International Journal of Surgical Oncology最新文献_第5页

Thyroidectomy as Treatment of Choice for Differentiated Thyroid Cancer 甲状腺切除术作为分化型甲状腺癌的治疗选择

IF 1.5

International Journal of Surgical Oncology Pub Date : 2019-10-13 DOI: 10.1155/2019/2715260

D. Giuffrida, R. Giuffrida, I. Puliafito, V. Vella, L. Memeo, C. Puglisi, C. Regalbuto, G. Pellegriti, S. Forte, A. Belfiore

{"title":"Thyroidectomy as Treatment of Choice for Differentiated Thyroid Cancer","authors":"D. Giuffrida, R. Giuffrida, I. Puliafito, V. Vella, L. Memeo, C. Puglisi, C. Regalbuto, G. Pellegriti, S. Forte, A. Belfiore","doi":"10.1155/2019/2715260","DOIUrl":"https://doi.org/10.1155/2019/2715260","url":null,"abstract":"Background Despite a large amount of data, the optimal surgical management of differentiated thyroid cancer remains controversial. Current guidelines recommend total thyroidectomy if primary thyroid cancer is >4 cm, while for tumors that are between 1 and 4 cm in size, either a bilateral or a unilateral thyroidectomy may be appropriate as surgical treatment. In general, total thyroidectomy would seem to be preferable because subtotal resection can be correlated with a higher risk of local recurrences and cervical lymph node metastases; on the other hand, total thyroidectomy is associated with more complications. Methods This is a retrospective study conducted on 359 patients with differentiated thyroid cancer, subjected to total thyroidectomy. Our aim was to correlate clinical and pathological features (extrathyroid tumor growth, bilaterality, nodal and distant metastasis) with patient (gender and age) and tumor (size and histotype) characteristics. Moreover, we recorded postoperative complications, including hypoparathyroidism and laryngeal nerve damage. Results In our study, we found a high occurrence of pathological features indicating cancer aggressiveness (bilaterality, nodal metastases, and extrathyroid invasion). On the other hand, total thyroidectomy was associated with relatively low postsurgical complication rates. Conclusions Our data support the view that total thyroidectomy remains the first choice for the routine treatment of differentiated thyroid cancer.","PeriodicalId":45960,"journal":{"name":"International Journal of Surgical Oncology","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2019-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/2715260","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44614760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Postsurgical Ultrasound Evaluation of Patients with Prosthesis in Acellular Dermal Matrix: Results from Monocentric Experience 脱细胞真皮基质假体术后超声评价:单中心经验的结果

IF 1.5

International Journal of Surgical Oncology Pub Date : 2019-06-16 DOI: 10.1155/2019/7437324

Ballesio Laura, Casinelli Alice, Gigli Silvia, Boldrini Cristiana, Di Taranto Giuseppe, Albano Antonio, Onesti Maria Giuseppina

引用次数: 7

Prognostic Factors and Survival Time in Patients with Small Bowel Tumors: A Retrospective Observational Study. 小肠肿瘤患者的预后因素和生存时间：回顾性观察研究

IF 1.6

International Journal of Surgical Oncology Pub Date : 2019-05-02 eCollection Date: 2019-01-01 DOI: 10.1155/2019/2912361

Shokouh Taghipour Zahir, Zahra Heidarymeybodi, Sogol AleSaeidi

{"title":"Prognostic Factors and Survival Time in Patients with Small Bowel Tumors: A Retrospective Observational Study.","authors":"Shokouh Taghipour Zahir, Zahra Heidarymeybodi, Sogol AleSaeidi","doi":"10.1155/2019/2912361","DOIUrl":"10.1155/2019/2912361","url":null,"abstract":"This study examines survival time in patients with small bowel tumors and determines its contributing factors. In this retrospective analytical study, the medical records of 106 patients with small bowel cancer (from 2006 to 2011) were investigated. The patients' data were extracted, including age, gender, clinical presentation, location of tumor, histological type, grade of tumor, site of metastasis, and type of treatment. The Kaplan-Meier test was used to estimate the overall survival time and the Log-rank test to compare the survival curves. The Cox regression was also used to evaluate the effect of the confounding variables on survival time. This study was conducted on 106 patients with a median age of 60 years (Min: 7, Max: 87). The tumor types included adenocarcinoma (n=78, 73.6%), MALToma (n=22, 20.8%), neuroendocrine tumors (n=4, 3.8%), and sarcoma (n=2. 1.8%). Grade 3 adenocarcinomas had a significantly lower survival time (HR: 1.48, 95% CI: 0.46-2.86; P=.001). Combined therapy (chemotherapy and surgery) vs. single-therapy (only surgery) had no significant effects on the survival of the patients with MALToma (5 vs. 3 months, 95% CI: 1.89-5.26; P=.06). There were no significant differences between the survival time in adenocarcinoma and MALToma (12 vs. 20 months, 95% CI: 6.24-24.76; P=.49). Tumor grade was the only independent prognostic factor that affected survival in adenocarcinoma. The patients diagnosed with MALToma in the study also had a poor prognosis, and the type of treatment had no significant effect on their survival.","PeriodicalId":45960,"journal":{"name":"International Journal of Surgical Oncology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2019-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37318206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Concise Review of Pelvic Radiation Therapy (RT) for Rectal Cancer with Synchronous Liver Metastases. 盆腔放疗(RT)治疗直肠癌伴同步肝转移的简要综述。

IF 1.5

International Journal of Surgical Oncology Pub Date : 2019-04-21 eCollection Date: 2019-01-01 DOI: 10.1155/2019/5239042

Omer Sager, Ferrat Dincoglan, Selcuk Demiral, Bora Uysal, Hakan Gamsiz, Bahar Dirican, Murat Beyzadeoglu

{"title":"A Concise Review of Pelvic Radiation Therapy (RT) for Rectal Cancer with Synchronous Liver Metastases.","authors":"Omer Sager, Ferrat Dincoglan, Selcuk Demiral, Bora Uysal, Hakan Gamsiz, Bahar Dirican, Murat Beyzadeoglu","doi":"10.1155/2019/5239042","DOIUrl":"https://doi.org/10.1155/2019/5239042","url":null,"abstract":"Background and objective: Colorectal cancer is a major health concern as a very common cancer and a leading cause of cancer-related mortality worldwide. The liver is a very common site of metastatic spread for colorectal cancers, and, while nearly half of the patients develop metastases during the course of their disease, synchronous liver metastases are detected in 15% to 25% of cases. There is no standardized treatment in this setting and no consensus exists on optimal sequencing of multimodality management for rectal cancer with synchronous liver metastases.Methods: Herein, we review the use of pelvic radiation therapy (RT) as part of potentially curative or palliative management of rectal cancer with synchronous liver metastases.Results: There is accumulating evidence on the utility of pelvic RT for facilitating subsequent surgery, improving local tumor control, and achieving palliation of symptoms in patients with stage IV rectal cancer. Introduction of superior imaging capabilities and contemporary RT approaches such as Intensity Modulated Radiation Therapy (IMRT) and Image Guided Radiation Therapy (IGRT) offer improved precision and toxicity profile of radiation delivery in the modern era.Conclusion: Even in the setting of stage IV rectal cancer with synchronous liver metastases, there may be potential for extended survival and cure by aggressive management of primary tumor and metastases in selected patients. Despite lack of consensus on sequencing of treatment modalities, pelvic RT may serve as a critical component of multidisciplinary management. Resectability of primary rectal tumor and liver metastases, patient preferences, comorbidities, symptomatology, and logistical issues should be thoroughly considered in decision making for optimal management of patients.","PeriodicalId":45960,"journal":{"name":"International Journal of Surgical Oncology","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2019-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/5239042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37281001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Oral Submucous Fibrosis in Pediatric Patients: A Systematic Review and Protocol for Management. 儿科患者口腔黏膜下纤维化：系统综述与管理方案

IF 1.6

International Journal of Surgical Oncology Pub Date : 2019-04-01 eCollection Date: 2019-01-01 DOI: 10.1155/2019/3497136

Anuj Jain, Saumya Taneja

{"title":"Oral Submucous Fibrosis in Pediatric Patients: A Systematic Review and Protocol for Management.","authors":"Anuj Jain, Saumya Taneja","doi":"10.1155/2019/3497136","DOIUrl":"10.1155/2019/3497136","url":null,"abstract":"Aim: To conduct a systematic review evaluating the cases of oral submucous fibrosis in pediatric patients.Material and method: Systematic review was conducted using PRISMA guidelines. The article focused on oral submucous fibrosis in pediatric patients were included. A total of five manuscripts were included in our systematic review. The prevalence of OSMF in pediatric patients, gender distribution, causes, and clinical presentation were reviewed.Results: On systematically reviewing, a total of 10 cases of OSMF in pediatric patients were found. The youngest patient reported to be diagnosed with OSMF was of 2.5 years of age. Female preponderance was noticed. All the patients had the habit of areca nut chewing which subsequently led to fibrosis.Conclusion: Such a rapid increase in the rate of OSMF among pediatric population is a potential danger to the society. The habit of areca nut chewing is the major cause for this dreadful condition. Lack of health consciousness and low level of education are the major factors for initiation of this habit among children. Therefore it is imperative for the parents and school as well as government authorities to take serious actions.","PeriodicalId":45960,"journal":{"name":"International Journal of Surgical Oncology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37216473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soft Tissue Sarcomas of the Thoracic Wall: More Prone to Higher Mortality, and Local Recurrence-A Single Institution Long-Term Follow-up Study. 胸壁软组织肉瘤:更高的死亡率和局部复发——一项单机构长期随访研究

IF 1.5

International Journal of Surgical Oncology Pub Date : 2019-03-04 eCollection Date: 2019-01-01 DOI: 10.1155/2019/2350157

Tine Rytter Soerensen, Mathias Raedkjaer, Peter Holmberg Jørgensen, Anette Hoejsgaard, Akmal Safwat, Thomas Baad-Hansen

{"title":"Soft Tissue Sarcomas of the Thoracic Wall: More Prone to Higher Mortality, and Local Recurrence-A Single Institution Long-Term Follow-up Study.","authors":"Tine Rytter Soerensen, Mathias Raedkjaer, Peter Holmberg Jørgensen, Anette Hoejsgaard, Akmal Safwat, Thomas Baad-Hansen","doi":"10.1155/2019/2350157","DOIUrl":"https://doi.org/10.1155/2019/2350157","url":null,"abstract":"Objectives: This study aims to assess the impact of surgical margin and malignancy grade on overall survival (OS) and local recurrence free rate (LRFR) for soft tissue sarcomas (STS) of the thoracic wall.Methods: This retrospective cohort study identified 88 patients, diagnosed and treated surgically for a nonmetastatic STS located in the thoracic wall between 1995 and 2013, using the population based and validated Aarhus Sarcoma Registry and Danish Sarcoma Registry. The Kaplan-Meier method was used to estimate OS and LRFR. Multivariate Cox analyses were used to determine prognostic factors for OS and LRFR.Results: The 5-year OS was 55% (95% confidence interval (CI): 0.44-0.65) and 5-year LRFR was 77% (95% CI: 0.67-0.85). High malignancy grade and intralesional/marginal resection were identified as negative predictors for OS. High grade was the only prognostic factor associated with a lower LRFR.Conclusions: In this large, single institution, study tumor grade was the key predictor for OS and LRFR. Surgical margin only statistically significantly influenced mortality, not local recurrence.","PeriodicalId":45960,"journal":{"name":"International Journal of Surgical Oncology","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/2350157","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37127618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Outcome of Cervical Lymph Nodes Dissection for Thyroid Cancer with Nodal Metastases: A Southeast Asian 3-Year Experience. 伴有淋巴结转移的甲状腺癌颈部淋巴结清扫的结果:东南亚3年的经验。

IF 1.5

International Journal of Surgical Oncology Pub Date : 2019-02-28 eCollection Date: 2019-01-01 DOI: 10.1155/2019/6109643

Raymond Z M Lim, Juin Y Ooi, Jih H Tan, Henry C L Tan, Seniyah M Sikin

{"title":"Outcome of Cervical Lymph Nodes Dissection for Thyroid Cancer with Nodal Metastases: A Southeast Asian 3-Year Experience.","authors":"Raymond Z M Lim, Juin Y Ooi, Jih H Tan, Henry C L Tan, Seniyah M Sikin","doi":"10.1155/2019/6109643","DOIUrl":"https://doi.org/10.1155/2019/6109643","url":null,"abstract":"Introduction: Therapeutic nodal dissection is still the mainstay of treatment for patients with lymph node metastases in many centres. The local data, however, on the outcome of therapeutic LND remains limited. Hence, this study aims to inform practice by presenting the outcomes of LND for thyroid cancer patients and our experience in a tertiary referral centre.Methods: This is a single-centre retrospective observational study in a Malaysian tertiary endocrine surgery referral centre. Patients who underwent total thyroidectomy with lymph node dissection between years 2013 and 2015 were included and electronic medical records over a 3-year follow-up period were reviewed. The outcomes of different lymph node dissection (LND), including central neck dissection, lateral neck dissection, or both, were compared.Results: Of the 43 subjects included, 28 (65.1%) had Stage IV cancer. Among the 43 subjects included, 8 underwent central LND, and 15 had lateral LND while the remaining 20 had dissection of both lateral and central lymph nodes. Locoregional recurrence was found in 16 (37.2%) of our subjects included, with no statistical difference between the central (2/8), lateral (7/15), and both (7/20). Postoperative hypocalcaemia occurred in 7 (16.3%) patients, and vocal cord palsy occurred in 5 (11.6%), whereas 9 patients (20.9%) required reoperation. Death occurred in 4 of our patients.Conclusion: High recurrence and reoperative rates were observed in our centre. While the routine prophylactic LND remains controversial, high risk patients may be considered for prophylactic LND. The long-term risk and benefit of prophylactic LND with individualised patient selection in the local setting deserve further studies.","PeriodicalId":45960,"journal":{"name":"International Journal of Surgical Oncology","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2019-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/6109643","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37116019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Comparison of Survival in Patients with Isolated Peritoneal Carcinomatosis from Colorectal Cancer Treated with Cytoreduction and Melphalan or Mitomycin-C as Hyperthermic Intraperitoneal Chemotherapy Agent. 细胞减量与美法兰或丝裂霉素c腹腔高温化疗对结直肠癌腹膜分离性癌患者生存的影响。

IF 1.5

International Journal of Surgical Oncology Pub Date : 2018-12-13 eCollection Date: 2018-01-01 DOI: 10.1155/2018/1920276

Arkadii Sipok, Armando Sardi, Carol Nieroda, Mary Caitlin King, Michelle Sittig, Vadim Gushchin

{"title":"Comparison of Survival in Patients with Isolated Peritoneal Carcinomatosis from Colorectal Cancer Treated with Cytoreduction and Melphalan or Mitomycin-C as Hyperthermic Intraperitoneal Chemotherapy Agent.","authors":"Arkadii Sipok, Armando Sardi, Carol Nieroda, Mary Caitlin King, Michelle Sittig, Vadim Gushchin","doi":"10.1155/2018/1920276","DOIUrl":"https://doi.org/10.1155/2018/1920276","url":null,"abstract":"Background: The role of hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis (PC) from colorectal cancer (CRC) is debated. Melphalan as a perfusion agent has also demonstrated survival benefit in other recurrent and chemoresistant malignancies. Thus, we hypothesize that melphalan as a HIPEC agent may improve overall survival (OS) and progression-free survival (PFS) in patients with PC from CRC.Methods: A retrospective review of a prospective database of 48 patients who underwent optimal CRS (CC-0/1) and HIPEC from 2001-2016 was performed. Nineteen had CRS/HIPEC with melphalan (group I) and 29 with mitomycin-C (group II). Survival was estimated using the Kaplan-Meier method. Cox regression was used for multivariate analysis. Perioperative variables were compared.Results: Mean age at CRS/HIPEC was 53±10 years. Median peritoneal cancer index (PCI) was 17 vs 13 in groups I and II, respectively (p=0.86). PCI≥20 occurred in 9 (47%) and 13 (45%) patients in groups I and II, respectively. Positive lymph nodes were identified in 8/19 (42%) vs 12/29 (41%) in groups I and II, respectively (p=0.73). Multivariate analysis identified PCI≥20 as a predictive factor of survival (HR: 7.5). Median OS in groups I and II was 36 and 28 months, respectively (p=0.54). Median PFS in groups I and II was 10 and 20 months, respectively (p=0.05).Conclusions: CRS/HIPEC with MMC had longer median PFS in PC from CRC. PCI≥20 was the only independent predictive factor for survival. Until longer follow-up is available, we recommend using MMC in CRS/HIPEC for PC from CRC. Further prospective randomized studies are necessary.","PeriodicalId":45960,"journal":{"name":"International Journal of Surgical Oncology","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2018-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/1920276","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36853487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Hepatic marker combination provides relevant score to predict severe morbidity after colorectal metastases-related major hepatectomy 肝标志物联合应用可为预测结直肠癌转移相关大肝切除术后的严重发病率提供相关评分

IF 1.5

International Journal of Surgical Oncology Pub Date : 2018-11-26 DOI: 10.31487/j.JSO.2018.01.004

A. Pontallier, C. Laurent, E. Buscail, F. Muscari, J. Adam, L. Chiche, S. Dabernat, V. Vendrely

{"title":"Hepatic marker combination provides relevant score to predict severe morbidity after colorectal metastases-related major hepatectomy","authors":"A. Pontallier, C. Laurent, E. Buscail, F. Muscari, J. Adam, L. Chiche, S. Dabernat, V. Vendrely","doi":"10.31487/j.JSO.2018.01.004","DOIUrl":"https://doi.org/10.31487/j.JSO.2018.01.004","url":null,"abstract":"Background and objectives: After hepatic resection, liver failure is not diagnosed until the postoperative \u0000day-5. The aim was to identify a biomarker predictive of severe morbidity, the day after major hepatectomy. \u0000Methods: This retrospective study included patients undergoing major hepatectomy for colorectal \u0000metastases, plasma hepatic marker concentrations being determined at postoperative day-one. Outcomes \u0000were 30-day severe morbidity (Dindo III to V) and grade C post-hepatectomy liver failure. \u0000Results: A total of 433 patients were included. Thirty-day severe morbidity, 90-day mortality and grade-C \u0000post-hepatectomy liver failure rates were 15.5%, 2.5% and 2.5% respectively. Using cut-offs determined \u0000by receiver operating characteristic curves the association of serum bilirubin ? 2.1 mg/dL (? 2 N) and \u0000aspartate-amino-transferase ? 450 IU/L (? 10 N) was selected for the best biochemical predictors of severe \u0000morbidity (sensitivity 38%, specificity 94%) and post-hepatectomy failure (sensitivity 100%, specificity \u000091%). In multivariate analysis, this score was independently associated with severe morbidity (HR = 5.98, \u000095% IC 2.65-13.89; P < 0.0001) \u0000Conclusions: The association of plasma bilirubin ? 2.1 mg/dL and aspartate-amino-transferase ? 450 IU/L \u0000is identified as a relevant predictor of severe morbidity and post-hepatectomy failure as early as the first \u0000postoperative day after major hepatectomy for colorectal metastases.","PeriodicalId":45960,"journal":{"name":"International Journal of Surgical Oncology","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2018-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85828804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Cervical Cancer: Predictive Relevance of Preoperative 3-Tesla Multiparametric Magnetic Resonance Imaging. 早期宫颈癌:术前3-特斯拉多参数磁共振成像的预测相关性。

IF 1.5

International Journal of Surgical Oncology Pub Date : 2018-08-01 eCollection Date: 2018-01-01 DOI: 10.1155/2018/9120753

Hyun Jin Roh, Kyung Bin Kim, Jong Hwa Lee, Hwa Jung Kim, Yong-Soon Kwon, Sang Hun Lee

{"title":"Early Cervical Cancer: Predictive Relevance of Preoperative 3-Tesla Multiparametric Magnetic Resonance Imaging.","authors":"Hyun Jin Roh, Kyung Bin Kim, Jong Hwa Lee, Hwa Jung Kim, Yong-Soon Kwon, Sang Hun Lee","doi":"10.1155/2018/9120753","DOIUrl":"https://doi.org/10.1155/2018/9120753","url":null,"abstract":"Objective: We assess the predictive significance of preoperative 3-Tesla multiparametric MRI findings.Methods: A total of 260 patients with FIGO IA2-IIA cervical cancer underwent primary surgical treatment between 2007 and 2016. Univariable and multivariable logistic regression analyses were used to assess the incremental prognostic significance.Results: The clinical predictive factors associated with pT2b disease were MRI parametrial invasion (PMI) (adjusted odds ratio (AOR) 3.77, 95% confidence interval(CI) 1.62-8.79; P=0.02) and MRI uterine corpus invasion (UCI) (AOR 9.99, 95% CI 4.11-24.32; P<0.0001). In multivariable analysis, for underdiagnoses, histologically squamous carcinoma versus adenocarcinoma and adenosquamous carcinoma (AOR 2.07, 95% CI 1.06-4.07; P=0.034) and MRI tumor size (AOR 0.76, 95% CI 0.63-0.92; P=0.005) were significant predictors; for overdiagnoses, these results were MRI tumor size (AOR 1.51, 95% CI 1.06-2.16; P=0.023), MRI PMI (AOR 71.73, 95% CI 8.89-611.38; P<0.0001) and MRI UCI (AOR 0.19, 95% CI 0.01-1.01; P=0.051).Conclusion: PMI and UCI on T2-weighted images through preoperative 3T MRI are useful coefficients for accurate prediction of the pT2b stage; however, careful surveillance is required. Therefore, preoperative decision-making for early cervical cancer patients based on MRI diagnosis should be considered carefully, particularly in the presence of factors that are known to increase the likelihood of misdiagnosis.","PeriodicalId":45960,"journal":{"name":"International Journal of Surgical Oncology","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/9120753","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36438440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9