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Mechanisms of Coronary Artery Spasm. 冠状动脉痉挛的机制。
IF 3
European Cardiology Review Pub Date : 2023-01-01 DOI: 10.15420/ecr.2022.55
Kensuke Nishimiya, Jun Takahashi, Kazuma Oyama, Yasuharu Matsumoto, Satoshi Yasuda, Hiroaki Shimokawa
{"title":"Mechanisms of Coronary Artery Spasm.","authors":"Kensuke Nishimiya,&nbsp;Jun Takahashi,&nbsp;Kazuma Oyama,&nbsp;Yasuharu Matsumoto,&nbsp;Satoshi Yasuda,&nbsp;Hiroaki Shimokawa","doi":"10.15420/ecr.2022.55","DOIUrl":"https://doi.org/10.15420/ecr.2022.55","url":null,"abstract":"<p><p>Recent clinical trials have highlighted that percutaneous coronary intervention in patients with stable angina provides limited additional benefits on top of optimal medical therapy. This has led to much more attention being paid to coronary vasomotion abnormalities regardless of obstructive or non-obstructive arterial segments. Coronary vasomotion is regulated by multiple mechanisms that include the endothelium, vascular smooth muscle cells (VSMCs), myocardial metabolic demand, autonomic nervous system and inflammation. Over the years, several animal models have been developed to explore the central mechanism of coronary artery spasm. This review summarises the landmark studies on the mechanisms of coronary vasospasm demonstrating the central role of Rho-kinase as a molecular switch of VSMC hypercontraction and the important role of coronary adventitial inflammation for Rho-kinase upregulation in VSMCs.</p>","PeriodicalId":45957,"journal":{"name":"European Cardiology Review","volume":"18 ","pages":"e39"},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/48/ecr-18-e39.PMC10345984.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9825941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Ablation as First-line Therapy for Atrial Fibrillation. 消融作为房颤的一线治疗。
IF 3
European Cardiology Review Pub Date : 2023-01-01 DOI: 10.15420/ecr.2023.04
Jason G Andrade
{"title":"Ablation as First-line Therapy for Atrial Fibrillation.","authors":"Jason G Andrade","doi":"10.15420/ecr.2023.04","DOIUrl":"https://doi.org/10.15420/ecr.2023.04","url":null,"abstract":"<p><p>AF is a chronic and progressive heart rhythm disorder characterised by exacerbations and remissions. Contemporary guidelines recommend antiarrhythmic drugs (AADs) as the initial therapy for the maintenance of sinus rhythm. However, these medications have modest efficacy and are associated with significant adverse effects. Several recent trials have evaluated catheter ablation as an initial therapy for AF, demonstrating that cryoballoon catheter ablation significantly improves arrhythmia outcomes (e.g. atrial tachyarrhythmia recurrence and arrhythmia burden), produces clinically meaningful improvements in patient-reported outcomes (e.g. symptoms and quality of life), and significantly decreases healthcare resource usage (e.g. hospitalisation), without increasing the risk of serious adverse events. Moreover, in contrast to antiarrhythmic drugs, catheter ablation appears to be disease-modifying, significantly reducing the progression of disease. These findings are relevant to patients, providers, and healthcare systems, helping inform the initial choice of rhythm-control therapy in patients with treatment-naïve AF.</p>","PeriodicalId":45957,"journal":{"name":"European Cardiology Review","volume":"18 ","pages":"e46"},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/07/8e/ecr-18-e46.PMC10398511.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9949543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Leadless Pacemakers: Current Achievements and Future Perspectives. 无导线起搏器:当前成就和未来展望。
IF 3
European Cardiology Review Pub Date : 2023-01-01 DOI: 10.15420/ecr.2022.32
Apostolos Ilias Vouliotis, Paul R Roberts, Polychronis Dilaveris, Konstantinos Gatzoulis, Arthur Yue, Konstantinos Tsioufis
{"title":"Leadless Pacemakers: Current Achievements and Future Perspectives.","authors":"Apostolos Ilias Vouliotis,&nbsp;Paul R Roberts,&nbsp;Polychronis Dilaveris,&nbsp;Konstantinos Gatzoulis,&nbsp;Arthur Yue,&nbsp;Konstantinos Tsioufis","doi":"10.15420/ecr.2022.32","DOIUrl":"https://doi.org/10.15420/ecr.2022.32","url":null,"abstract":"<p><p>Despite the technological advances in pacemaker technology, the transvenous implanted leads are still considered the Achilles' heel of this rhythm-control therapy. The leadless permanent pacemaker system was developed as an option to bypass the weakness of the transvenous approach. Advances in battery technology and deep miniaturisation of electronics now offer the opportunity to implant the whole pacemaker system into the right ventricle. This review aims to provide a comprehensive report on the advent of leadless pacemakers, their clinical usefulness and the future perspectives of this disruptive and promising technology. Further research is required before some of these technologies are safely and routinely used in clinical practice.</p>","PeriodicalId":45957,"journal":{"name":"European Cardiology Review","volume":"18 ","pages":"e49"},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/db/e1/ecr-18-e49.PMC10466270.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10138082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Evaluating the Effects of Melatonin on the Oxidative Stress and Duration of Atrial Fibrillation following Coronary Artery Bypass Graft Surgery: A Randomised Controlled Trial. 评估褪黑素对冠状动脉搭桥术后氧化应激和房颤持续时间的影响:一项随机对照试验。
IF 3
European Cardiology Review Pub Date : 2023-01-01 DOI: 10.15420/ecr.2023.18.PO8
Farzaneh Dastan, Saghar Barati, Zargham Hossein Ahmadi
{"title":"Evaluating the Effects of Melatonin on the Oxidative Stress and Duration of Atrial Fibrillation following Coronary Artery Bypass Graft Surgery: A Randomised Controlled Trial.","authors":"Farzaneh Dastan,&nbsp;Saghar Barati,&nbsp;Zargham Hossein Ahmadi","doi":"10.15420/ecr.2023.18.PO8","DOIUrl":"https://doi.org/10.15420/ecr.2023.18.PO8","url":null,"abstract":"","PeriodicalId":45957,"journal":{"name":"European Cardiology Review","volume":"18 ","pages":"e25"},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6a/82/ecr-18-e25.PMC10316341.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10179309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Randomised Double-blind Placebo-Controlled Multicentre Trial for the Effects of Yokukansan in Smokers with Depressive Tendencies. Yokukansan对有抑郁倾向的吸烟者疗效的随机双盲安慰剂对照多中心试验。
IF 3
European Cardiology Review Pub Date : 2023-01-01 DOI: 10.15420/ecr.2023.18.PO13
Maki Komiyama, Yuka Ozaki, Hiromichi Wada, Hajime Yamakage, Noriko Satoh-Asahara, Akihiro Yasoda, Yoichi Sunagawa, Tatsuya Morimoto, Yuko Takahashi, Koji Hasegawa
{"title":"Randomised Double-blind Placebo-Controlled Multicentre Trial for the Effects of Yokukansan in Smokers with Depressive Tendencies.","authors":"Maki Komiyama,&nbsp;Yuka Ozaki,&nbsp;Hiromichi Wada,&nbsp;Hajime Yamakage,&nbsp;Noriko Satoh-Asahara,&nbsp;Akihiro Yasoda,&nbsp;Yoichi Sunagawa,&nbsp;Tatsuya Morimoto,&nbsp;Yuko Takahashi,&nbsp;Koji Hasegawa","doi":"10.15420/ecr.2023.18.PO13","DOIUrl":"https://doi.org/10.15420/ecr.2023.18.PO13","url":null,"abstract":"","PeriodicalId":45957,"journal":{"name":"European Cardiology Review","volume":"18 ","pages":"e30"},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/51/1c/ecr-18-e30.PMC10316361.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9802286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Noise, Air, and Heavy Metal Pollution as Risk Factors for Endothelial Dysfunction. 噪音、空气和重金属污染是内皮功能障碍的危险因素。
IF 3
European Cardiology Review Pub Date : 2023-01-01 DOI: 10.15420/ecr.2022.41
Maria Teresa Bayo Jimenez, Omar Hahad, Marin Kuntic, Andreas Daiber, Thomas Münzel
{"title":"Noise, Air, and Heavy Metal Pollution as Risk Factors for Endothelial Dysfunction.","authors":"Maria Teresa Bayo Jimenez,&nbsp;Omar Hahad,&nbsp;Marin Kuntic,&nbsp;Andreas Daiber,&nbsp;Thomas Münzel","doi":"10.15420/ecr.2022.41","DOIUrl":"https://doi.org/10.15420/ecr.2022.41","url":null,"abstract":"<p><p>During the last two decades, large epidemiological studies have shown that the physical environment, including noise, air pollution or heavy metals, have a considerable impact on human health. It is known that the most common cardiovascular risk factors are all associated with endothelial dysfunction. Vascular tone, circulation of blood cells, inflammation, and platelet activity are some of the most essential functions regulated by the endothelium that suffer negative effects as a consequence of environmental pollution, causing endothelial dysfunction. In this review, we delineate the impact of environmental risk factors in connection to endothelial function. On a mechanistic level, a significant number of studies suggest the involvement of endothelial dysfunction to fundamentally drive the adverse endothelium health effects of the different pollutants. We focus on well-established studies that demonstrate the negative effects on the endothelium, with a focus on air, noise, and heavy metal pollution. This in-depth review on endothelial dysfunction as a consequence of the physical environment aims to contribute to the associated research needs by evaluating current findings from human and animal studies. From a public health perspective, these findings may also help to reinforce efforts promoting the research for adequate promising biomarkers for cardiovascular diseases since endothelial function is considered a hallmark of environmental stressor health effects.</p>","PeriodicalId":45957,"journal":{"name":"European Cardiology Review","volume":"18 ","pages":"e09"},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ef/54/ecr-18-e09.PMC10291605.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9725858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Water-soluble Vitamins in Reducing the Risk of Cardiovascular Heart Disease in Premature Ovarian Insufficiency Patients. 水溶性维生素在降低卵巢功能不全患者心血管心脏病风险中的作用。
IF 3
European Cardiology Review Pub Date : 2023-01-01 DOI: 10.15420/ecr.2023.18.PO18
Rushikesh Rajesh Patil
{"title":"Role of Water-soluble Vitamins in Reducing the Risk of Cardiovascular Heart Disease in Premature Ovarian Insufficiency Patients.","authors":"Rushikesh Rajesh Patil","doi":"10.15420/ecr.2023.18.PO18","DOIUrl":"https://doi.org/10.15420/ecr.2023.18.PO18","url":null,"abstract":"","PeriodicalId":45957,"journal":{"name":"European Cardiology Review","volume":"18 ","pages":"e35"},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/27/cd/ecr-18-e35.PMC10316346.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9802300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardio-oncology in 2022. 2022年的心脏肿瘤学。
IF 3
European Cardiology Review Pub Date : 2023-01-01 DOI: 10.15420/ecr.2022.45
Rebecca Dobson
{"title":"Cardio-oncology in 2022.","authors":"Rebecca Dobson","doi":"10.15420/ecr.2022.45","DOIUrl":"https://doi.org/10.15420/ecr.2022.45","url":null,"abstract":"","PeriodicalId":45957,"journal":{"name":"European Cardiology Review","volume":"18 ","pages":"e04"},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/22/d5/ecr-18-e04.PMC10345983.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9825938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular Risk Induced by the Presence of Non-alcoholic Fatty Liver Disease. 非酒精性脂肪性肝病诱发的心血管风险
IF 3
European Cardiology Review Pub Date : 2023-01-01 DOI: 10.15420/ecr.2023.18.PO6
Daciana Dascalu
{"title":"Cardiovascular Risk Induced by the Presence of Non-alcoholic Fatty Liver Disease.","authors":"Daciana Dascalu","doi":"10.15420/ecr.2023.18.PO6","DOIUrl":"https://doi.org/10.15420/ecr.2023.18.PO6","url":null,"abstract":"","PeriodicalId":45957,"journal":{"name":"European Cardiology Review","volume":"18 ","pages":"e23"},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dd/9b/ecr-18-e23.PMC10316373.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9802295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Sex-based Differences in Percutaneous Coronary Intervention Outcomes in Patients with Ischaemic Heart Disease. 缺血性心脏病患者经皮冠状动脉介入治疗结果的性别差异
IF 3
European Cardiology Review Pub Date : 2023-01-01 DOI: 10.15420/ecr.2022.24
Antonia Sambola, Bruno García Del Blanco, Vijay Kunadian, Birgit Vogel, Alaide Chieffo, María Vidal, Hanna Ratcovich, Giulia Botti, Chris Wilkinson, Roxana Mehran
{"title":"Sex-based Differences in Percutaneous Coronary Intervention Outcomes in Patients with Ischaemic Heart Disease.","authors":"Antonia Sambola,&nbsp;Bruno García Del Blanco,&nbsp;Vijay Kunadian,&nbsp;Birgit Vogel,&nbsp;Alaide Chieffo,&nbsp;María Vidal,&nbsp;Hanna Ratcovich,&nbsp;Giulia Botti,&nbsp;Chris Wilkinson,&nbsp;Roxana Mehran","doi":"10.15420/ecr.2022.24","DOIUrl":"https://doi.org/10.15420/ecr.2022.24","url":null,"abstract":"<p><p>In high-income countries, ischaemic heart disease is the leading cause of death in women and men, accounting for more than 20% of deaths in both sexes. However, women are less likely to receive guideline-recommended percutaneous coronary intervention (PCI) than men. Women undergoing PCI have poorer unadjusted outcomes because they are older and have greater comorbidity than men, but uncertainty remains whether sex affects outcome after these differences in clinical characteristics are considered. In this paper, we review recent published evidence comparing outcomes between men and women undergoing PCI. We focus on the sex differences in PCI outcomes in different scenarios: acute coronary syndromes, stable angina and complex lesions, including the approach of left main coronary artery. We also review how gender is considered in recent guidelines and offer a common clinical scenario to illustrate the contemporary management strategies an interventional cardiologist should consider when performing PCI on a female patient.</p>","PeriodicalId":45957,"journal":{"name":"European Cardiology Review","volume":"18 ","pages":"e06"},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/32/d4/ecr-18-e06.PMC10345982.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9825936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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