Soft Tissue Sarcomas of the Thoracic Wall: More Prone to Higher Mortality, and Local Recurrence-A Single Institution Long-Term Follow-up Study.

IF 1.6 Q4 ONCOLOGY

International Journal of Surgical Oncology Pub Date : 2019-03-04 eCollection Date: 2019-01-01 DOI:10.1155/2019/2350157

Tine Rytter Soerensen, Mathias Raedkjaer, Peter Holmberg Jørgensen, Anette Hoejsgaard, Akmal Safwat, Thomas Baad-Hansen

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引用次数: 6

Abstract

Objectives: This study aims to assess the impact of surgical margin and malignancy grade on overall survival (OS) and local recurrence free rate (LRFR) for soft tissue sarcomas (STS) of the thoracic wall.

Methods: This retrospective cohort study identified 88 patients, diagnosed and treated surgically for a nonmetastatic STS located in the thoracic wall between 1995 and 2013, using the population based and validated Aarhus Sarcoma Registry and Danish Sarcoma Registry. The Kaplan-Meier method was used to estimate OS and LRFR. Multivariate Cox analyses were used to determine prognostic factors for OS and LRFR.

Results: The 5-year OS was 55% (95% confidence interval (CI): 0.44-0.65) and 5-year LRFR was 77% (95% CI: 0.67-0.85). High malignancy grade and intralesional/marginal resection were identified as negative predictors for OS. High grade was the only prognostic factor associated with a lower LRFR.

Conclusions: In this large, single institution, study tumor grade was the key predictor for OS and LRFR. Surgical margin only statistically significantly influenced mortality, not local recurrence.

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胸壁软组织肉瘤:更高的死亡率和局部复发——一项单机构长期随访研究

目的:本研究旨在评估手术切缘和恶性肿瘤分级对胸壁软组织肉瘤(STS)总生存期(OS)和局部无复发率(LRFR)的影响。方法:这项回顾性队列研究确定了1995年至2013年间88例胸壁非转移性STS患者，使用基于人群并经过验证的奥胡斯肉瘤登记和丹麦肉瘤登记。采用Kaplan-Meier法估计OS和LRFR。多因素Cox分析用于确定OS和LRFR的预后因素。结果:5年OS为55%(95%可信区间(CI): 0.44-0.65)， 5年LRFR为77% (95% CI: 0.67-0.85)。高恶性程度和瘤内/边缘切除被认为是OS的阴性预测因素。高分级是唯一与低LRFR相关的预后因素。结论:在这个大型的单一机构中，肿瘤分级是OS和LRFR的关键预测因子。手术切缘仅对死亡率有统计学意义，对局部复发率无统计学意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Surgical Oncology ONCOLOGY-

CiteScore

3.70

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.