{"title":"Review of cardiovascular complications in children with sickle cell disease","authors":"Saswat Kumar Jha , Linhan Jasmine Ha , Maxon Bassett , Avery Silar , Brianna L. Gilner , Induja Gajendran , Preethi Marri","doi":"10.1016/j.ppedcard.2025.101836","DOIUrl":"10.1016/j.ppedcard.2025.101836","url":null,"abstract":"<div><h3>Background</h3><div>Cardiovascular complications in pediatric patients with sickle cell disease may be life-threatening.</div></div><div><h3>Aim of review</h3><div>The purpose of this article is to review cardiovascular problems associated with sickle cell disease in children and adolescents, including pathophysiology, clinical presentation, diagnosis, and treatment.</div></div><div><h3>Key scientific concepts of review</h3><div>Sickle cell disease is a hemoglobinopathy that causes red blood cell sickling and vaso-occlusive crises. Chronic anemia may cause high-output cardiac failure. Other cardiovascular abnormalities include pulmonary hypertension, increased tricuspid regurgitation velocity, increased right ventricular pressure, cardiomyopathy with left ventricular hypertrophy and dysfunction, and increased risk of myocardial infarction, dysrhythmia, and sudden cardiac death. Patients may have chronic hemolytic anemia, red blood cell sickling, vaso-occlusive crises, and cardiovascular symptoms including chest pain, palpitations, shortness of breath, and fatigue. Cardiovascular complications also may include stroke, acute renal failure, and priapism. Diagnosis includes family history and diagnostic tests such as complete blood count, electrocardiography, echocardiography, chest radiography, and pulmonary function tests. Treatment of sickle cell disease may include hydroxyurea and treatment of complications, including pain from vaso-occlusive crises and cardiovascular disease. Early detection and intervention are important to limit sequelae of cardiovascular complications, and regular cardiovascular screening in pediatric patients with sickle cell disease is recommended.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"78 ","pages":"Article 101836"},"PeriodicalIF":0.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144116169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Surveillance under siege: Safeguarding youth health in an era of public health defunding","authors":"Sarah E. Messiah , Deepali K. Ernest , Luyu Xie","doi":"10.1016/j.ppedcard.2025.101846","DOIUrl":"10.1016/j.ppedcard.2025.101846","url":null,"abstract":"","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"78 ","pages":"Article 101846"},"PeriodicalIF":0.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Outcomes of balloon angioplasty in infants with simple or complex recurrent coarctation of the aorta","authors":"Anders C. Jenson , Nathaniel W. Taggart","doi":"10.1016/j.ppedcard.2025.101852","DOIUrl":"10.1016/j.ppedcard.2025.101852","url":null,"abstract":"<div><h3>Background</h3><div>Recurrence of coarctation of the aorta (CoA) is a relatively common complication following surgical correction in neonates. Balloon angioplasty is the favored treatment for recurrent CoA in infancy and early childhood, but persistent or recurrent obstruction remains a challenging complication.</div></div><div><h3>Objectives</h3><div>This retrospective cohort study aims to assess outcomes of balloon angioplasty for infants with recurrent CoA based on the complexity of cardiac defects at the time of surgical intervention.</div></div><div><h3>Methods</h3><div>Data were analyzed from patients at a single tertiary care center who underwent balloon angioplasty for recurrent CoA within their first year of life between 2002 and 2021.</div></div><div><h3>Results</h3><div>A total of 41 patients were included and separated into simple (<em>n</em> = 26) or complex (<em>n</em> = 15) cohorts based on the coexisting cardiac defects present. These cohorts were similar in age, weight, sex, and time since initial surgical repair. The complex cohort had a significantly higher rate of subsequent coarctation re-intervention within a 2-year follow-up period (73 % vs. 31 %, <em>p</em> = 0.003, RR = 2.4; 95 % CI = 1.2–4.6, <em>p</em> = 0.003).</div></div><div><h3>Conclusion</h3><div>Our findings suggest that recurrent CoA in the presence of additional complex congenital heart disease may not be as amenable to balloon angioplasty in infants and should be considered when counseling patient families.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"78 ","pages":"Article 101852"},"PeriodicalIF":0.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jennifer Tollit , I-Ting Tu , Gabrielle Norrish , Ella Field , Jo Wray , Juan Pablo Kaski
{"title":"The diagnostic yield of cardiac screening in first-degree relatives of sudden arrhythmic death syndrome or unexplained cardiac arrest probands: A systematic review of the literature","authors":"Jennifer Tollit , I-Ting Tu , Gabrielle Norrish , Ella Field , Jo Wray , Juan Pablo Kaski","doi":"10.1016/j.ppedcard.2025.101816","DOIUrl":"10.1016/j.ppedcard.2025.101816","url":null,"abstract":"<div><h3>Background</h3><div>First-degree relatives of Sudden Arrhythmic Death Syndrome (SADS) or Unexplained Cardiac Arrest (UCA) are recommended to undergo clinical evaluation for potential inherited cardiac conditions (ICC). However, data on the yield of family screening in these populations remains scarce.</div></div><div><h3>Aim of review</h3><div>This systematic review aimed to explore the diagnostic yield of clinical screening of first-degree relatives of SADS or UCA probands. A secondary aim was to compare the diagnostic yield of adult-aged and pediatric-aged relatives.</div></div><div><h3>Key scientific concepts of review</h3><div>Included studies described the clinical cardiac screening and yield of first-degree relatives of SADS and UCA probands. Quality of selected studies was assessed using a modified Joanna Briggs Institute checklist.</div><div>14 studies met inclusion criteria for this review, together including 1646 first-degree relatives of SADS probands and 656 first-degree relatives of UCA probands. Overall diagnostic yield described ranged from 0 to 32 %. The combined mean diagnostic yield of SADS relatives did not differ significantly from that of relatives of UCA probands. Three studies described outcomes of clinical screening in pediatric relatives, with an overall reported yield of 9.4 % ± 3.4 %, not significantly different from adult populations. Whilst there is a clear indication for clinical screening of first-degree relatives following SADS or an UCA, a lack of well-designed large population-based studies means that the evidence base is not robust. The yield in reported literature varies considerably, with no difference between SADS and UCA cohorts and a similar yield in pediatric and adult relatives. This supports screening for all first-degree relatives regardless of age.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"78 ","pages":"Article 101816"},"PeriodicalIF":0.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sotalol: A new alternative in medically-resistant pediatric POTS-a case series","authors":"Neel Dayal , William A. Suarez , Blair Grubb","doi":"10.1016/j.ppedcard.2025.101842","DOIUrl":"10.1016/j.ppedcard.2025.101842","url":null,"abstract":"<div><div>Postural orthostatic tachycardia syndrome (POTS) causes an increase in heart rate of >40 beats per minute with positional change. We describe 3 interesting cases of “treatment-resistant” pediatric POTS patients with profound symptoms managed with sotalol. Treatment led to heart rate control and symptom improvement with no signs of toxicity.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"78 ","pages":"Article 101842"},"PeriodicalIF":0.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144196039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Steven E. Lipshultz , Stacy D. Fisher , Vivian I. Franco , Brandon J. Warrick , Sebastian M. Seifert , Alvin C. Bronstein
{"title":"Energy drink exposures and trends in children and young adults reported to the National Poison Data System","authors":"Steven E. Lipshultz , Stacy D. Fisher , Vivian I. Franco , Brandon J. Warrick , Sebastian M. Seifert , Alvin C. Bronstein","doi":"10.1016/j.ppedcard.2025.101819","DOIUrl":"10.1016/j.ppedcard.2025.101819","url":null,"abstract":"<div><h3>Background</h3><div>Energy drinks (EDs) may contain caffeine, amino acids, vitamins, and other ingredients that have been associated with serious adverse effects, primarily in children and young adults.</div></div><div><h3>Objectives</h3><div>We sought to understand ED exposures, including demographic trends, clinical effects, and outcomes in the US Poison Centers' National Poison Data System (NPDS), and compared similar reports of caffeinated beverages.</div></div><div><h3>Methods</h3><div>We analyzed all NPDS closed human exposures to single-use EDs reported to NPDS between October 1, 2010, and September 30, 2013.</div></div><div><h3>Results</h3><div>NPDS recorded 10,588 cases of ED exposure. Active ingredients were identified in 5139 (49 %) cases. Of the 4803 (93 %) exposures to alcohol-free EDs, 51 % were in children 5 years old or younger, 10 % were in children 6 to 12 years old, 16 % were in adolescents 13 to 19 years old, and 23 % were adults at least 20 years old. Unintentional exposures were highest in children 5 years old or younger (75 %). Intentional exposures were highest in adolescents (45 %). Moderate or major adverse outcomes from EDs containing multiple caffeine ingredients were more common than single ingredient caffeine products (23 % vs. 15 %; <em>P</em> < 0.001). Exposures associated with ethanol EDs had worse outcomes than those without (42 % vs. 19 %, respectively; <em>P</em> < 0.001). The most common clinical effects associated with ED exposures were neurologic (<em>N</em> = 1042, 22 %), gastrointestinal (<em>N</em> = 792, 17 %), and cardiovascular (<em>N</em> = 567, 12 %); 14 cases were life-threatening, and 1 adolescent girl with vascular Ehlers Danlos syndrome died. Recent follow up from January 1, 2020, to December 31, 2021, shows consistent trends in use and a clear difference between EDs and caffeinated beverage case numbers and medical outcomes. The number of cases was similar in each year except for a notable increase mid-2020, believed to be related to the pandemic, with our query returning 4367 reported ED cases between 2020 and 2021.</div></div><div><h3>Conclusion</h3><div>A substantial proportion of ED calls to poison centers involve children, some of whom experience severe neurologic and cardiac toxicity, among other symptoms. ED exposure calls are more common and have more medical severity than exposures to caffeine or coffee beans alone. The number and severity of adverse ED events warrant efforts to educate the public about the risks, especially in children.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"78 ","pages":"Article 101819"},"PeriodicalIF":0.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alex Ismael Catalán Cabrera, Hugo Martin Reyes Alban, Karen del Rosario Condori Alvino, Mónica Karem Medina Durand, Luis Jacinto De la Cruz Hilario, Nelly Tamayo Huiza
{"title":"Giant right atrial myxoma in pediatrics. Case report","authors":"Alex Ismael Catalán Cabrera, Hugo Martin Reyes Alban, Karen del Rosario Condori Alvino, Mónica Karem Medina Durand, Luis Jacinto De la Cruz Hilario, Nelly Tamayo Huiza","doi":"10.1016/j.ppedcard.2025.101856","DOIUrl":"10.1016/j.ppedcard.2025.101856","url":null,"abstract":"<div><h3>Introduction</h3><div>Myxoma is the most common benign cardiac tumor in adults; however, in children, it is less frequent than rhabdomyoma and fibroma. It shows a female predominance, with an incidence 1.5 to 2 times higher than in males. Only 22 % of myxomas develop in the right atrium, 2 % in the ventricles, and 1 % in the atrioventricular valve.</div></div><div><h3>Case report</h3><div>We present the case of a 10-year-old patient admitted with obstructive symptoms with right heart failure. Diagnostic imaging, including chest X-ray, transthoracic echocardiography, and computed tomography, revealed a giant intracardiac mass. Surgical excision of the tumor was performed 48 h after admission, with favorable postoperative evolution. Histopathological examination confirmed the diagnosis of cardiac myxoma.</div></div><div><h3>Conclusions</h3><div>Right atrial myxomas may present with dyspnea, syncope, ascites, and symptoms of right heart failure. Early diagnosis is crucial to prevent cerebrovascular events and allow for timely surgical treatment, thereby reducing preoperative and postoperative complications.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"78 ","pages":"Article 101856"},"PeriodicalIF":0.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sahar El Shedoudy , Reem Rashed , Asmaa El Fiky , Eman El Doklah
{"title":"Long-term outcomes following patent foramen ovale device closure: A single-center experience","authors":"Sahar El Shedoudy , Reem Rashed , Asmaa El Fiky , Eman El Doklah","doi":"10.1016/j.ppedcard.2025.101824","DOIUrl":"10.1016/j.ppedcard.2025.101824","url":null,"abstract":"<div><h3>Background</h3><div>Patent foramen ovale (PFO) transcatheter closure is recommended for carefully selected patients with cryptogenic stroke and transient ischemic attack (TIA). It has also been associated with significant improvement in the severity of refractory migraine headaches.</div></div><div><h3>Objective</h3><div>To report long-term outcome after PFO closure for patients with stroke, TIA, and refractory migraine.</div></div><div><h3>Methods</h3><div>This retrospective study represents a single-center experience including patients undergoing PFO transcatheter closure for stroke, TIA, or refractory migraine. Patients were followed at 1 and 6 months, one year, and then annually for at least 5 years after closure. After that, patients either attended annually or were followed by telephone interviews. Holter monitoring was done 1–3 months after closure, then selectively according to patient symptoms.</div></div><div><h3>Results</h3><div>We enrolled 480 patients undergoing PFO transcatheter closure between March 2001 and July 2020. 432 patients completed follow-up through August 2024. The follow-up duration ranged from (4–23) years. PFO closure was successful in all patients without complications. New onset atrial fibrillation (AF) occurred in 6 patients (1.39 %), typically later during follow-up (14.0 ± 4.1 years), all with cardiovascular risk factors. Cerebrovascular events recurred 0.31 events/100 person/years. Using the Log-rank test, event recurrence was more observed in patients >40 years in the presence of other cardiovascular risk factors and AF. Regarding Migraine, (82.4 %) of patients experienced complete resolution of symptoms, and (17.6 %) reported mild symptoms (Migraine Disability Assessment Questionnaire (MIDAS) grade I). The mean MIDAS score significantly improved; the mean before closure was 28.3 ± 7.23 and 0.83 ± 1.82 after closure (<em>P</em> = 0.001). The migraine persistence rate was 1.9 events per 100 person-years.</div></div><div><h3>Conclusions</h3><div>Percutaneous PFO closure is a safe and effective long-term intervention for preventing recurrent cerebrovascular events and significantly improves migraine symptoms.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"77 ","pages":"Article 101824"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ryan Kimball , Isaac J. Jacobs , Matthew W. Sorensen , Jeffrey A. Robinson
{"title":"Differences in school preparedness for sudden cardiac arrest based on automated external defibrillator availability and staff training between schools of different enrollment size","authors":"Ryan Kimball , Isaac J. Jacobs , Matthew W. Sorensen , Jeffrey A. Robinson","doi":"10.1016/j.ppedcard.2025.101831","DOIUrl":"10.1016/j.ppedcard.2025.101831","url":null,"abstract":"<div><h3>Background</h3><div>A school has a 1–2 % chance of having a sudden cardiac arrest (SCA) on its campus in any given year. Schools can be prepared by having automated external defibrillators (AEDs) readily accessible with staff trained in their use. The overall survival rate of SCA is less than 10 %. However, those who suffer SCA at a school that has an AED on-site have more than a 60 % chance of surviving to discharge. Currently, AEDs are not required in schools across all 50 states in the US.</div></div><div><h3>Objective</h3><div>Investigate the availability of AEDs in high schools across a state prior to any formal mandate and explore discrepancies among schools of varying enrollment sizes.</div></div><div><h3>Methods</h3><div>A 16-question survey about AED availability, accessibility, and percentage of staff trained for its use was distributed to every high school in Nebraska in July 2022.</div></div><div><h3>Results</h3><div>Schools with smaller enrollments were more likely to have AEDs accessible to the public (<em>p</em> = 0.047), available at all events (<em>p</em> = 0.0002), and over 50 % of staff trained for its use (<em>p</em> = 0.00019) than schools with larger enrollments. There was no correlation between number of AEDs and enrollment (R<sup>2</sup> = 0.172).</div></div><div><h3>Conclusions</h3><div>Most high schools have automated external defibrillators (AEDs), even without statewide mandates; however, continuing efforts are needed to ensure that AEDs at all schools are accessible to the public and that staff are appropriately trained. This study highlights the need for increased advocacy and targeted resource allocation, particularly for larger schools, to ensure appropriate/adequate AED distribution and emergency preparedness across all high schools.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"77 ","pages":"Article 101831"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mads Damkjær , Ester Garne , Maria Loane , Stine K. Urhoj , Elisa Ballardini , Clara Cavero-Carbonell , Alessio Coi , Laura García-Villodre , Joanne Given , Mika Gissler , Anna Heino , Sue Jordan , Elizabeth Limb , Amanda J. Neville , Anna Pierini , Anke Rissmann , Joachim Tan , Ieuan Scanlon , Joan K. Morris
{"title":"Surgical timing and mortality in nonsevere paediatric congenital heart disease: A EUROlinkCAT cohort analysis across Europe","authors":"Mads Damkjær , Ester Garne , Maria Loane , Stine K. Urhoj , Elisa Ballardini , Clara Cavero-Carbonell , Alessio Coi , Laura García-Villodre , Joanne Given , Mika Gissler , Anna Heino , Sue Jordan , Elizabeth Limb , Amanda J. Neville , Anna Pierini , Anke Rissmann , Joachim Tan , Ieuan Scanlon , Joan K. Morris","doi":"10.1016/j.ppedcard.2024.101808","DOIUrl":"10.1016/j.ppedcard.2024.101808","url":null,"abstract":"<div><h3>Background</h3><div>Management and outcomes amongst children with congenital heart defects (CHD) are relatively heterogeneous. Traditionally, the highest-risk conditions and procedures have received the most attention, with less focus on outcome for less severe CHDs.</div></div><div><h3>Objectives</h3><div>Evaluate the management of children born with certain less severe CHDs across Europe.</div></div><div><h3>Methods</h3><div>This population-based linkage cohort study included children diagnosed with ventricular septal defect (VSD), atrial septal defect (ASD), pulmonary valve stenosis (PS), and patent arterial duct (PDA) from nine European regions. Data on surgery/intervention and survival from 1995 to the age of 10 years or until the end of 2014 were collected through electronic linkage to mortality and hospital databases. Kaplan-Meier survival estimates and meta-analyses were used to analyze the proportion of children undergoing surgery/intervention and survival rates.</div></div><div><h3>Results</h3><div>The study included 20,608 children with the less severe CHDs. Surgical correction rates for the anomaly within the first year of life varied significantly, particularly for VSD. The median age for initial surgery/intervention was consistent for VSD but varied for other conditions. Most conditions were corrected in a single procedure, except for PS, which required a median of 1.7 (95 % CI; 1.4–2.0) interventions. Postoperative mortality was highest for neonates undergoing VSD surgery/intervention, 8.7 (95 % CI; 4.0–15.8) deaths per 100 surgeries. The overall 5-year survival rate for all conditions was approximately 98 %.</div></div><div><h3>Conclusion</h3><div>There was considerable variation in the management of less severe CHDs across Europe, particularly in the timing of surgical interventions. Despite these differences, the overall 5-year survival rate is comparable and high.</div></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":"77 ","pages":"Article 101808"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}