Performance of first-trimester fetal nuchal translucency, ductus venosus, tricuspid regurgitation in diagnosing congenital heart defects: A systematic review and meta-analysis

IF 0.6 Q4 PEDIATRICS

PROGRESS IN PEDIATRIC CARDIOLOGY Pub Date : 2025-04-23 DOI:10.1016/j.ppedcard.2025.101833

Behnaz Moradi , Payam Jannatdoust , Paria Shafiekhani , Mohamadreza Tahamtan , Gita Manzari Tavakoli , Parya Valizadeh , Pouya Ebrahimi , Niloofarsadaat Eshaghhosseiny , Farzan Moodi , Hamed Ghorani , Parisa Kohnepoushi , Mahshad Razaghi , Morteza Sanei Taheri , Delaram J. Ghadimi

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引用次数: 0

Abstract

Background

Congenital heart disease (CHD) is the main cause of perinatal morbidity and mortality. Nuchal Translucency (NT), Ductus Venosus (DV), and Tricuspid Regurgitation (TR) have shown potential in CHD detection.

Aim of review

We evaluated the pooled diagnostic test accuracy of these markers during the first-trimester screening.

Key scientific concepts of review

PubMed, Scopus, Web of Science, and Embase were searched. A bivariate random effects model created Summary Receiver Operating Characteristic (SROC) curves and the pooled sensitivities and specificities. Forty-two studies were included. For major CHDs, the pooled sensitivities and specificities were 43.1 % (95 % CI: 35.0 %–51.6 %) and 95.5 % (95 % CI: 93.5 %–96.9 %) for A/R DV a wave, 57.8 % (95 % CI: 43.3 %–71.0 %) and 88.8 % (95 % CI: 77.7 %–94.7 %) for abnormal DV-PIV, 37.0 % (95 % CI: 26.6 %–48.6 %) and 97.7 % (95 % CI: 94.6 %–99.1 %) for TR, 41.4 % (95 % CI: 23.2 %–62.2 %) and 93.7 % (95 % CI: 92.7 %–94.6 %) for NT > 95th percentile, and 26.6 % (95 % CI: 11.0 %–51.7 %) and 98.3 % (95 % CI: 97.5 %–98.9 %) for NT > 99th percentile. For the combined models in detecting major CHDs, the highest specificity of 97.8 % (95 % CI: 93.9 %–99.2 %) belonged to NT > 95th percentile and A/R DV a wave. The most sensitive tests were the combination of NT > 95th percentile or A/R DV a wave or TR 61.4 % (95 % CI: 49.7 %–71.9 %). Combining increased NT with the presence of A/R a-wave can help diagnose CHD, while normal NT, A/R DV a wave, and TR indicate lower CHD risk.

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早期妊娠胎儿颈透明、静脉导管、三尖瓣反流诊断先天性心脏缺陷的表现：一项系统回顾和荟萃分析

背景先天性心脏病（CHD）是围产期发病和死亡的主要原因。颈透明（NT）、静脉导管（DV）和三尖瓣返流（TR）显示出冠心病检测的潜力。回顾目的：我们评估了这些标志物在妊娠早期筛查时的综合诊断测试的准确性。检索了reviewPubMed、Scopus、Web of Science和Embase的关键科学概念。双变量随机效应模型建立了总接受者工作特征（SROC）曲线和合并的敏感性和特异性。纳入了42项研究。主要的冠心病,合用的敏感性和特异性分别为43.1% (95% CI: 35.0% - -51.6%)和95.5% (95% CI: 93.5% - -96.9%) / R DV波,57.8% (95% CI: 43.3% - -71.0%)和88.8% (95% CI: 77.7% - -94.7%) DV-PIV异常,37.0% (95% CI: 26.6% - -48.6%)和97.7% (95% CI: 94.6% - -99.1%) TR, 41.4% (95% CI: 23.2% - -62.2%)和93.7% (95% CI: 92.7% - -94.6%) NT祝辞第95个百分位,26.6% (95% CI: 11.0% - -51.7%)和98.3% (95% CI: 97.5% - -98.9%) NT祝辞第99个百分位。在检测主要冠心病的联合模型中，NT >的特异性最高，为97.8% (95% CI: 93.9% ~ 99.2%)；95百分位和A/R DV A波。最敏感的试验是NT >联合试验；第95百分位或A/R DV A波或TR 61.4% （95% CI: 49.7% - 71.9%）。NT升高合并A/R A波有助于诊断冠心病，而NT、A/R DV A波和TR正常则提示冠心病风险较低。

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来源期刊

PROGRESS IN PEDIATRIC CARDIOLOGY PEDIATRICS-

CiteScore

0.90

自引率

11.10%

发文量

审稿时长

75 days

期刊介绍： Progress in Pediatric Cardiology is an international journal of review presenting information and experienced opinion of importance in the understanding and management of cardiovascular diseases in children. Each issue is prepared by one or more Guest Editors and reviews a single subject, allowing for comprehensive presentations of complex, multifaceted or rapidly changing topics of clinical and investigative interest.