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Variability of lesions and lesion patterns in possible treponematosis cases: Insights from an archaeological site in Tomar, Portugal. 可能的三联体病病例中病变和病变模式的可变性:葡萄牙托马尔考古遗址的启示。
IF 0.4 4区 社会学
Anthropologischer Anzeiger Pub Date : 2025-02-11 DOI: 10.1127/anthranz/2024/1764
Ana Curto, Teresa Fernandes, Cláudia Relvado, Sónia Ferro, Célia Lopes
{"title":"Variability of lesions and lesion patterns in possible treponematosis cases: Insights from an archaeological site in Tomar, Portugal.","authors":"Ana Curto, Teresa Fernandes, Cláudia Relvado, Sónia Ferro, Célia Lopes","doi":"10.1127/anthranz/2024/1764","DOIUrl":"10.1127/anthranz/2024/1764","url":null,"abstract":"<p><p><i>Objective:</i> This study aims to describe various types of skeletal lesions and lesion patterns observed in five potential cases of treponematosis from the same archaeological site. <i>Material and methods:</i> The study examines five adult skeletons recovered from Santa Maria do Olival, Tomar, Portugal. Macroscopic observations were conducted on all remains, supplemented by relevant radiographic investigations. <i>Results:</i> The analyzed individuals exhibited diverse types of skeletal lesions and distinct patterns of lesion distribution. Radiocarbon dating of two of these skeletons locates them chronologically close to the beginning of the colonial period (15<sup>th</sup> century). <i>Discussion:</i> The findings indicate considerable variation in the lesions and lesion patterns associated with treponematosis, even within the same archaeological site. The radiocarbon data implies the presence of pre-Columbian treponemal disease or a rapid progression to the tertiary phase of the disease. This study represents the oldest cases of treponematosis in Portugal and the only one with more than one individual affected from the same archaeological site. Considering Portugal's prominent role in the European Age of Exploration, the study underscores the significance of pathogen exchanges between Europeans, South Americans, Africans, and Asians. Future investigations should reassess Iberian osteological collections from this time period, given the historical importance of Portugal and Spain in the intercontinental movements.</p>","PeriodicalId":46008,"journal":{"name":"Anthropologischer Anzeiger","volume":" ","pages":"107-122"},"PeriodicalIF":0.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141983521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Re-evaluating the human remains from El Bosquet cave (Mont-ral, Tarragona, Spain): healed trauma and forgotten past. 重新评估 El Bosquet 洞穴(西班牙塔拉戈纳蒙拉尔)的人类遗骸:愈合的创伤和被遗忘的过去。
IF 0.4 4区 社会学
Anthropologischer Anzeiger Pub Date : 2025-02-11 DOI: 10.1127/anthranz/2024/1782
Miguel Ángel Moreno-Ibáñez, Raquel Hernando, Marta Yustos, John C Willman, Josep M Vergès
{"title":"Re-evaluating the human remains from El Bosquet cave (Mont-ral, Tarragona, Spain): healed trauma and forgotten past.","authors":"Miguel Ángel Moreno-Ibáñez, Raquel Hernando, Marta Yustos, John C Willman, Josep M Vergès","doi":"10.1127/anthranz/2024/1782","DOIUrl":"10.1127/anthranz/2024/1782","url":null,"abstract":"<p><p>During the early development of archaeology in Spain, many of the materials obtained from excavations were later forgotten in museum deposits. However, re-investigation of these collections with contemporary methodologies can still contribute valuable knowledge. This study presents the case of El Bosquet Cave (Mont-ral, Tarragona, Spain), located in the Northeastern Iberian Peninsula. This cave was excavated and documented in 1956 and the recovered materials were transferred, years later, to the Reus Museum, where they are currently located. Our results provide a more precise Middle Bronze Age chronology for the site in addition to bioarchaeological conclusions on the human remains from four individuals. Of note is a healed mandibular fracture in one of the individuals. Trauma observed in human skeletal remains reflect the conditions and risks of human groups in relation to daily activities or may be the result of interpersonal violence. In the Iberian Peninsula there are very few documented cases of mandibular fractures in prehistoric populations. This study contributes to the knowledge of the populations of the recent prehistory in the region of Catalonia and highlights the importance of reanalyzing the collections that are deposited and, in many cases forgotten, in the different museums of the territory.</p>","PeriodicalId":46008,"journal":{"name":"Anthropologischer Anzeiger","volume":" ","pages":"63-72"},"PeriodicalIF":0.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in body proportions and body fat content in GH-deficient and non-GH-deficient children during the first year of growth hormone treatment. 生长激素缺乏症和非生长激素缺乏症儿童在接受生长激素治疗第一年期间身体比例和体内脂肪含量的变化。
IF 0.4 4区 社会学
Anthropologischer Anzeiger Pub Date : 2025-02-11 DOI: 10.1127/anthranz/2024/1763
Anna Majcher, Małgorzata Rumińska, Ewelina Witkowska-Sędek, Monika Paluchowska, Maria Krajewska, Dorota Artemniak-Wojtowicz, Beata Pyrżak
{"title":"Changes in body proportions and body fat content in GH-deficient and non-GH-deficient children during the first year of growth hormone treatment.","authors":"Anna Majcher, Małgorzata Rumińska, Ewelina Witkowska-Sędek, Monika Paluchowska, Maria Krajewska, Dorota Artemniak-Wojtowicz, Beata Pyrżak","doi":"10.1127/anthranz/2024/1763","DOIUrl":"10.1127/anthranz/2024/1763","url":null,"abstract":"<p><p><i>Introduction:</i> The growth hormone/insulin-like growth factor-1 axis (GH/IGF-1) is crucial for longitudinal bone growth and exerts several metabolic effects. It is debatable whether and how the recombinant human growth hormone (rhGH) treatment affects the trunk-limb proportions. <i>Aim of the study:</i> We aim to evaluate the changes in body proportions and body fat content in short children with growth hormone deficiency (GHD), children born small for gestational age (SGA), and girls with Turner syndrome (TS) during the first year of rhGH therapy. <i>Material and methods:</i> The data of 70 children with GHD, 40 children born SGA, and 36 girls with TS from 1998 to 2019 were analyzed. The following parameters were measured: height, body weight, sitting height, and two skinfolds on the arm above the triceps brachii and below the scapula at the beginning of rhGH therapy and after the first year of treatment. Sitting height and lower limb length were presented as percentages (%) of body height. Fat mass percentage (%FAT) was calculated using the Slaughter formula. <i>Results:</i> At the beginning of rhGH, TS girls had the greatest height deficit (-2.7 SDS), the highest sitting height (%), and the lowest lower limb length (%) compared to children with GHD and children born SGA. Moreover, TS girls had higher body weight SDS, BMI SDS compared to SGA children (<i>p</i> < 0.001), and higher %FAT compared to both GHD and SGA children (<i>p</i> < 0.001 for both). After the first year of rhGH therapy, a significant increase in lower limb share (%) and a decrease in %FAT were observed in all the study groups. TS girls still had significantly higher sitting height (%), shorter lower limbs (%), and higher %FAT, body weight SDS, and BMI SDS compared to children with GHD and children born SGA (<i>p</i> < 0.05 for all variables). <i>Conclusions:</i> Our results show that rhGH treatment could increase lower limb length in relation to height and reduce fat mass in treated children. Girls with TS had the largest baseline body disproportions and the highest body fat content. Despite a satisfactory reduction in height deficit, after the first year of rhGH therapy, these girls had still higher body weight SDS, BMI SDS, %FAT, the highest sitting height (%), and the lowest lower limb length (%) compared to children with GHD and born SGA.</p>","PeriodicalId":46008,"journal":{"name":"Anthropologischer Anzeiger","volume":" ","pages":"19-27"},"PeriodicalIF":0.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Man and humankind in motion how active is mankind today? 今天的人类有多活跃?
IF 0.4 4区 社会学
Anthropologischer Anzeiger Pub Date : 2024-12-12 DOI: 10.1127/anthranz/2024/1830
Annette Schneider
{"title":"Man and humankind in motion how active is mankind today?","authors":"Annette Schneider","doi":"10.1127/anthranz/2024/1830","DOIUrl":"https://doi.org/10.1127/anthranz/2024/1830","url":null,"abstract":"<p><p>Being physically active is fundamental to maintaining good health and plays an important role in childrens development. In adults, but also in children and adolescents, activity levels have been declining for years and sitting times are increasing, with the result that the physical activity recommendations developed by the WHO are no longer being achieved by everyone. The reasons for this lie in the changed living environment, which is becoming increasingly inactive. This trend has become even more pronounced due to the restrictions imposed by the corona virus pandemic. This particularly affected 10 to 17-year-olds, 50% of whom have reduced their activity time; this figure was 26% for 3 to 5-year-olds and 37% for 6 to 9-year-olds. Overall, 70% of children and young people have increased their (inactive) media time. There is an urgent need to design exercise programmes to increase physical activity by children and young people. The finding that sport is practised because it is fun would be helpful here. Furthermore, the lack of staff in day-care centres must be remedied, as this has proven to be the most important inhibiting factor for the implementation of physical activity programmes. As behavioural patterns are already formed in early childhood, the focus for promoting physical activity should be on the day-care centre setting.</p>","PeriodicalId":46008,"journal":{"name":"Anthropologischer Anzeiger","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of Multiple Myeloma from 19th century North America: Aligning the clinical and archaeological records. 19 世纪北美的一例多发性骨髓瘤:将临床和考古记录结合起来。
IF 0.4 4区 社会学
Anthropologischer Anzeiger Pub Date : 2024-08-23 DOI: 10.1127/anthranz/2024/1801
Shawn M Phillips
{"title":"A case of Multiple Myeloma from 19<sup>th</sup> century North America: Aligning the clinical and archaeological records.","authors":"Shawn M Phillips","doi":"10.1127/anthranz/2024/1801","DOIUrl":"10.1127/anthranz/2024/1801","url":null,"abstract":"<p><p>The first archaeological case of multiple myeloma (MM) from historic period North America is presented. Only 49 cases of MM have been reported from archaeological contexts and recent reviews have alternately rejected either 24 of the cases or all 49 cases and found them all to more likely be cases of metastatic carcinoma (MC). The trend in the debate over the interpretation of these cancers is that MC is an ancient disease while MM is likely a disease of modernity. MM was first recognized as a distinct form of cancer in 1873 with only 17 cases reported by 1900. The first North American clinically identified case of MM was reported in 1894. This study supports the suggestion that MM is a disease of modernity with the etiology likely linked to industrialization. The archaeological case presented here was interred circa 1880, in the same time frame that MM is recognized as a distinct disease and briefly predates the clinical reporting of MM in the US. Of note, the individual is associated with an institution that served societal dependents. As catchall warehouses for dependency it is not surprising to find conditions reflective of senescence. Such institutions provided hospice care for the terminally ill and can serve, as in this case, to align the archaeological and clinical records.</p>","PeriodicalId":46008,"journal":{"name":"Anthropologischer Anzeiger","volume":" ","pages":"421-431"},"PeriodicalIF":0.4,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of early childhood caries from a Medieval site in Southern Portugal: a multidisciplinary approach. 葡萄牙南部中世纪遗址中的一例幼儿龋齿:多学科方法。
IF 0.4 4区 社会学
Anthropologischer Anzeiger Pub Date : 2024-08-23 DOI: 10.1127/anthranz/2024/1759
Nestor Hernández Canales, Ricard A M P Gomes, Steve D Emslie, Cristin Teté Garcia, Francisco Curate, Ana Maria Silva
{"title":"A case of early childhood caries from a Medieval site in Southern Portugal: a multidisciplinary approach.","authors":"Nestor Hernández Canales, Ricard A M P Gomes, Steve D Emslie, Cristin Teté Garcia, Francisco Curate, Ana Maria Silva","doi":"10.1127/anthranz/2024/1759","DOIUrl":"10.1127/anthranz/2024/1759","url":null,"abstract":"<p><p>Dental caries is the most prevalent chronic infectious disease during childhood both in historical and contemporary times, but research focused on the oral health of non-adults from the past is still scant. As such, this study proposes a multidisciplinary approach to the differential diagnosis of severe dental lesions in a medieval non-adult skeleton. The skeleton of a three-year-old child recovered in the medieval necropolis of Cacela Velha (Portugal) was studied through macroscopic, radiological, elemental and stable isotope analyses. This individual exhibited enamel destruction and dentine exposure in both the maxillary and mandibular teeth, with the latter also showing changes in coloration. Elemental analysis showed that his skull presented lower values of Si, Cl, and Ca and higher of Cu compared to the control, while the concentration of P and S were significantly lower in the teeth. Early childhood caries is the most probable diagnosis for the dental lesions observed, apparently stemming from a reticulate of factors that include potential malnutrition, and the consumption of sugars in complementary feeding - even though historical sources point to the scarcity of sugar in Portugal during most of the Middle Ages.</p>","PeriodicalId":46008,"journal":{"name":"Anthropologischer Anzeiger","volume":" ","pages":"467-477"},"PeriodicalIF":0.4,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metastatic cancer in a medieval skeleton from the Principality of Liechtenstein. 列支敦士登公国一具中世纪骸骨中的转移性癌症。
IF 0.4 4区 社会学
Anthropologischer Anzeiger Pub Date : 2024-08-23 DOI: 10.1127/anthranz/2024/1749
Christine Cooper, Nikolai Goritschnig
{"title":"Metastatic cancer in a medieval skeleton from the Principality of Liechtenstein.","authors":"Christine Cooper, Nikolai Goritschnig","doi":"10.1127/anthranz/2024/1749","DOIUrl":"10.1127/anthranz/2024/1749","url":null,"abstract":"<p><p>We present a presumptive case of metastatic carcinoma in an individual from the 11<sup>th</sup>/12<sup>th</sup> century CE from Vaduz, Principality of Liechtenstein. The skeleton exhibits extensive new bone formation in the axial skeleton and the proximal humerus and femur. Radiological examinations revealed further sclerotic lesions in the clavicles, the manubrium, the sternum, the femoral diaphysis, and possibly the frontal. The pelvic bones and the sacrum, as well as the spine, are the most heavily affected skeletal regions. The newly formed bone in some lesions has a \"sun-burst\" appearance. The sex and age at death of the individual, the distribution and the osteoblastic nature of the lesions suggest that prostate carcinoma is the most likely primary tumor.</p>","PeriodicalId":46008,"journal":{"name":"Anthropologischer Anzeiger","volume":" ","pages":"401-408"},"PeriodicalIF":0.4,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140040639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the interplay of bone lesions: unraveling health implications and daily life challenges in an Iron Age skeleton from Ya'amun, Jordan. 探索骨骼病变的相互作用:揭示约旦雅蒙铁器时代骨骼对健康的影响和日常生活的挑战。
IF 0.4 4区 社会学
Anthropologischer Anzeiger Pub Date : 2024-08-23 DOI: 10.1127/anthranz/2024/1748
Mohammad Alrousan, Abdulla Al-Shorman, Ferran Estebaranz-Sánchez, Alejandro Pérez-Pérez, Eugénia Cunha
{"title":"Exploring the interplay of bone lesions: unraveling health implications and daily life challenges in an Iron Age skeleton from Ya'amun, Jordan.","authors":"Mohammad Alrousan, Abdulla Al-Shorman, Ferran Estebaranz-Sánchez, Alejandro Pérez-Pérez, Eugénia Cunha","doi":"10.1127/anthranz/2024/1748","DOIUrl":"10.1127/anthranz/2024/1748","url":null,"abstract":"<p><p>This study analyzed the paleopathological conditions of a 30-year-old male unearthed at the site of Ya'amun in northern Jordan. The skeleton was dated back to Iron age. The paleopathological examinations were performed using macroscopic and radiological analyses. The results revealed multiple significant bone lesions, including periosteal osteosarcoma of the right femur, plagiocephaly, asymmetry of the sacrum, vertebral fractures, anemia, and osteoarthritis. This case represents the first example of neoplasm and plagiocephaly in the Iron Age of the region. Despite enduring severe health conditions, the individual managed to reach the third decade while facing the demands of strenuous daily activities that exemplified the harsh living and subsistence conditions characteristic of the Iron Age.</p>","PeriodicalId":46008,"journal":{"name":"Anthropologischer Anzeiger","volume":" ","pages":"409-420"},"PeriodicalIF":0.4,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140159191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Late Antiquity case of a chronic osteomyelitis from the population of Cortijo Coracho, Córdoba, Spain (IV-VIII centuries AD). 西班牙科尔多瓦 Cortijo Coracho 人口中的一例古代晚期慢性骨髓炎病例(公元四至八世纪)。
IF 0.4 4区 社会学
Anthropologischer Anzeiger Pub Date : 2024-06-03 DOI: 10.1127/anthranz/2024/1722
Ricardo Ortega-Ruiz, Cristina Merlo Martín, Alessia Leggio, Daniel Botella Ortega
{"title":"A Late Antiquity case of a chronic osteomyelitis from the population of Cortijo Coracho, Córdoba, Spain (IV-VIII centuries AD).","authors":"Ricardo Ortega-Ruiz, Cristina Merlo Martín, Alessia Leggio, Daniel Botella Ortega","doi":"10.1127/anthranz/2024/1722","DOIUrl":"10.1127/anthranz/2024/1722","url":null,"abstract":"<p><p>The Cortijo Coracho archaeological site dates from the Late Antiquity period, from the 5<sup>th</sup> to the 8<sup>th</sup> century AD. During this period, a number of populations settled in the area (Germanic peoples until Visigothic rule, Byzantine until the arrival of the Arabs, etc.), each of them concentrating the historical characteristics in the Sub-Baetic that are currently known. The Cortijo Coracho archaeological site is currently located in the city of Lucena (Cordoba, Spain), found after the works on the A-45 motorway. The necropolis consists of 294 inhumations and the remains of a basilica, although after a series of surveys it is estimated that there are around 700 additional burials, which would make it the largest necropolis with ad sancti burials surrounding a martyrial basilica dating back to the 4<sup>th</sup> century AD. Among the burials, 397 subjects were recovered, which implies a large presence of shared and/or reused burials. These subjects were transferred to the city's museum, where they were examined, reorganised and classified. At this point, subjects of scientific interest were found, as is the case of subject 204, the topic of this article. This individual, described as an adult male, is an example of the living conditions of this period, since despite his injury on the left lower extremity, a double fracture aggravated by a chronic osteomyelitis infection, he continued to use that limb. This paper will give the details of that distinctive lesion and the possible hypotheses underlying it.</p>","PeriodicalId":46008,"journal":{"name":"Anthropologischer Anzeiger","volume":" ","pages":"351-360"},"PeriodicalIF":0.4,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139472267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suggested mechanism of CCR5Δ32, CCR2-64I and SDF 1-3'A allele frequency change in Polish and Lithuanian gene pools from the perspective of passing time. 从时间流逝的角度看波兰和立陶宛基因库中 CCR5Δ32、CCR2-64I 和 SDF 1-3'A 等位基因频率变化的建议机制。
IF 0.5 4区 社会学
Anthropologischer Anzeiger Pub Date : 2024-06-03 DOI: 10.1127/anthranz/2024/1637
Łukasz J Śledziński, Alicja Zamerska, Krystyna Jędrychowska-Dańska, Tadeusz Strózik, Tomasz Wasiak, Tomasz Płoszaj, Piotr Witas, Henryk W Witas, Maciej Borowiec, Justyna Agier
{"title":"Suggested mechanism of <i>CCR5Δ32, CCR2-64I</i> and <i>SDF 1-3'A</i> allele frequency change in Polish and Lithuanian gene pools from the perspective of passing time.","authors":"Łukasz J Śledziński, Alicja Zamerska, Krystyna Jędrychowska-Dańska, Tadeusz Strózik, Tomasz Wasiak, Tomasz Płoszaj, Piotr Witas, Henryk W Witas, Maciej Borowiec, Justyna Agier","doi":"10.1127/anthranz/2024/1637","DOIUrl":"10.1127/anthranz/2024/1637","url":null,"abstract":"<p><p>The study aimed to determine the frequency of the alleles associated with hereditary immune response in 16 historical populations and assess which evolutionary forces may have contributed to the observed frequency fluctuation. The analysed polymorphic sites are located in three genes - CCR5, CCR2 and SDF 1 (CXCL12). Protein products are involved in the innate immune response and are also involved in various types of infections, autoimmune diseases and tumours. The frequency of the alleles found in the DNA of the studied individuals was determined by the Sanger methodology and was compared with the data obtained for modern populations. To confirm the authenticity of the obtained results, mtDNA HVRI haplotypes of all the studied samples were obtained and compared with the genetic database of the laboratory personnel who came into contact with the studied material. Based on the variability of allele frequency, advanced biostatistical analysis was used to distinguish the effect of natural selection from genetic drift, i.e. the forces operating on the polymorphic sites studied. All procedures were performed according to the guidelines for working with ancient DNA to avoid contamination with modern DNA molecules. 681 samples from 39 archaeological sites in Poland and Lithuania dated to the 40<sup>th</sup> century BC and the 19<sup>th</sup> century were studied. The biostatistical analysis showed that the fluctuations in the frequency of CCR5Δ32 in the analysed time interval could be mainly the effect of genetic drift. Nevertheless, for CCR2-64I and SDF 1-3'A, the results confirm the suggestion of negative selection as the mechanism involved. Since all the polymorphic sites encode the elements of innate immune response that are indirectly associated with the process of an HPV infection and the development of cervical cancer, the human papillomavirus may be a good candidate for a selection coefficient affecting the frequency of CCR2-64I and SDF 1-3'A. However, for CCR5Δ32, selection was not detected despite its proven role in the molecular mechanism involved in the response to an HPV infection. The presented work seems to be the first in which the problem of the pattern of CCR5Δ32, CCR2-64I and SDF 1-3'A frequency fluctuations in a temporal perspective was discussed, proposing HPV as a factor influencing the occurrence of the CCR2 and SDF1 alleles.</p>","PeriodicalId":46008,"journal":{"name":"Anthropologischer Anzeiger","volume":" ","pages":"261-280"},"PeriodicalIF":0.5,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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