唐氏综合征新生儿主动脉弓的尺寸

IF 0.6 Q4 PEDIATRICS

PROGRESS IN PEDIATRIC CARDIOLOGY Pub Date : 2025-04-30 DOI:10.1016/j.ppedcard.2025.101835

Abhishek Chakraborty , Mohanageetha Ardhanari , Marjorie Gayanilo , Hanah Walker , Lindsey Bird , Nao Sasaki , Sethuraman Swaminathan

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引用次数: 0

摘要

背景先天性心脏病（CHD）是唐氏综合征患者发病和死亡的主要原因。目的本研究的目的是确定唐氏综合征患者主动脉弓尺寸异常的患病率。方法回顾性分析在杰克逊卫生系统出生的唐氏综合症患者14年的数据。回顾新生儿初始超声心动图是否存在冠心病，以及主动脉环、远端横弓和主动脉峡的尺寸，然后与年龄和性别匹配的队列进行比较。结果本研究共纳入138例患者。我们队列中先天性心脏病的总患病率为70.7% （n = 97）。其中，最常见的冠心病是室间隔缺损（VSD）（23.2%）、房间隔缺损（ASD）（24.6%）和房室间隔缺损（AVSD）（34.8%）。14例（10.1%）存在主动脉峡部发育不全，9例（6.5%）存在远端横弓发育不全。结论13.8%的唐氏综合征患者存在轻度主动脉弓发育不全且无缩窄。在21三体患者中，测量主动脉弓的尺寸可能需要特殊的形态图。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Aortic arch dimensions in neonates with Down syndrome

Background

Congenital heart disease (CHD) is a major cause of morbidity and mortality in patients with Down syndrome.

Objectives

The objective of this study is to identify the prevalence of abnormal aortic arch dimensions in patients with Down syndrome.

Methods

This was a retrospective chart review of patients with Down syndrome who were born at Jackson Health System over a 14-year period. The initial neonatal echocardiograms were reviewed for presence of CHD along with the dimensions of aortic annulus, distal transverse arch, and aortic isthmus, and then compared with age and sex matched cohorts.

Results

A total of 138 patients were included in this study. The overall prevalence of congenital heart disease in our cohort was 70.7 % (n = 97). Among those identified, the most common CHDs were ventricular septal defect (VSD) (23.2 %), atrial septal defect (ASD) (24.6 %), and atrioventricular septal defect (AVSD) (34.8 %) Fourteen patients (10.1 %) had aortic isthmus hypoplasia and 9 (6.5 %) had hypoplasia of the distal transverse arch.

Conclusion

Mild aortic arch hypoplasia without coarctation is found in 13.8 % of patients with Down syndrome. Specific nomograms may be necessary for measuring aortic arch dimensions in patients with Trisomy 21.

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来源期刊

PROGRESS IN PEDIATRIC CARDIOLOGY PEDIATRICS-

CiteScore

0.90

自引率

11.10%

发文量

审稿时长

75 days

期刊介绍： Progress in Pediatric Cardiology is an international journal of review presenting information and experienced opinion of importance in the understanding and management of cardiovascular diseases in children. Each issue is prepared by one or more Guest Editors and reviews a single subject, allowing for comprehensive presentations of complex, multifaceted or rapidly changing topics of clinical and investigative interest.