Tzu Chi Medical Journal最新文献_第9页

Inverse association of serum osteocalcin and bone mineral density in renal transplant recipients. 肾移植受者血清骨钙素与骨密度的负相关。

IF 1.5

Tzu Chi Medical Journal Pub Date : 2023-04-01 DOI: 10.4103/tcmj.tcmj_55_22

Wei-Chen Lin, Ming-Che Lee, Yen-Cheng Chen, Bang-Gee Hsu

{"title":"Inverse association of serum osteocalcin and bone mineral density in renal transplant recipients.","authors":"Wei-Chen Lin, Ming-Che Lee, Yen-Cheng Chen, Bang-Gee Hsu","doi":"10.4103/tcmj.tcmj_55_22","DOIUrl":"https://doi.org/10.4103/tcmj.tcmj_55_22","url":null,"abstract":"Objectives: Osteocalcin, a protein from osteoblasts, affects bone mineralization and turnover. This study evaluates the association between fasting serum osteocalcin and bone mineral density (BMD) in renal transplant recipients.Materials and methods: This study recruited 66 renal transplant recipients. We analyzed blood biochemistry studies from fasting blood samples. The serum osteocalcin levels were measured using a commercial enzyme immunoassay kit. We measure BMD by dual-energy X-ray absorptiometry in lumbar vertebrae (L2-L4). By the World Health Organization classification, we group recipients into three groups: normal, osteopenia, and osteoporosis.Results: Of the renal transplant recipients, 8 patients (12.1%) were osteoporosis, and 28 patients (42.4%) were osteopenia. From normal to osteoporosis groups, the osteoporosis group has highest serum osteocalcin (P < 0.001), alkaline phosphatase (P = 0.005), lowest body mass index (P = 0.015), and body weight (P = 0.008). Females had lower lumbar BMD than males among recruited renal transplant recipients (P = 0.023). In the multivariate forward stepwise linear regression analysis, body weight (adjusted R2 change = 0.138; P = 0.010), and logarithmically transformed osteocalcin (log-osteocalcin; adjusted R2 change = 0.131; P = 0.012) can predict lumbar BMD in the renal transplant recipients.Conclusion: Our study showed that fasting serum osteocalcin concentration was negatively correlated with the lumbar BMD in renal transplant recipients.","PeriodicalId":45873,"journal":{"name":"Tzu Chi Medical Journal","volume":"35 2","pages":"165-170"},"PeriodicalIF":1.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c6/1d/TCMJ-35-165.PMC10227676.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9567426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Changes of lower urinary tract function after robot-assisted radical prostatectomy: An urodynamic follow-up within 1 year. 机器人辅助根治性前列腺切除术后下尿路功能的变化:1年内的尿动力学随访。

IF 1.5

Tzu Chi Medical Journal Pub Date : 2023-04-01 DOI: 10.4103/tcmj.tcmj_96_22

Yuan-Hong Jiang, Hann-Chorng Kuo

{"title":"Changes of lower urinary tract function after robot-assisted radical prostatectomy: An urodynamic follow-up within 1 year.","authors":"Yuan-Hong Jiang, Hann-Chorng Kuo","doi":"10.4103/tcmj.tcmj_96_22","DOIUrl":"https://doi.org/10.4103/tcmj.tcmj_96_22","url":null,"abstract":"Objectives: This study investigated the changes of lower urinary tract function after robot-assisted radical prostatectomy (RaRP) with 1-year urodynamic follow-up.Materials and methods: Clinically localized prostate cancer patients receiving RaRP were prospectively enrolled. We analyzed their clinical symptoms, stress urinary incontinence (SUI) and urge urinary incontinence (UUI) status, and videourodynamic studies (VUDSs) during the postoperative 1st year.Results: In total, 74 patients were enrolled with a mean age of 69.4 ± 8.1 years, a mean total prostate volume of 34.7 ± 15.9 mL, a ≥pT3 stage proportion of 37.8%, and a positive surgical margin rate of 18.9%. The International Prostate Symptom Score significantly reduced from 7.3 ± 6.0 before surgery to 4.1 ± 4.1 at postoperative 1 year. Significantly increased full sensation, reduced detrusor voiding pressure, increased maximal urinary flow rate, and decreased bladder outlet obstruction index were noted at 1-year VUDS follow-up. The changes of VUDS parameters were significantly different between the patients with and without preoperative bladder outlet obstruction. At postoperative 1 year, 8.1% and 6.8% of patients experienced SUI and UUI, respectively. In multivariate analysis, the factors of T stage ≥3, preoperative detrusor overactivity (DO), and positive surgical margin were the independent predictors of immediate SUI and SUI at 3 and 12 months, respectively.Conclusion: During the 1st year after RaRP, patients experienced significant changes of lower urinary tract function demonstrated in VUDS with the improvement in clinical symptoms. Factors of T stage ≥3, preoperative DO, and positive surgical margin were the predictors of postoperative SUI.","PeriodicalId":45873,"journal":{"name":"Tzu Chi Medical Journal","volume":"35 2","pages":"158-164"},"PeriodicalIF":1.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b7/ae/TCMJ-35-158.PMC10227689.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9565966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application and future perspectives of gastric cancer technology based on artificial intelligence. 基于人工智能的胃癌技术的应用及未来展望。

IF 1.5

Tzu Chi Medical Journal Pub Date : 2023-04-01 DOI: 10.4103/tcmj.tcmj_305_22

Jyun-Guo Wang

引用次数: 0

Left ventricular diastolic reserve by exercise stress echocardiography in prediabetes. 运动应激超声心动图对前驱糖尿病患者左室舒张储备的影响。

IF 1.5

Tzu Chi Medical Journal Pub Date : 2023-04-01 DOI: 10.4103/tcmj.tcmj_151_22

Abdulameer Jasim Jawad Al-Gburi

{"title":"Left ventricular diastolic reserve by exercise stress echocardiography in prediabetes.","authors":"Abdulameer Jasim Jawad Al-Gburi","doi":"10.4103/tcmj.tcmj_151_22","DOIUrl":"https://doi.org/10.4103/tcmj.tcmj_151_22","url":null,"abstract":"Objectives: The objective of this study was to evaluate if the diastolic reserve is different in prediabetes versus control during exercise.Materials and methods: During the resting stage and graded supine bicycling exertion (25 W, 3 min increment), the mitral inflow and septal mitral annular velocities were determined in 50 patients with prediabetes (21 females, mean age 48 ± 16 years) and 50 gender- and age-matched controls. None demonstrated rest or inducible cardiac ischemia on echocardiography.Results: Between the two study groups, the velocities of the mitral inflow (E) and septal mitral annulus (E') at rest are not significantly different. E' during exercise, on the other hand, was significantly lower in individuals with prediabetes than in controls (8.57 ± 2.46 vs. 9.82 ± 2.42 cm/s at 25 W, P = 0.012; 9.42 ± 1.93 vs. 11.15±2.97 cm/s at 50 W, P = 0.001). E/E' behaves oppositely during exercise with a value that is significantly higher in patients with prediabetes.Conclusion: The diastolic reserve of the left ventricle, as determined by the change in E' and E/E' throughout exercise, is abnormal in individuals with prediabetes who do not have overt cardiac disease. Using exercise stress echocardiography may be helpful for the early recognition of subclinical diastolic dysfunction in prediabetics which may have clinical repercussions in the future.","PeriodicalId":45873,"journal":{"name":"Tzu Chi Medical Journal","volume":"35 2","pages":"188-192"},"PeriodicalIF":1.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/12/33/TCMJ-35-188.PMC10227684.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9565964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The rs568408 variant in the IL-12A gene is associated with risk for COVID-19 in Iraqi patients. IL-12A基因中的rs568408变异与伊拉克患者患COVID-19的风险有关。

IF 1.5

Tzu Chi Medical Journal Pub Date : 2023-04-01 DOI: 10.4103/tcmj.tcmj_223_22

Falah Hasan Obayes Al-Khikani, Zaytoon Abdulridha Alkhafaji

{"title":"The rs568408 variant in the IL-12A gene is associated with risk for COVID-19 in Iraqi patients.","authors":"Falah Hasan Obayes Al-Khikani, Zaytoon Abdulridha Alkhafaji","doi":"10.4103/tcmj.tcmj_223_22","DOIUrl":"https://doi.org/10.4103/tcmj.tcmj_223_22","url":null,"abstract":"Objectives: The objective of the current study was to check the link between potential polymorphism in IL12A rs568408 and the possible risk of COVID-19 in the Iraqi population.Materials and methods: Allele specific-polymerase chain reaction (PCR) technique was carried out for genotyping and detection of IL12A rs568408 gene polymorphism in a case-control study of 125 severe COVID-19 cases and 60 controls. Patients were admitted to either Marjan medical city or Al-Sadeq hospital's COVID-19 wards between January and June 2022 in Iraq. The diagnosis of COVID-19 in each patient was confirmed by severe acute respiratory coronavirus 2-positive reverse transcription-PCR.Results: The distribution of both genotyping and allele frequencies of IL-12A rs568408 revealed significant differences between patients and control groups (P = 0.006 and P = 0.001, respectively). The IL12A rs568408 AA and AG variant genotypes were associated with a significantly increased risk of COVID-19 (odds ratio [OR] = 5.19, 95% confidence interval [CI]: 1.13-23.82; P = 0.034) and (OR = 2.39, 95% CI = 1.16-4.94, P = 0.018), respectively, compared with the wild-type GG homozygote.Conclusion: These findings indicate that IL12A rs568408 GA/AA variant may contribute to the risk of COVID-19. This study is the first report about the association of IL12A rs568408 with COVID-19.","PeriodicalId":45873,"journal":{"name":"Tzu Chi Medical Journal","volume":"35 2","pages":"152-157"},"PeriodicalIF":1.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4a/f4/TCMJ-35-152.PMC10227677.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9559043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Orthopedic implant hypersensitivity: Characterization of clinical presentation and effects of photobiomodulation therapy. 骨科植入物过敏:临床表现和光生物调节治疗效果的表征。

IF 1.5

Tzu Chi Medical Journal Pub Date : 2023-04-01 DOI: 10.4103/tcmj.tcmj_255_22

Ro-Wei Wu, Chung-Hsing Chang

{"title":"Orthopedic implant hypersensitivity: Characterization of clinical presentation and effects of photobiomodulation therapy.","authors":"Ro-Wei Wu, Chung-Hsing Chang","doi":"10.4103/tcmj.tcmj_255_22","DOIUrl":"https://doi.org/10.4103/tcmj.tcmj_255_22","url":null,"abstract":"Objectives: Orthopedic implants have improved the quality of life in aging society but also induces several kinds of tissue reactions, referred to as orthopedic implant hypersensitivity (OIH). The aim of our study is to report the clinical characteristics of OIH and the effects of photobiomodulation therapy (PBMT) on these groups of patients.Materials and methods: We collected cases that complained of skin rashes with pruritus after orthopedic implants from January 2017 to June 2022 at the Dermatology clinic in Hualien Tzu Chi Hospital. We recorded the sites and material of orthopedic implants, skin lesions onset time, symptoms, location after implantation, and the disease duration. Laboratory tests were measured, including complete blood count, differential count, serum immunoglobulin E (IgE) level, as well as inflammatory and autoimmune markers. PBMT, including UVB311 nm or low-level laser therapy 808 nm, was performed. Dose, duration, and response were documented.Results: Fourteen patients were diagnosed with OIH; twelve presented with localized eczema at the implant sites, and two with generalized eczema. Eleven patients (78.6%) had either elevated eosinophils percentage (>6%) or IgE level (>200 U/mL) or both. Seven patients (50%) had favorable outcome after PBMT and successfully withdrew from systemic steroid.Conclusion: In our case series, localized eczema at implant sites was a common cutaneous presentation in OIH. Hence, a surgical scar at the eczema site or long-term waxing and waning generalized eczema should prompt physicians on the possibility of OIH. Blood eosinophils percentage and serum IgE level can be reference biomarkers for OIH. PBMT provides a noninvasive and effective treatment strategy for immune regulation and tissue regeneration.","PeriodicalId":45873,"journal":{"name":"Tzu Chi Medical Journal","volume":"35 2","pages":"176-181"},"PeriodicalIF":1.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bc/4b/TCMJ-35-176.PMC10227683.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9571331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application and future perspectives of gastric cancer technology based on artificial intelligence 基于人工智能的胃癌技术的应用及未来展望

Tzu Chi Medical Journal Pub Date : 2023-02-22 DOI: 10.4103/tcmj.tcmj-305-22

Jyun-Guo Wang

引用次数: 0

The clinical application of intravesical botulinum toxin A injection in patients with overactive bladder and interstitial cystitis. 膀胱内注射A型肉毒毒素治疗膀胱过动性间质性膀胱炎的临床应用。

IF 1.5

Tzu Chi Medical Journal Pub Date : 2023-01-01 DOI: 10.4103/tcmj.tcmj_313_21

Yuan-Hong Jiang, Jia-Fong Jhang, Hann-Chorng Kuo

{"title":"The clinical application of intravesical botulinum toxin A injection in patients with overactive bladder and interstitial cystitis.","authors":"Yuan-Hong Jiang, Jia-Fong Jhang, Hann-Chorng Kuo","doi":"10.4103/tcmj.tcmj_313_21","DOIUrl":"https://doi.org/10.4103/tcmj.tcmj_313_21","url":null,"abstract":"Botulinum toxin A (BoNT-A) has been widely used in several urological functional disorders including neurogenic detrusor overactivity (NDO), overactive bladder (OAB), lower urinary tract dysfunction, and interstitial cystitis/bladder pain syndrome (IC/BPS). Chronic inflammation is found in a large proportion of patients with OAB and IC/BPS. The chronic inflammation activates sensory afferents which resulting in central sensitization and bladder storage symptoms. Because BoNT-A can inhibit the sensory peptides released from the vesicles in sensory nerve terminals, the inflammation can be reduced and symptom subsided. Previous studies have demonstrated that the quality of life improved after BoNT-A injections, both in neurogenic and non-NDO. Although the use of BoNT-A in treatment of IC/BPS has not been approved by FDA, intravesical BoNT-A injection has been included in the AUA guideline as the fourth line therapy. Generally, intravesical injections of BoNT-A are well tolerated, though transient hematuria and urinary tract infection can occur after the procedure. In order to prevent these adverse events, experimental trials have been conducted to test if BoNT-A can be delivered into the bladder wall without intravesical injection under anesthesia such as using liposomes encapsulated BoNT-A or application of low energy shock wave on the bladder to facilitate BoNT-A penetrating across the urothelium and treat OAB or IC/BPS. This article reviews current clinical and basic researches of BoNT-A on OAB and IC/BPS.","PeriodicalId":45873,"journal":{"name":"Tzu Chi Medical Journal","volume":"35 1","pages":"31-37"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/02/31/TCMJ-35-31.PMC9972932.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9389135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Diagnostic and therapeutic roles of iron oxide nanoparticles in biomedicine. 氧化铁纳米颗粒在生物医学中的诊断和治疗作用。

IF 1.5

Tzu Chi Medical Journal Pub Date : 2023-01-01 DOI: 10.4103/tcmj.tcmj_65_22

Chia-Hung Lu, Jong-Kai Hsiao

{"title":"Diagnostic and therapeutic roles of iron oxide nanoparticles in biomedicine.","authors":"Chia-Hung Lu, Jong-Kai Hsiao","doi":"10.4103/tcmj.tcmj_65_22","DOIUrl":"https://doi.org/10.4103/tcmj.tcmj_65_22","url":null,"abstract":"Nanotechnology changed our understanding of physics and chemics and influenced the biomedical field. Iron oxide nanoparticles (IONs) are one of the first emerging biomedical applications of nanotechnology. The IONs are composed of iron oxide core exhibiting magnetism and coated with biocompatible molecules. The small size, strong magnetism, and biocompatibility of IONs facilitate the application of IONs in the medical imaging field. We listed several clinical available IONs including Resovist (Bayer Schering Pharma, Berlin, Germany) and Feridex intravenous (I.V.)/Endorem as magnetic resonance (MR) contrast agents for liver tumor detection. We also illustrated GastroMARK as a gastrointestinal contrast agent for MR imaging. Recently, IONs named Feraheme for treating iron-deficiency anemia have been approved by the Food and Drug Administration. Moreover, tumor ablation by IONs named NanoTherm has also been discussed. In addition to the clinical application, several potential biomedical applications of IONs including cancer-targeting capability by conjugating IONs with cancer-specific ligands, cell trafficking tools, or tumor ablation agents have also been discussed. With the growing awareness of nanotechnology, further application of IONs is still on the horizon that would shed light on biomedicine.","PeriodicalId":45873,"journal":{"name":"Tzu Chi Medical Journal","volume":"35 1","pages":"11-17"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0a/3f/TCMJ-35-11.PMC9972926.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10827926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Medical comorbidities as predictors of COVID-19 short-term mortality: A historical cohort study in Indonesia. 医学合并症作为COVID-19短期死亡率的预测因素:印度尼西亚的一项历史队列研究

IF 1.5

Tzu Chi Medical Journal Pub Date : 2023-01-01 DOI: 10.4103/tcmj.tcmj_144_22

Rizaldy Taslim Pinzon, Vanessa Veronica

{"title":"Medical comorbidities as predictors of COVID-19 short-term mortality: A historical cohort study in Indonesia.","authors":"Rizaldy Taslim Pinzon, Vanessa Veronica","doi":"10.4103/tcmj.tcmj_144_22","DOIUrl":"https://doi.org/10.4103/tcmj.tcmj_144_22","url":null,"abstract":"Objectives: In this study, we aimed to evaluate the relation of comorbidities to coronavirus disease 2019 (COVID-19) short-term mortality.Materials and methods: This was a single-center observational study with a historical cohort method at Bethesda Hospital Yogyakarta, Indonesia. COVID-19 diagnosis was made using reverse transcriptase-polymerase chain reaction on nasopharyngeal swabs. Patient data were obtained from digital medical records and used for Charlson Comorbidity Index assessments. Inhospital mortality was monitored throughout their hospital stay.Results: This study enrolled 333 patients. According to the total number of comorbidities in Charlson, 11.7% (n = 39) of patients had no comorbidities; 30.9% (n = 103) of patients had one comorbidity; 20.1% (n = 67) of patients had two comorbidities; and 37.2% (n = 124) of patients had more than three comorbidities. In multivariate analysis, these variables were significantly related to short-term mortality in COVID-19 patients: older age (odds ratio [OR] per year: 1.64; 95% confidence interval [CI]: 1.23-2.19; P 0.001), myocardial infarction (OR: 3.57; 95% CI: 1.49-8.56; P: 0.004), diabetes mellitus (OR: 2.41; 95 CI: 1.17-4.97; P: 0.017), renal disease (OR: 5.18; 95% CI: 2.07-12.97; P < 0.001), and longer duration of stay (OR: 1.20; 95% CI: 1.08-1.32; P < 0.001).Conclusion: This study revealed multiple short-term mortality predictors in COVID-19 patients. The coexistence of cardiovascular disease, diabetes, and renal problem is a significant predictor of short-term mortality in COVID-19 patients.","PeriodicalId":45873,"journal":{"name":"Tzu Chi Medical Journal","volume":"35 1","pages":"53-57"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c9/dd/TCMJ-35-53.PMC9972924.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9389130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1