PROGRESS IN PEDIATRIC CARDIOLOGY最新文献

{"title":"Treatment of a ventricular thrombus with rivaroxaban in a patient with hypoplastic left heart syndrome","authors":"Steven R. Scaglione ,&nbsp;Connor T.A. Smith ,&nbsp;Mark W. Russell ,&nbsp;Kurt R. Schumacher ,&nbsp;Ashley Huebschman ,&nbsp;Bronwyn Crandall ,&nbsp;Carlen G. Fifer","doi":"10.1016/j.ppedcard.2025.101875","DOIUrl":"10.1016/j.ppedcard.2025.101875","url":null,"abstract":"<div><div>Hypoplastic left heart syndrome (HLHS) is a severe form of congenital heart disease characterized by poor development of left-sided cardiac structures. The current standard of care aims to create a stable circulation that relies on a single ventricle (SV) by utilizing a series of staged palliative surgical operations, typically leading to a Fontan procedure. These patients are at higher risk of both systemic and intraventricular thromboembolism secondary to abnormal circulation and its sequelae, such as protein-losing enteropathy (PLE). The direct oral anticoagulant (DOACs) drug class acts by direct inhibition of factor Xa, and these medications are gaining popularity for the prevention and treatment of thromboses in the SV population due to their convenient oral route and lack of need for frequent therapeutic level monitoring. While the use of DOACs has been well explored in adult patients, there remains a paucity of literature reporting on DOAC use in the treatment of intraventricular thrombus in the pediatric SV population. We present the first reported case of rivaroxaban use to treat an intracardiac thrombus and describe the clinical course and outcome in a pediatric patient with Fontan circulation.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"79 ","pages":"Article 101875"},"PeriodicalIF":0.8,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145266619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systolic function of a single left ventricle and exercise capacity in adults after Fontan palliation: A preliminary study using exercise echocardiography","authors":"Małgorzata Kowalczyk ,&nbsp;Maria Kordybach-Prokopiuk ,&nbsp;Piotr Hoffman ,&nbsp;Mirosław Kowalski","doi":"10.1016/j.ppedcard.2025.101872","DOIUrl":"10.1016/j.ppedcard.2025.101872","url":null,"abstract":"<div><h3>Background</h3><div>Patients with functionally single ventricle after Fontan palliation are an increasingly large group in adult congenital heart disease departments. This cohort is also among the most complex to manage. However, many patients face a range of complications. Due to several reasons, patients following Fontan palliation experience significant reductions in exercise capacity. Cardiopulmonary exercise testing (CPET) provides means to assess exercise tolerance with objective parameters.</div></div><div><h3>Objectives</h3><div>The aim of the study is comparison of Stress Echocardiography (SE) parameters and CPET data in order to discover the potential relationship between them.</div></div><div><h3>Methods</h3><div>We enrolled 30 patients with a functionally single ventricle of left ventricle morphology who had undergone Fontan palliation and were hospitalized at the Department of Congenital Heart Defects between 2019 and 2021. The study was conducted using a bicycle ergometer in a semi-recumbent position. The parameters measured at rest and at peak exercise included the ejection fraction (EF) of the single ventricle and global longitudinal strain (GLS). The results of the current CPET were also incorporated. Demographic data, previous interventions, pharmacological treatment, and comorbidities were extracted from the patients' medical records.</div></div><div><h3>Results</h3><div>GLS measured at rest and EF measured at peak exercise correlated with Predicted Peak Oxygen Consumption (pVO2%pred).</div></div><div><h3>Conclusion</h3><div>GLS of the single left ventricle shows a meaningful association with pVO₂%pred and EF measured at peak exercise during stress echocardiography also correlates with pVO₂%pred, suggesting that both parameters provide complementary insights into the functional capacity and contractile reserve of the single ventricle in Fontan patients.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"79 ","pages":"Article 101872"},"PeriodicalIF":0.8,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145266618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A newborn case absent pulmonary valve with intact ventricular septum and UHL anomaly","authors":"Pelin Altınbezer ,&nbsp;Ömer Nuri Aksoy ,&nbsp;Utku Arman Örün","doi":"10.1016/j.ppedcard.2025.101873","DOIUrl":"10.1016/j.ppedcard.2025.101873","url":null,"abstract":"<div><div>Absent pulmonary valve is a very rare anomaly and is often seen together with tetralogy of Fallot. Absent pulmonary valve with intact ventricular septum without tetralogy of Fallot is a very rare condition, and right ventricular myocardial pathologies may accompany these patients. We present a newborn case with Uhl anomaly, intact ventricular septum, and absent pulmonary valve leaflets.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"79 ","pages":"Article 101873"},"PeriodicalIF":0.8,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145266617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous ventricular septal defect device closure in a child with Ebstein's anomaly – Hemodynamics and rationale in a rare combination of lesions","authors":"Sadik K.C. ,&nbsp;Chetan Kumar Nanjegowda ,&nbsp;Anand P. Subramanian","doi":"10.1016/j.ppedcard.2025.101871","DOIUrl":"10.1016/j.ppedcard.2025.101871","url":null,"abstract":"<div><div>Ebstein's anomaly is only rarely associated with a ventricular septal defect. We report device closure of a moderate-sized perimembranous ventricular septal defect in a child with Ebstein's anomaly and discuss the potential hemodynamic advantages of shunt elimination in this scenario.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"79 ","pages":"Article 101871"},"PeriodicalIF":0.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Energy drinks and our children: A time for action","authors":"James J. Shepherd","doi":"10.1016/j.ppedcard.2025.101870","DOIUrl":"10.1016/j.ppedcard.2025.101870","url":null,"abstract":"","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"79 ","pages":"Article 101870"},"PeriodicalIF":0.8,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of nonelective removal of peripherally inserted central catheters in children with heart disease","authors":"Nayana Maria Gomes de Souza,&nbsp;Patrícia Linard Avelar,&nbsp;Karla Maria Carneiro Rolim,&nbsp;René Rodrigues Pereira,&nbsp;Candice Torres de Melo Bezerra Cavalcante","doi":"10.1016/j.ppedcard.2025.101868","DOIUrl":"10.1016/j.ppedcard.2025.101868","url":null,"abstract":"<div><h3>Background</h3><div>In the pediatric population with heart disease, evidence has assessed the risk factors for all types of access devices. However, there is little evidence to elucidate the predictive factors that cause major complications for nonelective removal of peripherally inserted central catheters (PICC) in this population.</div></div><div><h3>Objective</h3><div>The purpose of this study was to identify predictors of nonelective removal of PICC in a pediatric population hospitalized for heart disease.</div></div><div><h3>Methods</h3><div>This was a retrospective cohort study with a sample of 559 PICC lines inserted in 412 neonates, infants, toddlers, children, and adolescents admitted to the tertiary Pediatric Cardiology Unit of a public hospital in northeastern Brazil. We followed the children from insertion until the removal of the PICC. Bivariate analysis and logistic regression were conducted to identify predictors of nonelective removal.</div></div><div><h3>Results</h3><div>Among the variables investigated that maintained statistical significance for nonelective PICC catheter removal were selection of the external jugular vein, number of venipunctures, noncentral location of the catheter tip, and use of prostaglandin E1(PGE1). The previous central venous catheter insertion was determined as a protective factor for nonelective PICC removal.</div></div><div><h3>Conclusion</h3><div>External jugular vein selection for insertion, multiple venipuncture attempts, use of PGE1, and noncentral catheter tip position were associated with nonelective removal of the PICC catheter due to complications.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"79 ","pages":"Article 101868"},"PeriodicalIF":0.8,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apnea mediated transient complete atrioventricular block in a pre-term neonate","authors":"Sakthi Saravanan ,&nbsp;Navaneetha Sasikumar ,&nbsp;Raman Krishna Kumar","doi":"10.1016/j.ppedcard.2025.101866","DOIUrl":"10.1016/j.ppedcard.2025.101866","url":null,"abstract":"<div><div>We present a previously unrecognized, reversible cause for complete atrioventricular block in the sick neonate. An 18 day old 33 weeker with Tetralogy of Fallot was admitted with sinus rhythm on ECG. Soon after, the baby developed episodes of apnea during which ECG showed complete atrioventricular block. This was unresponsive to atropine and isoprenaline, and heart rate continued to deteriorate. Mechanical ventilation was initiated in view of the critical condition and in preparation for an emergency temporary pacing wire insertion. Remarkably, ventilation restored sinus rhythm. The probable mechanisms by which apnea and acute hypoxia can cause atrioventricular block include carotid chemoreceptor mediated reflex vagal stimulation, depression of atrioventricular nodal conduction, and increase in endogenous adenosine levels. It is prudent to consider this reversible mechanism in the differential diagnosis of new onset atrioventricular block in the sick neonate, as early recognition may help avoid unnecessary invasive interventions.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"79 ","pages":"Article 101866"},"PeriodicalIF":0.8,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144893022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global trends in obesity and cardiovascular disease research among children and adolescents: A bibliometric analysis (1984–2024)","authors":"Deepanshi Saxena ,&nbsp;Sudip Bhattacharya ,&nbsp;Akanksha Singh ,&nbsp;Alok Singh","doi":"10.1016/j.ppedcard.2025.101867","DOIUrl":"10.1016/j.ppedcard.2025.101867","url":null,"abstract":"<div><h3>Background</h3><div>Childhood and adolescent obesity have emerged as significant public health concerns, contributing to an increased risk of cardiovascular disease (CVD) later in life. Over the past four decades, extensive research has examined the relationship between obesity and CVD among young populations, highlighting the need for early intervention strategies. Bibliometric analysis offers a comprehensive overview of research trends, influential studies, and key thematic areas within this field.</div></div><div><h3>Aim of review</h3><div>This study aims to map the scientific landscape of global research on obesity and cardiovascular disease among children and adolescents from 1984 to 2024. By employing bibliometric methods, we identify prolific authors, leading institutions, impactful publications, and emerging research themes, providing insights into the evolution of this critical area of study.</div></div><div><h3>Key scientific concepts of review</h3><div>The bibliometric analysis was conducted using the Scopus database, focusing on publication trends, citation networks, and keyword co-occurrence patterns. The study identifies research hotspots, including metabolic risk factors, lifestyle interventions, genetic predisposition, and public health policies targeting obesity-related CVD in young populations. Additionally, the review highlights collaborative networks among global researchers and suggests future directions for advancing knowledge and policy-making in this domain.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"79 ","pages":"Article 101867"},"PeriodicalIF":0.8,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiorenal fat, and carotid intima media thickness in children with end stage kidney disease in Fayoum governorate","authors":"Sara I. Abo Elnour ,&nbsp;Mahmoud I. Abo Elnour ,&nbsp;Heba A. Borayek","doi":"10.1016/j.ppedcard.2025.101869","DOIUrl":"10.1016/j.ppedcard.2025.101869","url":null,"abstract":"<div><h3>Background</h3><div>The fat surrounding the kidney, heart, and increased carotid intima media thickness (CIMT) have been closely related to adverse cardiovascular outcomes in children with end stage kidney disease (ESKD).</div></div><div><h3>Objectives</h3><div>To evaluate epicardial fat thickness (EFT), perirenal fat thickness (PFT), and CIMT in hemodialysis patients and to assess the risk factors for increasing the thickness of these parameters.</div></div><div><h3>Methods</h3><div>This case-control study included 60 children with ESKD on regular hemodialysis and 60 apparently healthy children. EFT was measured using two-dimensional echocardiography, whereas CIMT and PFT were measured utilizing neck Doppler and abdominal ultrasound, respectively.</div></div><div><h3>Results</h3><div>The case group had significantly impaired systolic function with lower ejection fraction (EF) (mean = −0.87 ± 1.3) compared to the control group (mean = 0.33 ± 0.48, <em>p</em> &lt; 0.0001) and impaired diastolic function with Tei index significantly higher in cases (mean = 0.56) compared to controls (0.37). We found a significant increase in EFT, CIMT, and PFT in cases compared to controls (all <em>p</em> &lt; 0.001). We observed significant positive correlations between PFT and duration of hemodialysis (<em>r</em> = 0.412, <em>p</em> = 0.024), serum urea (<em>r</em> = 0.370, <em>p</em> = 0.044), and serum creatinine (<em>r</em> = 0.373, <em>p</em> = 0.042). We found positive correlations between EFT and each of the interventricular septum (IVS) thickness (<em>r</em> = 0.462, p = 0.042) and left ventricular end diastolic diameter (LVEDD) (<em>r</em> = 0.508, <em>p</em> = 0.004).</div></div><div><h3>Conclusion</h3><div>Children with ESKD who undergo regular hemodialysis have left ventricular systolic and diastolic dysfunction. The EFT, CIMT, and PFT were higher in children with ESKD. PFT was positively associated with duration of hemodialysis, LVEDD, and Tei index. EFT was positively correlated with IVS thickness and LVEDD. Rather than using broad measures of total adiposity, assessments of PFT, CIMT, and epicardial fat are more practical techniques for assessing cardiovascular risk in children with ESKD.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"79 ","pages":"Article 101869"},"PeriodicalIF":0.8,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144889309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incessant fetal supraventricular tachycardia in a COVID-19 positive pregnancy","authors":"Anusha Bai Kalithkar ,&nbsp;Juanita Hunter","doi":"10.1016/j.ppedcard.2025.101865","DOIUrl":"10.1016/j.ppedcard.2025.101865","url":null,"abstract":"<div><div>Fetal tachyarrhythmia, defined as a fetal heart rate exceeding 180 beats per minute, is one of the common indications for referral to fetal cardiology. Emerging data suggest an increased incidence of fetal arrhythmias in pregnancies complicated by maternal COVID-19 infection. We report a case of fetal SVT in the setting of maternal COVID-19 infection and outline the clinical approach and therapeutic strategies employed in management.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"79 ","pages":"Article 101865"},"PeriodicalIF":0.8,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144893021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}