JGH Open最新文献

{"title":"Prevalence and Risk Factors of Celiac Disease in Patients With Non-Alcoholic Fatty Liver Disease: A Meta-Analysis","authors":"Narsimha Rao Keetha,&nbsp;Pegah Rashidian,&nbsp;Micah Fleischman,&nbsp;Fatemeh Mohammadyari,&nbsp;Michael T. Ulrich,&nbsp;Seyyed Mohammad Hashemi,&nbsp;Kiran Sandilya Balivada,&nbsp;Mohammad Amin karimi,&nbsp;Negin Letafatkar,&nbsp;Ehsan Amini-Salehi,&nbsp;Sandeep Samethadka Nayak","doi":"10.1002/jgh3.70434","DOIUrl":"10.1002/jgh3.70434","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant public health issue due to its close association with metabolic abnormalities. Concurrently, celiac disease (CD), an autoimmune disorder triggered by gluten, has been increasingly investigated in connection with various chronic conditions. Given the potential link between these two conditions, this systematic review and meta-analysis aimed to determine the prevalence of CD in individuals diagnosed with NAFLD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive literature search was performed in multiple databases including PubMed, Scopus, Embase, and Web of Science. Studies were considered eligible if they reported clear data regarding CD prevalence among NAFLD populations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Pooled data analysis revealed an overall CD prevalence of 3.8% (95% CI: 0.02–0.07) among NAFLD patients, with significant heterogeneity observed (<i>I</i>² = 97.36%, <i>p</i> &lt; 0.01). Further subgroup analyses demonstrated variations in CD prevalence related to disease characteristics; notably, the prevalence was higher among patients specifically evaluated for CD using serological and histological methods. Exploratory stratified analyses indicated that CD was more prevalent in patients with NAFLD who had lower body mass index (BMI), higher levels of aspartate aminotransferase (AST), lower hemoglobin (HB) concentrations, and reduced platelet (PLT) counts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The findings from this meta-analysis suggest a higher-than-expected prevalence of CD among patients with NAFLD, though the substantial heterogeneity across studies limits the precision of this estimate. These findings indicate that clinicians may consider selective screening for CD, particularly in patients presenting with specific clinical features. However, given the exploratory nature of the subgroup analyses and the variability in diagnostic approaches across included studies, larger prospective studies with standardized diagnostic criteria are needed to confirm these observations and better elucidate the relationship between these two conditions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"10 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13287081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Internet Advertising Approach to Raise Public Awareness About Metabolic Dysfunction-Associated Steatotic Liver Disease","authors":"Kaori Inoue,&nbsp;Kaoru Araki,&nbsp;Kaoru Shibayama,&nbsp;Tomomi Yada,&nbsp;Nagisa Hara,&nbsp;Satoshi Oeda,&nbsp;Kazuma Udo,&nbsp;Shohei Tobu,&nbsp;Shun Yamashita,&nbsp;Hiroshi Isoda,&nbsp;Yuichiro Eguchi,&nbsp;Keizo Anzai,&nbsp;Mitsuru Noguchi,&nbsp;Hirokazu Takahashi","doi":"10.1002/jgh3.70436","DOIUrl":"https://doi.org/10.1002/jgh3.70436","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Metabolic dysfunction-associated steatotic liver disease (MASLD), causing cirrhosis and liver cancer, is prevalent worldwide. Analyses of internet searches for “fatty liver” and methods to raise MASLD awareness are needed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively analyzed co-occurring terms with “fatty liver” and tracked search histories to identify key terms. In a comparative study, a banner advertisement about MASLD was shown to individuals searching for key terms (key term group: KTG) or regardless of the search terms (control group: CTR). The ad redirected viewers to an educational cartoon, followed by a questionnaire.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The most frequent co-occurrence term was “how to treat.” People searched mainly for lifestyle-related disease and diet terms. Key terms included “diet,” “blood sugar level,” “cholesterol,” “triglyceride,” “visceral fat,” and “antihypertensive drugs.” Banner views were 5 864 184 for KTG and 49 388 176 for CTR. KTG had a higher click-through rate than CTR (0.097% vs. 0.063%; <i>p</i> &lt; 0.001) and more survey responses (3.22% vs. 0.84%; <i>p</i> &lt; 0.001). KTG participants also had a greater intention to seek medical care early (60.2% vs. 42.4%; <i>p</i> = 0.003).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Search term-based advertising may help increase public awareness of MASLD and may encourage earlier intention to seek medical consultation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"10 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70436","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148282636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Lymph Node Metastasis Risk in Patients With Mucosal Gastric Cancer: A Comparison of the WHO and Japanese Criteria and Implications for Endoscopic Submucosal Dissection","authors":"Jane Chungyoon Kim,&nbsp;Yo-Seok Cho,&nbsp;Yoonjin Kwak,&nbsp;Seong-Ho Kong,&nbsp;Do Joong Park,&nbsp;Soo-Jeong Cho,&nbsp;Hyuk-Joon Lee,&nbsp;Hye Seung Lee,&nbsp;Han-Kwang Yang","doi":"10.1002/jgh3.70432","DOIUrl":"https://doi.org/10.1002/jgh3.70432","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>Endoscopic submucosal dissection (ESD) is an established treatment for early gastric cancer. However, concerns remain regarding the risk of lymph node metastasis (LNM) under expanded criteria and its applicability across different populations. This study assessed LNM risk in patients with mucosal gastric cancer using WHO and Japanese criteria.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study included 2232 patients with mucosal gastric cancer who underwent curative gastrectomy. Clinicopathological factors, including tumor size, histological type, ulceration, and lymphovascular invasion (LVI), were analyzed. Independent risk factors for LNM were identified through multivariate logistic regression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>LNM occurred in 3.5% of the patients. Undifferentiated-type (UD-type) tumors within the updated ESD criteria (size ≤ 2 cm, without ulceration) had a 2.1% LNM occurrence rate. In contrast, differentiated-type (D-type) tumors (no ulceration with size &gt; 2 cm or presence of ulceration with size ≤ 3 cm) showed 3.3% and 1.4% LNM occurrence rates, respectively. The pattern of lymph node metastasis at each station indicated that D1+ lymph node dissection is sufficient for mucosal gastric cancers. Multivariate analysis identified large tumor size, ulceration, UD-type, and LVI as significant LNM risk factors, with UD-type tumors consistently showing higher LNM rates than D-type tumors across different size categories.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings underscore the LNM risk in mucosal gastric cancer under the updated ESD criteria. Individualized treatment and counseling, particularly for young patients with good performance status, are essential. A cautious approach aligning treatment with patient characteristics is recommended.</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"10 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70432","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148282619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MEAT PIES: Mammalian Meat Allergy in Patients Investigated for Gastrointestinal Symptoms","authors":"Elias Bitzer,&nbsp;Peter Bourke,&nbsp;Shihaz Hussain","doi":"10.1002/jgh3.70433","DOIUrl":"10.1002/jgh3.70433","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alpha-gal syndrome (AGS), an IgE-mediated allergy to galactose-α-1,3-galactose acquired via tick bites, often presents with a delayed gastrointestinal (GI) phenotype without anaphylaxis. We evaluated a local diagnostic guideline in a Far North Queensland gastroenterology outpatient clinic.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective quality assurance audit at Cairns Hospital identified serum-specific IgE (ssIgE) requests to alpha-gal 12 months before and 6 months after guideline implementation (12 March 2025). ImmunoCAP ssIgE ≥ 0.1 kU/L was positive.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 19 patients tested, 5 (26%) were sensitized. All had GI-predominant symptoms—most commonly diarrhea (58%) and abdominal pain (53%)—with no anaphylaxis or respiratory features, and negative preliminary investigations including endoscopy. All three patients completing meat avoidance trials had symptom resolution. Diagnostic yield rose from 2/16 (12.5%) to 3/3 (100%) post-guideline, though testing was driven almost exclusively by a single clinician.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The GI phenotype of AGS is present and likely underrecognized in this tick-endemic region. Targeted ssIgE testing after careful clinical assessment yields high diagnostic value, supporting consideration of AGS in unexplained GI symptoms and extending the recognized distribution of the condition.</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"10 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13270493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148273322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Clinical Utility of the Apolipoprotein A2 Isoform Index as a Tumor Marker for Pancreatic Cancer”","authors":"","doi":"10.1002/jgh3.70431","DOIUrl":"10.1002/jgh3.70431","url":null,"abstract":"<p>\u0000 <span>T. Hoshino</span>, <span>M. Mizuide</span>, <span>Y. Suzuki</span>, <span>H. Yasuoka</span>, <span>A. Naganuma</span>, <span>T. Hatanaka</span>, <span>S. Kakizaki</span>, <span>S. Ryozawa</span>, “ <span>Clinical Utility of the Apolipoprotein A2 Isoform Index as a Tumor Marker for Pancreatic Cancer</span>,” <i>JGH Open</i> <span>10</span>, no. <span>3</span> (<span>2026</span>): e70375, https://doi.org/10.1002/jgh3.70375.\u0000 </p><p>In the published version, the second affiliation for the first author, Takashi Hoshino, was inadvertently omitted.</p><p>The correct affiliations for the first author should be as follows:</p><p>Takashi Hoshino^1,2</p><p>¹Department of Gastroenterology, NHO Takasaki General Medical Center, Takasaki, Japan</p><p>²Department of Gastroenterology, Saitama Medical University International Medical Center, Hidaka, Japan</p><p>We apologize for this error.</p>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"10 6","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13246472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148220166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and CT Imaging Features of Chronic Pancreatitis: A Cross-Sectional Study From Vietnam","authors":"Tran Thi Luong Vo,&nbsp;Nguyen Phuoc Ma,&nbsp;Dung Dang Quy Ho,&nbsp;Hoang Huu Bui","doi":"10.1002/jgh3.70430","DOIUrl":"10.1002/jgh3.70430","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Chronic pancreatitis (CP) is a progressive inflammatory condition with insidious and nonspecific symptoms; however, data on its clinical and computed tomography (CT) based characteristics in Vietnam remain limited. This study aimed to characterize the clinical features and contrast-enhanced CT findings of Vietnamese patients with CP and to assess the association between clinical manifestations and morphological severity using the Cambridge classification.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Results</h3>\u0000 \u0000 <p>We conducted a cross-sectional study of patients diagnosed with CP at a tertiary hospital in Ho Chi Minh City, Vietnam. Demographics, risk factors, clinical symptoms, and CT imaging characteristics were recorded. Morphologic severity was graded using the Cambridge system. A total of 160 patients were included; 85.6% were male, with a median age of 50 years. Alcohol-related disease was the predominant etiology (62.5%). Notably, 24.4% had disease onset before 35 years of age, and 33.1% had no prior history of acute pancreatitis. Abdominal pain was the most common symptom (87.5%), followed by weight loss and diabetes mellitus. CT imaging demonstrated advanced structural abnormalities, with pancreatic calcifications in 85.0% of patients, ductal dilatation in 73.1%, and 92.5% classified as Cambridge grade 4. Within this predominantly advanced-stage cohort, no statistically significant association was detected between clinical manifestations and CT-based morphological severity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In this tertiary-center CT-based cohort from Vietnam, CP was characterized by heterogeneous clinical manifestations and predominantly advanced CT abnormalities. The absence of a detectable symptom–severity association in this advanced-stage cohort supports the need for more comprehensive diagnostic approaches to enable earlier recognition of CP.</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"10 6","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13243886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148212703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors Associated With Gastroesophageal Reflux Disease Among Patients Attending Hospitals in Kabul, Afghanistan: A Case–Control Study","authors":"Hashmatullah Shoaib,&nbsp;Mohammad Sayed Behrad,&nbsp;Sayed Hussain Mosawi,&nbsp;Hadia Azami,&nbsp;Ghulam Mujtaba Shoaib,&nbsp;Ahmad Jamshid Mehrpoor,&nbsp;Ahmad Shoaib Omari,&nbsp;Ghulam Yahya Amiry,&nbsp;Mohammad Esmail Ahmadyar,&nbsp;Sayed Shaheen Shah Hashimi,&nbsp;Hedayatullah Ehsan","doi":"10.1002/jgh3.70429","DOIUrl":"https://doi.org/10.1002/jgh3.70429","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder with substantial impact on quality of life and healthcare systems. However, data on factors associated with GERD in Afghanistan remain limited, particularly in urban clinical settings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To identify demographic, lifestyle, and clinical factors associated with GERD among adult patients attending hospitals in Kabul, Afghanistan.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A hospital-based case–control study was conducted between January and December 2025 in three major hospitals in Kabul. A total of 715 participants, including 388 cases with typical GERD symptoms and 327 controls without recent reflux symptoms, were enrolled. Data were collected using a structured interviewer-administered questionnaire covering sociodemographic characteristics, lifestyle factors, anthropometric measurements, and clinical history. Associations were assessed using chi-square tests, followed by univariable and multivariable logistic regression analyses to estimate odds ratios (ORs) and 95% confidence intervals (CIs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean age of GERD cases was 37.55 ± 16.21 years, significantly lower than that of controls (44.21 ± 15.46 years). In multivariable analysis, female sex, age younger than 30 years, employment, cigarette smoking, naswar use, and recent weight gain were independently associated with increased odds of GERD. Recent weight gain showed the strongest association. Body mass index category, marital status, education level, place of residence, and self-reported stress were not independently associated with GERD after adjustment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>GERD among patients attending hospitals in Kabul is strongly associated with modifiable lifestyle and behavioral factors, particularly tobacco use and recent weight gain. Targeted preventive strategies and lifestyle-focused interventions integrated into primary and secondary healthcare services may help reduce the burden of GERD in Afghanistan.</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"10 6","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70429","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148153640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"10 5","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148087468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized Management of Cytopenias in Chronic Liver Disease: From Pathophysiology to Treatment Strategies.","authors":"Xiaoxiao Wang, Shuyan Fu, Xiaohong Zhu, Yanping Zhao","doi":"10.1002/jgh3.70421","DOIUrl":"10.1002/jgh3.70421","url":null,"abstract":"<p><p>Thrombocytopenia and leukopenia are among the most common hematological abnormalities in patients with chronic liver disease (CLD), particularly among those with cirrhosis. Thrombocytopenia and leukopenia are associated with increased risks of bleeding, infection, treatment delay, and poor clinical outcomes. Their pathogenesis is multifactorial, comprising hypersplenism-related sequestration, decreased synthesis of hematopoietic growth factors, such as thrombopoietin, bone marrow suppression, immune-mediated destruction, and systemic inflammation. This review summarizes the current understanding of the mechanisms underlying cytopenias in CLD and discusses available therapeutic strategies, including platelet transfusion, spleen-targeted interventions, thrombopoietin-based treatments, thrombopoietin receptor agonists, and granulocyte colony-stimulating factor. Particular attention is given to the efficacy and safety profiles of these treatment modalities and their potential risks, such as thromboembolic events due to thrombopoietin receptor agonists. Importantly, effective management of cytopenias in CLD should be tailored based on disease severity, etiology of cirrhosis, dominant pathophysiological mechanisms, thrombotic risk, and the urgency of invasive procedures. Integrating these factors into clinical decision-making may improve the outcomes of patients and optimize treatment choices. Future studies should focus on risk-stratified treatment algorithms, long-term safety of emerging agents, and combination therapeutic strategies.</p>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"10 5","pages":"e70421"},"PeriodicalIF":1.6,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13239880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148200513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"10 5","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148087467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}