Acta Dermatovenerologica Alpina Pannonica et Adriatica最新文献

Chronic vulvar itch: diagnostic and therapeutic challenges. 慢性外阴痒：诊断和治疗的挑战。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-09-01

Katarina Trčko

引用次数: 0

NTRK3-rearranged spindle cell neoplasm of the skin: diagnostic pitfalls of an emerging entity, a case report. ntrk3重排梭形细胞肿瘤的皮肤：一个新兴实体的诊断陷阱，一个病例报告。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-09-01

Andreia Coutada, Carla Di Loreto, Alenka Matjašič, Boštjan Luzar

引用次数: 0

Toxic epidermal necrolysis: lessons from three fatal cases. 中毒性表皮坏死松解：3例致命病例的经验教训。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-09-01

Marko Demenj, Vesna Reljić, Emilija Manojlović Gačić, Maja Vilotijević, Dubravka Živanović

{"title":"Toxic epidermal necrolysis: lessons from three fatal cases.","authors":"Marko Demenj, Vesna Reljić, Emilija Manojlović Gačić, Maja Vilotijević, Dubravka Živanović","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Toxic epidermal necrolysis (TEN) is a severe cutaneous adverse reaction triggered by various classes of drugs. Clinical manifestations include prodromal symptoms resembling a febrile illness, followed by skin and mucosal lesions. This study presents a series of fatal TEN cases, with a focus on factors that may have influenced mortality, including differential diagnoses, associated comorbidities, treatment choices, and complications of TEN.Methods: Data were collected from electronic medical records of patients hospitalized at a dermatology clinic.Results: Case 1 involved TEN in a 42-year-old female, initially misdiagnosed as mycoplasma-induced rash and mucositis (MIRM), who succumbed to sepsis. Case 2, a 50-year-old female with 80% of her body surface area affected, saw low-dose IVIg treatment prove ineffective, leading to multiorgan failure. Case 3 involved allopurinol-induced TEN in a 53-year-old with Balkan endemic nephropathy, resulting in fatal renal failure.Conclusions: The cases presented highlight potential challenges in differentiating TEN from MIRM in the early stages of TEN. High-dose IVIg is generally recommended, whereas the effectiveness of low-dose IVIg is inconsistent, and it proved insufficient in the case presented, potentially due to the presence of multiple comorbidities. Preexisting conditions such as renal disease significantly influence fatal outcomes in TEN patients.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 3","pages":"139-144"},"PeriodicalIF":1.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted therapy seems untargeted: TNF-α antagonists in psoriasis as an example. 靶向治疗似乎没有靶向性：TNF-α拮抗剂治疗牛皮癣就是一个例子。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-09-01

Manahel Mahmood Alsabbagh

{"title":"Targeted therapy seems untargeted: TNF-α antagonists in psoriasis as an example.","authors":"Manahel Mahmood Alsabbagh","doi":"","DOIUrl":"","url":null,"abstract":"Biologic therapies have emerged as targeted treatments in psoriasis, offering personalized options for patients. However, when examining the cytokine network in psoriasis, this raises the question of whether biologics should be viewed as targeted therapies. This article reviews the literature focusing on the impact of tumor necrosis factor (TNF)-α antagonists on the cytokine profile and immunocytes in psoriasis. The literature suggests that the effects of TNF-α antagonists extend beyond TNF-α. These agents have a significant influence on various cytokines of the innate and adaptive immune system, including interferon-γ, interleukin (IL)-1, IL-4, IL-6, IL-8, IL-12, IL-17, IL-22, IL-23, and IL-24 in blood and skin. In addition, TNF-α antagonists also affect immunocyte counts, such as neutrophil elastase-positive cells. This demonstrates that, even though biologic treatments were initially designed to target specific molecules structurally, their function should not be narrowly considered targeted. This concept has important implications in clinical practice, including for the understanding and knowledgeable prediction of drug-related side effects, such as colitis, inflammatory bowel disease, myocarditis, and infections, as well as for taking necessary precautions before prescribing medications.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 3","pages":"133-136"},"PeriodicalIF":1.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case report of lymphomatoid papulosis: uncovering a rare diagnosis from a common finger ulcer. 样淋巴瘤丘疹病1例报告：从一个常见的手指溃疡揭示一个罕见的诊断。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-09-01

Gökçe Işıl Kurmuş, Hanife Karataş, Elif Kaya, Ali Çınar, Selda Pelin Kartal

{"title":"A case report of lymphomatoid papulosis: uncovering a rare diagnosis from a common finger ulcer.","authors":"Gökçe Işıl Kurmuş, Hanife Karataş, Elif Kaya, Ali Çınar, Selda Pelin Kartal","doi":"","DOIUrl":"","url":null,"abstract":"Lymphomatoid papulosis (LyP) is a rare, chronic CD30+ cutaneous lymphoproliferative disorder characterized by recurrent, self-healing papulonodular lesions. Despite its benign clinical course, LyP histologically resembles malignant lymphomas, necessitating careful differentiation. A 42-year-old woman presented with a 3-year history of recurring ulcerated papulonodular lesions on her index finger. Histopathological examination revealed atypical CD30+ lymphoid proliferation, confirming LyP type A. Immunohistochemical analysis was positive for CD2, CD4, CD30, and multiple myeloma oncogene 1, while systemic malignancy was excluded. The patient was treated with low-dose methotrexate (15 mg/week), leading to symptom improvement. LyP is classified into five histological subtypes (A-E) and is often misdiagnosed due to its overlap with inflammatory and neoplastic conditions. While the condition typically resolves spontaneously, it is associated with an increased risk of secondary lymphomas, including mycosis fungoides and primary cutaneous anaplastic large cell lymphoma. Accurate diagnosis relies on clinical presentation, histopathological evaluation, and immunophenotyping. Awareness of LyP's clinical and pathological features is essential for appropriate management and surveillance.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 1","pages":"151-154"},"PeriodicalIF":1.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of alopecia areata with JAK inhibitors: a review of the literature. JAK抑制剂治疗斑秃：文献综述。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-09-01

Jaiden Townsend, Aleksandar Godic

引用次数: 0

Preventive and curative approaches to diaper dermatitis in children: a systematic review. 儿童尿布皮炎的预防和治疗方法：系统综述。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-09-01

Stella Gracia Octarica, Endra Yustin Ellistasari, Ayu Kusuma Dewi, Shelly Lavenia Sambodo, Rahmat Firdaus Dwi Utama, Sugih Primas Adjie

{"title":"Preventive and curative approaches to diaper dermatitis in children: a systematic review.","authors":"Stella Gracia Octarica, Endra Yustin Ellistasari, Ayu Kusuma Dewi, Shelly Lavenia Sambodo, Rahmat Firdaus Dwi Utama, Sugih Primas Adjie","doi":"","DOIUrl":"","url":null,"abstract":"Diaper dermatitis (DD) is a common inflammatory skin condition in the diaper area of infants, caused by a combination of host and environmental factors, such as moisture, friction, elevated skin pH, and prolonged exposure to urine and feces. This systematic review analyzed 13 studies involving 2,935 children to evaluate effective treatment and prevention strategies for DD. Key interventions identified include the use of disposable and emollient-containing diapers, gentle skincare practices (such as bathing every 1 to 2 days with mild cleansers and emollients), and pH-balanced wet wipes. Frequent diaper changes and allowing diaper-free time also help reduce skin irritation. Topical treatments, particularly emollients with zinc oxide or dexpanthenol, were found to be highly effective with minimal side effects. Preventive measures, such as using superabsorbent disposable diapers, regular application of barrier creams, and maintaining good hygiene, are crucial in reducing the incidence and severity of DD. In conclusion, a combined approach of proper diaper selection, gentle skincare, and judicious use of topical emollients is recommended for both treatment and prevention of DD in children.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 3","pages":"101-107"},"PeriodicalIF":1.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral lichen planus: key features of etiopathogenesis, diagnosis, and management. 口腔扁平苔藓：发病、诊断和治疗的关键特征。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-09-01

Ana Glavina, Lucija Zanze, Ema Barac, Bruno Špiljak, Duje Čulina, Liborija Lugović-Mihić

{"title":"Oral lichen planus: key features of etiopathogenesis, diagnosis, and management.","authors":"Ana Glavina, Lucija Zanze, Ema Barac, Bruno Špiljak, Duje Čulina, Liborija Lugović-Mihić","doi":"","DOIUrl":"","url":null,"abstract":"Oral lichen planus (OLP) is a chronic inflammatory autoimmune disease of unknown etiology. It is assumed that a genetic predisposition contributes to the development of the disease and influences the patient's response to various etiological factors such as autoimmune reactions to epithelial antigens, microorganisms, and stress. Immunopathogenesis is primarily driven by cell-mediated immune mechanisms, with T lymphocytes playing a central role. The clinical presentation of OLP is varied, and multiple clinical forms can occur in the same patient. OLP is categorized into six clinical types: reticular, papular, and plaque-like (hyperkeratotic variants), and atrophic, erosive, and bullous (erosive variants). The histopathological diagnosis of OLP is unique. Continuous follow-up of patients is crucial because OLP is considered an oral potentially malignant disorder (OPMD). Reported rates of malignant transformation vary, with a pooled estimate of 1.43% for OLP and 5.13% for OLP with dysplasia. Patient education plays a crucial role in treatment initiation and planning. A personalized treatment approach focuses on controlling inflammation and relieving symptoms such as pain and burning. Treatment should be individualized according to disease severity, subtype, and patient response, with constant monitoring for possible malignant transformation and comorbidities.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 ","pages":"109-115"},"PeriodicalIF":1.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of oral glutathione in reducing nitric oxide and IL-1α concentrations for clinical improvement in mild to moderate acne vulgaris: a randomized controlled trial. 口服谷胱甘肽降低一氧化氮和IL-1α浓度对轻度至中度寻常痤疮临床改善的有效性：一项随机对照试验

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-09-01

Ferra Olivia Mawu, Anis Irawan Anwar, Khairuddin Djawad, Agussalim Bukhari, Marlyn Grace Kapantow, Paulus Mario Christopher

{"title":"Effectiveness of oral glutathione in reducing nitric oxide and IL-1α concentrations for clinical improvement in mild to moderate acne vulgaris: a randomized controlled trial.","authors":"Ferra Olivia Mawu, Anis Irawan Anwar, Khairuddin Djawad, Agussalim Bukhari, Marlyn Grace Kapantow, Paulus Mario Christopher","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Acne vulgaris (AV) is a chronic inflammatory dermatosis predominantly affecting adolescents and young adults. Oxidative and nitrosative stress, marked by elevated nitric oxide (NO) and interleukin (IL)-1α, contributes to AV pathogenesis. Glutathione, a key antioxidant, may attenuate oxidative and nitrosative stress and modulate inflammatory pathways. This study investigates the effectiveness of oral glutathione supplementation on serum NO and IL-1α concentrations, and clinical improvement in mild to moderate AV patients.Methods: A randomized controlled trial was conducted involving 40 subjects diagnosed with mild to moderate AV. Participants were randomized to receive either 500 mg oral glutathione (n = 22) or placebo (n = 18) once daily for 4 weeks. Clinical severity of AV was assessed utilizing the Lehmann criteria. Serum levels of NO and IL-1α were measured at baseline and week 4.Results: At week 4, reductions in serum NO and IL-1α concentrations were observed in the glutathione group; however, these changes did not reach statistical significance (p > 0.05). Clinical improvement occurred in seven subjects (31.8%) in the glutathione group, with a reduction from moderate to mild severity. No adverse reactions were reported.Conclusions: Oral glutathione supplementation demonstrated a non-significant trend toward reducing oxidative and nitrosative stress markers and improving mild to moderate AV. Further studies are recommended to validate these findings.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 3","pages":"95-99"},"PeriodicalIF":1.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous B-cell pseudolymphoma treated with imiquimod. 咪喹莫特治疗皮肤b细胞假性淋巴瘤。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-09-01

Gökhan Okan, Cuyan Demirkesen

引用次数: 0