Acta Dermatovenerologica Alpina Pannonica et Adriatica最新文献_第7页

Immunohistochemical expression of vitamin D receptor and Wnt signaling pathway molecules in psoriasis. 银屑病中维生素 D 受体和 Wnt 信号通路分子的免疫组化表达。

IF 1.2

Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2023-12-01

Amina Ismaeel, Fatima Alhashimi, Zainab Almossali, Safa Alshaikh, Samvel Selvam, Duha Janahi

{"title":"Immunohistochemical expression of vitamin D receptor and Wnt signaling pathway molecules in psoriasis.","authors":"Amina Ismaeel, Fatima Alhashimi, Zainab Almossali, Safa Alshaikh, Samvel Selvam, Duha Janahi","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Psoriasis is a prevalent, complex, immune-mediated illness. There is some evidence in the literature supporting the involvement of the Wnt signaling pathway in psoriasis. No previous studies have focused on the association between the Wnt signaling pathway and vitamin D receptor (VDR) expression in psoriasis. This study investigates the expression of VDR and mediators of the canonical (β-catenin) and non-canonical (Wnt5a) Wnt signaling pathway in psoriatic lesional skin biopsy specimens compared to controls.Methods: A cross-sectional study conducted on skin punch biopsy specimens from 42 psoriasis patients were stained with VDR, β-catenin, and Wnt5a and compared with 42 control biopsies. Patients' demographics, clinical data, and serum vitamin D levels were recorded.Results: VDR showed nuclear localization with significant downregulation in the psoriasis specimens compared to controls. β-catenin (membranous) and Wnt5a (cytoplasmic) showed significant upregulation in the psoriasis specimens. When the expressions of VDR, β-catenin, and Wnt5a were compared based on disease severity, no differences were found between mild, moderate, and severe subgroups of the disease. Late-onset psoriasis patients had lower VDR and Wnt5a histoscores compared to the early-onset group. A trend toward a positive correlation was observed between the histoscores of VDR and Wnt5a.Conclusion: Our findings confirm the significance of VDR signaling in the pathophysiology of psoriasis and strengthen the relationship between this disease and the Wnt signaling pathway. There was evidence that there is an association between VDR status and Wnt5a expression.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"32 4","pages":"129-133"},"PeriodicalIF":1.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138832189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in trichotillomania: a narrative review. 毛发增多症的最新进展：叙述性综述。

IF 1.2

Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2023-12-01

Rachel E Christensen, Isabella Tan, Mohammad Jafferany

引用次数: 0

A dermatological perspective: eosinophilic eruption of hematoproliferative disease as a clinical and histological dilemma. 皮肤病学视角：血液增生性疾病的嗜酸性粒细胞爆发是临床和组织学难题。

IF 1.2

Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2023-12-01

Tijana Orlic, Snezana Minic, Emilija Manojlovic-Gacic, Dubravka Zivanovic, Igor Kapetanovic

{"title":"A dermatological perspective: eosinophilic eruption of hematoproliferative disease as a clinical and histological dilemma.","authors":"Tijana Orlic, Snezana Minic, Emilija Manojlovic-Gacic, Dubravka Zivanovic, Igor Kapetanovic","doi":"","DOIUrl":"","url":null,"abstract":"The emergence of de novo or recurrent cutaneous eruptions in individuals with hematological diseases presents a challenge when determining whether they indicate secondary dissemination or an unrelated diagnosis. Eosinophilic eruption of hematoproliferative disease is a rare nonspecific manifestation accompanying lymphoproliferative disorders, including chronic lymphocytic leukemia (CLL). We present the case of a 70-year-old man with CLL in remission (previously treated with two 6-month cycles of fludarabine-cyclophosphamide plus rituximab, 2 and 5 years earlier) with an acute, disseminated polymorphic skin eruption. Skin biopsies from two sites (bulla and infiltrated nodule) were taken for histopathological examination. The pathologist reported giant spongiform vesicle formation with eosinophils with dermal and hypodermal inflammatory infiltrate composed of lymphocytes (predominantly T cells, fewer B cells) and eosinophils. Secondary neoplasm dissemination and sarcoidosis were excluded by means of immunohistochemistry. A diagnosis of eosinophilic eruption of hematoproliferative disease in the CLL patient post-chemotherapy and without active disease was established. Two weeks after skin remission, the patient worsened with enlarged lymph nodes and a leukocyte count of 291 × 10^9/l. CLL relapse was confirmed. Leukocytapheresis was performed and ibrutinib 140 mg three times daily was prescribed. Our case underscores the importance of recognizing this relatively common but underreported eosinophilic eruption associated with hematoproliferative diseases.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"32 4","pages":"183-186"},"PeriodicalIF":1.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138832182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous manifestations of the COVID-19 pandemic in schoolchildren and adolescents. 学龄儿童和青少年的 COVID-19 皮肤表现。

IF 1.2

Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2023-12-01

Daniela Franulić, Ena Parać, Lorena Dolački, Iva Topalušić, Liborija Lugović-Mihić

{"title":"Cutaneous manifestations of the COVID-19 pandemic in schoolchildren and adolescents.","authors":"Daniela Franulić, Ena Parać, Lorena Dolački, Iva Topalušić, Liborija Lugović-Mihić","doi":"","DOIUrl":"","url":null,"abstract":"This review article focuses on cutaneous manifestations in schoolchildren and adolescents 6 to 18 years old connected with various aspects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, including personal protective equipment (PPE), SARS-CoV-2 infection, and the SARS-CoV-2 vaccine. The use of PPE has been associated with mask-related acne due to microbiome dysbiosis and disruption of skin homeostasis, leading to the emergence of new acne or exacerbation of preexisting acne. Chilblain-like lesions, erythema multiforme-like eruptions, and cutaneous manifestations of multisystem inflammatory syndrome related to SARS-CoV-2 are the most commonly described skin manifestations of SARS-CoV-2 infection. The proposed mechanisms involve either the direct interaction of the virus with the skin through cutaneous receptor angiotensin-converting enzyme 2 in the epidermal basal layer or hyperactive immune responses. The impact of SARS-CoV-2 infection has also been described on adnexa, including hair changes such as alopecia areata and telogen effluvium, as well as nail changes presenting as onychomadesis and periungual desquamation. Cutaneous adverse effects of the SARS-CoV-2 vaccine have been described in case reports and differ from those in adults. Therefore, there is a need for increased awareness regarding the most prevalent cutaneous manifestations associated with COVID-19 in children because they tend to be mild or nonspecific in nature.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"32 4","pages":"173-181"},"PeriodicalIF":1.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138832185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pembrolizumab-induced lichen planus in patients with metastatic melanoma: a report of two cases and prognostic implications of cutaneous immune-related adverse events. Pembrolizumab诱导的转移性黑色素瘤患者扁平苔藓：两例报告和皮肤免疫相关不良事件的预后影响。

IF 1.2

Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2023-09-01

Tanja Tirnanić, Danica Tiodorović, Nataša Vidović, Mirjana Balić, Nenad Petrov, Lidija Kandolf, Željko Mijušković

{"title":"Pembrolizumab-induced lichen planus in patients with metastatic melanoma: a report of two cases and prognostic implications of cutaneous immune-related adverse events.","authors":"Tanja Tirnanić, Danica Tiodorović, Nataša Vidović, Mirjana Balić, Nenad Petrov, Lidija Kandolf, Željko Mijušković","doi":"","DOIUrl":"","url":null,"abstract":"Patients receiving immune checkpoint inhibitors (ICIs) commonly experience cutaneous immune-related adverse events (irAEs). We present two cases, a 51-year-old female and a 70-year-old male, that were undergoing treatment with pembrolizumab for metastatic melanoma and developed scaly, erythematous papules on their skin. Following skin biopsies, histological analysis confirmed the diagnosis of lichen planus. In the first patient, acitretin at a dosage of 25 mg/day was administered for 6 months, resulting in complete resolution of lichen lesions. Imaging scans showed no signs of melanoma. The second patient was treated with topical betamethasone dipropionate ointment for several weeks, which led to a favorable therapeutic response. During follow-up, a thoracic CT scan showed several micronodular lesions in the right lung, whereas brain and abdomen CT scans showed no signs of the disease. Lichen planus is not a commonly reported irAE in patients treated with ICIs. This report underscores the importance of conducting skin biopsies in patients receiving ICI therapy and highlights the potential prognostic importance of skin irAEs in patients with melanoma receiving such treatment.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"32 3","pages":"119-122"},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41147812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the incidence of anogenital warts and serological test results for other sexually transmitted infections. 分析肛门生殖器疣的发病率和其他性传播感染的血清学检测结果。

IF 1.2

Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2023-09-01

Neşe Göçer Gürok

{"title":"Analysis of the incidence of anogenital warts and serological test results for other sexually transmitted infections.","authors":"Neşe Göçer Gürok","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Anogenital warts (AGWs) are proliferative lesions mainly presenting in the anal, genital, and perianal regions. They are one of the most prevalent sexually transmitted infections globally.Methods: The study included patients that presented at the Dermatology Clinic of Health Sciences, University Elaziğ, Fethi Sekin City Hospital between January 2019 and December 2022 and were diagnosed with AGWs. Patients that presented with this diagnosis and were screened for other sexually transmitted infections (HBsAg, anti-HBs, anti-HCV, anti-HIV, VDRL, and TPHA) were identified. Epidemiological and demographic patient data and the results of serological tests for other sexually transmitted infections in the last 4 years were analyzed. The patient data and examination results were collected retrospectively based on the hospital automated patient records.Results: AGW incidence was significantly higher in males. The mean patient age was 32, and the mean female patient age was lower than that of males. It was observed that the number of patients that were followed up with an AGW diagnosis increased significantly during the last 4 years (p < 0.05). The study detected 2.2% HBsAg, 0.6% TPHA, 0.3% VDRL, 0.5% anti-HCV, and 56.5% anti-HBs positivity. No anti-HIV-positive patients were identified. None of the patients had more than one sexually transmitted infection on serology testing.Conclusions: Although the serological findings were higher when compared to certain studies and quite low when compared to others, it would be beneficial to evaluate all patients with AGWs for other sexually transmitted infections.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"32 3","pages":"83-86"},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41143254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and efficacy of intralesional injection of enalapril versus triamcinolone acetonide in the treatment of keloids. 依那普利与曲安奈德病灶内注射治疗瘢痕疙瘩的安全性和有效性。

IF 1.2

Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2023-09-01

Basma Hamada Mohamed, Samar Eltahlawy, Walaa Ahmed Marzouk, Noha E Mohamad

{"title":"Safety and efficacy of intralesional injection of enalapril versus triamcinolone acetonide in the treatment of keloids.","authors":"Basma Hamada Mohamed, Samar Eltahlawy, Walaa Ahmed Marzouk, Noha E Mohamad","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Keloids are pathologic conditions characterized by fibroblast hyper-proliferation and excess collagen deposition. Enalapril, one of the angiotensin-converting enzyme inhibitors, has recently been highlighted as a new therapeutic modality in treating keloids. This study evaluates the effectiveness of intralesional injection of enalapril versus triamcinolone acetonide (TAA) in keloids.Methods: Forty patients with multiple keloids were enrolled in our study. Enalapril and TAA were injected intralesionally in one session per month for three sessions. The clinical outcomes were assessed via the Vancouver Scar Scale (VSS) and the Patient and Observer Scar Assessment Scale (POSAS).Results: In both groups, according to VSS and POSAS, there was a high statistically significant difference (p-value ≤ 0.01) before treatment, at the end of each session, and 3 months after treatment. There was no significant difference between both groups regarding degree of improvement. Patients treated with TAA developed more significant complications than those in the enalapril group (p-value < 0.05).Conclusions: Both enalapril and TAA had the same clinical effect. Enalapril could be a safe alternative to steroids in the treatment of keloid and hypertrophic scars. Further studies on enalapril are needed on a large sample of patients with further focus on the mechanism of this innovative drug.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"32 3","pages":"77-81"},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41137456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular epidemiology of the 2022 monkeypox virus outbreak in Slovenia. 斯洛文尼亚2022年猴痘病毒爆发的分子流行病学。

IF 1.2

Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2023-09-01

Katarina Resman Rus, Samo Zakotnik, Martin Sagadin, Nataša Knap, Alen Suljič, Tomaž Mark Zorec, Maja Mastnak, Miroslav Petrovec, Mario Poljak, Misa Korva, Tatjana Avšič-Županc

{"title":"Molecular epidemiology of the 2022 monkeypox virus outbreak in Slovenia.","authors":"Katarina Resman Rus, Samo Zakotnik, Martin Sagadin, Nataša Knap, Alen Suljič, Tomaž Mark Zorec, Maja Mastnak, Miroslav Petrovec, Mario Poljak, Misa Korva, Tatjana Avšič-Županc","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Monkeypox virus (MPXV), typically endemic in West and Central Africa, has raised global concern due to the recent outbreak in several non-endemic countries with human-to-human transmission. Here we present a comprehensive analysis of MPXV genomes from Slovenia.Methods: Two real-time polymerase chain reaction (RT-PCR) assays for Orthopoxvirus (OPV) and MPXV genes were used for laboratory confirmation of mpox. Complete MPXV genomic sequences were obtained using nanopore long reads and Illumina technology. Phylogenetic analyses compared the Slovenian MPXV sequences with the global sequences.Results: A total of 49 laboratory-confirmed mpox cases were diagnosed in Slovenia in 2022, mainly affecting males under 40. In 48 cases, a complete genome sequence was obtained and phylogenetic analysis revealed five distinct lineages (B.1, B.1.14, B.1.2, B.1.3, and A.2.1), with B.1 and B.1.3 dominating, suggesting multiple introductions into Slovenia. Genome analysis revealed significant divergence from the reference MPXV-M5312_HM12_Rivers.Conclusions: The genetic diversity observed in the Slovenian MPXV sequences sheds light on the complex dynamics of the 2022 mpox outbreak and highlights the need for further research to understand the impact of mutations on MPXV functional characteristics and their role in the evolution and diversification of current lineages.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"32 3","pages":"111-117"},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41152011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HIV-1 subtype diversity and phylogenetic insight into non-B subtype transmission in Slovenia, 1989-2013. 1989-2013年斯洛文尼亚HIV-1亚型多样性和对非B亚型传播的系统发育洞察。

IF 1.2

Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2023-09-01

Jana Mlakar, Maja M Lunar, Ana B Abecasis, Anne-Mieke Vandamme, Janez Tomažič, Tomaž D Vovko, Blaž Pečavar, Gabriele Turel, Mario Poljak

{"title":"HIV-1 subtype diversity and phylogenetic insight into non-B subtype transmission in Slovenia, 1989-2013.","authors":"Jana Mlakar, Maja M Lunar, Ana B Abecasis, Anne-Mieke Vandamme, Janez Tomažič, Tomaž D Vovko, Blaž Pečavar, Gabriele Turel, Mario Poljak","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Disease progression, drug resistance mutations, and treatment strategies may vary by HIV-1 subtype. This study determined HIV-1 subtypes circulating in Slovenia, a Central European country with an HIV-1 epidemic driven by men who have sex with men, focusing on molecular epidemiology of non-B subtypes.Methods: A total of 367 HIV-1 sequences were included. Subtype was assigned by employing eight different HIV subtyping tools coupled with maximum likelihood phylogenetic analyses.Results: The subtyping tools COMET, jpHMM, and REGA 3.0 exhibited the best performance on the dataset studied. Phylogenetic analyses showed a 14.7% prevalence of non-B subtypes, with subtype A detected most frequently (4.9%), followed by CRF02_AG (2.4%), subtype C (1.1%), subtypes D, G, and CRF01_AE (0.8% each), and subtypes F and CRF22_01A1 (0.3% each). A subtype could not be assigned to 12 sequences (3.3%), indicating potential unique recombinant forms. Non-B subtypes were significantly associated with a heterosexual route of transmission and infection acquired in Eastern Europe, Africa, or Asia.Conclusion: In a country where subtype B is predominant, non-B subtypes were observed in one out of seven patients, a non-negligible proportion, which underlines the importance of systematic surveillance of HIV subtype diversity and the corresponding molecular epidemiology.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"32 3","pages":"99-110"},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41160356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thirty years of Acta Dermatovenerologica Alpina Pannonica et Adriatica: from the journal's beginnings to an impact factor. 《Alpina Pannonica et Adriatica皮肤病学杂志》三十年：从该杂志的创办到影响因素。

IF 1.2

Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2023-09-01

Jovan Miljković, Anja Šterbenc

引用次数: 0