JGH Open最新文献

{"title":"Self-Injection Satisfaction and Safety of CT-P17 (Yuflyma), a High-Concentration Adalimumab Biosimilar, in Patients With Crohn's Disease: A Cross-Sectional Study","authors":"Fei Yang Pan,&nbsp;Thanaboon Chaemsupaphan,&nbsp;Sacha Cartwright,&nbsp;Rupert Leong","doi":"10.1002/jgh3.70230","DOIUrl":"https://doi.org/10.1002/jgh3.70230","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>CT-P17 (Yuflyma), a biosimilar to adalimumab (Humira), offers a cost-effective alternative with improved access for individuals with immune-mediated inflammatory diseases (IMIDs). Assessing patient experience with autoinjector usability and comfort is crucial for ensuring adherence and satisfaction. This study is the first to evaluate patient-reported satisfaction and safety of CT-P17 specifically in people with Crohn's disease (CD).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To evaluate patient satisfaction and safety of CT-P17 in CD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional study included 15 adults (median age 39.9 years) with CD from two Australian hospitals. All participants had prior experience with biologic therapy and used an autoinjector. Patients had either transitioned from adalimumab to CT-P17 or had been receiving CT-P17 for at least 4 weeks. Data collected included baseline demographics, the Harvey Bradshaw Index (HBI), and the Self-Injection Assessment Questionnaire (SIAQ), a validated instrument assessing patient experience, confidence, and satisfaction with self-injection. SIAQ domain scores ranged from 0 (worst) to 10 (best), with higher scores indicating more positive self-injection experiences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>SIAQ scores indicated positive patient experiences. Mean (SD) scores showed high comfort (8.33 ± 1.67), strong self-confidence (8.38 ± 1.53), positive self-image (9.00 ± 2.64), minimal pain/skin reactions (9.22 ± 0.93), and ease of use (8.80 ± 1.89). Overall satisfaction was high (8.76 ± 1.38). HBI scores remained low (mean 0.7), indicating stable disease control.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>CT-P17 is well-tolerated in CD patients, with high satisfaction and minimal injection discomfort. Its ergonomic autoinjector design supports ease of use. While larger studies are needed, these findings support the broader adoption of adalimumab biosimilars to enhance patient autonomy and reduce healthcare costs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"9 8","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70230","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144716615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Efficacy of Flupentixol-Melitracen for Treatment of Aerophagia in Adults: A Single-Center Parallel Randomized Controlled Trial","authors":"Sen-lin Zhu,&nbsp;Ping Li,&nbsp;Hui-wen Xu,&nbsp;Sheng Yao,&nbsp;Lin-lin Huang","doi":"10.1002/jgh3.70199","DOIUrl":"https://doi.org/10.1002/jgh3.70199","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study was designed to evaluate the efficacy and safety of short-term flupentixol-melitracen in adult patients with aerophagia through a single-center parallel randomized controlled trial.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Eligible patients were randomly divided into three groups based on the order of subjects. Each group consisted of 30 patients (15F/15M) who received 2 weeks of treatment. Groups 1, 2, and 3 were treated with itopride hydrochloride, flupentixol-melitracen, and the combination of two medicines, respectively. The mean scores of aerophagia symptom relief measured by the visual analogue scale (VAS) after treatment were used as the endpoints.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 90 patients were eligible for the study, of which 76 completed the 2-week treatment period. The scores indicating improvement of aerophagia by VAS showed significant improvement in Group 2 compared with Group 1 (6.92 ± 2.96 vs. 4.58 ± 4.08, <i>p</i> = 0.016) and Group 3 compared with Group 1 (7.34 ± 3.12 vs. 4.58 ± 4.08, <i>p</i> = 0.006). There was no significant difference between Group 2 and Group 3 (6.92 ± 2.96 vs. 7.34 ± 3.12, <i>p</i> = 0.618). The percentage of patients exhibiting scores indicating improvement of aerophagia by VAS ≥ 5 in Group 2 and Group 3 was significantly higher than Group 1 (<i>p</i> = 0.020, <i>p</i> = 0.007). The three groups had similar baseline characteristics and experienced similar non-serious adverse effects during the treatment period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The findings suggest that short-term treatment with flupentixol-melitracen, with or without a prokinetic benzamide derivative, is likely to improve symptoms of aerophagia in adults without significant adverse effects.</p>\u0000 \u0000 <p><b>Trial Registration:</b> ClinicalTrials.gov identifier: ChiCTR-IPR-15006869</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"9 8","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70199","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144716896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Trends in Cardiovascular Mortality in Underlying Viral Hepatitis: A Retrospective Analysis of Gender, Racial/Ethnic, and Regional Disparities","authors":"Wania Sultan,&nbsp;Haider Ashfaq,&nbsp;Hamza Ashraf,&nbsp;Ahmad Khan,&nbsp;Ayman Omair Hashmi,&nbsp;Muhammad Omar Larik,&nbsp;Maheen Zahid,&nbsp;Yasir Majeed,&nbsp;Pratik Bhattarai,&nbsp;Ashujot K. Dang,&nbsp;Ahmed Ali Aziz,&nbsp;Hafiz Muhammad Sharjeel Arshad","doi":"10.1002/jgh3.70235","DOIUrl":"https://doi.org/10.1002/jgh3.70235","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to investigate contemporary trends in mortality related to cardiovascular disease and viral hepatitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective analysis using data from the CDC-WONDER dataset. Our study cohort consisted of adults aged ≥ 15 years, where both cardiovascular disease and viral hepatitis were identified as an underlying or contributory cause of death between 1999 and 2020. Crude and age-adjusted mortality rates (AAMR) per 1 000 000 population were extracted. Joinpoint regression analysis was utilized to calculate annual percentage change (APC) of each trend.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The overall AAMR exhibited a notable increase from 15.2 in 1999 to 24.9 in 2020. However, a recent decline was observed from 2013 to 2020 (APC: −2.1; 95% confidence interval [CI]: −3.4 to 0.65). African Americans experienced the highest mortality rate, surpassing that of Whites by more than twofold (AAMR: 20.3). Middle-aged adults (35–54 years) faced the greatest mortality burden among all other age groups. Urban–rural disparities were significant, with urban areas showing substantially higher AAMRs compared to rural areas. Notably, urban AAMR decreased between 2013 and 2020 (APC: −2.7).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The observed decrease in mortality related to cardiovascular disease and viral hepatitis over the past decade can be attributed to several factors, including heightened awareness and screening efforts, the introduction of novel and improved direct-acting antiviral therapies, and the implementation of integrated public health models.</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"9 8","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70235","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variable Expressivity in Johanson-Blizzard Syndrome: A Case With Severe Manifestations and a Review of the Literature","authors":"Hanaa Ktyman,&nbsp;Dana Chaker,&nbsp;Haya Ahmad,&nbsp;Hazem Kamil,&nbsp;Ali Ajlouni","doi":"10.1002/jgh3.70236","DOIUrl":"https://doi.org/10.1002/jgh3.70236","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Johanson-Blizzard syndrome (JBS) is an exceedingly rare, autosomal recessively inherited disorder. It affects both males and females equally. Exocrine pancreatic insufficiency is the most common finding of the syndrome. The clinical presentation varies significantly among cases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 6-month-old infant was referred due to persistent diarrhea and failure to gain weight. The diagnosis of JBS was made based on family history and medical investigations; pancreatic enzymes (Pancreatin) were the first line of therapy besides the fluids, blood transfusions, and vitamins. The exact cause of death remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This case highlights the severe systemic nature of JBS. Early recognition and comprehensive management are crucial for improving outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"9 8","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70236","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal Ultrasound's New Target: Idiopathic Mesenteric Vein Sclerosing Enteritis","authors":"Qianjiang Luo,&nbsp;Xiaoshan Huang,&nbsp;Zhong Zheng,&nbsp;Luhong Zhu,&nbsp;Mei Luo,&nbsp;Wenxing Zhang,&nbsp;Qinglian Zhong,&nbsp;Jian Huang,&nbsp;Yuhang Zhou,&nbsp;Jin Li,&nbsp;Wanjie Zhu","doi":"10.1002/jgh3.70217","DOIUrl":"https://doi.org/10.1002/jgh3.70217","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>As a rare clinical entity within the non-thrombotic ischemic colitis spectrum, idiopathic mesenteric phlebosclerotic colitis (IMPC) has been increasingly recognized to exhibit a pathogenic correlation with extended herbal medicine consumption.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 48-year-old female complained of abdominal pain for over 3 years was diagnosed IMPC and concurrent <i>Entamoeba coli</i> infection. The patient underwent non-targeted pharmacotherapy, which yielded poor results. In this case, we introduced a non-invasive diagnostic tool, gastrointestinal ultrasound (GIUS), to assist in the diagnosis. Additionally, we observed this patient developed opportunistic infections of the gastrointestinal tract, a phenomenon that appears to be associated with compromised immune function and reduced microbial defense capabilities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Gastrointestinal ultrasound was introduced to assist in diagnosis of IMPC in this case. Currently, treatment options for severe IMPC are limited, highlighting the need for further research into its mechanisms and therapeutic approaches.</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"9 7","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70217","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With the Severity of Chronic Constipation Among Japanese University Students","authors":"Nhu Thi Hanh Vu,&nbsp;Huong Tu Lam,&nbsp;Shunsuke Miyauchi,&nbsp;Naoki Ishiuchi,&nbsp;Atsuo Yoshino,&nbsp;Yoshie Miyake,&nbsp;Shiro Oka,&nbsp;Yuri Okamoto,&nbsp;Duc Trong Quach,&nbsp;Shinji Tanaka,&nbsp;Toru Hiyama","doi":"10.1002/jgh3.70218","DOIUrl":"https://doi.org/10.1002/jgh3.70218","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>Chronic constipation (CC) is a prevalent gastrointestinal disorder in which individuals with more severe CC significantly decrease their quality of life and often require more active medical intervention. This study aimed to identify the rate and risk factors associated with moderate-to-severe CC among Japanese university students.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional study was conducted among university students diagnosed with CC according to the Rome IV criteria at Hiroshima University, Hiroshima, Japan. The online questionnaire collected data on demographics, lifestyle habits, family history of constipation, and psychological assessments via the Beck Depression Inventory, Eating Attitudes Test-26, and Bulimic Investigatory Test. CC severity was classified based on the Bristol Stool Form Scale (BSFS), spontaneous bowel movements (SBM), and associated symptoms. Multivariate logistic regression analysis was performed to determine independent risk factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 779 CC participants, 47% were classified as having moderate-to-severe CC. Independent risk factors associated with moderate-to-severe CC included age of CC onset &lt; 18 years (OR: 1.374, 95% CI: 1.017–1.857), female sex (OR: 1.444, 95% CI: 1.058–1.969), family history of CC (OR: 1.449, 95% CI: 1.072–1.958), and sleep duration ≤ 6 h per day (OR: 1.350, 95% CI: 1.011–1.802).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Moderate-to-severe CC was highly common among Japanese students with CC, and risk factors included early onset, female sex, family history of CC, and short sleep duration. These findings suggest that early diagnosis and development of management strategies may be needed to enhance the quality of life and health outcomes of affected individuals.</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"9 7","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70218","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Genetic Variation on Drug Response in Adult IBD: A Systematic Review","authors":"Masomeh Askari,&nbsp;Shaghayegh Baradaran Ghavami,&nbsp;Nayeralsadat Fatemi,&nbsp;Mahya Haghipanah,&nbsp;Nesa Kazemifard,&nbsp;Hamid Asadzadeh Aghdaei,&nbsp;Makan Cheraghpour,&nbsp;Hamid Mahdizadeh,&nbsp;Shabnam Shahrokh,&nbsp;Mehdi Totonchi","doi":"10.1002/jgh3.70172","DOIUrl":"https://doi.org/10.1002/jgh3.70172","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>A major characterization of inflammatory bowel disease (IBD) is significant heterogeneity in treatment responses. Despite the increase in therapeutic agents, discovering an optimal patient-level treatment is still a major milestone. This study aims to provide a systematic review of the existing literature on the predictive biomarkers of the response to IBD treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>On April 15, 2025, a literature search was conducted using the PubMed and Scopus databases, as well as a manual search. Controlled trials, case–control studies, cross-sectional studies, and cohort studies addressing predictive biomarkers for treatment response in adults with IBD were eligible for inclusion. The CASP tool was used to assess the quality of the methodologies employed in the included research. Due to a lack of information and expected heterogeneity, a qualitative study was planned instead of a quantitative one.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 7570 identified articles, 31 met the inclusion criteria. DNA markers were assessed as predictive biomarkers. The majority of studies attempted to predict the response to anti-TNF drugs. There is significant variability across studies in both the definition of response and the considered biomarkers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>At the moment, no biomarker provides sufficient predictive ability for clinical practice. Thus, we are still in the early stages of the quest for predictive biomarkers, and existing literature is lacking. Future studies should address the large heterogeneity among patients within prospective trials by conducting objective response evaluations. Prediction models are likely to be developed by combining multiple molecular markers from integrated omics levels and clinical characteristics.</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"9 7","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70172","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Risk Prediction of Advanced Colorectal Neoplasia Among Diabetic Patients: A Derivation and Validation Study”","authors":"","doi":"10.1002/jgh3.70213","DOIUrl":"https://doi.org/10.1002/jgh3.70213","url":null,"abstract":"<p>M. C. S. Wong, E. Y. M. Leung, H. H. X. Wang, and J. Huang. “Risk Prediction of Advanced Colorectal Neoplasia Among Diabetic Patients: A Derivation and Validation Study,” <i>JGH Open</i> 8, no. 5 (2024): e13062, https://doi.org/10.1002/jgh3.13062.</p><p>The authors would like to correct the authorship of their paper by adding Sarah Tsz Yui Yau, who contributed to the analysis of this project, to the author list.</p><p>This update to the author list has also been made on the article directly.</p><p>We apologize for this error.</p>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"9 7","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Fiber Intake Enhances Clostridia Bacteria and Reduces Clinical Relapse in Patients With Clinically Quiescent Inflammatory Bowel Disease: A Prospective Longitudinal Study","authors":"Julajak Limsrivilai,&nbsp;Phalat Sathirawich,&nbsp;Onuma Sattayalertyanyong,&nbsp;Pornpoj Pramyothin,&nbsp;Iyarit Thaipisuttikul,&nbsp;Nonthalee Pausawasdi,&nbsp;Phunchai Charatcharoenwitthaya,&nbsp;Rungnapha Sarasak,&nbsp;Perapon Nitayanon,&nbsp;Phutthaphorn Phaophu,&nbsp;Nichcha Subdee,&nbsp;Sathaporn Manatsathit","doi":"10.1002/jgh3.70219","DOIUrl":"https://doi.org/10.1002/jgh3.70219","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>A high-fiber, low-animal-protein, and low-saturated-fat diet may modulate gut dysbiosis and benefit inflammatory bowel disease (IBD). This study investigated the effects of this diet on clinical relapses, fecal calprotectin, and gut microbiota in patients with clinically quiescent IBD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Sixty-one patients with IBD were enrolled (23 Crohn's disease and 38 ulcerative colitis). All patients were in clinical remission and had maintained unchanged treatment for at least 2 months. They were advised to increase fiber intake and decrease animal protein and saturated fat consumption. Assessments were performed at baseline, week 6, and every 12 weeks until flare or study completion at 54 weeks. Fecal calprotectin and microbiota were analyzed at baseline and upon study completion. The effect of each dietary component on outcomes was analyzed separately.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The cumulative flare rate was 22.6%. Increased fiber intake was significantly associated with a lower incidence of clinical flares. Flare rates were 12.6%, 20.5%, and 46.5% in the increased, unchanged, and decreased fiber intake groups, respectively, with significant differences between the increased and decreased groups (<i>p</i> = 0.03). Fecal calprotectin, however, was not significantly different in those who increased fiber intake compared to those who did not. Microbiota analysis showed a significant increase in the Clostridia class in the increased fiber intake group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Increasing dietary fiber increased Clostridia class bacteria and was associated with a longer time to flare in patients with clinically quiescent IBD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"9 7","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70219","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the Link Between GERD and Hypertension: Coincidence or Causal Connection?","authors":"Maryam AlAlawi,&nbsp;Sanjiv Mahadeva","doi":"10.1002/jgh3.70234","DOIUrl":"https://doi.org/10.1002/jgh3.70234","url":null,"abstract":"<p>Gastroesophageal reflux disease (GERD) and hypertension (HTN) are prevalent conditions that pose significant health challenges globally.</p><p>The prevalence of GERD is increasing, with pooled rates varying by geographic region. Several risk factors—such as age, alcohol consumption, BMI, pregnancy, education level, marital status, and medication use—contribute to its rise. As a result, GERD is now recognized not just as a gastrointestinal disorder but as a condition with systemic implications affecting multiple body systems [<span>1</span>]. GERD has also been observed to occur alongside metabolic syndrome and cardiovascular disease [<span>2</span>]. GERD symptoms can range from heartburn, dry cough, vomiting, hoarseness, and chest pain to difficulty swallowing, among others. This wide variety of symptoms can make diagnosis challenging or delayed, particularly because they may also indicate other gastrointestinal conditions such as eosinophilic esophagitis, functional dyspepsia, and gastroparesis [<span>3</span>]. Although lifestyle modifications and dietary changes are the primary treatments for GERD, some patients do not respond to these approaches and may require medications like antacids or proton pump inhibitors. In more severe cases, endoscopic or surgical interventions may be necessary.</p><p>Hypertension is the most significant preventable risk factor for cardiovascular disease (CVD) and overall mortality globally [<span>4</span>]. This is primarily due to an aging population, unhealthy diets high in salt, and insufficient physical activity. Hypertension may be discovered incidentally or, in some cases, may present with symptoms such as headaches or complications like myocardial infarction, stroke, kidney failure, and other related conditions. The growing availability of various antihypertensive medications may have played a role in stabilizing or reducing the prevalence of hypertension in recent decades.</p><p>Although previous studies indicate a potential association between GERD and hypertension, the results have been inconsistent, with some studies reporting conflicting outcomes.</p><p>Hypertension was found to be linked to a 1.5-fold increased risk of developing GERD [<span>5</span>]. Considering hypertension as an inflammatory condition has prompted research into the involvement of vascular and other organ inflammation in its development. One suggested mechanism involves systemic inflammatory responses associated with GERD [<span>6</span>].</p><p>Two studies published in JGH Open have recently explored this relationship further. Bushi et al. [<span>7</span>] conducted a systematic review and meta-analysis to examine the relationship between GERD and hypertension, aiming to clarify the findings of earlier studies. The evidence was derived from observational studies with varying designs, including retrospective cohort, cross-sectional, and prospective approaches; however, this may limit the ability to establish a definitive associa","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"9 7","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70234","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}