Acta Dermatovenerologica Alpina Pannonica et Adriatica最新文献_第6页

A case report of lymphomatoid papulosis: uncovering a rare diagnosis from a common finger ulcer. 样淋巴瘤丘疹病1例报告：从一个常见的手指溃疡揭示一个罕见的诊断。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-09-01

Gökçe Işıl Kurmuş, Hanife Karataş, Elif Kaya, Ali Çınar, Selda Pelin Kartal

{"title":"A case report of lymphomatoid papulosis: uncovering a rare diagnosis from a common finger ulcer.","authors":"Gökçe Işıl Kurmuş, Hanife Karataş, Elif Kaya, Ali Çınar, Selda Pelin Kartal","doi":"","DOIUrl":"","url":null,"abstract":"Lymphomatoid papulosis (LyP) is a rare, chronic CD30+ cutaneous lymphoproliferative disorder characterized by recurrent, self-healing papulonodular lesions. Despite its benign clinical course, LyP histologically resembles malignant lymphomas, necessitating careful differentiation. A 42-year-old woman presented with a 3-year history of recurring ulcerated papulonodular lesions on her index finger. Histopathological examination revealed atypical CD30+ lymphoid proliferation, confirming LyP type A. Immunohistochemical analysis was positive for CD2, CD4, CD30, and multiple myeloma oncogene 1, while systemic malignancy was excluded. The patient was treated with low-dose methotrexate (15 mg/week), leading to symptom improvement. LyP is classified into five histological subtypes (A-E) and is often misdiagnosed due to its overlap with inflammatory and neoplastic conditions. While the condition typically resolves spontaneously, it is associated with an increased risk of secondary lymphomas, including mycosis fungoides and primary cutaneous anaplastic large cell lymphoma. Accurate diagnosis relies on clinical presentation, histopathological evaluation, and immunophenotyping. Awareness of LyP's clinical and pathological features is essential for appropriate management and surveillance.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 1","pages":"151-154"},"PeriodicalIF":1.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of alopecia areata with JAK inhibitors: a review of the literature. JAK抑制剂治疗斑秃：文献综述。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-09-01

Jaiden Townsend, Aleksandar Godic

引用次数: 0

Preventive and curative approaches to diaper dermatitis in children: a systematic review. 儿童尿布皮炎的预防和治疗方法：系统综述。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-09-01

Stella Gracia Octarica, Endra Yustin Ellistasari, Ayu Kusuma Dewi, Shelly Lavenia Sambodo, Rahmat Firdaus Dwi Utama, Sugih Primas Adjie

{"title":"Preventive and curative approaches to diaper dermatitis in children: a systematic review.","authors":"Stella Gracia Octarica, Endra Yustin Ellistasari, Ayu Kusuma Dewi, Shelly Lavenia Sambodo, Rahmat Firdaus Dwi Utama, Sugih Primas Adjie","doi":"","DOIUrl":"","url":null,"abstract":"Diaper dermatitis (DD) is a common inflammatory skin condition in the diaper area of infants, caused by a combination of host and environmental factors, such as moisture, friction, elevated skin pH, and prolonged exposure to urine and feces. This systematic review analyzed 13 studies involving 2,935 children to evaluate effective treatment and prevention strategies for DD. Key interventions identified include the use of disposable and emollient-containing diapers, gentle skincare practices (such as bathing every 1 to 2 days with mild cleansers and emollients), and pH-balanced wet wipes. Frequent diaper changes and allowing diaper-free time also help reduce skin irritation. Topical treatments, particularly emollients with zinc oxide or dexpanthenol, were found to be highly effective with minimal side effects. Preventive measures, such as using superabsorbent disposable diapers, regular application of barrier creams, and maintaining good hygiene, are crucial in reducing the incidence and severity of DD. In conclusion, a combined approach of proper diaper selection, gentle skincare, and judicious use of topical emollients is recommended for both treatment and prevention of DD in children.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 3","pages":"101-107"},"PeriodicalIF":1.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral lichen planus: key features of etiopathogenesis, diagnosis, and management. 口腔扁平苔藓：发病、诊断和治疗的关键特征。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-09-01

Ana Glavina, Lucija Zanze, Ema Barac, Bruno Špiljak, Duje Čulina, Liborija Lugović-Mihić

{"title":"Oral lichen planus: key features of etiopathogenesis, diagnosis, and management.","authors":"Ana Glavina, Lucija Zanze, Ema Barac, Bruno Špiljak, Duje Čulina, Liborija Lugović-Mihić","doi":"","DOIUrl":"","url":null,"abstract":"Oral lichen planus (OLP) is a chronic inflammatory autoimmune disease of unknown etiology. It is assumed that a genetic predisposition contributes to the development of the disease and influences the patient's response to various etiological factors such as autoimmune reactions to epithelial antigens, microorganisms, and stress. Immunopathogenesis is primarily driven by cell-mediated immune mechanisms, with T lymphocytes playing a central role. The clinical presentation of OLP is varied, and multiple clinical forms can occur in the same patient. OLP is categorized into six clinical types: reticular, papular, and plaque-like (hyperkeratotic variants), and atrophic, erosive, and bullous (erosive variants). The histopathological diagnosis of OLP is unique. Continuous follow-up of patients is crucial because OLP is considered an oral potentially malignant disorder (OPMD). Reported rates of malignant transformation vary, with a pooled estimate of 1.43% for OLP and 5.13% for OLP with dysplasia. Patient education plays a crucial role in treatment initiation and planning. A personalized treatment approach focuses on controlling inflammation and relieving symptoms such as pain and burning. Treatment should be individualized according to disease severity, subtype, and patient response, with constant monitoring for possible malignant transformation and comorbidities.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 ","pages":"109-115"},"PeriodicalIF":1.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of oral glutathione in reducing nitric oxide and IL-1α concentrations for clinical improvement in mild to moderate acne vulgaris: a randomized controlled trial. 口服谷胱甘肽降低一氧化氮和IL-1α浓度对轻度至中度寻常痤疮临床改善的有效性：一项随机对照试验

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-09-01

Ferra Olivia Mawu, Anis Irawan Anwar, Khairuddin Djawad, Agussalim Bukhari, Marlyn Grace Kapantow, Paulus Mario Christopher

{"title":"Effectiveness of oral glutathione in reducing nitric oxide and IL-1α concentrations for clinical improvement in mild to moderate acne vulgaris: a randomized controlled trial.","authors":"Ferra Olivia Mawu, Anis Irawan Anwar, Khairuddin Djawad, Agussalim Bukhari, Marlyn Grace Kapantow, Paulus Mario Christopher","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Acne vulgaris (AV) is a chronic inflammatory dermatosis predominantly affecting adolescents and young adults. Oxidative and nitrosative stress, marked by elevated nitric oxide (NO) and interleukin (IL)-1α, contributes to AV pathogenesis. Glutathione, a key antioxidant, may attenuate oxidative and nitrosative stress and modulate inflammatory pathways. This study investigates the effectiveness of oral glutathione supplementation on serum NO and IL-1α concentrations, and clinical improvement in mild to moderate AV patients.Methods: A randomized controlled trial was conducted involving 40 subjects diagnosed with mild to moderate AV. Participants were randomized to receive either 500 mg oral glutathione (n = 22) or placebo (n = 18) once daily for 4 weeks. Clinical severity of AV was assessed utilizing the Lehmann criteria. Serum levels of NO and IL-1α were measured at baseline and week 4.Results: At week 4, reductions in serum NO and IL-1α concentrations were observed in the glutathione group; however, these changes did not reach statistical significance (p > 0.05). Clinical improvement occurred in seven subjects (31.8%) in the glutathione group, with a reduction from moderate to mild severity. No adverse reactions were reported.Conclusions: Oral glutathione supplementation demonstrated a non-significant trend toward reducing oxidative and nitrosative stress markers and improving mild to moderate AV. Further studies are recommended to validate these findings.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 3","pages":"95-99"},"PeriodicalIF":1.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous B-cell pseudolymphoma treated with imiquimod. 咪喹莫特治疗皮肤b细胞假性淋巴瘤。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-09-01

Gökhan Okan, Cuyan Demirkesen

引用次数: 0

Unraveling the role of IL-17 in lichen planus: a comparative investigation of clinical variability and immunopathogenic pathways. 揭示IL-17在扁平苔藓中的作用：临床变异性和免疫致病途径的比较研究。

IF 0.6

Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-06-01

Maja Tolušić Levak, Mirta Pauzar, Vera Plužarić, Nika Franceschi, Biljana Pauzar, Jasmina Rajc, Marija Delaš Aždajić, Martina Mihalj

{"title":"Unraveling the role of IL-17 in lichen planus: a comparative investigation of clinical variability and immunopathogenic pathways.","authors":"Maja Tolušić Levak, Mirta Pauzar, Vera Plužarić, Nika Franceschi, Biljana Pauzar, Jasmina Rajc, Marija Delaš Aždajić, Martina Mihalj","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Lichen planus (LP) is a chronic T cell-mediated inflammatory disease affecting the skin and mucosa. Interleukin-17 (IL-17), a pro-inflammatory cytokine, has been implicated in LP pathogenesis, but its tissue-level expression across clinical variants remains underexplored. This study compares IL-17 expression in healthy skin and LP lesions and assesses variations based on clinical presentation.Methods: This cross-sectional retrospective study included 20 LP skin samples and 10 healthy controls. The sample collection spanned a period of 10 years. IL-17 expression was assessed via immunohistochemistry and quantified using a modified Q score. Samples were categorized by mucosal involvement and lesion distribution. Statistical analysis was performed with the Mann-Whitney U test.Results: IL-17 was absent in healthy skin but present in all LP samples. IL-17 expression was significantly higher in patients with both skin and oral mucosal involvement compared to those with cutaneous LP (p = 0.003). No significant difference was observed between generalized and localized LP.Conclusions: The results indicate a distinct increase in IL-17 expression in LP lesions, particularly with mucosal involvement, supporting its role in LP pathogenesis. These findings suggest IL-17 as a potential biomarker and therapeutic target, warranting further investigation in larger cohorts.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 2","pages":"51-54"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pbserum Specific Acne Scars®: a cutting-edge approach utilizing triple enzymatic synergy combined with microneedling for post-acne scar repair. Pbserum特异性痤疮疤痕®：一种利用三重酶协同作用结合微针治疗痤疮后疤痕的尖端方法。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-06-01

Melania Batistella, Erick Santaella, Sandra Oliveira, Claudia Maan, Valeria Kopytina, Jorge López Berroa

{"title":"Pbserum Specific Acne Scars®: a cutting-edge approach utilizing triple enzymatic synergy combined with microneedling for post-acne scar repair.","authors":"Melania Batistella, Erick Santaella, Sandra Oliveira, Claudia Maan, Valeria Kopytina, Jorge López Berroa","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: The integration of active ingredients into scientifically backed formulations is an innovative approach to remodeling post-acne atrophic scars, stimulating regenerative processes. Microneedling, a minimally invasive procedure, promotes collagen production and enhances skin penetration of cosmeceutical products such as Pbserum Specific Acne Scars®, which combines collagenases G and H with hyaluronate r-lyase and other ingredients, including allantoin, zinc sulfate, vitamin A, vitamin B3, niacinamide, and melatonin. These components modulate inflammation, fibrosis, oxidative stress, and aging. This study assesses the efficacy and safety of treatment for ameliorating atrophic acne scars.Methods: Twenty-nine patients were treated with Pbserum Specific Acne Scars® applied by microneedling for 4 months in four sessions on the middle or lower third of the face and/or periocular area. The scar size (according to EvaFace® analysis), deep skin hydration (measured with a Moisturemeter® D device), severity (assessed using the échelle d'évaluation clinique des cicatrices d'acne and Goodman and Baron scales), clinical efficacy (evaluated using Global Aesthetic Improvement Scale), quality of life (measured using Facial Acne Scar Quality of Life questionnaire), and subject satisfaction were analyzed.Results: Significant improvements were observed in all parameters evaluated, especially after four applications, demonstrating clinical efficacy. Patient satisfaction levels were notably high.Conclusions: The treatment significantly improved skin texture and scar appearance after four applications over a period of 4 months.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 2","pages":"65-72"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary cutaneous CD4-positive small or medium T-cell lymphoproliferative disorder: a case report and literature review. 原发性皮肤 CD4 阳性中小型 T 细胞淋巴组织增生性疾病：病例报告和文献综述。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-06-01

Katarina Trčko, Nuša Lukinovič, Daja Šekoranja

引用次数: 0

Two cases of bizarre acquired localised hyperpigmentation disorders - similar yet different diagnostic challenges: two case reports and a brief literature review. 两例奇异的获得性局部色素沉着过度障碍-相似但不同的诊断挑战：两例病例报告和简短的文献回顾。

IF 0.6

Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-06-01

Laura Đorđević Betetto, Boštjan Luzar, Aleksandra Bergant Suhodolčan

{"title":"Two cases of bizarre acquired localised hyperpigmentation disorders - similar yet different diagnostic challenges: two case reports and a brief literature review.","authors":"Laura Đorđević Betetto, Boštjan Luzar, Aleksandra Bergant Suhodolčan","doi":"","DOIUrl":"","url":null,"abstract":"Cutaneous pigmentation disorders are one of the leading causes of dermatological consultation globally. Hyperpigmentation disorders constitute a group of distinct medical conditions that may be either congenital and associated with various concurrent comorbidities, or acquired due to cutaneous, environmental, or systemic conditions or factors. Due to numerous causes and an often atypical clinical picture, diagnosis can be challenging. Furthermore, although the changes in skin color are not inherently harmful, they can result in significant cosmetic disfigurement and have psychological and social repercussions, particularly given that some hyperpigmentation is irreversible due to the limited effectiveness of current treatments. This article presents two cases exhibiting somewhat similar but different acquired localized hyperpigmentation. We review the current literature with emphasis on the diagnostic approach to this entity and specific acquired hyperpigmentation disorders, in particular drug-induced and paraneoplastic. We emphasize the importance of interdisciplinary cooperation among different specialists, particularly in complicated cases and those that accompany systemic diseases.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 2","pages":"89-93"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0