Acta Dermatovenerologica Alpina Pannonica et Adriatica最新文献

Flap design challenges for upper lip defect: a case series. 上唇缺损皮瓣设计的挑战：一个案例系列。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-07-09

Nugrohoaji Dharmawan, Prasetyadi Mawardi, Ayu Kusuma Dewi

引用次数: 0

Unraveling the role of IL-17 in lichen planus: a comparative investigation of clinical variability and immunopathogenic pathways. 揭示IL-17在扁平苔藓中的作用：临床变异性和免疫致病途径的比较研究。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-06-01

Maja Tolušić Levak, Mirta Pauzar, Vera Plužarić, Nika Franceschi, Biljana Pauzar, Jasmina Rajc, Marija Delaš Aždajić, Martina Mihalj

{"title":"Unraveling the role of IL-17 in lichen planus: a comparative investigation of clinical variability and immunopathogenic pathways.","authors":"Maja Tolušić Levak, Mirta Pauzar, Vera Plužarić, Nika Franceschi, Biljana Pauzar, Jasmina Rajc, Marija Delaš Aždajić, Martina Mihalj","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Lichen planus (LP) is a chronic T cell-mediated inflammatory disease affecting the skin and mucosa. Interleukin-17 (IL-17), a pro-inflammatory cytokine, has been implicated in LP pathogenesis, but its tissue-level expression across clinical variants remains underexplored. This study compares IL-17 expression in healthy skin and LP lesions and assesses variations based on clinical presentation.Methods: This cross-sectional retrospective study included 20 LP skin samples and 10 healthy controls. The sample collection spanned a period of 10 years. IL-17 expression was assessed via immunohistochemistry and quantified using a modified Q score. Samples were categorized by mucosal involvement and lesion distribution. Statistical analysis was performed with the Mann-Whitney U test.Results: IL-17 was absent in healthy skin but present in all LP samples. IL-17 expression was significantly higher in patients with both skin and oral mucosal involvement compared to those with cutaneous LP (p = 0.003). No significant difference was observed between generalized and localized LP.Conclusions: The results indicate a distinct increase in IL-17 expression in LP lesions, particularly with mucosal involvement, supporting its role in LP pathogenesis. These findings suggest IL-17 as a potential biomarker and therapeutic target, warranting further investigation in larger cohorts.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 2","pages":"51-54"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pbserum Specific Acne Scars®: a cutting-edge approach utilizing triple enzymatic synergy combined with microneedling for post-acne scar repair. Pbserum特异性痤疮疤痕®：一种利用三重酶协同作用结合微针治疗痤疮后疤痕的尖端方法。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-06-01

Melania Batistella, Erick Santaella, Sandra Oliveira, Claudia Maan, Valeria Kopytina, Jorge López Berroa

{"title":"Pbserum Specific Acne Scars®: a cutting-edge approach utilizing triple enzymatic synergy combined with microneedling for post-acne scar repair.","authors":"Melania Batistella, Erick Santaella, Sandra Oliveira, Claudia Maan, Valeria Kopytina, Jorge López Berroa","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: The integration of active ingredients into scientifically backed formulations is an innovative approach to remodeling post-acne atrophic scars, stimulating regenerative processes. Microneedling, a minimally invasive procedure, promotes collagen production and enhances skin penetration of cosmeceutical products such as Pbserum Specific Acne Scars®, which combines collagenases G and H with hyaluronate r-lyase and other ingredients, including allantoin, zinc sulfate, vitamin A, vitamin B3, niacinamide, and melatonin. These components modulate inflammation, fibrosis, oxidative stress, and aging. This study assesses the efficacy and safety of treatment for ameliorating atrophic acne scars.Methods: Twenty-nine patients were treated with Pbserum Specific Acne Scars® applied by microneedling for 4 months in four sessions on the middle or lower third of the face and/or periocular area. The scar size (according to EvaFace® analysis), deep skin hydration (measured with a Moisturemeter® D device), severity (assessed using the échelle d'évaluation clinique des cicatrices d'acne and Goodman and Baron scales), clinical efficacy (evaluated using Global Aesthetic Improvement Scale), quality of life (measured using Facial Acne Scar Quality of Life questionnaire), and subject satisfaction were analyzed.Results: Significant improvements were observed in all parameters evaluated, especially after four applications, demonstrating clinical efficacy. Patient satisfaction levels were notably high.Conclusions: The treatment significantly improved skin texture and scar appearance after four applications over a period of 4 months.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 2","pages":"65-72"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary cutaneous CD4-positive small or medium T-cell lymphoproliferative disorder: a case report and literature review. 原发性皮肤 CD4 阳性中小型 T 细胞淋巴组织增生性疾病：病例报告和文献综述。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-06-01

Katarina Trčko, Nuša Lukinovič, Daja Šekoranja

引用次数: 0

Two cases of bizarre acquired localised hyperpigmentation disorders - similar yet different diagnostic challenges: two case reports and a brief literature review. 两例奇异的获得性局部色素沉着过度障碍-相似但不同的诊断挑战：两例病例报告和简短的文献回顾。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-06-01

Laura Đorđević Betetto, Boštjan Luzar, Aleksandra Bergant Suhodolčan

{"title":"Two cases of bizarre acquired localised hyperpigmentation disorders - similar yet different diagnostic challenges: two case reports and a brief literature review.","authors":"Laura Đorđević Betetto, Boštjan Luzar, Aleksandra Bergant Suhodolčan","doi":"","DOIUrl":"","url":null,"abstract":"Cutaneous pigmentation disorders are one of the leading causes of dermatological consultation globally. Hyperpigmentation disorders constitute a group of distinct medical conditions that may be either congenital and associated with various concurrent comorbidities, or acquired due to cutaneous, environmental, or systemic conditions or factors. Due to numerous causes and an often atypical clinical picture, diagnosis can be challenging. Furthermore, although the changes in skin color are not inherently harmful, they can result in significant cosmetic disfigurement and have psychological and social repercussions, particularly given that some hyperpigmentation is irreversible due to the limited effectiveness of current treatments. This article presents two cases exhibiting somewhat similar but different acquired localized hyperpigmentation. We review the current literature with emphasis on the diagnostic approach to this entity and specific acquired hyperpigmentation disorders, in particular drug-induced and paraneoplastic. We emphasize the importance of interdisciplinary cooperation among different specialists, particularly in complicated cases and those that accompany systemic diseases.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 2","pages":"89-93"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of foreign body granulomas with combined enzyme therapy. 酶联合治疗异物肉芽肿。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-06-01

Desirée Giselle Castelanich, Delfina Pascuzzi, Jorge López Berroa

引用次数: 0

Detection of serum and tissue levels of interleukin 39 in psoriasis: a case control study. 银屑病患者血清和组织白细胞介素39水平的检测：一项病例对照研究。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-06-01

Mohammed Hassan, Talal A Abd El-Raheem, Olfat G Shaker, Hagar Ali Kamal, Sara M Yaseen, Amira E Soliman

{"title":"Detection of serum and tissue levels of interleukin 39 in psoriasis: a case control study.","authors":"Mohammed Hassan, Talal A Abd El-Raheem, Olfat G Shaker, Hagar Ali Kamal, Sara M Yaseen, Amira E Soliman","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Psoriasis is a chronic immune-mediated disorder with a genetic component that primarily affects the skin and has potential systemic involvement. Advances in understanding the interaction between the innate and adaptive immune systems have facilitated improved disease management.Methods: This study included 25 patients with psoriasis and 20 healthy controls of both sexes. All participants underwent detailed medical history-taking and dermatological examination, including assessment of the body surface area and the Psoriasis Area and Severity Index (PASI). Blood samples (3 ml) were collected from all subjects, and 4 mm lesional skin punch biopsies were obtained from psoriatic patients and healthy controls.Results: Serum and tissue levels of interleukin 39 (IL-39) were significantly elevated in psoriatic patients compared to healthy individuals. Patients with a positive family history of psoriasis showed higher serum IL-39 levels than those without such a history. In addition, psoriatic individuals with diabetes mellitus or hypertension had higher serum IL-39 levels than those without these comorbidities. A statistically significant correlation was found between disease severity and serum IL-39 concentration.Conclusions: Elevated serum and tissue IL-39 levels in psoriatic patients suggest a potential role for IL-39 in the pathogenesis of psoriasis, highlighting its possible utility as a biomarker or therapeutic target.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 2","pages":"45-49"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of clinical and lifestyle factors associated with disease severity in adult patients with scalp seborrheic dermatitis: a retrospective analysis. 评估与成人头皮脂溢性皮炎患者疾病严重程度相关的临床和生活方式因素：回顾性分析

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-06-01

Nazlı Caf, Mustafa Tümtürk, Defne Özkoca

{"title":"Evaluation of clinical and lifestyle factors associated with disease severity in adult patients with scalp seborrheic dermatitis: a retrospective analysis.","authors":"Nazlı Caf, Mustafa Tümtürk, Defne Özkoca","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Scalp seborrheic dermatitis (SSD) is a prevalent and chronic dermatological condition. Although various mechanisms have been proposed, its precise etiology and exacerbating factors remain unclear. This study aimed to identify the factors influencing clinical severity in individuals with SSD; to assess the associations between severity and variables such as gender, age at disease onset, treatment history, and the presence of comorbid systemic or dermatological conditions; and to determine potential triggering factors.Methods: A total of 198 adult patients diagnosed with SSD were included in this retrospective study. Collected data included demographic characteristics, smoking and alcohol use, Fitzpatrick skin type, age at disease onset, duration of the most recent flare, frequency of hair washing, and the season during which the patient presented. Clinical severity of SSD was assessed by a dermatologist. In addition, the presence of systemic and dermatological comorbidities, as well as patient-reported triggering factors, was documented.Results: A statistically significant difference in SSD severity was observed between sexes, with higher severity noted in male patients (p = 0.006). No significant associations were found between SSD severity and age, Fitzpatrick skin type, smoking or alcohol use, season of presentation/flare up, or the presence of systemic diseases. However, SSD severity differed significantly based on the presence of onychomycosis (p = 0.001).Conclusions: The significant association between the frequency of onychomycosis and the severity of SSD highlights a potential link involving shared immunologic, microbial, and skin barrier dysfunctions underlying both conditions.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 2","pages":"57-62"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous paradoxical inflammatory reaction of erythema induratum of Bazin to standard antituberculosis treatment. 巴赞硬化性红斑对标准抗结核治疗的皮肤反常炎症反应。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-06-01

Miloš D Pavlović, Motunrayo Adisa

{"title":"Cutaneous paradoxical inflammatory reaction of erythema induratum of Bazin to standard antituberculosis treatment.","authors":"Miloš D Pavlović, Motunrayo Adisa","doi":"","DOIUrl":"","url":null,"abstract":"Cutaneous tuberculosis (TBC) is rather rare and has diverse clinical presentations relative to host immunity and the number of bacilli present in the tissue. A group of cutaneous lesions called tuberculids represent a strong, delayed-type hypersensitivity reaction to mycobacteria. Among them, erythema induratum of Bazin (EIB) typically presents as tender erythematous nodules that ulcerate and are usually confined to the posterior aspects of the calves. Paradoxical reactions (PRs) to appropriate treatment involving the skin have mostly been described in the setting of miliary tuberculosis. These PRs are encountered in infectious and inflammatory diseases during the institution of appropriate treatment representing a worsening or relapse of disease under treatment or unmasking of subclinical disease. This case report describes a patient with EIB developing a necrotic PR shortly after initiation of antituberculosis therapy. The skin lesions cleared with a topical corticosteroid treatment and continued antituberculosis therapy. It is important to recognize cutaneous PR in the setting of treated cutaneous TBC and to reassure patients about the excellent outcome that can be achieved with continuation of treatment.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 ","pages":"85-87"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nail psoriasis or trachyonychia? Can dermoscopy differentiate them? 甲癣还是短甲癣？皮肤镜能区分吗？

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-03-25

Ahu Yorulmaz

引用次数: 0