Acta Dermatovenerologica Alpina Pannonica et Adriatica最新文献_第7页

Treatment of foreign body granulomas with combined enzyme therapy. 酶联合治疗异物肉芽肿。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-06-01

Desirée Giselle Castelanich, Delfina Pascuzzi, Jorge López Berroa

引用次数: 0

Detection of serum and tissue levels of interleukin 39 in psoriasis: a case control study. 银屑病患者血清和组织白细胞介素39水平的检测：一项病例对照研究。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-06-01

Mohammed Hassan, Talal A Abd El-Raheem, Olfat G Shaker, Hagar Ali Kamal, Sara M Yaseen, Amira E Soliman

{"title":"Detection of serum and tissue levels of interleukin 39 in psoriasis: a case control study.","authors":"Mohammed Hassan, Talal A Abd El-Raheem, Olfat G Shaker, Hagar Ali Kamal, Sara M Yaseen, Amira E Soliman","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Psoriasis is a chronic immune-mediated disorder with a genetic component that primarily affects the skin and has potential systemic involvement. Advances in understanding the interaction between the innate and adaptive immune systems have facilitated improved disease management.Methods: This study included 25 patients with psoriasis and 20 healthy controls of both sexes. All participants underwent detailed medical history-taking and dermatological examination, including assessment of the body surface area and the Psoriasis Area and Severity Index (PASI). Blood samples (3 ml) were collected from all subjects, and 4 mm lesional skin punch biopsies were obtained from psoriatic patients and healthy controls.Results: Serum and tissue levels of interleukin 39 (IL-39) were significantly elevated in psoriatic patients compared to healthy individuals. Patients with a positive family history of psoriasis showed higher serum IL-39 levels than those without such a history. In addition, psoriatic individuals with diabetes mellitus or hypertension had higher serum IL-39 levels than those without these comorbidities. A statistically significant correlation was found between disease severity and serum IL-39 concentration.Conclusions: Elevated serum and tissue IL-39 levels in psoriatic patients suggest a potential role for IL-39 in the pathogenesis of psoriasis, highlighting its possible utility as a biomarker or therapeutic target.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 2","pages":"45-49"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of clinical and lifestyle factors associated with disease severity in adult patients with scalp seborrheic dermatitis: a retrospective analysis. 评估与成人头皮脂溢性皮炎患者疾病严重程度相关的临床和生活方式因素：回顾性分析

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-06-01

Nazlı Caf, Mustafa Tümtürk, Defne Özkoca

{"title":"Evaluation of clinical and lifestyle factors associated with disease severity in adult patients with scalp seborrheic dermatitis: a retrospective analysis.","authors":"Nazlı Caf, Mustafa Tümtürk, Defne Özkoca","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Scalp seborrheic dermatitis (SSD) is a prevalent and chronic dermatological condition. Although various mechanisms have been proposed, its precise etiology and exacerbating factors remain unclear. This study aimed to identify the factors influencing clinical severity in individuals with SSD; to assess the associations between severity and variables such as gender, age at disease onset, treatment history, and the presence of comorbid systemic or dermatological conditions; and to determine potential triggering factors.Methods: A total of 198 adult patients diagnosed with SSD were included in this retrospective study. Collected data included demographic characteristics, smoking and alcohol use, Fitzpatrick skin type, age at disease onset, duration of the most recent flare, frequency of hair washing, and the season during which the patient presented. Clinical severity of SSD was assessed by a dermatologist. In addition, the presence of systemic and dermatological comorbidities, as well as patient-reported triggering factors, was documented.Results: A statistically significant difference in SSD severity was observed between sexes, with higher severity noted in male patients (p = 0.006). No significant associations were found between SSD severity and age, Fitzpatrick skin type, smoking or alcohol use, season of presentation/flare up, or the presence of systemic diseases. However, SSD severity differed significantly based on the presence of onychomycosis (p = 0.001).Conclusions: The significant association between the frequency of onychomycosis and the severity of SSD highlights a potential link involving shared immunologic, microbial, and skin barrier dysfunctions underlying both conditions.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 2","pages":"57-62"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous paradoxical inflammatory reaction of erythema induratum of Bazin to standard antituberculosis treatment. 巴赞硬化性红斑对标准抗结核治疗的皮肤反常炎症反应。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-06-01

Miloš D Pavlović, Motunrayo Adisa

{"title":"Cutaneous paradoxical inflammatory reaction of erythema induratum of Bazin to standard antituberculosis treatment.","authors":"Miloš D Pavlović, Motunrayo Adisa","doi":"","DOIUrl":"","url":null,"abstract":"Cutaneous tuberculosis (TBC) is rather rare and has diverse clinical presentations relative to host immunity and the number of bacilli present in the tissue. A group of cutaneous lesions called tuberculids represent a strong, delayed-type hypersensitivity reaction to mycobacteria. Among them, erythema induratum of Bazin (EIB) typically presents as tender erythematous nodules that ulcerate and are usually confined to the posterior aspects of the calves. Paradoxical reactions (PRs) to appropriate treatment involving the skin have mostly been described in the setting of miliary tuberculosis. These PRs are encountered in infectious and inflammatory diseases during the institution of appropriate treatment representing a worsening or relapse of disease under treatment or unmasking of subclinical disease. This case report describes a patient with EIB developing a necrotic PR shortly after initiation of antituberculosis therapy. The skin lesions cleared with a topical corticosteroid treatment and continued antituberculosis therapy. It is important to recognize cutaneous PR in the setting of treated cutaneous TBC and to reassure patients about the excellent outcome that can be achieved with continuation of treatment.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 ","pages":"85-87"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Furuncular myiasis caused by Dermatobia hominis in a Slovenian traveler. 斯洛文尼亚旅行者因人皮癣引起的镰状蝇病。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-03-01

Mark Sergej Bartenjev, Jan Stanič, Mateja Dolenc Voljč, Igor Bartenjev

引用次数: 0

Sexually transmissible bacterial enteric pathogens. 性传播的细菌肠道病原体。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-03-01

Mateja Pirš, Tadeja Kotar

{"title":"Sexually transmissible bacterial enteric pathogens.","authors":"Mateja Pirš, Tadeja Kotar","doi":"","DOIUrl":"","url":null,"abstract":"Bacterial enteric pathogens can be transmitted through sexual contact, with gay, bisexual, and other men who have sex with men (gbMSM) being particularly at risk. The factors and dynamics involved in sexual transmission of bacterial enteric pathogens remain incompletely understood. Intestinal pathogens with a low infectious dose, particularly Shigella spp., followed by Campylobacter spp., which has a relatively higher infectious dose, are more likely to spread through sexual contact. Asymptomatic carriers of bacterial enteric pathogens may play a role in transmission through sexual activity. Recommendations for prevention of sexual transmission of bacterial enteric pathogens include engaging in less risky sexual behavior, minimizing oral-anal contact during sexual activity, maintaining good personal hygiene, and using protective measures such as cleaning sex toys. If a partner has diarrhea, it is recommended to avoid sexual contact during active illness and for at least 1 to 2 weeks after the symptoms have resolved. In addition, oral-anal contact should be avoided for 4 to 6 weeks following resolution of symptoms. Increasing awareness of the possible sexual transmission of bacterial enteric pathogens among at-risk groups is essential for encouraging behavioral changes. Similarly, raising awareness among clinicians that care for at-risk groups is essential for providing appropriate counseling and improving patient management.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 1","pages":"21-25"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of overnight leave-on sandwich therapy with 5% cysteamine and ectoine cream compared to hydroquinone 4% cream for treatment of melasma: a double-blind randomized controlled trial. 与4%对苯二酚乳膏治疗黄褐斑的疗效比较：一项双盲随机对照试验。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-03-01

Arie Kusumawardani, Alamanda Murasmita, Ervina Rosmarwati, Lilik Norawati Ashadi, Silvia V Setiawan, Sinta Murlistyarini, Nurrahma Wahyu Fitriyani

{"title":"Efficacy of overnight leave-on sandwich therapy with 5% cysteamine and ectoine cream compared to hydroquinone 4% cream for treatment of melasma: a double-blind randomized controlled trial.","authors":"Arie Kusumawardani, Alamanda Murasmita, Ervina Rosmarwati, Lilik Norawati Ashadi, Silvia V Setiawan, Sinta Murlistyarini, Nurrahma Wahyu Fitriyani","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Melasma is a common hypermelanosis presenting as dark patches on sun-exposed skin. Its treatment remains challenging due to slow response, especially in chronic cases. This study compares the efficacy of 5% cysteamine with ectoine cream versus 4% hydroquinone with ectoine cream in treating melasma.Methods: A double-blind randomized controlled trial was conducted from January to March 2024 across three centers in Indonesia: Dr. Moewardi Hospital (Surakarta), Gatot Soebroto Army Hospital (Jakarta), and Dr. Saiful Anwar Hospital (Malang). Participants were randomly assigned to Group A (5% cysteamine + ectoine) or Group B (4% hydroquinone + ectoine). Efficacy was evaluated using the modified Melasma Area and Severity Index (mMASI) and the JANUS-I skin analyzer. Quality of life was assessed using Melasma Quality of Life Scale (MELASQoL) and Dermatology Life Quality Index (DLQI) questionnaires.Results: Both groups demonstrated reduced mMASI and JANUS-I scores, with slightly greater improvement in Group A, although the difference was not statistically significant (p > 0.05). Quality of living also improved in both groups, with no significant difference between them (p > 0.05).Conclusions: Both treatment regimens effectively improved melasma pigmentation and QoL. Either 5% cysteamine with ectoine or 4% hydroquinone with ectoine can be considered viable treatment options for melasma.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 1","pages":"1-4"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Superficial basal cell carcinoma masquerading as pruritic dermatitis on the upper eyelid. 表面基底细胞癌伪装为上眼睑瘙痒性皮炎。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-03-01

Angie Priscila Mariños, Jenny Valverde-López, Pedro Cárdenas Cruz

引用次数: 0

Effects of oral minoxidil on serum VEGF and hair regrowth in androgenetic alopecia. 口服米诺地尔对雄激素性脱发患者血清VEGF及毛发再生的影响。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-03-01

Ahmed Abdulhussein Kawen

{"title":"Effects of oral minoxidil on serum VEGF and hair regrowth in androgenetic alopecia.","authors":"Ahmed Abdulhussein Kawen","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Androgenetic alopecia (AGA) is a common hair loss condition characterized by follicular miniaturization. Vascular endothelial growth factor (VEGF) plays a key role in promoting angiogenesis and supporting hair follicle growth. Oral minoxidil has been suggested to upregulate VEGF levels, enhancing hair regrowth.Methods: This prospective study included 50 participants divided into two groups: oral minoxidil (1 mg/day; n = 25) and control (n = 25). Serum VEGF levels were measured at baseline and after 12 weeks of treatment. Hair growth parameters, including hair count, diameter, shedding, and pull test results, were assessed systematically.Results: Baseline VEGF levels were similar between groups (p = 0.1873). Post-treatment, VEGF levels increased significantly in the minoxidil group (217.88 ± 22.65 pg/ml vs. 142.81 ± 23.14 pg/ml in the control, p < 0.0001). Hair count and diameter improved significantly (p < 0.0001 and p = 0.0040, respectively), with reductions in shedding and pull test results (p < 0.0001). Positive correlations were observed between VEGF and hair count (r = 0.9965), whereas shedding showed negative correlations (r = -0.5374).Conclusions: Oral minoxidil significantly enhances VEGF levels, promoting hair growth and reducing shedding. VEGF serves as a promising biomarker for assessing treatment effectiveness and understanding the angiogenic mechanisms involved in AGA.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"34 1","pages":"7-12"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kawasaki-like illness following COVID-19 infection in a minor β-thalassemic girl. 小β-地中海贫血女孩COVID-19感染后的川崎样疾病。

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Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2025-03-01

Giusto Trevisan, Serena Bergamo, Serena Bonin

引用次数: 0