Association of HLA class II gene polymorphisms and expression levels of ORAI1/STIM1 genes in HIV-1‒positive patients with HIV-related dermatoses in Latvia.

IF 0.6 Q4 DERMATOLOGY

Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2024-06-01

Alena Soha, Inga Azina, Darja Arina Miskina, Viktorija Murasko, Maksims Zolovs, Andris Rubins

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引用次数: 0

Abstract

Introduction: This study explores the immunogenetic associations of human leukocyte antigens (HLA) and the calcium release-activated calcium modulator 1 (ORAI1) and stromal interaction molecule 1 (STIM1) genes in HIV-1‒positive patients with HIV-related skin disorders.

Methods: This study assessed the distribution of variants of HLA class II alleles and expression levels of ORAI1 and STIM1 genes in the blood between HIV-1‒positive patients with HIV-related skin disorders and the control group with no HIV within the Latvian population.

Results: The research group comprised 115 HIV-1‒positive patients with HIV-related skin disorders, and the control group included 80 healthy individuals. Risk alleles (HLA- DQB1*02:01-0301 and HLA-DQA1*01:01-0501) and protective alleles (HLA-DRB1*07-13, DRB1*01-13, DRB1*04-11, and HLA-DQA1*05:01-0501) showed statistical significance in the groups. In 38 out of 115 patients, higher expression levels of ORAI1 and STIM1 genes were detected in the blood at the beginning of treatment. A significantly higher level of the microribonucleic acid (mRNA) ORAI1 gene was also found in the control group.

Conclusions: The results demonstrate that HLA class II alleles are associated with a trend toward risk/protection concerning HIV-related skin disorders in HIV-1‒positive patients. It was also shown that a low level of ORAI1 mRNA and the risk allele HLA-DQB1*0201-0301 were simultaneously present in the research group.

本刊更多论文

拉脱维亚艾滋病毒相关皮肤病的 HIV-1 阳性患者中 HLA II 类基因多态性与 ORAI1/STIM1 基因表达水平的关联。

导言：本研究探讨了HIV-1阳性皮肤病患者的人类白细胞抗原（HLA）与钙释放激活钙调节剂1（ORAI1）和基质相互作用分子1（STIM1）基因的免疫遗传学关联：本研究评估了拉脱维亚人群中患有 HIV 相关皮肤病的 HIV-1 阳性患者与未感染 HIV 的对照组之间的 HLA II 类等位基因变体分布以及 ORAI1 和 STIM1 基因在血液中的表达水平：研究组由 115 名 HIV-1 阳性皮肤病患者组成，对照组包括 80 名健康人。研究组中的风险等位基因（HLA- DQB1*02:01-0301 和 HLA-DQA1*01:01-0501）和保护性等位基因（HLA-DRB1*07-13、DRB1*01-13、DRB1*04-11 和 HLA-DQA1*05:01-0501）具有统计学意义。在 115 名患者中，有 38 人在治疗开始时的血液中检测到 ORAI1 和 STIM1 基因表达水平较高。在对照组中也发现 ORAI1 基因的微核糖核酸（mRNA）水平明显较高：结论：研究结果表明，HLA II 类等位基因与 HIV-1 阳性患者患艾滋病相关皮肤病的风险/保护趋势有关。结论：研究结果表明，HLA II 类等位基因与 HIV-1 阳性患者出现与 HIV 相关的皮肤病的风险/保护趋势有关。研究结果还显示，研究组中同时存在低水平的 ORAI1 mRNA 和风险等位基因 HLA-DQB1*0201-0301。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Dermatovenerologica Alpina Pannonica et Adriatica DERMATOLOGY-

CiteScore

1.70

自引率

8.30%

发文量