Follicular Lymphoma Manifesting as an Isolated Colorectal Polyp-Like Morphology

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY

JGH Open Pub Date : 2025-04-30 DOI:10.1002/jgh3.70170

Yasuhiko Hamada, Yuhei Umeda, Hayato Nakagawa

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Abstract

Background

Primary gastrointestinal (GI) follicular lymphoma (FL) is a rare entity, and colorectal FL presenting as a solitary polyp is particularly uncommon.

Case Presentation

A 60-year-old woman presented with hematochezia. Colonoscopy incidentally identified an 8-mm polyp in the transverse colon, which was subsequently removed via cold snare polypectomy. Histopathological examination confirmed Grade 1 FL, with immunohistochemical analysis revealing positivity for CD10, CD20, and Bcl-2. Further diagnostic evaluation demonstrated FL involvement in the proximal jejunum, leading to a diagnosis of clinical stage I primary GI-FL. The patient elected to undergo a watch-and-wait approach.

Conclusion

This case highlights the potential for colorectal-FL lesions to be misidentified as adenomatous polyps, posing a diagnostic challenge.

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滤泡性淋巴瘤表现为孤立的结肠息肉样形态

背景：原发性胃肠道滤泡性淋巴瘤（FL）是一种罕见的疾病，结直肠滤泡性淋巴瘤表现为孤立性息肉尤为罕见。病例表现一名60岁妇女，以便血表现。结肠镜检查偶然发现横结肠一个8毫米息肉，随后通过冷圈套息肉切除术切除。组织病理学检查证实为1级FL，免疫组织化学分析显示CD10， CD20和Bcl-2阳性。进一步的诊断评估显示FL累及空肠近端，导致临床I期原发性GI-FL的诊断。病人选择了观察和等待的方法。结论本病例强调了结直肠fl病变被误诊为腺瘤性息肉的可能性，对诊断提出了挑战。

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