Acta Dermatovenerologica Alpina Pannonica et Adriatica最新文献_第2页

Nestin expression in nodular and acral lentiginous melanoma: associations with ulceration and invasion factors in Mexican patients. 巢蛋白在结节性和肢端色素性黑色素瘤中的表达：与墨西哥患者的溃疡和侵袭因素有关。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-03-01

Araceli Barrera-Jacome, Fernando Fernandez-Ramirez, Miguel A Pardiño-Vega, Norma E Herrera-Gonzalez

{"title":"Nestin expression in nodular and acral lentiginous melanoma: associations with ulceration and invasion factors in Mexican patients.","authors":"Araceli Barrera-Jacome, Fernando Fernandez-Ramirez, Miguel A Pardiño-Vega, Norma E Herrera-Gonzalez","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: There are still many gaps in the understanding of melanoma subtypes in Mexico. Currently, there is a growing search for prognostic markers and potential therapeutic targets for melanoma treatment. Nestin has been identified as a marker of angiogenesis, invasiveness, and shortened survival in various tumor types, and therefore we evaluated nestin expression in two types of melanoma tissue to investigate its possible clinical and pathological associations.Methods: Immunohistochemistry using a polyclonal antibody was performed on selected paraffin blocks. Nestin expression was assessed by two independent dermatopathologists, yielding a kappa index of 0.83 (indicating almost perfect agreement). Nestin expression levels in these types of melanoma were evaluated in relation to Breslow index, Clark level, ulceration, and mitotic rate. Statistical analysis was performed using Pearson correlation, chi-square tests, and analysis of variance (ANOVA).Results: Eighty-three melanoma cases were diagnosed based on clinical and histopathological criteria: 47 were nodular melanoma, and 36 were acral lentiginous melanoma. High nestin expression was mainly found in nodular melanoma (p = 0.0001). This subtype was also more frequently associated with a deeper Clark level of invasion and showed a 37.5-fold increased risk of histological ulceration. A lower but relevant level of nestin expression was observed in acral lentiginous melanoma, which has rarely been reported in the literature.Conclusions: Elevated nestin expression was statistically associated with nodular melanoma and a deeper Clark level of invasion. In addition, it was significantly linked to an increased risk of histological ulceration.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"35 1","pages":"1-5"},"PeriodicalIF":1.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends and determinants of hepatitis C virus infection among people living with HIV in Slovenia: a nationwide study, 1986-2024. 斯洛文尼亚艾滋病毒感染者中丙型肝炎病毒感染的趋势和决定因素：1986-2024年的一项全国性研究

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-03-01

Maja M Lunar, Katja Seme, Mario Poljak

{"title":"Trends and determinants of hepatitis C virus infection among people living with HIV in Slovenia: a nationwide study, 1986-2024.","authors":"Maja M Lunar, Katja Seme, Mario Poljak","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) share transmission routes and cause significant morbidity and mortality worldwide. Three previous nationwide studies reported a low prevalence of HCV infection among Slovenian people living with HIV (PLWH).Methods: Data were collected de novo from 526 PLWH newly diagnosed with HIV in Slovenia between January 1st, 2014, and December 31st, 2024, and combined with data from previous studies on this topic.Results: Altogether 1,085 (93%) PLWH were tested for HCV at HIV diagnosis: 82 (7.6%) had anti-HCV antibodies (49 or 59.8% of them viremic), and three had HCV RNA only, resulting in an HCV prevalence of 7.8%. A significant increase in the prevalence of HCV infection has been observed over the last decade. HCV infection was significantly associated with female sex, foreign nationality, parenteral HIV transmission route, and non-B HIV subtype. The most frequent HCV genotypes were 1 (60%), 3 (22%), and 4 (16%), markedly different than previously found in the general population.Conclusions: The overall prevalence of HCV infection among PLWH in Slovenia remains low, but a significant increase has been observed in the last decade compared to the previous one. Such a situation requires further regular and tight monitoring to allow timely interventions if and when needed.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":" ","pages":"33-36"},"PeriodicalIF":1.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146182976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced cutaneous squamous cell carcinoma of the left auricle: a radical but effective surgical approach. 左耳廓晚期皮肤鳞状细胞癌：一种根治但有效的手术方法。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-03-01

Dragana Petrović Popović, Dimitrije Brašanac, Mirjana Petrovic Elbaz, Marijan Novaković

{"title":"Advanced cutaneous squamous cell carcinoma of the left auricle: a radical but effective surgical approach.","authors":"Dragana Petrović Popović, Dimitrije Brašanac, Mirjana Petrovic Elbaz, Marijan Novaković","doi":"","DOIUrl":"","url":null,"abstract":"Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer. Although it has a good prognosis, cSCC of the ear is associated with a poorer outcome. Reconstruction following total ear amputation because of a cSCC of the ear can be challenging, especially in elderly patients. Currently, to the best of our knowledge, the number of published articles discussing reconstruction modalities following total ear amputation is relatively limited. A 95-year-old patient presented with an advanced form of cSCC of the left ear. Total ear amputation and defect reconstruction using a large preauricular transposition flap was performed. Because the patient was blind, there was no need to save the helix fold or tragus as an eyewear holder. Postoperative flap viability was good and, after complete site healing, the patient and his family were satisfied with its aesthetic appearance. Histopathological analysis showed poorly differentiated cSCC penetrating the surface of the auricular cartilage, with wide clear surgical margins. Total ear amputation in cases of advanced cutaneous carcinomas is very rare and lacks reconstructive modalities. In this patient, it provided him with tumor-free status as well as a satisfactory aesthetic appearance with good quality of life.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":" ","pages":"51-53"},"PeriodicalIF":1.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant cutaneous melanoma presenting with hemorrhagic complications. 巨大的皮肤黑色素瘤表现为出血性并发症。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-02-13

Klemen Lovšin, Ana Plesničar, Romi Cencelj-Arnež, Alenka Matjašič, Boštjan Luzar

引用次数: 0

Dermatomyositis in women: a 15-year retrospective analysis of clinical patterns, malignancy risk, and long-term outcomes at a tertiary center. 女性皮肌炎：一个三级中心的临床模式、恶性风险和长期结果的15年回顾性分析。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-12-01

Marija Malinić, Vesna Reljić, Jelena Vuković, Srdjan Tanasilović, Dubravka Živanović

{"title":"Dermatomyositis in women: a 15-year retrospective analysis of clinical patterns, malignancy risk, and long-term outcomes at a tertiary center.","authors":"Marija Malinić, Vesna Reljić, Jelena Vuković, Srdjan Tanasilović, Dubravka Živanović","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Dermatomyositis is an inflammatory disease that affects the skin and skeletal muscles, with variants including clinically amyopathic dermatomyositis and malignancy-associated dermatomyositis.Methods: This research analyzes the characteristics of dermatomyositis in women. A retrospective cross-sectional study evaluated clinical presentation, muscle involvement, immunological markers, association with malignancy, complications, and mortality in females during a 15-year follow-up at a tertiary dermatology center.Results: Thirty women (mean age 63.6 ± 11.6 years) were analyzed. The most common skin manifestations were the V-sign (73.3%), followed by a heliotrope rash and Gottron's papules (70.0% each). Periungual erythema appeared in 50.0%, and the shawl sign in 46.7%. Receiver operating characteristic curve analysis linked the V-sign with age ≥ 62.5 years (area under the curve = 0.75) and periungual erythema with age ≤ 68.5 (area under the curve = 0.76). Muscle weakness was present in 63.3% of cases. Myositis-associated autoantibodies and myositis-specific autoantibodies were positive in 53.3%. Seven patients (23.3%) had malignancy-associated dermatomyositis, including ovarian, breast, endometrial, lung, gastric, and nasopharyngeal cancers.Conclusions: The V-sign, a heliotrope rash, and Gottron's papules were the most common skin findings. Muscle involvement affected nearly two-thirds of patients. Malignancy was detected in almost a quarter of patients, emphasizing the need for thorough evaluation and early diagnosis, especially in cancer-associated cases.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 4","pages":"165-169"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pityriasis lichenoides: a university department long-term follow-up study. 地衣样糠疹：一所大学院系长期随访研究。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-12-01

Svetlana Popadić, Jovan Lalošević, Branislav Lekić, Mirjana Milinković Srećković, Snežana Minić, Dušan Škiljević, Dubravka Živanović, Jelena Cakić, Jovana Popadić, Miloš Nikolić

{"title":"Pityriasis lichenoides: a university department long-term follow-up study.","authors":"Svetlana Popadić, Jovan Lalošević, Branislav Lekić, Mirjana Milinković Srećković, Snežana Minić, Dušan Škiljević, Dubravka Živanović, Jelena Cakić, Jovana Popadić, Miloš Nikolić","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Pityriasis lichenoides (PL) predominantly affects children and young adults. Its etiology is unclear, and the condition ranges from a harmless inflammatory disease to possible progression or pre-manifestation of cutaneous T-cell lymphoma.Methods: A long-term cohort included 242 patients with PL of all age groups diagnosed and treated at our department from 2009 to 2019. Follow-up lasted until 2024. We analyzed the disease duration, demographic and clinical features, and outcomes in our patients.Results: The cohort of PL patients studied included 107 adults and 135 children. A total of 221/242 (91%) patients were followed for 5 to 15 years (the median follow-up period was 9.9 years). No statistically significant difference (p > 0.05) in disease duration or lesion distribution was found between different PL forms in children or adults. The results show a male-to-female ratio of 1.7:1 for pediatric patients and 0.6:1 for adults, with a higher incidence of male patients among children (p < 0.01). During the follow-up period, no progression to cutaneous T-cell lymphoma was established.Conclusions: PL encompasses a spectrum of papulosquamous disorders with male predominance among children and female predominance in adults. In addition, the study results underscore the benign course of PL.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 4","pages":"189-191"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145794848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zebrafish as a new approach methodology (NAM) in dermatology: current research and the regulatory landscape focusing on sustainable development goals. 斑马鱼作为一种新的皮肤病学方法（NAM）：目前的研究和关注可持续发展目标的监管格局。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-12-01

Sourik Mukherjee, Aman Kumar Mohanty, Abhijit Poddar

{"title":"Zebrafish as a new approach methodology (NAM) in dermatology: current research and the regulatory landscape focusing on sustainable development goals.","authors":"Sourik Mukherjee, Aman Kumar Mohanty, Abhijit Poddar","doi":"","DOIUrl":"","url":null,"abstract":"The conventional dependence on mammalian models in dermatological research is increasingly subject to ethical and sustainability-focused scrutiny, prompting a transition toward new approach methodologies (NAMs). Within this paradigm, zebrafish (Danio rerio) have surfaced as a persuasive alternative due to their genetic and physiological congruence with human skin, optical clarity during early developmental stages, accelerated life cycle, prolific reproductive capacity, and economically viable maintenance. This review describes recent research using zebrafish models in dermatology, including skin pigmentation disorders, barrier function, wound healing and regeneration, pharmacological discovery, genetic and inflammatory skin conditions, and melanoma. By examining the research, ethical, and logistical merits of zebrafish NAMs, this review emphasizes their contribution to fostering more humane and efficient research frameworks. Such integration also aligns with various United Nations Sustainable Development Goals (SDGs) 3, 9, 12, 13, 14, and 17, particularly regarding the accessible biomedical innovation in low- and middle-income countries (LMICs). The review also recognizes ongoing challenges, such as regulatory fragmentation and inconsistent validation of dermatological endpoints, which impede widespread translational acceptance. It concludes by presenting strategic recommendations for international collaboration, targeted financial support, cross-sector partnerships, and regulatory harmonization to realize the potential of zebrafish-based NAMs in dermatological research.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 4","pages":"193-202"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy of cysteamine as a melasma therapy: a systematic review of trial studies. 半胱胺治疗黄褐斑的疗效：试验研究的系统回顾。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-12-01

Arie Kusumawardani, Stella Gracia Octarica, Ayu Kusuma Dewi, Shelly Lavenia Sambodo, Rahmat Firdaus Dwi Utama, Sugih Primas Adjie

{"title":"The efficacy of cysteamine as a melasma therapy: a systematic review of trial studies.","authors":"Arie Kusumawardani, Stella Gracia Octarica, Ayu Kusuma Dewi, Shelly Lavenia Sambodo, Rahmat Firdaus Dwi Utama, Sugih Primas Adjie","doi":"","DOIUrl":"","url":null,"abstract":"Melasma is a chronic and refractory hyperpigmentation disorder that predominantly affects women and individuals with darker skin tones. Treatment remains challenging due to issues related to efficacy, side effects, and high recurrence rates. Cysteamine is a depigmenting agent that has demonstrated promising outcomes in melasma management with minimal adverse effects. This study evaluates the effectiveness of cysteamine as a treatment for melasma. A systematic review was conducted using databases from PubMed, Google Scholar, and ScienceDirect, including articles published over the past 10 years (2013-2023). Eight studies met the inclusion criteria for this review. Cysteamine showed good therapeutic efficacy, reflected in reductions in the melasma area and severity index (MASI) ranging from 1.5 to 10.07, with a mean decrease of 5.73. No severe adverse effects were reported, and only mild reactions such as erythema, itching, irritation, dry skin, tingling, and burning sensations were noted. Overall, cysteamine is demonstrated to be an effective and safe therapy for melasma, offering satisfactory clinical improvement with minimal side effects.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 4","pages":"205-209"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145794973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acrocyanosis: primary or secondary form? An observational study. 肢青症：原发性还是继发性？一项观察性研究。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-12-01

Salvino Bilancini, Massimo Lucchi, Giusto Trevisan, Luigi Di Pino, Sandro Tucci

{"title":"Acrocyanosis: primary or secondary form? An observational study.","authors":"Salvino Bilancini, Massimo Lucchi, Giusto Trevisan, Luigi Di Pino, Sandro Tucci","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Acrocyanosis is the most common form of angiodystonic vascular acrosyndrome, characterized by functional microcirculatory alterations without structural vessel damage. It is traditionally classified as either primary or secondary, the latter often associated with underlying conditions.Methods: Some observations suggest a frequent association between acrocyanosis and connective tissue diseases (CTDs). To investigate this, we conducted a study on 53 patients diagnosed with acrocyanosis: 45 females and eight males, 15 to 82 years old, with a mean age of 35 years. Secondary acrocyanosis was identified in 24 patients (45.3%).Results: Advanced age (≥ 40 years) was a significant risk factor for secondary acrocyanosis (relative risk = 2.5, 95% confidence interval: 1.4-4.5, p = 0.002). No significant differences were observed between sexes. CTDs were the most common conditions associated with acrocyanosis (32% of the study population and 71% of the secondary forms).Conclusions: Although generally considered benign, acrocyanosis may indicate an underlying systemic disease. Clinical examination remains essential for the diagnosis of acrocyanosis. Our findings reveal a high prevalence of secondary acrocyanosis associated with CTDs. Patients with strong clinical suspicion should be referred to specialized centers for capillaroscopy and antinuclear antibody testing.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 4","pages":"177-180"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nail psoriasis or trachyonychia? Can dermoscopy differentiate them? 甲癣还是短甲癣？皮肤镜能区分吗？

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-12-01

Ahu Yorulmaz

引用次数: 0