Acta Dermatovenerologica Alpina Pannonica et Adriatica最新文献

NTRK3-rearranged spindle cell neoplasm of the skin: diagnostic pitfalls of an emerging entity, a case report.

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-02-16

Andreia Coutada, Carla Di Loreto, Alenka Matjašič, Boštjan Luzar

引用次数: 0

A case report of lymphomatoid papulosis: uncovering a rare diagnosis from a common finger ulcer.

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-02-16

Gökçe Işıl Kurmuş, Hanife Karataş, Elif Kaya, Ali Çınar, Selda Pelin Kartal

{"title":"A case report of lymphomatoid papulosis: uncovering a rare diagnosis from a common finger ulcer.","authors":"Gökçe Işıl Kurmuş, Hanife Karataş, Elif Kaya, Ali Çınar, Selda Pelin Kartal","doi":"","DOIUrl":"","url":null,"abstract":"Lymphomatoid papulosis (LyP) is a rare, chronic CD30+ cutaneous lymphoproliferative disorder characterized by recurrent, self-healing papulonodular lesions. Despite its benign clinical course, LyP histologically resembles malignant lymphomas, necessitating careful differentiation. A 42-year-old woman presented with a 3-year history of recurring ulcerated papulonodular lesions on her index finger. Histopathological examination revealed atypical CD30+ lymphoid proliferation, confirming LyP type A. Immunohistochemical analysis was positive for CD2, CD4, CD30, and MUM-1, while systemic malignancy was excluded. The patient was treated with low-dose methotrexate (15 mg/week), leading to symptom improvement. LyP is classified into five histological subtypes (A-E) and is often misdiagnosed due to its overlap with inflammatory and neoplastic conditions. While the condition typically resolves spontaneously, it is associated with an increased risk of secondary lymphomas, including mycosis fungoides and primary cutaneous anaplastic large cell lymphoma. Accurate diagnosis relies on clinical presentation, histopathological evaluation, and immunophenotyping. Awareness of LyP's clinical and pathological features is essential for appropriate management and surveillance.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 1","pages":"actaapa.2025.2"},"PeriodicalIF":0.6,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Superficial basal cell carcinoma masquerading as pruritic dermatitis on the upper eyelid. 表面基底细胞癌伪装为上眼睑瘙痒性皮炎。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-01-13

Angie Priscila Mariños, Jenny Valverde-López, Pedro Cárdenas Cruz

引用次数: 0

Targeting kallikrein proteases for dandruff therapy. 针对小肽激酶蛋白酶治疗头皮屑。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2024-12-01

Hendra Wijaya Wong, Ivan Kurniadi, Kris Herawan Timotius

{"title":"Targeting kallikrein proteases for dandruff therapy.","authors":"Hendra Wijaya Wong, Ivan Kurniadi, Kris Herawan Timotius","doi":"","DOIUrl":"","url":null,"abstract":"Kallikrein proteases (KPs) are vital enzymes involved in the formation of dermatosomes and are regulated by the body's internal inhibitors. Maintaining a balance between KPs and their inhibitors is essential for promoting a healthy scalp. The scalp specifically contains two KPs: human kallikrein (hK) 5 and hK7, which are encoded by their respective genes. In addition, the serine protease inhibitor Kazal-type 5 (SPINK5) gene encodes the lympho-epithelial Kazal-type‒related inhibitor (LEKTI), which effectively inhibits both hK5 and hK7. The normal desquamation process relies on the availability and activity of hK5 and hK7, along with their regulation by LEKTI. When LEKTI levels are insufficient, it results in abnormal desquamation characterized by the overactivity of hK5 and hK7. Consequently, KPs, particularly hK5 and hK7, present promising targets for novel treatments aimed at reducing flake formation associated with dandruff. KP inhibitors are crucial components in targeting these proteases. In this review, literature on KPs, dandruff, and their inhibitors was analyzed to elucidate the roles of KPs in dandruff pathogenesis and to evaluate the therapeutic potential of KP inhibitor-based approaches for managing this condition.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"33 4","pages":"171-176"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Acute psoriasis exacerbation by recombinant zoster vaccine: a case report. 重组带状疱疹疫苗导致急性银屑病加重：病例报告。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2024-12-01

Moteb Khalaf Alotaibi

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A rare case and literature review of bullous pemphigoid appearing in the setting of lichen sclerosus: a dermatopathological conundrum and what to expect. 一例罕见病例和文献综述：在硬皮病背景下出现的大疱性类天疱疮：皮肤病理学难题和预期结果。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2024-12-01

Tijana Orlić, Igor Kapetanović, Vesna Reljić, Snežana Minić, Dubravka Živanović

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Cutaneous angiosarcoma masquerading as photodermatitis: a case report. 伪装成光化性皮炎的皮肤血管肉瘤：病例报告。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2024-12-01

Njoud AlNodali, Nouf Alqahtani, Aisha Sharafuddin, Rana Atef, Hanadi AlNodali, Mohammad Dhulaimi, Bander Alshomrani, Yazeed Alwagdani

引用次数: 0

Sexually transmitted shigellosis. 性传播志贺氏菌病。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2024-12-01

Mateja Pirš

{"title":"Sexually transmitted shigellosis.","authors":"Mateja Pirš","doi":"","DOIUrl":"","url":null,"abstract":"Shigellae can be transmitted through sexual contact, especially among gay, bisexual, and other men who have sex with men (gbMSM). The dynamics and factors contributing to sexual transmission of shigellosis are not yet fully understood. Shigella spp. are intestinal pathogens with a low infectious dose, making them more likely to spread through sexual contact. Asymptomatic carriage may also contribute to its transmission through sexual activity. Recommendations for prevention of sexual transmission of shigellosis include less risky sexual behavior, the use of protective measures, thorough cleaning of sex toys, and good personal hygiene. If a partner has diarrhea, it is recommended to avoid sexual contact during and for at least 1 to 2 weeks after the symptoms have resolved, and to refrain from oral-anal contact for 4 to 6 weeks. Globally, the burden of shigellosis is highest in low- and middle-income countries, particularly among young children. In high-income countries, international travelers and gbMSM are considered the main risk groups for shigellosis. Raising awareness about the possible sexual transmission of shigellosis among at-risk groups is necessary. Increasing awareness among clinicians about the potential for sexual transmission of shigellosis is vital to ensure appropriate counseling and patient management.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"33 4","pages":"199-203"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tolerability and efficacy of botulinum toxin injection in the treatment of bromhidrosis: a systematic review and meta-analysis of clinical trials. 肉毒杆菌毒素注射治疗腋臭的耐受性和疗效：临床试验的系统回顾和荟萃分析。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2024-12-01

Muhammad Candragupta Jihwaprani, Tiara Dinar Ismirahmadani, Yipeng Sun, Ayu Wikan Sayekti, Idris Sula, Nazmus Saquib

{"title":"Tolerability and efficacy of botulinum toxin injection in the treatment of bromhidrosis: a systematic review and meta-analysis of clinical trials.","authors":"Muhammad Candragupta Jihwaprani, Tiara Dinar Ismirahmadani, Yipeng Sun, Ayu Wikan Sayekti, Idris Sula, Nazmus Saquib","doi":"","DOIUrl":"","url":null,"abstract":"This review evaluates the risks and benefits of botulinum toxin (BTX) therapy for treating bromhidrosis. A search was conducted across six databases, including clinical trials comparing BTX therapy with BTX-free controls. The analyzed outcomes included pooled adverse events (AEs), treatment success, ≥ 50% overall improvement, and recurrence rates. Subgroup and sensitivity analyses were performed. Fourteen trials involving 1,293 participants were eligible. The BTX group experienced significantly fewer AEs than controls (relative risk [RR], 95% confidence interval [CI]: 0.33 [0.20-0.54]). Subgroup analysis indicated that the AE reduction was significant only when compared to small skin incision procedures. Overall, BTX did not show significant treatment success (RR [95% CI]: 1.06 [0.85-1.34]) or ≥ 50% improvement (RR [95% CI]: 0.98 [0.93-1.03]). However, BTX demonstrated superior treatment success compared to electrocauterization (RR [95% CI]: 1.45 [1.15-1.83]) and ethanol injection (RR [95% CI]: 2.27 [1.49-3.45]). Against placebos, BTX significantly reduced odor intensity (mean difference [95% CI]: 1.39 [-2.63 to -0.16]). Nevertheless, the recurrence rate was significantly higher in the BTX group (RR [95% CI]: 3.80 [1.06-13.67]). Notably, most studies (n = 9) were of low quality. In conclusion, although BTX is safe, it is not effective for the treatment of bromhidrosis.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"33 4","pages":"179-187"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hospitalized hidradenitis suppurativa patients at a university clinic: a fifteen-year retrospective analysis of hospitalized patients with a focus on sex differences. 一所大学门诊住院化脓性汗腺炎患者：对住院患者15年的回顾性分析，重点关注性别差异。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2024-12-01

Dubravka Živanović, Marko Demenj, Miloš Nikolić, Dušan Škiljević, Mirjana Milinković Srećković, Snežana Minić, Neda Delić, Svetlana Popadić

{"title":"Hospitalized hidradenitis suppurativa patients at a university clinic: a fifteen-year retrospective analysis of hospitalized patients with a focus on sex differences.","authors":"Dubravka Živanović, Marko Demenj, Miloš Nikolić, Dušan Škiljević, Mirjana Milinković Srećković, Snežana Minić, Neda Delić, Svetlana Popadić","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Hidradenitis suppurativa (HS) is a chronic skin disease marked by recurrent abscesses, sinus tracts, and scarring, often accompanied by systemic symptoms. Diagnosed clinically, HS affects around 0.4% of people in western populations, but standardized treatment options are limited, leading to inconsistent outcomes. This study retrospectively analyzes 15 years of HS cases in southeastern Europe to better understand regional characteristics and treatment responses.Methods: This is a retrospective, cross-sectional study encompassing 103 HS patients hospitalized from 2007 to 2022 at a university dermatology and venereology clinic.Results: Women were younger than men at onset of HS (19 vs. 28 years old) and at first hospitalization (31 vs. 39 years old). Men were most often diagnosed as Hurley stage III at hospital admission (50.8%), whereas women predominantly had Hurley stage II (57.5%, p = 0.032). Trunk involvement was more prevalent in women (62.5% vs. 41.3%, p = 0.036) and the back of the neck in men (30.2% vs. 7.5%, p = 0.006). Obesity was the most commonly found concurrent disease (35.9%) overall, and a history of acne was the most frequent dermatological comorbidity (29.1%). HS patients had a fivefold increase in their chance of having psoriasis. The most commonly employed systemic treatments were oral antibiotics: rifampicin with clindamycin (62.1%) followed by tetracyclines (42.7%).Conclusions: HS patients had a fivefold higher likelihood of having psoriasis. Female patients were less likely to experience severe disease presentations. Although metabolic syndrome and its components were relatively common, they showed no correlation with disease severity. Treatment approaches for HS varied notably between males and females.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"33 4","pages":"163-169"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0