Acta Dermatovenerologica Alpina Pannonica et Adriatica最新文献_第2页

A comparison of dermoscopic features of pigmented purpuric dermatoses and pigmented purpuric dermatosis-like mycosis fungoides. 色素性紫癜性皮肤病与色素性紫癜样蕈样真菌病的皮肤镜特征比较。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-09-01

Handan Merve Erol Mart, Zeynep Keskin, Hatice Sanli, Aylin Okcu Heper, Ayca Kirmizi, Bengu Nisa Akay

{"title":"A comparison of dermoscopic features of pigmented purpuric dermatoses and pigmented purpuric dermatosis-like mycosis fungoides.","authors":"Handan Merve Erol Mart, Zeynep Keskin, Hatice Sanli, Aylin Okcu Heper, Ayca Kirmizi, Bengu Nisa Akay","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Pigmented purpuric dermatosis-like mycosis fungoides (PPD-MF) is an uncommon clinical presentation of mycosis fungoides characterized by purpuric lesions that may closely mimic pigmented purpuric dermatosis (PPD). This study evaluates dermoscopic features that may help differentiate PPD-MF from PPD.Methods: This retrospective study assesses the diagnostic utility of dermoscopy in distinguishing PPD from PPD-MF. It included 11 patients with histopathologically confirmed PPD-MF and 19 patients with PPD. Categorical variables were compared using Fisher's exact test.Results: Curved vessels, straight vessels, serpentine vessels, and curved linear vessels with a terminal dot were significantly more frequent in PPD-MF. In contrast, an orangish-brown background and white lines were significantly more common in PPD.Conclusions: Dermoscopy may provide useful supportive clues for distinguishing PPD-MF from PPD, particularly through the assessment of vascular morphology and background color. However, because of overlapping clinical and dermoscopic features, dermoscopic findings should be interpreted together with clinicopathological and immunohistochemical evaluation. Further studies with larger sample sizes and follow-up data are warranted to validate these findings.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"35 3","pages":"167-172"},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microneedling and narrowband UVB in vitiligo: clinical insights on the efficacy and patterns of repigmentation. 微针和窄带UVB治疗白癜风的疗效和模式的临床观察。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-09-01

Mohammad Salem Hareedy, Manar Hamdy, Essamelden Mohamed Mohamed, Mofreh Mansour

{"title":"Microneedling and narrowband UVB in vitiligo: clinical insights on the efficacy and patterns of repigmentation.","authors":"Mohammad Salem Hareedy, Manar Hamdy, Essamelden Mohamed Mohamed, Mofreh Mansour","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Vitiligo is a relatively common acquired pigmentary disorder, characterized by a progressive loss of melanocytes. In stable vitiligo, treatment via microneedling followed by narrowband ultraviolet B (NB-UVB) phototherapy showed significant improvement. The goal of this study was to evaluate and compare the safety and efficacy of microneedling with NB-UVB versus NB-UVB alone in the treatment of stable vitiligo.Methods: This comparative study included 92 vitiligo lesions from 46 patients with stable vitiligo (confirmed by Wood's lamp) treated at the Assiut University Hospitals dermatology outpatient clinic between October 2023 and June 2024. All patients underwent a detailed history, general and local examination, and a Vitiligo Extent Score (VES) assessment. Lesions were divided into two groups: Group 1 (n = 46) received weekly microneedling plus NB-UVB twice a week, and Group 2 (n = 46) received NB-UVB twice a week only, both for 3 months.Results: Both groups showed a significant decrease in the VES; however, Group 1 demonstrated significantly greater improvement compared to Group 2 (p < 0.001). Furthermore, lesions on the upper extremities and trunk in Group 1 exhibited a significantly higher VES score reduction after treatment compared to Group 2 (p = 0.03 and 0.01, respectively). Peripheral repigmentation was the most common pattern, followed by perifollicular and mixed repigmentation, with no significant difference between the groups.Conclusions: Microneedling plus NB-UVB had significantly higher efficacy than NB-UVB alone, especially on the trunk and upper extremities. A peripheral repigmentation pattern was most common, followed by perifollicular and mixed repigmentation.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"35 3","pages":"153-158"},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced optical microscopy for skin imaging: from confocal to novel techniques. 用于皮肤成像的先进光学显微镜：从共聚焦到新技术。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-09-01

Svetoslava Troyanova-Slavkova, Dimitar Slavkov, Preslav Vasilev, Petranka Troyanova

{"title":"Advanced optical microscopy for skin imaging: from confocal to novel techniques.","authors":"Svetoslava Troyanova-Slavkova, Dimitar Slavkov, Preslav Vasilev, Petranka Troyanova","doi":"","DOIUrl":"","url":null,"abstract":"Timely and accurate diagnosis of dermatological diseases remains a global challenge, particularly in healthcare systems with limited access to dermatopathology services. Advanced optical microscopy techniques have emerged as powerful tools for non-invasive skin imaging, offering real-time visualization of microscopic structures with near-histological resolution. Reflectance confocal microscopy (RCM) and ex vivo confocal microscopy (EVCM) have achieved significant clinical traction, demonstrating high concordance with conventional histopathology and high diagnostic accuracy for melanocytic lesions and non-melanoma skin cancers. In parallel, developments in optical coherence tomography (OCT) and its variants-including dynamic OCT and line-field confocal OCT (LC-OCT)-provide complementary morphological and vascular information with greater penetration depth. LC-OCT further combines near-cellular resolution with simultaneous vertical and horizontal imaging, narrowing the gap between non-invasive imaging and histopathology. Emerging multimodal imaging platforms integrating OCT, Raman spectroscopy, photoacoustic tomography, and ultrasound, together with artificial intelligence-assisted image analysis, continue to expand the diagnostic capabilities of optical microscopy. Although RCM, EVCM, OCT, and LC-OCT are increasingly being incorporated into routine dermatological practice, several emerging technologies remain largely confined to specialized academic centers because of their cost, technical complexity, and limited clinical validation. This narrative review summarizes current evidence on confocal microscopy and related optical imaging technologies for skin diagnostics, emphasizing diagnostic performance, clinical utility, implementation challenges, and future directions.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"35 3","pages":"201-205"},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regional quantitative digital trichoscopy in female hair loss: a comparative study. 区域定量数字毛发镜检查女性脱发的比较研究。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-09-01

Artina Pajaziti, Besa Gacaferi

{"title":"Regional quantitative digital trichoscopy in female hair loss: a comparative study.","authors":"Artina Pajaziti, Besa Gacaferi","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Differentiating types of hair loss in the female population is often challenging because these conditions frequently present with overlapping clinical features, especially in early or diffuse forms of hair loss. Quantitative digital trichoscopy allows objective assessment of hair and follicular parameters and may improve diagnostic accuracy. The objective of this study was to compare regional quantitative digital trichoscopic features in female patients with androgenetic alopecia (AGA) and chronic telogen effluvium (TE) under comparable clinical conditions, and to identify parameters useful for differentiating miniaturizing from non-miniaturizing alopecia.Methods: This cross-sectional single-center study included 143 adult female patients with chronic TE (n = 74) and AGA (n = 69). Standardized digital trichoscopy was used to assess quantitative parameters in three scalp regions, followed by regional and intergroup comparisons and correlation analyses.Results: Chronic TE demonstrated preserved trichoscopic parameters across scalp regions, whereas AGA showed region-dependent miniaturization-related changes, with the strongest discriminatory pattern observed in the frontal scalp.Conclusions: Regional quantitative digital trichoscopy allows differentiation between common causes of female hair loss, particularly through frontal scalp assessment.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"35 3","pages":"147-151"},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amyopathic dermatomyositis presenting as severe alopecia and prominent eyelid edema: a case report and literature review. 以严重脱发及眼睑水肿为表现的淀粉性皮肌炎1例报告及文献复习。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-09-01

Nika Jutraž, Katja Perdan Pirkmajer, Bor Hrvatin Stančič

引用次数: 0

Association between intestinal fatty acid-binding protein and acne severity: evidence for gut barrier dysfunction in acne vulgaris. 肠道脂肪酸结合蛋白与痤疮严重程度的关系：寻常痤疮肠道屏障功能障碍的证据。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-06-01

Gülhan Aksoy Saraç, Burak Celik, Merve Kaya, Andaç Uzdoğan, Akın Aktaş

{"title":"Association between intestinal fatty acid-binding protein and acne severity: evidence for gut barrier dysfunction in acne vulgaris.","authors":"Gülhan Aksoy Saraç, Burak Celik, Merve Kaya, Andaç Uzdoğan, Akın Aktaş","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Acne vulgaris is a common inflammatory dermatosis with a multifactorial pathogenesis. Recent research suggests that alterations in the gut-skin axis and impaired intestinal barrier function may contribute to acne pathogenesis; however, direct evaluation of gut barrier integrity in acne patients remains limited. The objective of this study was to assess intestinal barrier integrity in patients with acne vulgaris by measuring serum intestinal fatty acid-binding protein (I-FABP) levels and to evaluate the association between I-FABP levels and acne severity.Methods: This single-center, prospective case-control study included 77 patients with acne vulgaris and 77 age- and sex-matched controls without acne. Acne severity was assessed using the Global Acne Grading System. Serum I-FABP levels were measured using an enzyme-linked immunosorbent assay.Results: Median serum I-FABP levels were significantly higher in patients with acne vulgaris than in controls (32.03 [7-107] pg/ml vs. 22.81 [12-189] pg/ml, p = 0.002). I-FABP levels differed significantly across acne severity grades (p < 0.001), with progressively higher levels observed from mild to very severe acne. A strong positive correlation was identified between acne severity and serum I-FABP levels (Spearman r = 0.797, p < 0.001). No significant association was found between I-FABP levels and body mass index.Conclusions: Serum I-FABP levels are significantly elevated in patients with acne vulgaris and correlate strongly with disease severity. These findings support the hypothesis that impaired intestinal barrier function may contribute to both the development and progression of acne vulgaris, highlighting the potential role of the gut-skin axis in acne pathogenesis.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"35 2","pages":"73-76"},"PeriodicalIF":1.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148165031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the effects of cinobufagin on G361 melanoma cells and a comparison with paclitaxel. 蟾毒球蛋白对G361黑色素瘤细胞影响的评价及与紫杉醇的比较。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-06-01

Gulhan Gurel, Mujgan Ercan, Sefa Celik, Rumeysa Cinar, Serkan Sen

{"title":"Evaluation of the effects of cinobufagin on G361 melanoma cells and a comparison with paclitaxel.","authors":"Gulhan Gurel, Mujgan Ercan, Sefa Celik, Rumeysa Cinar, Serkan Sen","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: The pathophysiology of melanoma is considerably complex. Wnt signaling via the β-catenin / transcription factor 7-like 2 / lymphoid enhancer-binding factor 1 (LEF1) complex, microphthalmia-associated transcription factor, tyrosinase-related protein-2, tyrosinase, and cyclin-dependent kinase 2 are reported to activate the transcriptional gene expression associated with pigmentation and the differentiation and proliferation of melanocytes and malignant melanoma cells. Cinobufagin, a common active ingredient in traditional Chinese medicine, has been approved in China as a chemotherapeutic agent for the treatment of liver and prostate cancer. The primary aim of this study is to evaluate the effects of cinobufagin, paclitaxel, and their combination (cinobufagin/paclitaxel) on melanoma cells, both individually and in combination, in the G361 melanoma cell line.Methods: Within the study, half maximal inhibitory concentration doses were determined based on the [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay, caspase-3 levels were measured using an enzyme-linked immunosorbent assay method, and mRNA expression levels were analyzed using RT-PCR.Results: The use of cinobufagin/paclitaxel was found to increase caspase-3 levels by more than the use of cinobufagin alone; moreover, cinobufagin treatment decreased the expression of the β-catenin, c-myc, and cyclin D1 genes, whereas cinobufagin/paclitaxel was found to increase the mRNA expression of all genes considered (Bax, caspase-3, Bcl2, β-catenin, c-myc, Wnt, and cyclin D1).Conclusions: Cinobufagin can therefore be considered a promising natural pharmaceutical agent for the targeted treatment of cancers with high levels of LEF1.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"35 2","pages":"85-90"},"PeriodicalIF":1.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148165004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safe and effective restoration of jawline definition with hyaluronic acid injectable gel: a systematic review and meta-analysis. 透明质酸注射凝胶安全有效地修复下颌轮廓：一项系统回顾和荟萃分析。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-06-01

Amir Hashemloo, Maryam Milanifard

{"title":"Safe and effective restoration of jawline definition with hyaluronic acid injectable gel: a systematic review and meta-analysis.","authors":"Amir Hashemloo, Maryam Milanifard","doi":"","DOIUrl":"","url":null,"abstract":"A well-defined jawline is an important aspect of facial aesthetics, contributing to overall appearance. This feature is particularly sought after by individuals, especially older adults, who are interested in enhancing their facial contours. This systematic review and meta-analysis evaluates safety and effectiveness following use of VYC-25L, a hyaluronic acid-based injectable gel, for restoration of jawline definition. VYC-25L is a soft tissue filler designed to add volume, lift, and contour to the jawline area, providing a non-surgical solution for improving facial aesthetics. This meta-analysis included two randomized controlled trials and three cohort studies of international databases-PubMed, EMBASE, Web of Science, and Cochrane Library-from January 2015 to May 2025, using keywords aligned with the study objective. The VYC-25L group had significantly higher responder rates on the Allergan Loss of Jawline Definition Scale (ALJDS) compared to the control group (71%; p < 0.001; 95% confidence interval [CI] [48%, 94%]). The most common event was swelling (effect size [ES]: 81%; 95% CI [69%, 92%]), lumps/bumps (ES: 83%; 95% CI [66%, 99%]), pain after injection (ES: 79%; 95% CI [62%, 96%]), and tenderness to touch (ES: 76%; 95% CI [61%, 92%]). In summary, VYC-25L appears to be an effective treatment for jawline definition, with a predictable adverse event profile.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"35 2","pages":"93-98"},"PeriodicalIF":1.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148165013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Types of phacomatosis pigmentovascularis associated with nevus cesius. 与子宫痣相关的色素血管性色素瘤的类型。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-06-01

Daniele Torchia

{"title":"Types of phacomatosis pigmentovascularis associated with nevus cesius.","authors":"Daniele Torchia","doi":"","DOIUrl":"","url":null,"abstract":"Phacomatosis pigmentovascularis (PPV) is a term encompassing a group of disorders characterized by the coexistence of segmental pigmented nevi of melanocytic origin and segmental capillary nevi. Several variants are characterized by a hallmark nevus cesius. Systematic reviews on the topic are lacking. An extensive review and critical reassessment of worldwide literature was carried out. A total of 435, 17, 19, and 17 cases of phacomatosis cesioflammea, phacomatosis cesiomarmorata, phacomatosis cesioflammeomarmorata, and phacomatosis melanocesioflammea, respectively, were identified. Specific clinical manifestations emerged for each variant. Postzygotic mosaic mutations affecting the GNAQ or GNA11 genes have been identified for all these entities. Four cases of nevus cesius associated with nevus anemicus (NA) were also retrieved. Phacomatosis cesioflammea is confirmed to be the most common PPV type by far. Its extracutaneous manifestations mostly consist of Sturge-Weber-Klippel-Trénaunay syndrome-like abnormalities, and ocular melanoma is a rare but relevant occurrence. The clinical associations of phacomatosis cesioflammeomarmorata mostly seem to result from the presence of cutis marmorata telangiectatica congenita. Phacomatosis cesioflammeomarmorata seems to resemble phacomatosis cesioflammea in several respects. A high frequency of NA and the Klippel-Trénaunay phenotype (or leg-length discrepancy) was observed in phacomatosis melanocesioflammea. The existence of \"pseudodidymosis cesioanemica\" is also corroborated.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"35 2","pages":"113-120"},"PeriodicalIF":1.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148164994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant cutaneous melanoma presenting with hemorrhagic complications. 巨大的皮肤黑色素瘤表现为出血性并发症。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-06-01

Klemen Lovšin, Ana Plesničar, Romi Cencelj-Arnež, Alenka Matjašič, Boštjan Luzar

引用次数: 0