Acta Dermatovenerologica Alpina Pannonica et Adriatica最新文献

Successful treatment of recalcitrant pemphigus vulgaris with cold argon plasma. 冷氩等离子体治疗难治性寻常型天疱疮成功。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-09-27

Danijela Milčić, Marko Demenj, Maja Vilotijević, Mirjana Milinković Srećković

{"title":"Successful treatment of recalcitrant pemphigus vulgaris with cold argon plasma.","authors":"Danijela Milčić, Marko Demenj, Maja Vilotijević, Mirjana Milinković Srećković","doi":"","DOIUrl":"","url":null,"abstract":"Pemphigus vulgaris is a severe autoimmune blistering disease that occasionally develops lesions refractory to conventional systemic immunosuppressive therapy. We report the first documented case of successful treatment of therapy-resistant pemphigus vulgaris using cold atmospheric plasma. A 34-year-old woman presented with extensive oral and genital erosions that dramatically improved after initiating therapy with pulse corticosteroids in combination with cyclophosphamide. In the following weeks, she developed treatment-resistant facial erosions that persisted for 6 months despite aggressive systemic therapy consisting of intravenous immunoglobulin, azathioprine, and plasmapheresis. After 3 weekly cold atmospheric plasma treatments at 33 to 37 °C with a 2 cm torch gap for 3 min per treatment zone, the patient had remarkable clinical improvement, with an estimated > 80% epithelialization of facial erosions within 4 weeks, progressing to complete epithelialization by week 6. Disease activity assessment using the Pemphigus Disease Activity Index confirmed rapid improvement from a baseline of 14 to 0 within 6 weeks. Indirect immunofluorescence was negative throughout treatment. Sustained disease remission was achieved for 24 months. This novel application of cold atmospheric plasma is a promising therapeutic approach for recalcitrant lesions of pemphigus vulgaris.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":" ","pages":"actaapa.2026.26"},"PeriodicalIF":1.0,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary cutaneous extraskeletal Ewing sarcoma of the scalp. 头皮的原发性皮肤骨骼外尤文氏肉瘤。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-09-27

Chaimae Bouhamdi, Hanane Baybay, Nawal Hammas, Zakia Douhi, Meryem Soughi, Sara Elloudi, Fatima Zahra Mernissi

{"title":"Primary cutaneous extraskeletal Ewing sarcoma of the scalp.","authors":"Chaimae Bouhamdi, Hanane Baybay, Nawal Hammas, Zakia Douhi, Meryem Soughi, Sara Elloudi, Fatima Zahra Mernissi","doi":"","DOIUrl":"","url":null,"abstract":"Primary cutaneous extraskeletal Ewing sarcoma (PCES) is an exceptionally rare variant of the Ewing sarcoma family of tumors, typically arising in the dermis or subcutis without osseous involvement. Due to its clinical mimicry of benign lesions and poorly defined dermoscopic features, early recognition can be challenging. To date, fewer than 20 well-documented cases have been reported in the literature. A 21-year-old male presented with a subcutaneous scalp mass with a reported 3-year clinical evolution. Dermatologic examination revealed a well-circumscribed vascularized lesion, and dermoscopy showed a polymorphous vascular pattern with arborizing and linear vessels, along with rainbow areas. Magnetic resonance imaging showed a non-invasive soft tissue mass. Histopathology confirmed a small round blue cell tumor with cluster of differentiation 99 (CD99) expression, and fluorescence in situ hybridization (FISH) analysis demonstrated Ewing sarcoma breakpoint region 1 (EWSR1) rearrangement, confirming PCES. The patient responded well to neoadjuvant chemotherapy and underwent surgical and radiotherapeutic management. This case is one of the very few reported instances of PCES with detailed dermatologic and dermoscopic documentation prior to oncologic intervention. It underscores the critical role of dermatologists in identifying rare soft tissue tumors. Prompt biopsy and molecular confirmation remain essential, and multidisciplinary care is key to improving outcomes in this rare malignancy.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":" ","pages":"actaapa.2026.22"},"PeriodicalIF":1.0,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leukemia cutis exhibiting Darier's sign: a rare presentation of acute monoblastic leukemia. 皮肤白血病呈达里尔征：急性单核细胞白血病的罕见表现。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-09-27

İdil Sena Canver, Turan Bayhan, Esra Karakuş, Esra Kiratli Nalbant

引用次数: 0

Pediatric alopecia universalis with poliosis post-psychosocial stress: a case report on methotrexate and adjunctive management. 小儿普遍脱发伴脊髓灰质炎后社会心理应激：甲氨蝶呤和辅助治疗一例报告。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-09-27

Karen Paola David, Carlos Solórzano Flores, Andrea Pineda, Abner Baquedano

{"title":"Pediatric alopecia universalis with poliosis post-psychosocial stress: a case report on methotrexate and adjunctive management.","authors":"Karen Paola David, Carlos Solórzano Flores, Andrea Pineda, Abner Baquedano","doi":"","DOIUrl":"","url":null,"abstract":"Alopecia areata (AA) is an immune-mediated non-scarring hair loss disorder. Severe forms, including alopecia totalis and alopecia universalis (AU), are rare in children and often refractory. Psychosocial stress has been implicated as a trigger, and pigmentary changes may occur during regrowth. We report a 9-year-old girl from Honduras with AU involving the scalp, eyebrows, eyelashes, and forearms, with nail pitting following a significant psychosocial stressor. Laboratory studies showed normal thyroid function and low vitamin D levels. Initial treatment included topical clobetasol propionate 0.05% for 6 months, topical minoxidil 5% for 12 months, and oral vitamin D supplementation for 6 months, with minimal response. Systemic therapy was initiated with oral corticosteroids (1 mg/kg/day) tapered over 4 months, followed by oral methotrexate (12 mg/m²/week) for 1 year; topical therapies were maintained concurrently throughout systemic treatment. Hair regrowth began at 3 months of methotrexate, initially as diffuse poliosis, followed by complete terminal hair regrowth and normalization of nail changes. Psychological support was provided throughout management. This case highlights psychosocial stress as a potential contributor in pediatric AU and supports a multidisciplinary approach. Methotrexate was effective and well tolerated, and poliosis may be a marker of follicular recovery.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":" ","pages":"actaapa.2026.25"},"PeriodicalIF":1.0,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary cutaneous CD4+ small or medium T-cell lymphoproliferative disorder: a case report and review of treatment options. 原发性皮肤CD4+小或中t细胞淋巴增生性疾病：一例报告和治疗方案的回顾。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-09-27

Aleksandar Godic, Mark J Wilsher

{"title":"Primary cutaneous CD4+ small or medium T-cell lymphoproliferative disorder: a case report and review of treatment options.","authors":"Aleksandar Godic, Mark J Wilsher","doi":"","DOIUrl":"","url":null,"abstract":"Primary cutaneous CD4+ small or medium T-cell lymphoproliferative disorder (PCSMLPD) is a rare indolent cutaneous lymphoid proliferation accounting for approximately 2% of all cutaneous lymphomas. It typically presents as a solitary nodule on the face, neck, or upper trunk and is associated with an excellent prognosis. This review evaluates current treatment options for PCSMLPD and discusses outcomes reported in the literature. Management strategies include watchful waiting, surgical excision, low-dose radiotherapy, topical or intralesional steroids, and, in selected cases, systemic therapies such as methotrexate or doxycycline. Spontaneous regression following diagnostic biopsy has also been documented. Analysis of the largest published series demonstrates that complete surgical excision provides the highest rate of complete remission and the lowest risk of recurrence, making it the preferred first-line treatment for localized disease. Low-dose radiotherapy is highly effective for patients that are unsuitable for surgery, for recurrent lesions, or for lesions on the face, whereas topical or intralesional steroids may achieve remission in selected cases but are associated with a higher likelihood of requiring additional treatment. Relapses are uncommon and generally occur within the first 2 years after diagnosis, supporting regular clinical follow-up during this period. Staging examinations are no longer recommended in patients with a typical clinicopathological presentation. Overall, PCSMLPD has an excellent prognosis, and conservative skin-directed therapies are usually sufficient to achieve durable disease control, with surgical excision remaining the treatment of choice.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":" ","pages":"actaapa.2026.24"},"PeriodicalIF":1.0,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis-specific systemic inflammatory responses to narrowband UVB phototherapy: evidence from hemogram-derived biomarkers. 窄带UVB光疗的诊断特异性全身炎症反应：来自血象衍生生物标志物的证据。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-09-01

Efe Görkem Apaydın, Seçil Soylu, Yeşim Akpınar Kara, Eda Kılınç Eşki

{"title":"Diagnosis-specific systemic inflammatory responses to narrowband UVB phototherapy: evidence from hemogram-derived biomarkers.","authors":"Efe Görkem Apaydın, Seçil Soylu, Yeşim Akpınar Kara, Eda Kılınç Eşki","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Narrowband ultraviolet B (NB-UVB) phototherapy is widely used for inflammatory dermatoses and selected cutaneous lymphomas. Beyond its local skin effects, NB-UVB may also induce systemic immunomodulatory changes. Hemogram-derived indices, including the systemic inflammatory index (SII) and neutrophil-to-lymphocyte ratio (NLR), are practical markers of systemic inflammation.Methods: This multicenter retrospective cohort study included 46 patients treated with NB-UVB phototherapy for psoriasis, mycosis fungoides (MF), prurigo nodularis, or other inflammatory dermatoses. Complete blood count parameters obtained before treatment and after 8 to 10 weeks were used to calculate SII and NLR. Biomarker changes were analyzed in the overall cohort and diagnostic subgroups.Results: Overall, NB-UVB did not significantly change SII or NLR (p = 0.409 and p = 0.756, respectively). Subgroup analyses demonstrated numerical differences among diagnostic groups. MF demonstrated the greatest numerical reductions in mean SII and NLR, decreasing by 26.05% and 18.58%, respectively, although without statistical significance (p = 0.138 and p = 0.345). Psoriasis showed modest non-significant reductions, whereas prurigo nodularis showed non-significant increases. Percentage changes in SII and NLR were strongly correlated (Spearman's rho = 0.869, p < 0.001). CRP remained stable (p = 0.939).Conclusions: NB-UVB did not significantly alter systemic inflammatory indices overall, but subgroup-specific response patterns, particularly in MF, suggest possible diagnosis-specific numerical trends.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"35 3","pages":"161-165"},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of topical polypeptide gel in accelerating early healing of diabetic ulcers: a randomized controlled trial. 外用多肽凝胶加速糖尿病溃疡早期愈合的疗效：一项随机对照试验。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-09-01

Stella Gracia Octarica, Suci Widhiati, Endra Yustin Ellistasari, Indah Julianto, Nugrohoaji Dharmawan, Eva Niamuzisilawati

{"title":"Efficacy of topical polypeptide gel in accelerating early healing of diabetic ulcers: a randomized controlled trial.","authors":"Stella Gracia Octarica, Suci Widhiati, Endra Yustin Ellistasari, Indah Julianto, Nugrohoaji Dharmawan, Eva Niamuzisilawati","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Diabetic ulcer (DU) remains a major health problem with high morbidity and treatment cost. Effective, rapid, and affordable treatment is essential for its management. Topical polypeptide gel has regenerative, angiogenic, and anti-inflammatory properties that may accelerate wound healing. However, clinical evidence regarding effectiveness is limited.Methods: A double-blinded randomized controlled trial was conducted involving 26 subjects with DU, randomly allocated into an intervention group that received 7% topical polypeptide and a control group that received hydrocolloid gel. Wound healing was assessed by measuring ulcer surface area reduction on days 7, 14, and 21 compared to baseline.Results: The polypeptide gel group demonstrated significantly greater absolute ulcer size reduction on day 7 (p = 0.002) and day 14 (p = 0.004), whereas the difference in absolute area did not reach statistical significance on day 21 (p = 0.106). When healing was expressed as the percentage of wound reduction from baseline, the polypeptide gel group showed significantly greater wound closure at all three time points, including day 21 (day 7: 66.4% vs. 16.8%, p < 0.001; day 14: 83.3% vs. 27.8%, p < 0.001; day 21: 92.7% vs. 41.5%, p = 0.002), with large effect sizes.Conclusions: Topical 7% polypeptide gel was associated with significantly greater reduction in diabetic ulcer surface area compared with hydrocolloid gel. Although the difference in absolute area reduction did not reach statistical significance at day 21, the relative reduction from baseline remained significantly greater in the polypeptide gel group at all three time points, indicating a sustained healing advantage.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"35 3","pages":"139-145"},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of generalized bullous fixed drug eruption resembling toxic epidermal necrolysis. 一例罕见的广泛性大疱性固定药疹，类似中毒性表皮坏死松解。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-09-01

Maja Vilotijevic, Danijela Milcic, Branislav Lekic, Martina Bosic, Dusan Skiljevic, Mirjana Milinkovic Sreckovic

{"title":"A rare case of generalized bullous fixed drug eruption resembling toxic epidermal necrolysis.","authors":"Maja Vilotijevic, Danijela Milcic, Branislav Lekic, Martina Bosic, Dusan Skiljevic, Mirjana Milinkovic Sreckovic","doi":"","DOIUrl":"","url":null,"abstract":"Generalized bullous fixed drug eruption (GBFDE) is a rare and severe adverse drug reaction characterized by widespread blisters and erosions involving at least 10% of the body surface. GBFDE can mimic Stevens-Johnson syndrome and toxic epidermal necrolysis (TEN), both clinically and histologically. We present the case of a 76-year-old woman with extensive painful blisters and erosions affecting approximately 70% of her skin, including the oral and genital mucosa, accompanied by an impaired general condition, strongly suggesting TEN. However, the absence of Nikolsky's sign, together with slate-gray hyperpigmentation, pointed toward GBFDE, later supported by histopathological analysis. Paracetamol was identified as the most likely causative agent. Following discontinuation of the culprit drug, the patient was treated with high-dose corticosteroids and antibiotics within a multidisciplinary care approach. After 3 weeks of hospitalization, the skin lesions healed with residual hyperpigmentation, and her condition stabilized. Our case highlights the challenge of differentiating between two uncommon severe disorders with overlapping clinical and histopathological features, including extensive epidermal necrosis and subepidermal blistering. Clinical and pathological correlation by experienced physicians is essential for distinguishing GBFDE from TEN because their management strategies differ, impacting both patient outcomes and healthcare costs.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":" ","pages":"207-210"},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of emollients on skin barrier function in patients with atopic dermatitis: a systematic review and meta-analysis. 润肤剂对特应性皮炎患者皮肤屏障功能的影响：系统回顾和荟萃分析。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-09-01

Qianqian Yang, Wenjin Zhang

{"title":"Effect of emollients on skin barrier function in patients with atopic dermatitis: a systematic review and meta-analysis.","authors":"Qianqian Yang, Wenjin Zhang","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Atopic dermatitis (AD) primarily arises from skin barrier dysfunction. Emollients serve as a primary management modality for AD patients. They can enhance skin barrier function through multiple mechanisms. However, previous research has not established definitive conclusions about their effectiveness or ideal usage duration. This study systematically analyzes emollients' actual barrier-repairing effects by synthesizing current evidence.Methods: We screened 14 relevant studies from four databases: PubMed, Embase, Web of Science, and Cochrane Library. Ten of these human randomized controlled trials were included in the meta-analysis, which mainly examined the effects of emollients on transepidermal water loss (TEWL), skin hydration (capacitance value), and skin acidity (pH). We further compared the effects of different application times on TEWL in subgroups. Data were analyzed using Review Manager 5.4, and the results are expressed as effect estimates with 95% confidence intervals (CIs).Results: The TEWL values of AD patients using emollients were significantly lower than those of the control group, with statistical significance at 2 weeks and 4 weeks of continuous use. Skin capacitance values were significantly higher in the emollient group than in the control group, and there was no significant difference in skin pH between the two groups of patients.Conclusions: The combined data suggest that emollients can reduce TEWL values and improve skin hydration in patients with AD, with statistically significant effects observed after 2 weeks and 4 weeks of continuous use. However, the improvement of skin pH by emollients has not been confirmed, and the efficacy of use for ≥6 weeks remains inconclusive due to limited evidence. More research is needed to explore this in the future.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"35 3","pages":"187-199"},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosome-based therapy for androgenetic alopecia: a systematic review of preclinical mechanisms and efficacy. 基于外泌体的治疗雄激素性脱发：临床前机制和疗效的系统综述。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-09-01

Adniana Nareswari, Paramasari Dirgahayu, Ratih Puspita Febrinasari

{"title":"Exosome-based therapy for androgenetic alopecia: a systematic review of preclinical mechanisms and efficacy.","authors":"Adniana Nareswari, Paramasari Dirgahayu, Ratih Puspita Febrinasari","doi":"","DOIUrl":"","url":null,"abstract":"Androgenetic alopecia (AGA) is a progressive hair disorder with a substantial psychosocial impact. Current therapies have variable efficacy and adherence challenges. Exosomes are emerging as regenerative candidates. We systematically appraised preclinical (in vivo / in vitro) evidence on exosome-based intervention for AGA following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines, searching PubMed and Scopus. Eligible studies evaluated exosome or extracellular vesicle interventions in androgen-related alopecia models. Of 352 records, 16 studies met inclusion criteria, most employing male C57BL/6 mice with testosterone or dihydrotestosterone (DHT) induction alongside assays in dermal papilla cells (DPCs) and hair follicle stem cells. Sources include mesenchymal stem cell derived, DPC-derived, platelet-rich plasma derived, and engineered/primed exosomes, predominantly delivered via local intradermal/subcutaneous routes or topical microneedles/hydrogels over 2 to 4 weeks. Across studies, exosomes improved hair coverage and density, anagen/telogen ratio, follicle diameter, dermal thickness, and proliferation markers, while reducing apoptosis; mechanistic signals consistently showed reactivation of Wnt/β-catenin and down-modulation of TGF-β/SMAD3, with additional angiogenic support, anti-inflammatory effects, and mitigation of oxidative stress, and adverse signals were minimal in animals. Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) appraisal indicated generally low risk with common concerns regarding blinding and allocation concealment. Overall, exosome therapy demonstrates compelling preclinical efficacy for AGA via multi-target regenerative mechanisms.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"35 3","pages":"175-185"},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0