi":"10.1016/j.ppedcard.2025.101887","DOIUrl":"10.1016/j.ppedcard.2025.101887","url":null,"abstract":"<div><h3>Background</h3><div>Patients with chronotropic incompetence can benefit from permanent pacemakers (PPM) with rate responsive (RR) pacing. This feature employs an accelerometer and allows for heart rate (HR) adaptation based on sensed patient activity. Due to congenital heart disease (CHD) and other constraints, pediatric patients may have an epicardial pacing system with a generator implanted in the abdomen. No studies have investigated if the site of generator implantation impacts the functionality of RR pacing.</div></div><div><h3>Objectives</h3><div>The aim of this prospective study was to evaluate the difference in RR functionality of accelerometer-based pacemakers between patients with a generator placed in the abdomen versus thoracic location.</div></div><div><h3>Methods</h3><div>Pediatric patients with a pacemaker implanted for complete heart block or sinus node dysfunction were enrolled. The pacemakers were temporarily reprogrammed to standardized RR parameters including activity thresholds, activity setpoints, and a HR range of 60–175 beats per minute. The participants then completed a standard Bruce protocol treadmill stress. HRs were measured at 30 second intervals.</div></div><div><h3>Results</h3><div>Ten pediatric patients with PPMs – five with abdominal and five with thoracic placement – were enrolled. No significant differences were found between the groups in age or exercise duration. There were no differences in the primary or secondary outcomes between the groups including HR change during exercise, maximum HR achieved, and time to maximum HR.</div></div><div><h3>Conclusion</h3><div>PPM generator location does not seem to result in differences in RR functionality. These findings support individualized PPM programming and highlight the need for further pediatric-focused device research.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"79 ","pages":"Article 101887"},"PeriodicalIF":0.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145525856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiorenal fat, and carotid intima media thickness in children with end stage kidney disease in Fayoum governorate","authors":"Sara I. Abo Elnour ,&nbsp;Mahmoud I. Abo Elnour ,&nbsp;Heba A. Borayek","doi":"10.1016/j.ppedcard.2025.101869","DOIUrl":"10.1016/j.ppedcard.2025.101869","url":null,"abstract":"<div><h3>Background</h3><div>The fat surrounding the kidney, heart, and increased carotid intima media thickness (CIMT) have been closely related to adverse cardiovascular outcomes in children with end stage kidney disease (ESKD).</div></div><div><h3>Objectives</h3><div>To evaluate epicardial fat thickness (EFT), perirenal fat thickness (PFT), and CIMT in hemodialysis patients and to assess the risk factors for increasing the thickness of these parameters.</div></div><div><h3>Methods</h3><div>This case-control study included 60 children with ESKD on regular hemodialysis and 60 apparently healthy children. EFT was measured using two-dimensional echocardiography, whereas CIMT and PFT were measured utilizing neck Doppler and abdominal ultrasound, respectively.</div></div><div><h3>Results</h3><div>The case group had significantly impaired systolic function with lower ejection fraction (EF) (mean = −0.87 ± 1.3) compared to the control group (mean = 0.33 ± 0.48, <em>p</em> &lt; 0.0001) and impaired diastolic function with Tei index significantly higher in cases (mean = 0.56) compared to controls (0.37). We found a significant increase in EFT, CIMT, and PFT in cases compared to controls (all <em>p</em> &lt; 0.001). We observed significant positive correlations between PFT and duration of hemodialysis (<em>r</em> = 0.412, <em>p</em> = 0.024), serum urea (<em>r</em> = 0.370, <em>p</em> = 0.044), and serum creatinine (<em>r</em> = 0.373, <em>p</em> = 0.042). We found positive correlations between EFT and each of the interventricular septum (IVS) thickness (<em>r</em> = 0.462, p = 0.042) and left ventricular end diastolic diameter (LVEDD) (<em>r</em> = 0.508, <em>p</em> = 0.004).</div></div><div><h3>Conclusion</h3><div>Children with ESKD who undergo regular hemodialysis have left ventricular systolic and diastolic dysfunction. The EFT, CIMT, and PFT were higher in children with ESKD. PFT was positively associated with duration of hemodialysis, LVEDD, and Tei index. EFT was positively correlated with IVS thickness and LVEDD. Rather than using broad measures of total adiposity, assessments of PFT, CIMT, and epicardial fat are more practical techniques for assessing cardiovascular risk in children with ESKD.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"79 ","pages":"Article 101869"},"PeriodicalIF":0.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144889309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “Addressing the unseen risk: Expanding pediatric cascade screening to prevent channelopathy-related sudden cardiac death”","authors":"Scott Kendall","doi":"10.1016/j.ppedcard.2025.101863","DOIUrl":"10.1016/j.ppedcard.2025.101863","url":null,"abstract":"","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"79 ","pages":"Article 101863"},"PeriodicalIF":0.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incessant fetal supraventricular tachycardia in a COVID-19 positive pregnancy","authors":"Anusha Bai Kalithkar ,&nbsp;Juanita Hunter","doi":"10.1016/j.ppedcard.2025.101865","DOIUrl":"10.1016/j.ppedcard.2025.101865","url":null,"abstract":"<div><div>Fetal tachyarrhythmia, defined as a fetal heart rate exceeding 180 beats per minute, is one of the common indications for referral to fetal cardiology. Emerging data suggest an increased incidence of fetal arrhythmias in pregnancies complicated by maternal COVID-19 infection. We report a case of fetal SVT in the setting of maternal COVID-19 infection and outline the clinical approach and therapeutic strategies employed in management.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"79 ","pages":"Article 101865"},"PeriodicalIF":0.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144893021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Energy drinks and our children: A time for action","authors":"James J. Shepherd","doi":"10.1016/j.ppedcard.2025.101870","DOIUrl":"10.1016/j.ppedcard.2025.101870","url":null,"abstract":"","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"79 ","pages":"Article 101870"},"PeriodicalIF":0.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative treatment contributions to post-traumatic stress symptoms in preschool-aged children after cardiac surgery","authors":"Kelly A. Hardy ,&nbsp;Mary S. Dietrich ,&nbsp;Mary Jo Gilmer ,&nbsp;D. Catherine Fuchs ,&nbsp;Terrah Foster Akard","doi":"10.1016/j.ppedcard.2025.101879","DOIUrl":"10.1016/j.ppedcard.2025.101879","url":null,"abstract":"<div><h3>Background</h3><div>Advancements in pediatric cardiac surgery have led to improved survival for congenital heart disease. Children who survive cardiac surgery are at high risk for non-cardiac comorbidities, including post-traumatic stress symptoms (PTSS). However, few studies have examined PTSS in preschool children following cardiac surgery.</div></div><div><h3>Objective</h3><div>The purpose of this study was to examine relationships between postoperative variables (cardiac physiology, postoperative intensive care unit length of stay, duration of mechanical ventilation, and number of prior surgeries) and the development of PTSS in children between three and six years old following cardiac surgery.</div></div><div><h3>Methods</h3><div>Primary caregivers of children aged three to six years who underwent cardiac surgery between 2018 and 2020 were invited to participate in this cross-sectional, descriptive study. We obtained data related to the child's surgery through medical chart review. Caregivers completed the Young Child Posttraumatic Stress Disorder Checklist to explore child PTSS. We assessed the strength and direction of the relationships between postoperative variables and child PTSS using correlational methods.</div></div><div><h3>Results</h3><div>Caregivers of children with single ventricle physiology reported greater child PTSS than those with biventricular physiology. Length of stay, duration of mechanical ventilation, and number of prior surgeries were not significantly associated with child PTSS.</div></div><div><h3>Conclusion</h3><div>Results demonstrated that preschool-aged children may develop PTSS following cardiac surgery. Those with single ventricle physiology may be more susceptible to the development of PTSS than children with biventricular physiology. Additional work is needed to identify risk factors for the development of PTSS in preschool children following cardiac surgery.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"79 ","pages":"Article 101879"},"PeriodicalIF":0.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to letter: Temperature management during neonatal ASO","authors":"Uri Pollak","doi":"10.1016/j.ppedcard.2025.101881","DOIUrl":"10.1016/j.ppedcard.2025.101881","url":null,"abstract":"","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"79 ","pages":"Article 101881"},"PeriodicalIF":0.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}