Treatment of foreign body granulomas with combined enzyme therapy.

Introduction: Granulomas are focal aggregates of inflammatory cells that form in response to a persistent inflammatory stimulus. Available therapies include surgical and nonsurgical management, and current evidence is based on case series or case reports.

Methods: Two case reports of foreign body granulomas treated with a combination of recombinant enzymes (hyaluronidase, collagenase, and lipase of bacterial origin) are presented.

Results: Following three sessions of combined enzyme treatment with a scheduled protocol, both patients showed clinical improvement without any reported adverse events.

Conclusions: Combined enzyme therapy is an effective, safe, minimally invasive, innovative approach for the treatment of foreign body granulomas.