Journal of Transplantation最新文献_第8页

Lung Transplantation in Patients with High Lung Allocation Scores in the US: Evidence for the Need to Evaluate Score Specific Outcomes 美国高肺分配评分患者的肺移植:需要评估评分特定结果的证据

IF 2.5

Journal of Transplantation Pub Date : 2015-12-21 DOI: 10.1155/2015/836751

J. Hayanga, Alena Lira, T. Vlahu, Jingyan Yang, J. Aboagye, Heather K. Hayanga, J. Luketich, J. D’Cunha

{"title":"Lung Transplantation in Patients with High Lung Allocation Scores in the US: Evidence for the Need to Evaluate Score Specific Outcomes","authors":"J. Hayanga, Alena Lira, T. Vlahu, Jingyan Yang, J. Aboagye, Heather K. Hayanga, J. Luketich, J. D’Cunha","doi":"10.1155/2015/836751","DOIUrl":"https://doi.org/10.1155/2015/836751","url":null,"abstract":"Objective. The lung allocation score (LAS) resulted in a lung transplantation (LT) selection process guided by clinical acuity. We sought to evaluate the relationship between LAS and outcomes. Methods. We analyzed Scientific Registry of Transplant Recipient (SRTR) data pertaining to recipients between 2005 and 2012. We stratified them into quartiles based on LAS and compared survival and predictors of mortality. Results. We identified 10,304 consecutive patients, comprising 2,576 in each LAS quartile (quartile 1 (26.3–35.5), quartile 2 (35.6–39.3), quartile 3 (39.4–48.6), and quartile 4 (48.7–95.7)). Survival after 30 days (96.9% versus 96.8% versus 96.0% versus 94.8%), 90 days (94.6% versus 93.7% versus 93.3% versus 90.9%), 1 year (87.2% versus 85.0% versus 84.8% versus 80.9%), and 5 years (55.4% versus 54.5% versus 52.5% versus 48.8%) was higher in the lower groups. There was a significantly higher 5-year mortality in the highest LAS group (HR 1.13, p = 0.030, HR 1.17, p = 0.01, and HR 1.17, p = 0.02) comparing quartiles 2, 3, and 4, respectively, to quartile 1. Conclusion. Overall, outcomes in recipients with higher LAS are worse than those in patients with lower LAS. These data should inform more individualized evidence-based discussion during pretransplant counseling.","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2015 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2015-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/836751","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65175937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Risk Factors Associated with Increased Morbidity in Living Liver Donation 与活体肝脏捐献发病率增加相关的危险因素

IF 2.5

Journal of Transplantation Pub Date : 2015-12-15 DOI: 10.1155/2015/949674

H. Candido, E. A. da Fonseca, F. Feier, R. Pugliese, Marcel A. Benavides, E. Silva, Karina Gordon, M. G. de Abreu, J. Canet, P. Chapchap, J. S. Neto

{"title":"Risk Factors Associated with Increased Morbidity in Living Liver Donation","authors":"H. Candido, E. A. da Fonseca, F. Feier, R. Pugliese, Marcel A. Benavides, E. Silva, Karina Gordon, M. G. de Abreu, J. Canet, P. Chapchap, J. S. Neto","doi":"10.1155/2015/949674","DOIUrl":"https://doi.org/10.1155/2015/949674","url":null,"abstract":"Living donor liver donation (LDLD) is an alternative to cadaveric liver donation. We aimed at identifying risk factors and developing a score for prediction of postoperative complications (POCs) after LDLD in donors. This is a retrospective cohort study in 688 donors between June 1995 and February 2014 at Hospital Sírio-Libanês and A.C. Camargo Cancer Center, in São Paulo, Brazil. Primary outcome was POC graded ≥III according to the Clavien-Dindo classification. Left lateral segment (LLS), left lobe (LL), and right lobe resections (RL) were conducted in 492 (71.4%), 109 (15.8%), and 87 (12.6%) donors, respectively. In total, 43 (6.2%) developed POCs, which were more common after RL than LLS and LL (14/87 (16.1%) versus 23/492 (4.5%) and 6/109 (5.5%), resp., p < 0.001). Multivariate analysis showed that RL resection (OR: 2.81, 95% CI: 1.32 to 3.01; p = 0.008), smoking status (OR: 3.2, 95% CI: 1.35 to 7.56; p = 0.012), and blood transfusion (OR: 3.15, 95% CI: 1.45 to 6.84; p = 0.004) were independently associated with POCs. RL resection, intraoperative blood transfusion, and smoking were associated with increased risk for POCs in donors.","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2015 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2015-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/949674","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64177889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Plasma Exchange for the Recurrence of Primary Focal Segmental Glomerulosclerosis in Adult Renal Transplant Recipients: A Meta-Analysis 血浆置换治疗成人肾移植受者原发性局灶节段性肾小球硬化复发:荟萃分析

IF 2.5

Journal of Transplantation Pub Date : 2015-11-30 DOI: 10.1155/2015/639628

G. Vlachopanos, A. Georgalis, H. Gakiopoulou

{"title":"Plasma Exchange for the Recurrence of Primary Focal Segmental Glomerulosclerosis in Adult Renal Transplant Recipients: A Meta-Analysis","authors":"G. Vlachopanos, A. Georgalis, H. Gakiopoulou","doi":"10.1155/2015/639628","DOIUrl":"https://doi.org/10.1155/2015/639628","url":null,"abstract":"Background. Posttransplant recurrence of primary focal segmental glomerulosclerosis (rFSGS) in the form of massive proteinuria is not uncommon and has detrimental consequences on renal allograft survival. A putative circulating permeability factor has been implicated in the pathogenesis leading to widespread use of plasma exchange (PLEX). We reviewed published studies to assess the role of PLEX on treatment of rFSGS in adults. Methods. Eligible manuscripts compared PLEX or variants with conventional care for inducing proteinuria remission (PR) in rFSGS and were identified through MEDLINE and reference lists. Data were abstracted in parallel by two reviewers. Results. We detected 6 nonrandomized studies with 117 cases enrolled. In a random effects model, the pooled risk ratio for the composite endpoint of partial or complete PR was 0,38 in favour of PLEX (95% CI: 0,23–0,61). No statistical heterogeneity was observed among included studies (I 2 = 0%, p = 0,42). On average, 9–26 PLEX sessions were performed to achieve PR. Renal allograft loss due to recurrence was lower (range: 0%–67%) in patients treated with PLEX. Conclusion. Notwithstanding the inherent limitations of small, observational trials, PLEX appears to be effective for PR in rFSGS. Additional research is needed to further elucidate its optimal use and impact on long-term allograft survival.","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2015 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2015-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/639628","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65074119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Psychosocial Status of Liver Transplant Candidates in Iran and Its Correlation with Health-Related Quality of Life and Depression and Anxiety 伊朗肝移植候选者的社会心理状态及其与健康相关生活质量、抑郁和焦虑的相关性

IF 2.5

Journal of Transplantation Pub Date : 2015-11-15 DOI: 10.1155/2015/329615

M. Banihashemi, M. Hafezi, M. Nasiri-toosi, A. Jafarian, M. Abbasi, M. Arbabi, M. Abdi, Mahzad Khavarian, A. Nejatisafa

{"title":"Psychosocial Status of Liver Transplant Candidates in Iran and Its Correlation with Health-Related Quality of Life and Depression and Anxiety","authors":"M. Banihashemi, M. Hafezi, M. Nasiri-toosi, A. Jafarian, M. Abbasi, M. Arbabi, M. Abdi, Mahzad Khavarian, A. Nejatisafa","doi":"10.1155/2015/329615","DOIUrl":"https://doi.org/10.1155/2015/329615","url":null,"abstract":"Objectives. The study was aimed at providing a psychosocial profile for Iranian liver transplant candidates referred to an established liver transplantation program. Material and Methods. Patients assessed for liver transplant candidacy in Imam Khomeini Hospital (Tehran, Iran) between March 2013 and September 2014 were included. The following battery of tests were administered: Psychosocial Assessment of Candidates for Transplant (PACT), the Short-Form health survey (SF-36), and Hospital Anxiety and Depression Scale (HADS). Results. Psychosocial assessment in 205 liver transplant candidates revealed significant impairments in several SF-36 domains; social functioning was the least and physical functioning was the most impaired domains. The prevalence of cases with probable anxiety and depressive disorders, according to HADS, was 13.8% and 5.6%, respectively. According to PACT, 24.3% of the assessed individuals were considered good or excellent candidates. In 11.2%, transplantation seemed poor candidate due to at least one major psychosocial or lifestyle risk factor. Poor candidate quality was associated with impaired health-related quality of life and higher scores on anxiety and depression scales (p < 0.05). Conclusions. Transplant programs could implement specific intervention programs based on normative databases to address the psychosocial issues in patients in order to improve patient care, quality of life, and transplant outcomes.","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2015 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2015-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/329615","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64905899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Risk-adjusted analysis of relevant outcome drivers for patients after more than two kidney transplants. 两次以上肾移植患者相关结果驱动因素的风险调整分析。

IF 2.5

Journal of Transplantation Pub Date : 2015-01-01 Epub Date: 2015-02-01 DOI: 10.1155/2015/712049

Lampros Kousoulas, Florian W R Vondran, Paulina Syryca, Juergen Klempnauer, Harald Schrem, Frank Lehner

{"title":"Risk-adjusted analysis of relevant outcome drivers for patients after more than two kidney transplants.","authors":"Lampros Kousoulas, Florian W R Vondran, Paulina Syryca, Juergen Klempnauer, Harald Schrem, Frank Lehner","doi":"10.1155/2015/712049","DOIUrl":"https://doi.org/10.1155/2015/712049","url":null,"abstract":"Renal transplantation is the treatment of choice for patients suffering end-stage renal disease, but as the long-term renal allograft survival is limited, most transplant recipients will face graft loss and will be considered for a retransplantation. The goal of this study was to evaluate the patient and graft survival of the 61 renal transplant recipients after second or subsequent renal transplantation, transplanted in our institution between 1990 and 2010, and to identify risk factors related to inferior outcomes. Actuarial patient survival was 98.3%, 94.8%, and 88.2% after one, three, and five years, respectively. Actuarial graft survival was 86.8%, 80%, and 78.1% after one, three, and five years, respectively. Risk-adjusted analysis revealed that only age at the time of last transplantation had a significant influence on patient survival, whereas graft survival was influenced by multiple immunological and surgical factors, such as the number of HLA mismatches, the type of immunosuppression, the number of surgical complications, need of reoperation, primary graft nonfunction, and acute rejection episodes. In conclusion, third and subsequent renal transplantation constitute a valid therapeutic option, but inferior outcomes should be expected among elderly patients, hyperimmunized recipients, and recipients with multiple operations at the site of last renal transplantation. ","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2015 ","pages":"712049"},"PeriodicalIF":2.5,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/712049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33089289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Breakdown in the organ donation process and its effect on organ availability. 器官捐献过程中的故障及其对器官可用性的影响。

IF 2.5

Journal of Transplantation Pub Date : 2015-01-01 Epub Date: 2015-04-09 DOI: 10.1155/2015/831501

Manik Razdan, Howard B Degenholtz, Jeremy M Kahn, Julia Driessen

{"title":"Breakdown in the organ donation process and its effect on organ availability.","authors":"Manik Razdan, Howard B Degenholtz, Jeremy M Kahn, Julia Driessen","doi":"10.1155/2015/831501","DOIUrl":"https://doi.org/10.1155/2015/831501","url":null,"abstract":"Background. This study examines the effect of breakdown in the organ donation process on the availability of transplantable organs. A process breakdown is defined as a deviation from the organ donation protocol that may jeopardize organ recovery. Methods. A retrospective analysis of donation-eligible decedents was conducted using data from an independent organ procurement organization. Adjusted effect of process breakdown on organs transplanted from an eligible decedent was examined using multivariable zero-inflated Poisson regression. Results. An eligible decedent is four times more likely to become an organ donor when there is no process breakdown (adjusted OR: 4.01; 95% CI: 1.6838, 9.6414; P < 0.01) even after controlling for the decedent's age, gender, race, and whether or not a decedent had joined the state donor registry. However once the eligible decedent becomes a donor, whether or not there was a process breakdown does not affect the number of transplantable organs yielded. Overall, for every process breakdown occurring in the care of an eligible decedent, one less organ is available for transplant. Decedent's age is a strong predictor of likelihood of donation and the number of organs transplanted from a donor. Conclusion. Eliminating breakdowns in the donation process can potentially increase the number of organs available for transplant but some organs will still be lost. ","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2015 ","pages":"831501"},"PeriodicalIF":2.5,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/831501","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33156690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Proximal Tubular Injury in Medullary Rays Is an Early Sign of Acute Tacrolimus Nephrotoxicity. 髓质射线近端肾小管损伤是急性他克莫司肾毒性的早期征象。

IF 2.5

Journal of Transplantation Pub Date : 2015-01-01 Epub Date: 2015-06-24 DOI: 10.1155/2015/142521

Diane Cosner, Xu Zeng, Ping L Zhang

{"title":"Proximal Tubular Injury in Medullary Rays Is an Early Sign of Acute Tacrolimus Nephrotoxicity.","authors":"Diane Cosner, Xu Zeng, Ping L Zhang","doi":"10.1155/2015/142521","DOIUrl":"https://doi.org/10.1155/2015/142521","url":null,"abstract":"Tacrolimus (FK506) is one of the principal immunosuppressive agents used after solid organ transplantations to prevent allograft rejection. Chronic renal injury induced by tacrolimus is characterized by linear fibrosis in the medullary rays; however, the early morphologic findings of acute tacrolimus nephrotoxicity are not well characterized. Kidney injury molecule-1 (KIM-1) is a specific injury biomarker that has been proven to be useful in the diagnosis of mild to severe acute tubular injury on renal biopsies. This study was motivated by a patient with acute kidney injury associated with elevated serum tacrolimus levels in whom KIM-1 staining was present only in proximal tubules located in the medullary rays in the setting of otherwise normal light, immunofluorescent, and electron microscopy. We subsequently evaluated KIM-1 expression in 45 protocol and 39 indicated renal transplant biopsies to determine whether higher serum levels of tacrolimus were associated with acute segment specific injury to the proximal tubule, as reflected by KIM-1 staining in the proximal tubules of the cortical medullary rays. The data suggest that tacrolimus toxicity preferentially affects proximal tubules in medullary rays and that this targeted injury is a precursor lesion for the linear fibrosis seen in chronic tacrolimus toxicity. ","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2015 ","pages":"142521"},"PeriodicalIF":2.5,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/142521","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34028448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Factors Associated with Uncontrolled Hypertension among Renal Transplant Recipients Attending Nephrology Clinics in Nairobi, Kenya. 在肯尼亚内罗毕肾病诊所就诊的肾移植受者中与未控制的高血压有关的因素。

IF 2.5

Journal of Transplantation Pub Date : 2015-01-01 Epub Date: 2015-07-14 DOI: 10.1155/2015/746563

Mary N Kubo, Joshua K Kayima, Anthony J Were, Seth O McLigeyo, Elijah N Ogola

{"title":"Factors Associated with Uncontrolled Hypertension among Renal Transplant Recipients Attending Nephrology Clinics in Nairobi, Kenya.","authors":"Mary N Kubo, Joshua K Kayima, Anthony J Were, Seth O McLigeyo, Elijah N Ogola","doi":"10.1155/2015/746563","DOIUrl":"10.1155/2015/746563","url":null,"abstract":"Objective. To determine the factors associated with poor blood pressure control among renal transplant recipients in a resource-limited setting. Methods. A cross-sectional study was carried out on renal transplant recipients at the Kenyatta National Hospital. Sociodemographic details, blood pressure, urine albumin : creatinine ratio, and adherence using the MMAS-8 questionnaire were noted. Independent factors associated with uncontrolled hypertension were determined using logistic regression analysis. Results. 85 subjects were evaluated. Mean age was 42.4 (SD ± 12.2) years, with a male : female ratio of 1.9 : 1. Fifty-five patients (64.7%) had uncontrolled hypertension (BP ≥ 130/80 mmHg). On univariate analysis, male sex (OR 3.7, 95% CI 1.4-9.5, p = 0.006), higher levels of proteinuria (p = 0.042), and nonadherence to antihypertensives (OR 18, 95% CI 5.2-65.7, p < 0.001) were associated with uncontrolled hypertension. On logistic regression analysis, male sex (adjusted OR 4.6, 95% CI 1.1-19.0, p = 0.034) and nonadherence (adjusted OR 33.8, 95% CI 8.6-73.0, p < 0.001) were independently associated with uncontrolled hypertension. Conclusion. Factors associated with poor blood pressure control in this cohort were male sex and nonadherence to antihypertensives. Emphasis on adherence to antihypertensive therapy must be pursued within this population. ","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2015 ","pages":"746563"},"PeriodicalIF":2.5,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34077447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The benefit of sirolimus maintenance immunosuppression and rabbit antithymocyte globulin induction in liver transplant recipients that develop acute kidney injury in the early postoperative period. 西罗莫司维持免疫抑制和兔抗胸腺细胞球蛋白诱导对术后早期发生急性肾损伤的肝移植受者的益处

IF 2.5

Journal of Transplantation Pub Date : 2015-01-01 Epub Date: 2015-03-11 DOI: 10.1155/2015/926168

Benjamin T Duhart, Winston A Ally, Amy G Krauss, Joanna Q Hudson, James D Eason, Vinaya Rao, Jason M Vanatta

{"title":"The benefit of sirolimus maintenance immunosuppression and rabbit antithymocyte globulin induction in liver transplant recipients that develop acute kidney injury in the early postoperative period.","authors":"Benjamin T Duhart, Winston A Ally, Amy G Krauss, Joanna Q Hudson, James D Eason, Vinaya Rao, Jason M Vanatta","doi":"10.1155/2015/926168","DOIUrl":"https://doi.org/10.1155/2015/926168","url":null,"abstract":"Published data are limited describing renal outcomes in orthotopic liver transplant (OLT) recipients prescribed sirolimus (SRL) maintenance immunosuppression (MIS) and rabbit antithymocyte globulin (rATG) induction. We investigated whether SRL MIS and rATG induction facilitated recovery of acute kidney injury in the early postoperative period. This retrospective descriptive study screened 308 consecutive OLTs performed between 2006 and 2009. All patients received rATG induction with steroid avoidance. MIS consisted of SRL or TAC with mycophenolate mofetil. A total of 197 patients were included: 168 (85%) received TAC and 29 (15%) received SRL for a median of 365 days. Demographics were similar between groups except for a higher incidence of pretransplant renal dysfunction in the SRL recipients (SRL 59% versus TAC 21%; P < 0.05). The eGFR was significantly (P < 0.05) higher for all time points in the TAC group with the exception of month 2. However, improvement in eGFR was significantly (P < 0.05) greater in the SRL group postoperatively. Our study suggests that rATG induction and SRL maintenance immunosuppression facilitate renal recovery for liver transplant recipients that develop acute kidney injury in the early postoperative period. ","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2015 ","pages":"926168"},"PeriodicalIF":2.5,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/926168","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33206459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Nationwide Assessment of the Burden of Urinary Tract Infection among Renal Transplant Recipients. 肾移植受者尿路感染负担的全国评估。

IF 2.5

Journal of Transplantation Pub Date : 2015-01-01 Epub Date: 2015-02-25 DOI: 10.1155/2015/854640

Benjamin J Becerra, Monideepa B Becerra, Nasia Safdar

{"title":"A Nationwide Assessment of the Burden of Urinary Tract Infection among Renal Transplant Recipients.","authors":"Benjamin J Becerra, Monideepa B Becerra, Nasia Safdar","doi":"10.1155/2015/854640","DOIUrl":"https://doi.org/10.1155/2015/854640","url":null,"abstract":"Objective. Evaluate the prevalence and outcomes of urinary tract infection (UTI) among renal transplant recipients. Methods. A secondary analysis of the Nationwide Inpatient Sample 2009–2011 was conducted. Survey-weighted multivariable regression analyses were used to examine the impact of UTI on transplant complications, total charges, and length of stay. Results. A total of 1,044 renal transplant recipients, representing a population estimate of 49,862, were included in the study. UTI was most common in transplant recipients with hypertension (53%) and prevalence was noted to be 28.2 and 65.9 cases per 1,000 for men and women, respectively. UTI increased the likelihood of transplant complications (182% for men, 169% for women). Total charges were 28% higher among men as compared to 22% among women with UTI. Such infection also increased the length of stay by 87% among men and 74% among women. Discussion. UTI in renal transplant recipients was associated with prolonged length of stay, total charges, and increased odds of transplant complications. Interventions to prevent UTI among such patients should be a priority area for future research and practice.","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2015 ","pages":"854640"},"PeriodicalIF":2.5,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/854640","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33164185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13