PROGRESS IN PEDIATRIC CARDIOLOGY最新文献

{"title":"Response to “Addressing the unseen risk: Expanding pediatric cascade screening to prevent channelopathy-related sudden cardiac death”","authors":"Scott Kendall","doi":"10.1016/j.ppedcard.2025.101863","DOIUrl":"10.1016/j.ppedcard.2025.101863","url":null,"abstract":"","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"79 ","pages":"Article 101863"},"PeriodicalIF":0.8,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing the unseen risk: Expanding pediatric cascade screening to prevent channelopathy-related sudden cardiac death","authors":"Brijesh Sathian, Javed Iqbal, Syed Muhammad Ali","doi":"10.1016/j.ppedcard.2025.101862","DOIUrl":"10.1016/j.ppedcard.2025.101862","url":null,"abstract":"","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"79 ","pages":"Article 101862"},"PeriodicalIF":0.8,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonged lactic acidosis following congenital cardiac surgery: A case report highlighting the potential role of thiamine deficiency","authors":"Ahmed Abdulgawad ,&nbsp;Ahmed Mansour ,&nbsp;Mohammed Bin Joubah ,&nbsp;Yasser Balubaid ,&nbsp;Gaser Abdelmohsen","doi":"10.1016/j.ppedcard.2025.101861","DOIUrl":"10.1016/j.ppedcard.2025.101861","url":null,"abstract":"<div><h3>Background</h3><div>Lactic acidosis is a critical metabolic derangement frequently observed following pediatric cardiac surgery, often attributed to low cardiac output and resultant tissue hypoperfusion. However, thiamine deficiency can disrupt aerobic metabolism, leading to excessive lactate accumulation. Infants undergoing complex surgical interventions risk developing thiamine deficiency in the postoperative period, especially if prolonged parenteral nutrition is administered without adequate supplementation.</div></div><div><h3>Case description</h3><div>A full-term female neonate diagnosed with transposition of the great arteries underwent an arterial switch operation on day 11 of life. Her postoperative course was complicated by feeding intolerance, suspected necrotizing enterocolitis (NEC), and prolonged parenteral nutrition (TPN). Despite the resolution of sepsis and NEC being ruled out, persistent lactic acidosis and feeding intolerance continued. On postoperative day 57, thiamine deficiency was suspected and treated with intravenous supplementation. After thiamin therapy, there was a rapid decline in lactate levels (from 14 mmol/L to &lt;2 mmol/L within 24 h) and resolution of clinical symptoms.</div></div><div><h3>Conclusion</h3><div>This case illustrates how thiamine deficiency may contribute to persistent lactic acidosis and feeding intolerance in neonates receiving prolonged TPN following complex cardiac surgery, underscoring the value of considering nutritional deficiencies in the differential diagnosis. Early recognition and timely supplementation can significantly improve outcomes, emphasizing the need for clinical awareness and routine thiamine supplementation in high-risk postoperative care.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"78 ","pages":"Article 101861"},"PeriodicalIF":0.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHD infant mortality disparities in the USA: Positive changes in the previously worst performing state","authors":"E. McGovern ,&nbsp;L. Bezold ,&nbsp;D. Winlaw ,&nbsp;N.J. Ollberding ,&nbsp;M.M. Hossain ,&nbsp;S. Shahanavaz","doi":"10.1016/j.ppedcard.2025.101860","DOIUrl":"10.1016/j.ppedcard.2025.101860","url":null,"abstract":"<div><h3>Background</h3><div>From 2006 to 2015, Kentucky had the highest rate of infant mortality attributable to congenital heart disease (CHD) in the USA. Across the country, mortality was associated with male sex, prematurity, non-Hispanic black race, lower maternal education, higher % of poverty, and increasing distance from a top 50 cardiac center.</div></div><div><h3>Objectives</h3><div>We sought to update these observations during a more contemporary era, with specific emphasis on Kentucky's performance.</div></div><div><h3>Methods</h3><div>The National Center for Health Statistics linked birth and infant death period data sets from 2016 to 2020 were used to calculate the incidence of CHD infant mortality. Chi-square tests were conducted to test for differences in deaths according to factors of interest for the entire USA and Kentucky. We also examined the mortality rate in Kentucky, which differed from 2016 to 2017 vs. 2018–2020, which coincided with the creation of a joint program between one of Kentucky's pediatric cardiac centers and a top 50 center in Ohio.</div></div><div><h3>Results</h3><div>There was a national trend for improvement in CHD infant mortality. The national mortality rate in 2016–2020 was 0.3 deaths per 1000 live births compared to 0.34 in 2006–2015 (<em>p</em> &lt; 0.001). Kentucky was no longer among the worst in the USA. In the USA, male sex, prematurity, non-Hispanic black race, lower level of maternal education, and healthcare payment not by private insurance were associated with a higher incidence of mortality (<em>p</em> &lt; 0.001). For Kentucky, prematurity, non-Hispanic black race, poverty, and healthcare payment other than private insurance increased CHD infant mortality. Mortality rates in Kentucky for 2016–2017 and 2018–2020 were similar.</div></div><div><h3>Conclusion</h3><div>CHD infant mortality improved in the more contemporary era, and Kentucky was no longer the worst performing state. Male sex, prematurity, non-Hispanic black race, lower level of maternal education, and poverty continue to be associated with a higher incidence of CHD infant mortality.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"78 ","pages":"Article 101860"},"PeriodicalIF":0.8,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144721315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparticipation screening and electrocardiograms in athletes","authors":"Peter Rippey ,&nbsp;Jada Ashford ,&nbsp;Zachariah El-fallah ,&nbsp;Korey Shively ,&nbsp;Jorge Sucar ,&nbsp;Christian Cooper ,&nbsp;Emily Ribeiro ,&nbsp;Samantha Glenn Etheredge ,&nbsp;Cade C. Smelley ,&nbsp;Lynn A. Batten","doi":"10.1016/j.ppedcard.2025.101859","DOIUrl":"10.1016/j.ppedcard.2025.101859","url":null,"abstract":"<div><h3>Background</h3><div>Sudden cardiac arrest occurs in 1 per 50,000 to 80,000 people per year. Preparticipation screening may identify athletes who may be at risk for developing sudden cardiac arrest.</div></div><div><h3>Aim of review</h3><div>The purpose of this article is to review the etiologies of sudden cardiac arrest, preparticipation screening, and use of electrocardiograms in screening athletes for cardiac problems.</div></div><div><h3>Key scientific concepts of review</h3><div>Sudden cardiac arrest may occur in young athletes who have hypertrophic cardiomyopathy, anomalous origin of a coronary artery, arrhythmogenic right ventricular cardiomyopathy, dilated cardiomyopathy, aortic dissection, myocarditis, Wolff-Parkinson-White syndrome, long QT syndrome, Brugada syndrome, commotio cordis, aortic valve stenosis, coarctation of the aorta, congenital heart block, short QT syndrome, or coronary artery disease. Preparticipation screening may include history, physical examination, and an electrocardiogram. Several guidelines for screening are available. The American Heart Association 14-element screening protocol includes seven questions about personal history, three questions about family history, and four physical examination findings. The electrocardiogram may identify cardiac conditions such as cardiomyopathy, Wolff-Parkinson-White syndrome, and long QT syndrome that may not manifest on physical examination. Widespread use of an electrocardiogram in screening may be limited by cost and practitioner training. Successful implementation of the use of an electrocardiogram in screening may depend on specific training for practitioners in interpreting the electrocardiogram in young athletes. It is important to identify specialists who may help with further evaluation of any findings consistent with critical cardiovascular disease.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"78 ","pages":"Article 101859"},"PeriodicalIF":0.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144711870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histoplasma endocarditis in a prosthetic pulmonary valve: A case report","authors":"Sharadhi Thalner ,&nbsp;Reem Youssef ,&nbsp;James Wood ,&nbsp;Jeremy L. Herrmann ,&nbsp;J.P. Lavik ,&nbsp;Erin Rudzinski ,&nbsp;Umesh Dyamenahalli ,&nbsp;Mark Ayers","doi":"10.1016/j.ppedcard.2025.101853","DOIUrl":"10.1016/j.ppedcard.2025.101853","url":null,"abstract":"<div><h3>Introduction</h3><div>Infective endocarditis (IE) following transcatheter pulmonary valve placement is a significant concern. Fungal endocarditis, though rare, poses significant diagnostic and therapeutic challenges, particularly when caused by <em>Histoplasma capsulatum</em>.</div></div><div><h3>Case report</h3><div>We present a 24-year-old female with tetralogy of Fallot (ToF) and a history of transcatheter prosthetic pulmonary valve replacement, who developed IE secondary to active histoplasmosis. Initial symptoms included worsening fatigue and jaundice, leading to hospitalization. Echocardiography revealed new stenosis of the pulmonary valve, prompting further investigation. Despite negative blood cultures, serological and molecular tests for histoplasmosis were positive, confirming the diagnosis. Treatment commenced with amphotericin B, followed by surgical valve replacement two weeks later, revealing hyphal elements indicative of <em>H. capsulatum</em>. The patient subsequently received prolonged antifungal therapy with itraconazole with near complete resolution of symptoms and a mild residual gradient.</div></div><div><h3>Conclusion</h3><div>This case emphasizes the necessity for heightened awareness of fungal pathogens in patients with prosthetic devices, particularly in the context of culture-negative endocarditis. Early diagnosis and intervention, including surgical resection and appropriate antifungal treatment, are critical for improving patient outcomes.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"78 ","pages":"Article 101853"},"PeriodicalIF":0.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balloon- versus self-expandable stents in the endovascular treatment of adults with aortic coarctation: A systematic review and meta-analysis","authors":"Kristine Santos ,&nbsp;Luísa Zanelatto de Araujo ,&nbsp;Sriharsha Koduru ,&nbsp;Mislav Planinc","doi":"10.1016/j.ppedcard.2025.101854","DOIUrl":"10.1016/j.ppedcard.2025.101854","url":null,"abstract":"<div><h3>Background</h3><div>Coarctation of the aorta (CoA) is a congenital cardiovascular defect that may persist into adulthood. Endovascular stenting has become the preferred approach, with balloon-expandable stents (BES) and self-expandable stents (SES) being commonly used. However, there is a notable paucity of comparative data evaluating their relative safety and efficacy.</div></div><div><h3>Objectives</h3><div>We aimed to compare the outcomes of BES and SES in the endovascular management of adults with CoA.</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis were performed by searching MEDLINE, Scopus, and the Cochrane Library for studies directly comparing BES and SES in adult CoA patients. Eligible studies included randomized controlled trials and observational studies. Pooled odds ratios (OR) with 95 % confidence intervals (CI) were calculated using a random-effects model.</div></div><div><h3>Results</h3><div>Three studies (one RCT, two observational), comprising 282 patients, were included, of whom 53.5 % received BES. No significant differences were observed in the cumulative peri-procedural complications [OR 2.5; 95 % CI 0.4 to 18.2; <em>p</em> = 0.07, I² = 9 %], stent migration [OR 1.1; 95 % CI 0.3 to 4.0; <em>p</em> = 0.94; I² = 51 %], and persistent hypertension post-intervention [OR 0.8; 95 % CI 0.4 to 1.6; <em>p</em> = 0.60; I² = 0 %]. Heterogeneity was minimal across most outcomes.</div></div><div><h3>Conclusion</h3><div>Our analysis suggests that BES and SES offer comparable safety and efficacy in the endovascular treatment of adult CoA. However, the small number of studies and wide confidence intervals warrant cautious interpretation. These findings highlight the need for larger, prospective randomized trials to better guide stent selection in this population.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"78 ","pages":"Article 101854"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant right atrial myxoma in pediatrics. Case report","authors":"Alex Ismael Catalán Cabrera,&nbsp;Hugo Martin Reyes Alban,&nbsp;Karen del Rosario Condori Alvino,&nbsp;Mónica Karem Medina Durand,&nbsp;Luis Jacinto De la Cruz Hilario,&nbsp;Nelly Tamayo Huiza","doi":"10.1016/j.ppedcard.2025.101856","DOIUrl":"10.1016/j.ppedcard.2025.101856","url":null,"abstract":"<div><h3>Introduction</h3><div>Myxoma is the most common benign cardiac tumor in adults; however, in children, it is less frequent than rhabdomyoma and fibroma. It shows a female predominance, with an incidence 1.5 to 2 times higher than in males. Only 22 % of myxomas develop in the right atrium, 2 % in the ventricles, and 1 % in the atrioventricular valve.</div></div><div><h3>Case report</h3><div>We present the case of a 10-year-old patient admitted with obstructive symptoms with right heart failure. Diagnostic imaging, including chest X-ray, transthoracic echocardiography, and computed tomography, revealed a giant intracardiac mass. Surgical excision of the tumor was performed 48 h after admission, with favorable postoperative evolution. Histopathological examination confirmed the diagnosis of cardiac myxoma.</div></div><div><h3>Conclusions</h3><div>Right atrial myxomas may present with dyspnea, syncope, ascites, and symptoms of right heart failure. Early diagnosis is crucial to prevent cerebrovascular events and allow for timely surgical treatment, thereby reducing preoperative and postoperative complications.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"78 ","pages":"Article 101856"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal management of severe tricuspid dysplasia with circular shunt using NSAID therapy: A novel approach","authors":"Sofia Rito ,&nbsp;João Dias ,&nbsp;Patrícia Vaz Silva ,&nbsp;Iolanda Ferreira ,&nbsp;Maria Emanuel Amaral ,&nbsp;Paula Martins ,&nbsp;António Pires","doi":"10.1016/j.ppedcard.2025.101857","DOIUrl":"10.1016/j.ppedcard.2025.101857","url":null,"abstract":"<div><div>Tricuspid valve dysplasia (TVD) is a rare congenital heart defect that can lead to a life-threatening fetal circulation compromise. We report a case of a fetus with TVD diagnosed at 22 weeks gestation, characterized by severe tricuspid regurgitation, retrograde flow through the ductus arteriosus, and pulmonary regurgitation (circular shunt). Prenatal management with nonsteroidal anti-inflammatory drugs (NSAIDs), both ibuprofen (400–600 mg, every 8 h) and indomethacin (50 mg, every 8 h), was initiated at 28 weeks gestation, and continued until birth, to promote ductal constriction and antegrade flow through it, thus terminating or reducing the circular shunt. Despite the challenging management with NSAIDs, it was possible to achieve a near term delivery and conservative neonatal management.</div><div>This case highlights the potential of NSAIDs as a therapeutic option in managing severe TVD with a circular shunt, improving fetal survival and prolonging pregnancy for better neonatal outcomes.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"78 ","pages":"Article 101857"},"PeriodicalIF":0.6,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of congenital heart disease among neonates in Fayoum district","authors":"Sayed Ali Amin,&nbsp;Sumer Nady Mohamed Elfakhrany,&nbsp;Ahmed Mahmoud Abd Elmoktader","doi":"10.1016/j.ppedcard.2025.101858","DOIUrl":"10.1016/j.ppedcard.2025.101858","url":null,"abstract":"<div><h3>Background</h3><div>Congenital heart disease (CHD) is a significant structural irregularity in the heart's chambers or major vessels, affecting its function.</div></div><div><h3>Objectives</h3><div>To determine the occurrence of CHD among newborns in the Fayoum district of Egypt.</div></div><div><h3>Methods</h3><div>This cross-sectional observational study included 2247 live births. Subjects were selected over a two-year period from neonates born at Fayoum University Hospital, Fayoum Insurance Hospital, and five other general hospitals between January 2018 and December 2019.</div></div><div><h3>Results</h3><div>Among the studied sample, 2192 newborns (97.6 %) had no congenital heart defect, while 55 (2.4 %) were diagnosed with CHD. Parental consanguinity was reported in 19 cases (34.5 %) with CHD. Among the acyanotic CHD cases: 13 (23.6 %) had ventricular septal defect, 7 (12.7 %) had patent ductus arteriosus, 6 (10.9 %) had atrial septal defect, 5 (9.1 %) had pulmonary stenosis, 2 (3.6 %) had aortic stenosis, 2 (3.6 %) had atrioventricular canal defect, 1 (1.8 %) had coarctation of the aorta, and 1 (1.8 %) had peripheral pulmonary stenosis. Regarding cyanotic CHD, 7 patients (12.7 %) had tetralogy of Fallot, 4 (7.3 %) had pulmonary atresia, 3 (5.5 %) had transposition of the great arteries, and one patient (1.8 %) each had complex CHD, single ventricle, total anomalous pulmonary venous return, and tricuspid atresia.</div></div><div><h3>Conclusion</h3><div>The study reveals that the birth prevalence of CHD in the Fayoum district is consistent with global estimates. Acyanotic CHD, particularly ventricular septal defect, was the most commonly observed cardiac anomaly.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"78 ","pages":"Article 101858"},"PeriodicalIF":0.6,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}