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Erythema exudativum multiforme-like exanthema in a patient with Q fever: a case report and literature review. Q热并发多形性渗出性红斑1例并文献复习。
IF 1.2
Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2023-06-01
Nika Jutraž, Borut Žgavec, Violeta Hosta, Svjetlana Ponorac
{"title":"Erythema exudativum multiforme-like exanthema in a patient with Q fever: a case report and literature review.","authors":"Nika Jutraž,&nbsp;Borut Žgavec,&nbsp;Violeta Hosta,&nbsp;Svjetlana Ponorac","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Q fever is a rare worldwide zoonosis, caused by the rickettsial bacteria Coxiella burnetii. There are many clinical manifestations of infection, but the most common ones are fever, atypical pneumonia, and/or liver disease. Cutaneous involvement, however, is not a typical feature of Q fever, but it is nevertheless present in up to 20% of cases. We present a 42-year-old male patient with Q fever and erythema exudativum multiforme (EEM)-like parainfectious exanthema, which to the best of our knowledge has not been described before. We recommend considering Coxiella burnetii infection in the differential diagnosis of an EEM-like rash in a patient with an unexplained or \"query\" fever.</p>","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"32 2","pages":"67-70"},"PeriodicalIF":1.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9692909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exanthematous lichen planus in a child and Mycoplasma pneumoniae: a case report and literature review. 儿童扁平苔疹伴肺炎支原体:1例报告并文献复习。
IF 1.2
Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2023-06-01
Olga Točkova, Marija Boljanović, Borut Žgavec, Svjetlana Ponorac
{"title":"Exanthematous lichen planus in a child and Mycoplasma pneumoniae: a case report and literature review.","authors":"Olga Točkova,&nbsp;Marija Boljanović,&nbsp;Borut Žgavec,&nbsp;Svjetlana Ponorac","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lichen planus (LP) is a chronic inflammatory disease of the skin and mucous membranes. The disease usually affects adults and is only rarely encountered in children. Typically, skin lesions include violaceous, polygonal, flat papules and plaques, affecting predilection sites such as the wrists, ankles, and lower back. However, clinical presentation can be heterogeneous and is often atypical in children. Various precipitating factors are known to play an important role in the pathogenesis of lichen planus, some of which may also be coincidental. LP occurring after an infection with Mycoplasma pneumoniae is a rare occurrence. We present the case of a 13-year-old boy with pruritic papular skin lesions on the extremities and trunk. In view of the clinical and histopathological findings, LP exanthematicus was diagnosed. To the best of our knowledge, our case is the first of pediatric exanthematous LP after M. pneumoniae infection that has been reported so far.</p>","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"32 2","pages":"63-66"},"PeriodicalIF":1.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9695892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum survivin in acne versus post-acne scarring and the possible effect of isotretinoin therapy on its level. 痤疮患者血清生存素与痤疮后瘢痕形成及异维甲酸治疗对其水平的可能影响。
IF 1.2
Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2023-03-01 DOI: 10.15570/actaapa.2023.2
T. Hussein, Nourane Tawfik Abdelsalam Tawfik, Mennatullah Mohamed Abbas Abd-Rabboh, Alsayeda A A Taha
{"title":"Serum survivin in acne versus post-acne scarring and the possible effect of isotretinoin therapy on its level.","authors":"T. Hussein, Nourane Tawfik Abdelsalam Tawfik, Mennatullah Mohamed Abbas Abd-Rabboh, Alsayeda A A Taha","doi":"10.15570/actaapa.2023.2","DOIUrl":"https://doi.org/10.15570/actaapa.2023.2","url":null,"abstract":"INTRODUCTION Acne vulgaris is a common chronic inflammatory disorder of the pilosebaceous unit. Survivin is an apoptosis inhibitor protein, and it contributes crucially to cell cycle regulation. This study measures the serum level of survivin in acne and post-acne scarring patients, and assesses the possible effect of isotretinoin therapy on its level. METHODS Sixty participants, including 40 acne patients (Group IA, IB), and 20 age- and sex-matched controls (Group II) were included. Group IA included 20 patients with active moderate-to-severe acne without scarring, and this group was further prescribed oral isotretinoin therapy for 3 months. Group IB included 20 patients with post-acne scarring of a duration not more than 6 months, without evident active acne lesions. Serum survivin levels were measured in the three groups using an enzyme-linked immunosorbent assay. RESULTS There was a statistically significant higher serum survivin level in the acne scar group, followed by the active acne group, than in controls. In addition, there was a statistically significant reduction in survivin levels after treatment, and it was positively correlated with a reduction in the global acne grading system (GAGS) in the active acne group. CONCLUSIONS Survivin may play a role in the evolution of acne and acne scarring, and it could be a possible target for isotretinoin therapy.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"58 1","pages":"7-10"},"PeriodicalIF":1.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85093976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dermoscopy: the ultimate tool for diagnosis of nail psoriasis? A review of the diagnostic utility of dermoscopy in nail psoriasis. 皮肤镜检查:指甲银屑病的终极诊断工具?皮肤镜检查在甲癣诊断中的应用综述。
IF 1.2
Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2023-03-01 DOI: 10.15570/actaapa.2023.3
A. Yorulmaz
{"title":"Dermoscopy: the ultimate tool for diagnosis of nail psoriasis? A review of the diagnostic utility of dermoscopy in nail psoriasis.","authors":"A. Yorulmaz","doi":"10.15570/actaapa.2023.3","DOIUrl":"https://doi.org/10.15570/actaapa.2023.3","url":null,"abstract":"Dermoscopy is a highly practical noninvasive diagnostic tool. Several dermoscopic algorithms have been proposed in the evaluation of skin diseases, which allow clinicians not only to identify and make differential diagnosis, but also to determine the treatment choices in challenging clinical circumstances. Over the years, we have witnessed a rapid increase in the utilization of dermoscopy in the assessment of nail disorders. However, to assess the diagnostic utility of dermoscopy in inflammatory nail diseases, current evidence is insufficient. Nail psoriasis is a significant challenge because of the difficulties in its diagnosis. Detection of nail involvement is of utmost importance in psoriasis because it is highly associated with arthritis, which is an indication for systemic treatment. Dermoscopy holds promise as a potential tool in the diagnosis of nail psoriasis, capable of providing characteristic clinical findings without any delay and discomfort. This review summarizes current evidence regarding the unique dermoscopic features of nail psoriasis. It addresses whether dermoscopy may serve as the gold-standard diagnostic tool, excluding the necessity of histopathological examination for the ultimate diagnosis of nail psoriasis.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"12 1","pages":"11-15"},"PeriodicalIF":1.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89531268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Primary biliary cholangitis-cause or association with psoriasis: a case report. 原发性胆道胆管炎与牛皮癣相关:1例报告。
IF 1.2
Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2023-03-01 DOI: 10.15570/actaapa.2023.6
Patricija Tomše, Valerija Balkovec
{"title":"Primary biliary cholangitis-cause or association with psoriasis: a case report.","authors":"Patricija Tomše, Valerija Balkovec","doi":"10.15570/actaapa.2023.6","DOIUrl":"https://doi.org/10.15570/actaapa.2023.6","url":null,"abstract":"Primary biliary cholangitis is a chronic progressive cholestatic granulomatous and destructive inflammatory lesion of small intralobular and septal bile ducts that primarily affects women. The exact etiology of this disease has not yet been elucidated; however, it is believed to be the result of a combination of environmental triggers in genetically predisposed individuals. It can manifest itself simultaneously with, before, or after the onset of psoriasis and other skin autoimmune diseases. Standard treatment is ursodeoxycholic acid. A 65-year-old patient presenting with elevated hepatic laboratory findings that had persisted for several years and normal abdominal ultrasound was additionally diagnosed with primary biliary cholangitis after 2 years on a biological drug for psoriasis. She did not have other symptoms except elevated liver tests. The skin showed a strong response to biological therapy and treatment with ursodeoxycholic acid prompted lowering of liver enzymes. The skin was clear all throughout the treatment. This article emphasizes the importance of additional diagnostic workups in patients with psoriasis and elevated hepatic laboratory findings.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"58 1","pages":"23-26"},"PeriodicalIF":1.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77180648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Treatment of periorbital syringomas with intradermal botulinum toxin A monotherapy versus carbon dioxide laser: a case report. 皮内肉毒杆菌毒素A单药治疗与二氧化碳激光治疗眼眶周围注射器瘤1例报告。
IF 1.2
Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2023-03-01 DOI: 10.15570/actaapa.2023.4
Sheila Hustadi Budiawan, A. Arimuko, L. Norawati, A. Madjid, W. Widita
{"title":"Treatment of periorbital syringomas with intradermal botulinum toxin A monotherapy versus carbon dioxide laser: a case report.","authors":"Sheila Hustadi Budiawan, A. Arimuko, L. Norawati, A. Madjid, W. Widita","doi":"10.15570/actaapa.2023.4","DOIUrl":"https://doi.org/10.15570/actaapa.2023.4","url":null,"abstract":"Syringomas are eccrine-derived benign adnexal neoplasms with the highest prevalence in early adulthood. They predominantly occur in females. They are commonly located on the face, particularly the lower eyelids, which have a high demand for cosmetic enhancement. Periorbital syringomas continue to pose a therapeutic challenge, with no consistently effective treatment available. Intradermal injection of botulinum toxin A is one of the new treatment modalities for periorbital syringomas. We report a case of periorbital syringomas in a 53-year-old female patient successfully treated using intradermal botulinum toxin A monotherapy as a painless cost-effective treatment that produced better long-term results than carbon dioxide laser.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"23 1","pages":"17-18"},"PeriodicalIF":1.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82226125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Linear IgA bullous dermatosis in an acute myeloid leukemia patient: a rare case report. 急性髓系白血病患者线状IgA大疱性皮肤病:罕见病例报告。
IF 1.2
Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2023-03-01
Deisy Vania Kianindra, Amelia Rosa, Dina Pebriany, Wiwiek Dewiyanti, Asnawi Madjid
{"title":"Linear IgA bullous dermatosis in an acute myeloid leukemia patient: a rare case report.","authors":"Deisy Vania Kianindra,&nbsp;Amelia Rosa,&nbsp;Dina Pebriany,&nbsp;Wiwiek Dewiyanti,&nbsp;Asnawi Madjid","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Linear IgA bullous dermatosis (LABD) is a rare autoimmune bullous disease characterized by linear IgA deposition along the skin basal membrane. In children, LABD classically presents with a \"cluster of jewels\" appearance, whereas in adults the classic presentation is itchy papules with tense vesicles and bullae on an erythematous base. We report the case of a 41-year-old woman with LABD that we suspect was induced by acute myeloid leukemia presenting with multiple vesicles and bullae that coalesced, forming the typical clinical manifestation of LABD and confirmed with histopathological and direct immunofluorescence. The patient was treated with a combination of oral and topical corticosteroids with excellent results.</p>","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"32 1","pages":"19-22"},"PeriodicalIF":1.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9161397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of periorbital syringomas with intradermal botulinum toxin A monotherapy versus carbon dioxide laser: a case report. 皮内肉毒杆菌毒素A单药治疗与二氧化碳激光治疗眼眶周围注射器瘤1例报告。
IF 1.2
Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2023-03-01
Sheila Hustadi Budiawan, Abraham Arimuko, Lilik Norawati, Asnawi Madjid, Widya Widita
{"title":"Treatment of periorbital syringomas with intradermal botulinum toxin A monotherapy versus carbon dioxide laser: a case report.","authors":"Sheila Hustadi Budiawan,&nbsp;Abraham Arimuko,&nbsp;Lilik Norawati,&nbsp;Asnawi Madjid,&nbsp;Widya Widita","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Syringomas are eccrine-derived benign adnexal neoplasms with the highest prevalence in early adulthood. They predominantly occur in females. They are commonly located on the face, particularly the lower eyelids, which have a high demand for cosmetic enhancement. Periorbital syringomas continue to pose a therapeutic challenge, with no consistently effective treatment available. Intradermal injection of botulinum toxin A is one of the new treatment modalities for periorbital syringomas. We report a case of periorbital syringomas in a 53-year-old female patient successfully treated using intradermal botulinum toxin A monotherapy as a painless cost-effective treatment that produced better long-term results than carbon dioxide laser.</p>","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"32 1","pages":"17-18"},"PeriodicalIF":1.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9169792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alterations in the spatiotemporal expression pattern of geminin during human epidermal morphogenesis. 人表皮形态发生过程中双联蛋白时空表达模式的变化。
IF 1.2
Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2023-03-01
Efstathia Pasmatzi, Alexandra Monastirli, Zoi Lygerou, Stavros Taraviras, Stavros Kakkos, George Stamatiou, Dionysios Tsambaos
{"title":"Alterations in the spatiotemporal expression pattern of geminin during human epidermal morphogenesis.","authors":"Efstathia Pasmatzi,&nbsp;Alexandra Monastirli,&nbsp;Zoi Lygerou,&nbsp;Stavros Taraviras,&nbsp;Stavros Kakkos,&nbsp;George Stamatiou,&nbsp;Dionysios Tsambaos","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Geminin, a (25 kDa) protein, was originally identified as a key regulator of DNA replication licensing in the cell cycle and of cell fate during embryonic nervous system formation. Although geminin is involved in mechanisms underlying the regulation of transcription and patterning in embryonic development, its expression and possible significance in human epidermal morphogenesis remains unknown.</p><p><strong>Methods: </strong>Forty-one skin biopsy specimens obtained from human fetuses (10th to 23rd week of estimated gestational age) were processed for immunohistochemistry using a primary rabbit polyclonal antibody against geminin.</p><p><strong>Results: </strong>Distinct and statistically significant qualitative and quantitative alterations in the spatiotemporal expression pattern of geminin were observed in the developing human epidermis.</p><p><strong>Conclusions: </strong>The highly ordered expression of geminin in different layers of fetal human epidermis reported here for the first time suggests that this protein may play a significant role in epidermal morphogenesis. However, the mechanisms underlying the alterations of the geminin expression pattern during fetal development at the molecular level remain to be elucidated. Further studies are now warranted to address whether the expression pattern of geminin in the developing human epidermis is disturbed in fetuses with genodermatoses and whether these disturbances might be important for prenatal diagnosis of genodermatoses.</p>","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"32 1","pages":"1-5"},"PeriodicalIF":1.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9526881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alterations in the spatiotemporal expression pattern of geminin during human epidermal morphogenesis. 人表皮形态发生过程中双联蛋白时空表达模式的变化。
IF 1.2
Acta Dermatovenerologica Alpina Pannonica et Adriatica Pub Date : 2023-03-01 DOI: 10.15570/actaapa.2023.1
Efstathia Pasmatzi, A. Monastirli, Z. Lygerou, S. Taraviras, Stavros K. Kakkos, G. Stamatiou, D. Tsambaos
{"title":"Alterations in the spatiotemporal expression pattern of geminin during human epidermal morphogenesis.","authors":"Efstathia Pasmatzi, A. Monastirli, Z. Lygerou, S. Taraviras, Stavros K. Kakkos, G. Stamatiou, D. Tsambaos","doi":"10.15570/actaapa.2023.1","DOIUrl":"https://doi.org/10.15570/actaapa.2023.1","url":null,"abstract":"INTRODUCTION\u0000Geminin, a (25 kDa) protein, was originally identified as a key regulator of DNA replication licensing in the cell cycle and of cell fate during embryonic nervous system formation. Although geminin is involved in mechanisms underlying the regulation of transcription and patterning in embryonic development, its expression and possible significance in human epidermal morphogenesis remains unknown.\u0000\u0000\u0000METHODS\u0000Forty-one skin biopsy specimens obtained from human fetuses (10th to 23rd week of estimated gestational age) were processed for immunohistochemistry using a primary rabbit polyclonal antibody against geminin.\u0000\u0000\u0000RESULTS\u0000Distinct and statistically significant qualitative and quantitative alterations in the spatiotemporal expression pattern of geminin were observed in the developing human epidermis.\u0000\u0000\u0000CONCLUSIONS\u0000The highly ordered expression of geminin in different layers of fetal human epidermis reported here for the first time suggests that this protein may play a significant role in epidermal morphogenesis. However, the mechanisms underlying the alterations of the geminin expression pattern during fetal development at the molecular level remain to be elucidated. Further studies are now warranted to address whether the expression pattern of geminin in the developing human epidermis is disturbed in fetuses with genodermatoses and whether these disturbances might be important for prenatal diagnosis of genodermatoses.","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"69 1","pages":"1-5"},"PeriodicalIF":1.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87204652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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