Acta Dermatovenerologica Alpina Pannonica et Adriatica最新文献_第3页

Flap design challenges for upper lip defect: a case series. 上唇缺损皮瓣设计的挑战：一个案例系列。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-06-01

Nugrohoaji Dharmawan, Prasetyadi Mawardi, Ayu Kusuma Dewi

引用次数: 0

Acidity difference and skin Staphylococcus spp. colonization in preterm and term newborns. 早产儿和足月新生儿的酸度差异和皮肤葡萄球菌定植。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-06-01

Osdatilla Esa Putri, Suci Widhiati, Prasetyadi Mawardi, Arie Kusumawardani, Nurrachmat Mulianto, Dwi Hidayah, Pristiawan Navy Endraputra

{"title":"Acidity difference and skin Staphylococcus spp. colonization in preterm and term newborns.","authors":"Osdatilla Esa Putri, Suci Widhiati, Prasetyadi Mawardi, Arie Kusumawardani, Nurrachmat Mulianto, Dwi Hidayah, Pristiawan Navy Endraputra","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Term and preterm newborns have differences in skin structure. Preterm newborns have skin structures that are more susceptible to various disorders. These differences are believed to impact skin pH regulation and bacterial colonization, particularly Staphylococcus spp. This study investigates the acidity difference and skin Staphylococcus spp. colonization in preterm and term newborns.Methods: This is a descriptive observational study with a cross-sectional design. The study compared skin pH and Staphylococcus spp. colonization between term (37-41 weeks) and preterm (28-36 weeks) newborns. Skin pH was measured using a skin pH meter, and Staphylococcus spp. colonization was assessed through bacterial identification and colony-forming unit (CFU) testing. Assessments were conducted within the first 24 hours of life.Results: There were 29 participants in this study: 16 preterm newborns and 13 term newborns. The preterm group was dominated by subjects with alkaline skin pH (80%), and the term group was dominated by subjects with acidic skin pH (71%). Positive Staphylococcus spp. colonization was more prevalent in the preterm group (62%) than in the term group (38%).Conclusions: Skin pH differed between preterm and term newborns, with relatively higher skin pH in the preterm group. Staphylococcus spp. was also more prevalent in the preterm group.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"35 2","pages":"79-82"},"PeriodicalIF":1.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148165008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Successful treatment of dupilumab-induced rosacea with upadacitinib in a patient with atopic dermatitis. upadacitinib在特应性皮炎患者中成功治疗dupilumab诱导的酒糟。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-06-01

Selami Aykut Temiz, Ayman Abdelmaksoud, Hasan Emre İlgenli, Recep Dursun, Uwe Wollina

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A biomarker-guided therapeutic map for alopecia: in vivo evidence and clinical implications. 生物标志物引导的脱发治疗图：体内证据和临床意义。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-06-01

Adniana Nareswari, Didik Gunawan Tamtomo, Harijono Kariosentono, Ratih Puspita Febrinasari, Muhammad Eko Irawanto, Paramasari Dirgahayu

{"title":"A biomarker-guided therapeutic map for alopecia: in vivo evidence and clinical implications.","authors":"Adniana Nareswari, Didik Gunawan Tamtomo, Harijono Kariosentono, Ratih Puspita Febrinasari, Muhammad Eko Irawanto, Paramasari Dirgahayu","doi":"","DOIUrl":"","url":null,"abstract":"Alopecia is a multifactorial disorder involving disruption of immune, oxidative, apoptotic, and regenerative pathways in the hair follicle microenvironment. Despite therapeutic advances, clinical responses remain inconsistent, partly due to the limited understanding of underlying molecular targets. Integrating biomarker data may help clarify disease mechanisms and guide more targeted interventions. This review synthesizes in vivo animal evidence on six key biomarkers-tumor necrosis factor (TNF)-α, interleukin (IL)-6, malondialdehyde (MDA), caspase-3, vascular endothelial growth factor (VEGF), and β-catenin-and integrates their therapeutic implications into a biomarker-centered framework. A systematic search identified 15 animal studies (2014-2024) evaluating these biomarkers in alopecia models. TNF-α and IL-6 were generally elevated, indicating inflammation and immune-mediated follicular damage, whereas MDA reflected oxidative stress and caspase-3 activation marked apoptosis-driven regression. In contrast, VEGF and β-catenin were suppressed in alopecia but restored by effective interventions, supporting angiogenesis and Wnt-mediated regeneration. Various therapeutic approaches, including botanical extracts, bioactive compounds, sustained-release finasteride, microneedling, and nanoparticle-based delivery systems, were shown to reduce destructive biomarkers while enhancing regenerative pathways. Overall, alopecia can be conceptualized as an imbalance between degenerative and regenerative mechanisms, and a biomarker-guided therapeutic map may provide a useful translational framework for developing more precise and multitargeted treatment strategies.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"35 2","pages":"101-111"},"PeriodicalIF":1.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148165010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Transcriptome dissection reveals shared upregulated genes and enriched pathways involved in skin disease concurrence. 转录组解剖揭示了参与皮肤病并发的共同上调基因和富集通路。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-06-01

Manahel Mahmood Alsabbagh

{"title":"Transcriptome dissection reveals shared upregulated genes and enriched pathways involved in skin disease concurrence.","authors":"Manahel Mahmood Alsabbagh","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: The coexistence of skin diseases is common. Although molecular studies have made significant efforts to understand each disease entity, the shared molecular basis explaining their concurrence remains largely unknown. This study aims to identify common upregulated genes in skin diseases that may serve as potential biomarkers.Methods: Gene expression datasets were retrieved from online databases and compared to healthy controls, focusing on genes common between concurrent diseases. The pathways these molecules are involved in were then analyzed, and their protein-protein interactions were illustrated.Results: The analysis revealed that SLC44A5 is strongly upregulated in psoriasis and vitiligo; ARNTL2 is upregulated in lichen planus and vitiligo; HIST1H2BG is upregulated in lichen planus and psoriasis; S100A7A is upregulated in psoriasis and alopecia areata; CXCL9 is strongly upregulated in vitiligo and alopecia areata, as well as in lichen planus and alopecia areata, and cutaneous lupus erythematosus and lichen planus; and SERPINB4 is upregulated in acne and rosacea.Conclusions: This study enhances the understanding of skin disease concurrence and lays the groundwork for studying these diseases at a genomic level. It also helps identify common therapeutic targets that work for coexisting diseases.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"35 2","pages":"67-70"},"PeriodicalIF":1.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148164969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herpes zoster-like reaction triggered by the recombinant vaccine against herpes zoster (Shingrix). 带状疱疹重组疫苗（Shingrix）引发的带状疱疹样反应。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-04-09

Miloš D Pavlović, Violeta Hosta

引用次数: 0

Evaluation of methotrexate and its influence on serum autoantibodies against BP180 in patients with bullous pemphigoid: a pilot study. 评价甲氨蝶呤及其对大疱性类天疱疮患者血清BP180自身抗体的影响：一项初步研究。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-03-01

Riccardo Balestri, Giacomo Clarizio, Giulia Rech, Federica Filippi, Lidia Sacchelli, Camilla Loi, Federico Bardazzi

引用次数: 0

Intravenous longevity therapy: a critical review of evidence, mechanisms, and clinical utility. 静脉长寿疗法：证据、机制和临床应用的重要回顾。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-03-01

Aleksandar Godic, Jaiden Townsend

{"title":"Intravenous longevity therapy: a critical review of evidence, mechanisms, and clinical utility.","authors":"Aleksandar Godic, Jaiden Townsend","doi":"","DOIUrl":"","url":null,"abstract":"Intravenous administration of high-dose vitamins, minerals, amino acids, coenzyme Q10, α-lipoic acid, glutathione, and nicotinamide adenine dinucleotide has emerged as a popular longevity therapy, targeting key molecular processes, oxidative stress, mitochondrial decline, chronic inflammation, and genomic instability, which drive and accelerate aging. The rationale is that intravenous administration facilitates supraphysiological plasma concentrations, bypassing gastrointestinal absorption limitations to more effectively target these age-promoting mechanisms. Evidence from preclinical models and small clinical series reports transient reductions in oxidative biomarkers, modest improvements in fatigue syndromes, and anecdotal enhancements in skin elasticity. However, these findings are predominantly derived from disease-specific or aesthetic contexts rather than studies involving healthy aging populations. Crucially, few studies incorporate validated biomarkers of aging such as epigenetic age or telomere length, and placebo-controlled trials are scarce and underpowered or they yield conflicting results. Additional challenges include pharmacokinetic limitations, procedural risks, and substantial heterogeneity of infusion protocols, all of which hinder reliable interpretation. Until rigorously designed, adequately powered randomized controlled trials demonstrate reproducible long-term efficacy and safety, intravenous longevity therapy should be regarded as an experimental intervention rather than an evidence-based dermatological or anti-aging practice.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"35 1","pages":"39-43"},"PeriodicalIF":1.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous melanoma histopathologic features and laboratory findings as predictors of sentinel lymph node status and progression-free survival: a single-center experience. 皮肤黑色素瘤组织病理学特征和实验室结果作为前哨淋巴结状态和无进展生存的预测因素：单中心经验。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-03-01

Nikola Pantić, Jelena Pantović, Milica Kotur, Simona Petričević, Olga Radivojević, Katja Petrović, Nevena Vujošević, Lenka Grujičić, Isidora Grozdić Milojević, Dragana Šobić Šaranović, Vera Artiko, Strahinja Odalović

{"title":"Cutaneous melanoma histopathologic features and laboratory findings as predictors of sentinel lymph node status and progression-free survival: a single-center experience.","authors":"Nikola Pantić, Jelena Pantović, Milica Kotur, Simona Petričević, Olga Radivojević, Katja Petrović, Nevena Vujošević, Lenka Grujičić, Isidora Grozdić Milojević, Dragana Šobić Šaranović, Vera Artiko, Strahinja Odalović","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Cutaneous melanoma (CM) is the most aggressive cutaneous malignancy. The aim of the study was to determine the predictive value of primary tumor histopathologic features and laboratory findings used in routine CM follow-up for sentinel lymph node biopsy (SLNB) results and progression-free survival (PFS).Methods: This retrospective study included 157 patients. Planar images were acquired after an intradermal injection of 18 to 30 MBq of 99mTc-nanocolloid in 0.3 ml at two to eight sites 5 to 10 mm from the surgical scar. SLN excision was performed a day after lymphoscintigraphy.Results: In a logistic regression analysis, Breslow thickness, ulceration status, and mitotic rate showed possible predictive significance for SLNB results, with serum lactate dehydrogenase (LDH) being the only independent predictor (p = 0.042). The difference in survival distributions reached statistical significance for Breslow thickness, mitotic rate, and LDH (p < 0.05, Kaplan-Meier, log-rank test). In a Cox regression analysis, Breslow thickness was a possible predictor of PFS and mitotic rate was an independent predictor (p = 0.025).Conclusions: LDH is an independent predictor of SLN histopathology findings, and mitotic rate is an independent predictor of PFS.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":" ","pages":"13-20"},"PeriodicalIF":1.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical features of 109 patients with primary cicatricial alopecia: a 15-year retrospective study. 109例原发性瘢痕性脱发患者的临床特征：一项15年回顾性研究。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2026-03-01

Özge Zorlu, Hülya Albayrak, Sema Aytekin

{"title":"Clinical features of 109 patients with primary cicatricial alopecia: a 15-year retrospective study.","authors":"Özge Zorlu, Hülya Albayrak, Sema Aytekin","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Given the limited data on primary cicatricial alopecias (PCAs), which cause permanent hair loss, this study investigates the demographic and clinical characteristics, applied treatments, and disease course of PCA patients.Methods: Medical records of 109 PCA patients that attended an outpatient clinic between 2010 and 2025 were retrospectively reviewed. Demographic and clinical characteristics, and treatment approaches were retrieved from patient files.Results: Lymphocytic PCA (83.5%) was the most frequent type, followed by neutrophilic PCA (15.6%). Classic lichen planopilaris (LPP-C) was the leading lymphocytic subtype (39.4%), and folliculitis decalvans (12%) was the most common neutrophilic PCA. Lymphocytic PCAs showed female predominance, whereas male predominance was present in neutrophilic PCAs (p < 0.001). Disease onset occurred at an older age in lymphocytic PCAs compared to the neutrophilic group (42.0 ± 11.8 and 30.2 ± 11.4 years, p < 0.001). Pain and nodule/pustule formation were more frequent in neutrophilic PCAs (p < 0.001). Topical/intralesional corticosteroids and hydroxychloroquine were mainly used in lymphocytic PCAs, whereas oral antibiotics and isotretinoin were preferred in neutrophilic PCAs.Conclusions: PCA frequency may vary geographically. LPP-C was the most common subtype. Early diagnosis and timely treatment are essential to prevent irreversible hair loss and optimize cosmetic outcomes.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"35 1","pages":"23-30"},"PeriodicalIF":1.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0