Acta Dermatovenerologica Alpina Pannonica et Adriatica最新文献

Amyopathic dermatomyositis presenting as severe alopecia and prominent eyelid edema: a case report and literature review. 以严重脱发及眼睑水肿为表现的淀粉性皮肌炎1例报告及文献复习。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-04-23

Nika Jutraž, Katja Perdan Pirkmajer, Bor Hrvatin Stančič

引用次数: 0

A rare case of generalized bullous fixed drug eruption resembling toxic epidermal necrolysis. 一例罕见的广泛性大疱性固定药疹，类似中毒性表皮坏死松解。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-04-21

Maja Vilotijevic, Danijela Milcic, Branislav Lekic, Martina Bosic, Dusan Skiljevic, Mirjana Milinkovic Sreckovic

{"title":"A rare case of generalized bullous fixed drug eruption resembling toxic epidermal necrolysis.","authors":"Maja Vilotijevic, Danijela Milcic, Branislav Lekic, Martina Bosic, Dusan Skiljevic, Mirjana Milinkovic Sreckovic","doi":"","DOIUrl":"","url":null,"abstract":"Generalized bullous fixed drug eruption (GBFDE) is a rare and severe adverse drug reaction characterized by widespread blisters and erosions involving at least 10% of the body surface. GBFDE can mimic Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), both clinically and histologically. We present the case of a 76-year-old woman with extensive painful blisters and erosions affecting approximately 70% of her skin, including the oral and genital mucosa, accompanied by an impaired general condition, strongly suggesting TEN. However, the absence of Nikolsky's sign, together with slate-gray hyperpigmentation, pointed toward GBFDE, later supported by histopathological analysis. Paracetamol was identified as the most likely causative agent. Following discontinuation of the culprit drug, the patient was treated with high-dose corticosteroids and antibiotics within a multidisciplinary care approach. After 3 weeks of hospitalization, the skin lesions healed with residual hyperpigmentation, and her condition stabilized. Our case highlights the challenge of differentiating between two uncommon severe disorders with overlapping clinical and histopathological features, including extensive epidermal necrosis and subepidermal blistering. Clinical and pathological correlation by experienced physicians is essential for distinguishing GBFDE from TEN because their management strategies differ, impacting both patient outcomes and healthcare costs.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":" ","pages":"actaapa.2026.12"},"PeriodicalIF":1.0,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herpes zoster-like reaction triggered by the recombinant vaccine against herpes zoster (Shingrix). 带状疱疹重组疫苗（Shingrix）引发的带状疱疹样反应。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-04-09

Miloš D Pavlović, Violeta Hosta

引用次数: 0

Evaluation of methotrexate and its influence on serum autoantibodies against BP180 in patients with bullous pemphigoid: a pilot study. 评价甲氨蝶呤及其对大疱性类天疱疮患者血清BP180自身抗体的影响：一项初步研究。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-03-01

Riccardo Balestri, Giacomo Clarizio, Giulia Rech, Federica Filippi, Lidia Sacchelli, Camilla Loi, Federico Bardazzi

引用次数: 0

Intravenous longevity therapy: a critical review of evidence, mechanisms, and clinical utility. 静脉长寿疗法：证据、机制和临床应用的重要回顾。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-03-01

Aleksandar Godic, Jaiden Townsend

{"title":"Intravenous longevity therapy: a critical review of evidence, mechanisms, and clinical utility.","authors":"Aleksandar Godic, Jaiden Townsend","doi":"","DOIUrl":"","url":null,"abstract":"Intravenous administration of high-dose vitamins, minerals, amino acids, coenzyme Q10, α-lipoic acid, glutathione, and nicotinamide adenine dinucleotide has emerged as a popular longevity therapy, targeting key molecular processes, oxidative stress, mitochondrial decline, chronic inflammation, and genomic instability, which drive and accelerate aging. The rationale is that intravenous administration facilitates supraphysiological plasma concentrations, bypassing gastrointestinal absorption limitations to more effectively target these age-promoting mechanisms. Evidence from preclinical models and small clinical series reports transient reductions in oxidative biomarkers, modest improvements in fatigue syndromes, and anecdotal enhancements in skin elasticity. However, these findings are predominantly derived from disease-specific or aesthetic contexts rather than studies involving healthy aging populations. Crucially, few studies incorporate validated biomarkers of aging such as epigenetic age or telomere length, and placebo-controlled trials are scarce and underpowered or they yield conflicting results. Additional challenges include pharmacokinetic limitations, procedural risks, and substantial heterogeneity of infusion protocols, all of which hinder reliable interpretation. Until rigorously designed, adequately powered randomized controlled trials demonstrate reproducible long-term efficacy and safety, intravenous longevity therapy should be regarded as an experimental intervention rather than an evidence-based dermatological or anti-aging practice.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"35 1","pages":"39-43"},"PeriodicalIF":1.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous melanoma histopathologic features and laboratory findings as predictors of sentinel lymph node status and progression-free survival: a single-center experience. 皮肤黑色素瘤组织病理学特征和实验室结果作为前哨淋巴结状态和无进展生存的预测因素：单中心经验。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-03-01

Nikola Pantić, Jelena Pantović, Milica Kotur, Simona Petričević, Olga Radivojević, Katja Petrović, Nevena Vujošević, Lenka Grujičić, Isidora Grozdić Milojević, Dragana Šobić Šaranović, Vera Artiko, Strahinja Odalović

{"title":"Cutaneous melanoma histopathologic features and laboratory findings as predictors of sentinel lymph node status and progression-free survival: a single-center experience.","authors":"Nikola Pantić, Jelena Pantović, Milica Kotur, Simona Petričević, Olga Radivojević, Katja Petrović, Nevena Vujošević, Lenka Grujičić, Isidora Grozdić Milojević, Dragana Šobić Šaranović, Vera Artiko, Strahinja Odalović","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Cutaneous melanoma (CM) is the most aggressive cutaneous malignancy. The aim of the study was to determine the predictive value of primary tumor histopathologic features and laboratory findings used in routine CM follow-up for sentinel lymph node biopsy (SLNB) results and progression-free survival (PFS).Methods: This retrospective study included 157 patients. Planar images were acquired after an intradermal injection of 18 to 30 MBq of 99mTc-nanocolloid in 0.3 ml at two to eight sites 5 to 10 mm from the surgical scar. SLN excision was performed a day after lymphoscintigraphy.Results: In a logistic regression analysis, Breslow thickness, ulceration status, and mitotic rate showed possible predictive significance for SLNB results, with serum lactate dehydrogenase (LDH) being the only independent predictor (p = 0.042). The difference in survival distributions reached statistical significance for Breslow thickness, mitotic rate, and LDH (p < 0.05, Kaplan-Meier, log-rank test). In a Cox regression analysis, Breslow thickness was a possible predictor of PFS and mitotic rate was an independent predictor (p = 0.025).Conclusions: LDH is an independent predictor of SLN histopathology findings, and mitotic rate is an independent predictor of PFS.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":" ","pages":"13-20"},"PeriodicalIF":1.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical features of 109 patients with primary cicatricial alopecia: a 15-year retrospective study. 109例原发性瘢痕性脱发患者的临床特征：一项15年回顾性研究。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-03-01

Özge Zorlu, Hülya Albayrak, Sema Aytekin

{"title":"Clinical features of 109 patients with primary cicatricial alopecia: a 15-year retrospective study.","authors":"Özge Zorlu, Hülya Albayrak, Sema Aytekin","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Given the limited data on primary cicatricial alopecias (PCAs), which cause permanent hair loss, this study investigates the demographic and clinical characteristics, applied treatments, and disease course of PCA patients.Methods: Medical records of 109 PCA patients that attended an outpatient clinic between 2010 and 2025 were retrospectively reviewed. Demographic and clinical characteristics, and treatment approaches were retrieved from patient files.Results: Lymphocytic PCA (83.5%) was the most frequent type, followed by neutrophilic PCA (15.6%). Classic lichen planopilaris (LPP-C) was the leading lymphocytic subtype (39.4%), and folliculitis decalvans (12%) was the most common neutrophilic PCA. Lymphocytic PCAs showed female predominance, whereas male predominance was present in neutrophilic PCAs (p < 0.001). Disease onset occurred at an older age in lymphocytic PCAs compared to the neutrophilic group (42.0 ± 11.8 and 30.2 ± 11.4 years, p < 0.001). Pain and nodule/pustule formation were more frequent in neutrophilic PCAs (p < 0.001). Topical/intralesional corticosteroids and hydroxychloroquine were mainly used in lymphocytic PCAs, whereas oral antibiotics and isotretinoin were preferred in neutrophilic PCAs.Conclusions: PCA frequency may vary geographically. LPP-C was the most common subtype. Early diagnosis and timely treatment are essential to prevent irreversible hair loss and optimize cosmetic outcomes.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"35 1","pages":"23-30"},"PeriodicalIF":1.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical characteristics, associated comorbidities, and treatment approaches in pyoderma gangrenosum: a single-center retrospective analysis. 坏疽性脓皮病的临床特征、相关合并症和治疗方法：一项单中心回顾性分析

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-03-01

Tatjana Radević, Tanja Tirnanić, Ivana Ilijin, Lidija Kandolf, Željko Mijušković

{"title":"Clinical characteristics, associated comorbidities, and treatment approaches in pyoderma gangrenosum: a single-center retrospective analysis.","authors":"Tatjana Radević, Tanja Tirnanić, Ivana Ilijin, Lidija Kandolf, Željko Mijušković","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Pyoderma gangrenosum (PG) is a rare destructive neutrophilic dermatosis of unknown etiology, associated with systemic diseases in approximately 50% to 75% of cases.Methods: We conducted a search of the hospital database to retrieve medical records of patients diagnosed with PG at our facility between 1995 and 2019. The diagnosis was validated through clinical characteristics, histopathological examination, and necessary tests to rule out other dermatoses. Data on demographics, disease presentation, comorbidities, and treatment strategies were collected and evaluated.Results: The analysis included 44 patients, 27 (61.4%) females and 17 (38.6%) males. The median age at presentation was 46.5 years (range 15-73). The most common location was the lower leg, in 32 (72.7%) patients. The ulcerative variant was found in 37 (84.1%) patients. In 11 patients (25%) an association with inflammatory bowel disease (IBD) was found. Hematological disorders occurred in five (11.4%) patients and rheumatoid arthritis in four (9.1%). Treatment was started with systemic corticosteroids (CS) in 36 (83.7%) patients, and pulse corticosteroid therapy was administered in five (11.4%) patients. The most frequently used steroid-sparing agent was dapsone, in 18 (40.9%) patients.Conclusion: PG often presents with associated systemic conditions, but it may also appear idiopathically. CS remain the mainstay of treatment, complemented by immunosuppressants and biologics such as infliximab for IBD-associated cases.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"35 1","pages":"7-11"},"PeriodicalIF":1.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subcutaneous panniculitis-like T-cell lymphoma with hemophagocytic lymphohistiocytosis in a psoriasis patient after sequential biologics including extended brodalumab: a case report. 1例银屑病患者在序贯生物制剂（包括扩展brodalumab）后出现皮下泛膜炎样t细胞淋巴瘤伴噬血细胞淋巴组织细胞增多症：1例报告

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-03-01

Po-Yu Chen, Yu-Hsuan Ho, Chi-Shun Yang, Chien-Shan Chiu

引用次数: 0

The impact of celebrities disclosing skin cancer: the example of Gordon Ramsay. 名人披露皮肤癌的影响：戈登·拉姆齐的例子。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-03-01

Nicolas Kluger

{"title":"The impact of celebrities disclosing skin cancer: the example of Gordon Ramsay.","authors":"Nicolas Kluger","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Celebrity disclosures of health conditions can influence public awareness and searches for health information. On August 30th, 2025, Gordon Ramsay announced on Instagram (> 19 million followers) that he had undergone surgery for basal cell carcinoma (BCC). This study evaluates the impact of this announcement on online search behavior.Methods: Google Trends data were analyzed for the terms \"Gordon Ramsay,\" \"basal cell carcinoma,\" \"skin cancer,\" \"photoprotection,\" and \"sunscreen\" worldwide and in the United Kingdom from August 2023 to September 2025. Wikimedia Pageviews Analysis was used to assess daily visits to the BCC article in multiple languages.Results: Ramsay's announcement generated a marked but transient surge in searches for \"basal cell carcinoma,\" with an associated 1,800% increase in combined queries and a 218% rise in daily Wikipedia pageviews. The effect was most prominent in English-speaking countries and briefly in the Czech Republic following local media coverage. No increase was observed for prevention-related terms. Comparisons with other celebrities show that Ramsay had the highest impact over the past 9 years.Conclusions: Celebrity health announcements can trigger immediate spikes in public information seeking, but the effect is brief and geographically limited. However, heightened awareness may not necessarily lead to sustained engagement or preventive behavior.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"35 1","pages":"45-49"},"PeriodicalIF":1.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0