JGH Open最新文献

{"title":"Temporal Trends in Mortality Location Among Patients With Intrahepatic Cholangiocarcinoma in the USA: A Retrospective Observational Analysis of National Center for Health Statistics Mortality Data","authors":"Muhammad Ahmad Nadeem,&nbsp;Abdullah Khan,&nbsp;Ahsan Raza Raja,&nbsp;Usama Hussain Kamal,&nbsp;Abdul Rafeh Awan,&nbsp;Jibran Ikram,&nbsp;Asad Ullah,&nbsp;Marjan Khan,&nbsp;Abu Baker Sheikh,&nbsp;Amir Humza Sohail","doi":"10.1002/jgh3.70182","DOIUrl":"https://doi.org/10.1002/jgh3.70182","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Intrahepatic cholangiocarcinoma (ICC) is a malignancy with rising incidence and mortality in the United States. This study aimed to investigate temporal trends in the place of death among patients with ICC and assess demographic disparities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used the CDC WONDER database (2003–2020) for a retrospective study of patients who died from intrahepatic cholangiocarcinoma identified through death certificates. Place of death was categorized as hospice, home, inpatient, nursing home, or other. Age-adjusted mortality rates were calculated per 100 000. Temporal trends were assessed using the Mann-Kendall trend test, and associations between demographic characteristics and place of death were examined using the <i>χ</i>² test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 101 631 ICC-related deaths (AAMR: 1.61; 95% CI 1.60–1.62), the AAMR rose from 1.19 (95% CI 1.15–1.23) in 2003 to 2.04 (95% CI 2.00–2.08) in 2020. Over the study period, home was the most frequent place of death (44.6%), followed by inpatient facilities (28.4%), hospice (11.1%), and nursing homes (9.5%). Deaths at home and in hospice increased significantly (<i>p</i> &lt; 0.01), while inpatient and nursing home deaths declined (<i>p</i> &lt; 0.01). Disparities were observed across race, sex, age groups, and urbanization. Younger patients more often died in inpatient facilities, and minority racial groups were less likely to die at home or utilize hospice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>ICC-related deaths in the USA nearly doubled over the study period, with a marked shift from inpatient and nursing home deaths to hospice and home. Demographic disparities in end-of-life care underscore the need for targeted interventions to improve equitable access to palliative services.</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"9 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70182","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Lubiprostone as an Adjunct Therapy for Bowel Preparation in Colonoscopy: A Meta-Analysis of Randomized Controlled Trials","authors":"Fariha Hasan,&nbsp;Muhammad Shahzil,&nbsp;Ayesha Liaquat,&nbsp;Fatima Farooqi,&nbsp;Avneet Singh,&nbsp;Alexander Garcia,&nbsp;Muhammad Yafaa Naveed Chaudhary,&nbsp;Dushyant Singh Dahiya,&nbsp;Tanay-Veer Gandhi,&nbsp;Andrew Alabd,&nbsp;Rachel Frank","doi":"10.1002/jgh3.70186","DOIUrl":"https://doi.org/10.1002/jgh3.70186","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The quality of bowel preparation has a significant impact on the success of colonoscopy. Currently, osmotically balanced polyethylene glycol electrolyte (PEG-E) solutions are most commonly used for bowel preparation. Recently, lubiprostone (LBP) has been considered a potentially effective adjunct to PEG. We conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the safety and efficacy of LBP in bowel preparation for colonoscopy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Following PRISMA guidelines, we systematically screened PubMed, Embase, Web of Science, and Cochrane Library for RCTs on LBP as an adjunct to PEG-E for improving bowel preparation quality for colonoscopy. Statistical analysis was performed on RevMan, using a random-effects model with the generic inverse variance method to address clinical heterogeneity; results were significant at <i>p</i> &lt; 0.05. Outcomes were reported as relative risks and standard errors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This meta-analysis included seven RCTs with 1206 patients. Adding LBP did not increase the likelihood of an excellent bowel preparation [RR = 1.28, 95% CI: 0.94–1.74, <i>p</i> = 0.12] or contribute to poor preparation [RR = 0.61, 95% CI: 0.36–1.04; <i>p</i> = 0.07]. It also did not affect procedure time [MD = −0.74, 95% CI: −2.91–1.43; <i>p</i> = 0.50], polyp detection rate [RR = 1.07, 95% CI: 0.90–1.26; <i>p</i> = 0.45], or adenoma detection rate [RR = 1.09, 95% CI: 0.75–1.57; <i>p</i> = 0.66].</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our meta-analysis found that LBP, explored as an adjunct to PEG-E solutions for bowel preparation, offers no significant additive effect on preparation quality before colonoscopy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"9 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70186","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving Trends in Pediatric Inflammatory Bowel Disease Management in Japan: A Decade of Nationwide Data","authors":"Miki Urushiyama,&nbsp;Kunio Tarasawa,&nbsp;Rintaro Moroi,&nbsp;Hideya Iwaki,&nbsp;Yusuke Hoshi,&nbsp;Hiroshi Nagai,&nbsp;Yusuke Shimoyama,&nbsp;Takeo Naito,&nbsp;Fumihiko Kakuta,&nbsp;Hisashi Shiga,&nbsp;Shin Hamada,&nbsp;Yoichi Kakuta,&nbsp;Kiyohide Fushimi,&nbsp;Yoshitaka Kinouchi,&nbsp;Daiki Abukawa,&nbsp;Kenji Fujimori,&nbsp;Atsushi Masamune","doi":"10.1002/jgh3.70175","DOIUrl":"https://doi.org/10.1002/jgh3.70175","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study aimed to investigate the trends in pediatric inflammatory bowel diseases (IBD) management in Japan over the past decade.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively analyzed data from Japan's nationwide database from 2012 to 2022. Patients aged ≤ 15 years diagnosed with Crohn's disease (CD) or ulcerative colitis (UC) were included. Trends in the use of biologics, capsule endoscopy, total parenteral nutrition (TPN), elemental diets, surgery, and granulocyte and monocyte apheresis (GMA) were examined using the Cochrane–Armitage and Jonckheere–Terpstra trend tests.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 8037 and 6153 pediatric UC and CD admissions, respectively, the use of biologics increased significantly (CD: from 46.0% to 53.6%; UC: from 15.0% to 33.0%, <i>p</i> &lt; 0.0001). The use of capsule endoscopy in pediatric patients with CD increased markedly from 6.6% to 16.7% (<i>p</i> &lt; 0.0001), whereas TPN use decreased from 8.4% to 3.0% (<i>p</i> &lt; 0.0001). Surgery rates for patients with CD remained at approximately 5%, whereas those for patients with UC decreased (from 3.7% to 1.7%, <i>p</i> = 0.002). Elemental diets for pediatric patients with CD increased (from 54.4% to 66.2%, <i>p</i> &lt; 0.0001). The use of GMA decreased significantly in patients with UC (from 12.1% to 2.7%, <i>p</i> &lt; 0.0001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The use of biologics and capsule endoscopy has increased in pediatric patients with IBD, whereas the use of more invasive treatments has decreased. These trends suggest a shift toward less invasive and more targeted therapeutic strategies in managing pediatric patients with IBD in Japan.</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"9 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The War in Gaza and Barriers to Inflammatory Bowel Disease Care","authors":"Yotam Elimeleh,&nbsp;Ofer Ben-Bassat,&nbsp;Ariel Benzvi,&nbsp;Eran Zittan","doi":"10.1002/jgh3.70184","DOIUrl":"https://doi.org/10.1002/jgh3.70184","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Stress is associated with inflammatory bowel disease (IBD) development and exacerbation. We evaluated the impact of the war in Gaza on Israeli IBD patients and related barriers to IBD care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Adult IBD patients were blindly enrolled to complete a patient-reported-outcome electronic questionnaire assessing symptoms, hospitalizations, medications, psychosocial factors, economic issues, and adherence to therapy during wartime.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, 526 participants completed the questionnaire, 67% with CD and 33% with UC. Fifty one percent had moderate–severe IBD patients. Compared to central residents, residents of peripheral regions described a higher need for financial support as their main missing aspect in IBD coping (26% vs. 17%), had increased financial difficulties attributed to wartime that led them to skip therapy (21% vs. 9%), and reported increased rates of requiring financial support to purchase biological medications (13% vs. 3%). Compared to mild patients, moderate–severe patients reported significantly more disease aggravations (47% vs. 23%), hospitalizations (16% vs. 2%), greater need for financial support as their main missing aspect in IBD coping (31% vs. 11%), increased financial difficulties attributed to wartime that led them to skip medical therapy (32% vs. 3%), increased rates of missing IBD medical therapy owing to wartime-related stress (34% vs. 11%), and increased daily cannabis use (21% vs. 9%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Periphery-residents with IBD experience more financial difficulties, hospitalizations, and disease exacerbation during wartime. Efforts should be taken to minimize disparities in medical care availability and accessibility, with special emphasis on moderate–severe patients who are more prone to disease aggravations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"9 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70184","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocuff-Assisted Colonoscopy for Identifying Sessile Serrated Polyps and Adenomas During Routine Colorectal Cancer Screening: A Retrospective Cohort Study","authors":"Ammad Javaid Chaudhary,&nbsp;Muhammad Saad Faisal,&nbsp;Abdullah Sohail,&nbsp;Hope Baldwin,&nbsp;Kevin Harris,&nbsp;Muhammad Shahzil,&nbsp;Muhammad Salman Faisal,&nbsp;Avi Toiv,&nbsp;Keith Mullins,&nbsp;Suraj Suresh","doi":"10.1002/jgh3.70173","DOIUrl":"https://doi.org/10.1002/jgh3.70173","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Polyps located in less accessible areas of the colon, such as inner curves of flexures, are often difficult to visualize. Colonoscope attachments such as the Endocuff have been developed to improve the visualization of these polyps. We aimed to assess the utility of Endocuff-assisted colonoscopy (EAC) in the detection of tubular adenomas and sessile serrated polyps (SSP) compared to conventional colonoscopy during routine colorectal cancer screening.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients and Methods</h3>\u0000 \u0000 <p>This retrospective cohort study included patients who underwent colorectal cancer screening with either conventional colonoscopy or EAC between November 2022 and March 2023. The primary outcomes were SSP and tubular adenoma detection rates. Secondary outcomes included total procedure time, cecal intubation time, and ileal intubation rates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 435 patients included, 189 (43%) underwent EAC, and 246 (57%) underwent conventional colonoscopy. The mean ± standard deviation number of polyps detected was 1.7 ± 2.2, the mean procedure time was 18.7 ± 7.5 min, and the mean cecal intubation time was 4.4 ± 3.3 min, with no significant differences between groups. A smaller proportion of patients in the EAC group had successful ileal intubation (14% vs. 55%; <i>p</i> &lt; 0.01). The tubular adenoma detection rate was similar between EAC and conventional colonoscopy (41% vs. 39%; <i>p</i> = 0.70), but the SSP detection rate was significantly higher with EAC (16% vs. 8.5%; <i>p</i> &lt; 0.01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>EAC may enhance the detection of difficult-to-visualize SSPs during screening colonoscopies without affecting overall procedure time. However, physicians should consider the examination indication when selecting EAC, as ileal intubation may be more challenging.</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"9 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70173","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasogastric Delivery of Fecal Microbiota Transplantation for the Treatment of Fulminant Clostridioides difficile Infection: A Case Report","authors":"Amitjeet Singh,&nbsp;Edward Young,&nbsp;Aashish Maurya,&nbsp;Arvind Rajagopalan","doi":"10.1002/jgh3.70177","DOIUrl":"https://doi.org/10.1002/jgh3.70177","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Clostridioides difficile infection (CDI) is a significant cause of antibiotic-associated diarrhea with high morbidity and mortality, particularly in cases of fulminant disease. Fecal microbiota transplantation (FMT) has demonstrated efficacy in treating severe and refractory CDI, typically administered via colonoscopy. However, in cases complicated by toxic megacolon, alternative methods of FMT delivery may be necessary.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Report</h3>\u0000 \u0000 <p>This case report describes a 46-year-old female with cirrhosis and fulminant CDI complicated by toxic megacolon. Due to the patient's hemodynamic instability and contraindications to endoscopic FMT delivery, a novel approach of nasogastric FMT administration was utilized. The patient received a combination of enema-delivered and nasogastric FMT alongside standard antibiotic therapy. This approach resulted in rapid clinical improvement, with resolution of toxic megacolon, normalization of inflammatory markers, and avoidance of colectomy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>This report highlights the successful use of nasogastric FMT in a patient with fulminant CDI, offering a potential alternative delivery route when colonoscopic administration is contraindicated. To our knowledge, this is the first reported case of nasogastric FMT successfully resolving <i>C. difficile</i>-associated toxic megacolon.</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"9 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70177","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balancing Panels: Lets Call on Women Speakers","authors":"Swapna Gayam,&nbsp;Hamsika Moparty,&nbsp;Manya Pala,&nbsp;Shivangi Kothari","doi":"10.1002/jgh3.70178","DOIUrl":"https://doi.org/10.1002/jgh3.70178","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Gender inequality in medical conference speaking is glaring, women are vastly under-represented. Lack of gender diversity in leadership spills into speaking opportunities at conferences, leading to a self-propagating cycle of gender inequality. Breaking this cycle is vital to closing the gap, since speaking at conferences is a key element of academic advancement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This manuscript aims to highlight the paucity of women speakers at medical conferences despite adequate expertise, the importance of bringing balance to the stage and ways to improve visibility of women speakers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Extensive search was conducted for articles on pubmed, google scholar, Science Direct, WVU Library database using manels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Increased visibility of women on stage encourages women attendees and trainees to pursue leadership and speaking opportunities, which is key to “closing the gender gap” for future generations. Gender balanced panels on stage is an important aspect of “Diversity and Inclusion,” which will motivate and encourage other women workforce to follow suit.</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"9 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Wirsungocele Induced Chronic Pancreatitis by Endoscopic Retrograde Cholangiopancreatography and Stent Placement: A Case Report","authors":"Nouraiz Mehmood,&nbsp;Abdul Ahad Riaz,&nbsp;Allahdad Khan,&nbsp;Humaira Siddique,&nbsp;Abdul Sattar Anjum,&nbsp;Mohamed Antar","doi":"10.1002/jgh3.70179","DOIUrl":"https://doi.org/10.1002/jgh3.70179","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Wirsungocele is a rare cystic dilatation of the terminal main pancreatic duct, analogous to choledochocele and santorinicele. It has been associated with recurrent acute or chronic pancreatitis, though its pathogenesis remains unclear. Diagnostic imaging such as MRCP and ERCP plays a pivotal role, and endoscopic intervention is considered the gold standard treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Report</h3>\u0000 \u0000 <p>A 10-year-old boy presented with recurrent abdominal pain and fever since age four, diagnosed repeatedly with acute pancreatitis. Imaging via CT, MRCP, and ERCP revealed focal saccular dilation of the distal pancreatic duct consistent with Wirsungocele, along with pancreatic duct stricture and stones. The patient underwent ERCP with pancreatic sphincterotomy, extraction of cheesy material, and placement of a 5 Fr × 5 cm pancreatic duct stent. Post-procedure, the patient showed marked clinical and radiological improvement with no recurrence of symptoms at one-month follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This case highlights a rare pediatric presentation of Wirsungocele-induced chronic pancreatitis successfully managed with ERCP and stent placement. Early recognition and intervention can lead to significant symptomatic relief and ductal improvement. Further long-term follow-up is necessary to evaluate recurrence and guide future management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"9 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70179","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review and Meta-Analysis of the Effects of Intestinal Microbiota on Liver Disease Using Mendelian Randomization","authors":"Chenyang Xu,&nbsp;Xinrui Li,&nbsp;Hui Wang,&nbsp;Zihan Yue,&nbsp;Linyuan Shen,&nbsp;Jianan He,&nbsp;Zheng Liu,&nbsp;Weiying Zhao","doi":"10.1002/jgh3.70165","DOIUrl":"https://doi.org/10.1002/jgh3.70165","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Objective</h3>\u0000 \u0000 <p>The global incidence of liver diseases is on the rise, and targeting gut microbiota has become a new strategy for treating liver diseases. This study provides a comprehensive and objective analysis of the potential protective role of gut microbiota in liver disease, highlighting the need for continued research in this area.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>After literature screening, 24 related articles were included in the study. After article quality and risk of bias assessment, data extraction and data collation were carried out, and then comprehensive analysis was carried out using stata12.0 software.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>From the perspective of microbial community, most of the microbial communities at the phylum level are risk factors; from the perspective of the top ten families, the intestinal microbial communities play an obvious harmful role in Primary Biliary Cholangitis.From the perspective of disease, the microbial communities at the genus level mostly have protective effects on Chronic Hepatitis B ,Fatty Liver;and Primary Liver Cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Gut microbiota plays a significant role in the occurrence of liver diseases, and different bacterial levels play different roles in the disease.</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"9 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70165","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global and Chinese Burden of Inflammatory Bowel Disease From 1990 to 2021: A Systematic Analysis and Prediction of Disease Burden","authors":"An Luo,&nbsp;Dongying Yao,&nbsp;Miao Wang,&nbsp;Liwen Jin,&nbsp;Zhihua Ran","doi":"10.1002/jgh3.70160","DOIUrl":"https://doi.org/10.1002/jgh3.70160","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Recent shifts in the global epidemiology of inflammatory bowel disease (IBD), particularly in emerging industrialized nations like China, underscore the need for in-depth analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Utilizing the Global Burden Of Disease (GBD) 2021 database, we systematically examined IBD incidence, prevalence, death rates, and disability-adjusted life years (DALYs) across Global, different social development index (SDI) regions, and countries from 1990 to 2021. Age-standardized rates (ASR) and statistical metrics (APC, EAPC, AAPC) were employed to assess trends in IBD development, and a Bayesian age-period-cohort (BAPC) model was used to forecast future scenarios.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In 2021, the highest IBD incidence rates were observed in Canada (26.83/100000), Greenland (24.57/100000), and New Zealand (23.69/100000), markedly contrasting China's rate of 1.4/100000. Globally, IBD incidence increased modestly from 4.22/100000 in 1990 to 4.45/100000 in 2021 (EAPC = 0.29%). China experienced a more pronounced rise, with incidence jumping from 0.74/100000 to 1.4/100000 (EAPC = 2.93%). Notably, China also witnessed substantial declines in IBD deaths (56.00%) and DALYs (58.22%). The Middle SDI region exhibited a greater magnitude of change than Global and other SDI regions. The temporal trends in the incidence and prevalence of IBD in the countries are predominantly influenced by the period up to the year 2015. In China, between the ages of 15 and 49, the incidence and prevalence of IBD are projected to remain consistent with current standards, while the death rate and DALYs are predicted to exhibit a sustained decline.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Despite the notable increase in IBD incidence in China, significant reductions in mortality and morbidity demonstrate the effectiveness of medical interventions and health system improvements.</p>\u0000 </section>\u0000 </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"9 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70160","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}