Acta Dermatovenerologica Alpina Pannonica et Adriatica最新文献_第5页

Acrocyanosis: primary or secondary form? An observational study. 肢青症：原发性还是继发性？一项观察性研究。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-12-01

Salvino Bilancini, Massimo Lucchi, Giusto Trevisan, Luigi Di Pino, Sandro Tucci

{"title":"Acrocyanosis: primary or secondary form? An observational study.","authors":"Salvino Bilancini, Massimo Lucchi, Giusto Trevisan, Luigi Di Pino, Sandro Tucci","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Acrocyanosis is the most common form of angiodystonic vascular acrosyndrome, characterized by functional microcirculatory alterations without structural vessel damage. It is traditionally classified as either primary or secondary, the latter often associated with underlying conditions.Methods: Some observations suggest a frequent association between acrocyanosis and connective tissue diseases (CTDs). To investigate this, we conducted a study on 53 patients diagnosed with acrocyanosis: 45 females and eight males, 15 to 82 years old, with a mean age of 35 years. Secondary acrocyanosis was identified in 24 patients (45.3%).Results: Advanced age (≥ 40 years) was a significant risk factor for secondary acrocyanosis (relative risk = 2.5, 95% confidence interval: 1.4-4.5, p = 0.002). No significant differences were observed between sexes. CTDs were the most common conditions associated with acrocyanosis (32% of the study population and 71% of the secondary forms).Conclusions: Although generally considered benign, acrocyanosis may indicate an underlying systemic disease. Clinical examination remains essential for the diagnosis of acrocyanosis. Our findings reveal a high prevalence of secondary acrocyanosis associated with CTDs. Patients with strong clinical suspicion should be referred to specialized centers for capillaroscopy and antinuclear antibody testing.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 4","pages":"177-180"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nail psoriasis or trachyonychia? Can dermoscopy differentiate them? 甲癣还是短甲癣？皮肤镜能区分吗？

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-12-01

Ahu Yorulmaz

引用次数: 0

Effectiveness of baricitinib in severe alopecia areata in real life: a retrospective study of 87 patients. 巴西替尼治疗现实生活中严重斑秃的有效性：一项87例患者的回顾性研究。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-12-01

Nouf M Aleid, Sara F Alhuwairini, Ghadah A Almuhana, Shaikah A Al-Aojan, Samiah A Abanomy, Hind M Almohanna

{"title":"Effectiveness of baricitinib in severe alopecia areata in real life: a retrospective study of 87 patients.","authors":"Nouf M Aleid, Sara F Alhuwairini, Ghadah A Almuhana, Shaikah A Al-Aojan, Samiah A Abanomy, Hind M Almohanna","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Alopecia areata (AA) is an autoimmune condition characterized by non-scarring hair loss. The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway is believed to play a central role in the autoimmune inflammatory processes underlying AA. Baricitinib, an oral JAK inhibitor, has been approved by the Food and Drug Administration (FDA) for the treatment of severe AA. This study evaluates the efficacy and safety of baricitinib in the management of AA.Methods: A retrospective cohort study was conducted on patients with AA receiving baricitinib 4 mg daily and that had completed a 1-year follow-up. Disease severity was assessed at baseline and the end of follow-up using the Severity of Alopecia Tool (SALT) score. Adverse events were systematically recorded.Results: Among 87 patients included in the analysis, the mean age was 29.84 years, and the mean baseline SALT score was 77.07%. After a mean of 52 weeks, 37.20% of patients achieved a SALT score ≤ 20. A significant reduction in SALT scores was observed at the end of follow-up (p < 0.001). In addition, 72.40% of patients experienced mild or no adverse events, and no serious adverse events were reported.Conclusions: In this 52-week real-world cohort, baricitinib demonstrated both effectiveness and good tolerability in the treatment of severe AA. These findings contribute to the understanding of long-term outcomes with baricitinib therapy.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 4","pages":"183-186"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145794539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of keratoacanthoma following CO2 laser resurfacing: a case report and literature review. CO2激光置换后角膜棘瘤的发展：1例报告及文献复习。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-12-01

Artina Pajaziti, Antigona B Gerqari, Laura Pajaziti

引用次数: 0

The prevalence of hair loss and its association with iron deficiency among adolescents in northern Sudan: a school-based cross-sectional study. 苏丹北部青少年脱发的流行及其与缺铁的关系：一项基于学校的横断面研究。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-12-01

Moteb K Alotaib, Ishag Adam

{"title":"The prevalence of hair loss and its association with iron deficiency among adolescents in northern Sudan: a school-based cross-sectional study.","authors":"Moteb K Alotaib, Ishag Adam","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Alopecia and iron deficiency are significant public health issues in northern Sudan, and no research about this topic has been conducted. The aim is to examine the prevalence of iron deficiency and alopecia and associated factors among adolescents in northern Sudan.Methods: A cross-sectional study was conducted through a questionnaire and clinical examination.Results: A total of 312 adolescents participated: 147 males (47.1%) and 165 females (52.9%). Among them, 21.2% of adolescents exhibited alopecia. Females experienced higher rates of alopecia, with 93.9% affected compared to 6.1% of males. Serum ferritin was significantly lower in adolescents with alopecia compared to those without it (6.05 [2.58‒12.63] vs. 9.40 [4.88‒23.40] μg/l, p = 0.002). Multivariate analysis indicated that iron deficiency (adjusted odds ratio [AOR] = 1.97, 95% confidence interval [CI] = 1.04-3.71) was associated with alopecia. However, age, body mass index, and parental education level showed no association. Among the adolescents with alopecia, 27.3% had patchy alopecia, 37.9% had diffuse alopecia, and 34.8% had traction alopecia.Conclusion: There is a significant prevalence of adolescent alopecia, predominantly among females. Iron deficiency was a key factor associated with alopecia, underscoring the importance of nutritional monitoring in this population.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 4","pages":"159-163"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145794906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of adherence and knowledge retention for adrenaline autoinjector use in hymenoptera venom-allergic patients with c-KIT p.D816V. c-KIT p.D816V膜翅目毒液过敏患者肾上腺素自动注射器使用依从性和知识保留的评价

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-12-01

Tea Močnik, Mitja Košnik

{"title":"Evaluation of adherence and knowledge retention for adrenaline autoinjector use in hymenoptera venom-allergic patients with c-KIT p.D816V.","authors":"Tea Močnik, Mitja Košnik","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Severe anaphylaxis in patients with clonal mast cell disorders highlights the need for proper use of adrenaline autoinjectors. This study assessed knowledge retention and adherence to autoinjector use in c-KIT p.D816V-positive individuals with hymenoptera venom allergy undergoing venom immunotherapy (VIT) and prescribed two autoinjectors.Methods: Seventy-one VIT patients received personalized autoinjector education, with knowledge assessed at 3, 4 to 12, 12 to 24, and > 24 months. Fifteen patients 5 years post-VIT underwent video-based retraining and were assessed 1 month later.Results: Knowledge retention was 82.3% at 3 months, dropping to 40.0% at 12 to 24 months (p = 0.0160) and 22.2% after 24 months (p = 0.0005), indicating a clear decline over time. Common errors included ignoring the safety cap (16.7%), insufficient injection force, finger injection risk, and upper arm activation (totaling 19.0%). In addition, 19.8% failed to hold the autoinjector in the muscle for 3 seconds, 26.9% did not know to lie supine during anaphylaxis, and 14.3% did not seek emergency help. In the video-retrained group, 80.0% lacked proficiency 1 month later, 73.3% were unaware of the second dose, and 66.7% did not carry their devices.Conclusions: Ongoing tailored education is essential to ensure effective autoinjector use, especially in c-KIT p.D816V-positive venom-allergic patients. Video instruction alone may be insufficient.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 4","pages":"171-174"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145794804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic vulvar itch: diagnostic and therapeutic challenges. 慢性外阴痒：诊断和治疗的挑战。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-09-01

Katarina Trčko

引用次数: 0

Toxic epidermal necrolysis: lessons from three fatal cases. 中毒性表皮坏死松解：3例致命病例的经验教训。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-09-01

Marko Demenj, Vesna Reljić, Emilija Manojlović Gačić, Maja Vilotijević, Dubravka Živanović

{"title":"Toxic epidermal necrolysis: lessons from three fatal cases.","authors":"Marko Demenj, Vesna Reljić, Emilija Manojlović Gačić, Maja Vilotijević, Dubravka Živanović","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Toxic epidermal necrolysis (TEN) is a severe cutaneous adverse reaction triggered by various classes of drugs. Clinical manifestations include prodromal symptoms resembling a febrile illness, followed by skin and mucosal lesions. This study presents a series of fatal TEN cases, with a focus on factors that may have influenced mortality, including differential diagnoses, associated comorbidities, treatment choices, and complications of TEN.Methods: Data were collected from electronic medical records of patients hospitalized at a dermatology clinic.Results: Case 1 involved TEN in a 42-year-old female, initially misdiagnosed as mycoplasma-induced rash and mucositis (MIRM), who succumbed to sepsis. Case 2, a 50-year-old female with 80% of her body surface area affected, saw low-dose IVIg treatment prove ineffective, leading to multiorgan failure. Case 3 involved allopurinol-induced TEN in a 53-year-old with Balkan endemic nephropathy, resulting in fatal renal failure.Conclusions: The cases presented highlight potential challenges in differentiating TEN from MIRM in the early stages of TEN. High-dose IVIg is generally recommended, whereas the effectiveness of low-dose IVIg is inconsistent, and it proved insufficient in the case presented, potentially due to the presence of multiple comorbidities. Preexisting conditions such as renal disease significantly influence fatal outcomes in TEN patients.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 3","pages":"139-144"},"PeriodicalIF":1.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NTRK3-rearranged spindle cell neoplasm of the skin: diagnostic pitfalls of an emerging entity, a case report. ntrk3重排梭形细胞肿瘤的皮肤：一个新兴实体的诊断陷阱，一个病例报告。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-09-01

Andreia Coutada, Carla Di Loreto, Alenka Matjašič, Boštjan Luzar

引用次数: 0

Targeted therapy seems untargeted: TNF-α antagonists in psoriasis as an example. 靶向治疗似乎没有靶向性：TNF-α拮抗剂治疗牛皮癣就是一个例子。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-09-01

Manahel Mahmood Alsabbagh

{"title":"Targeted therapy seems untargeted: TNF-α antagonists in psoriasis as an example.","authors":"Manahel Mahmood Alsabbagh","doi":"","DOIUrl":"","url":null,"abstract":"Biologic therapies have emerged as targeted treatments in psoriasis, offering personalized options for patients. However, when examining the cytokine network in psoriasis, this raises the question of whether biologics should be viewed as targeted therapies. This article reviews the literature focusing on the impact of tumor necrosis factor (TNF)-α antagonists on the cytokine profile and immunocytes in psoriasis. The literature suggests that the effects of TNF-α antagonists extend beyond TNF-α. These agents have a significant influence on various cytokines of the innate and adaptive immune system, including interferon-γ, interleukin (IL)-1, IL-4, IL-6, IL-8, IL-12, IL-17, IL-22, IL-23, and IL-24 in blood and skin. In addition, TNF-α antagonists also affect immunocyte counts, such as neutrophil elastase-positive cells. This demonstrates that, even though biologic treatments were initially designed to target specific molecules structurally, their function should not be narrowly considered targeted. This concept has important implications in clinical practice, including for the understanding and knowledgeable prediction of drug-related side effects, such as colitis, inflammatory bowel disease, myocarditis, and infections, as well as for taking necessary precautions before prescribing medications.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 3","pages":"133-136"},"PeriodicalIF":1.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0