Journal of Transplantation最新文献_第7页

Manipulation of Ovarian Function Significantly Influenced Sarcopenia in Postreproductive-Age Mice 卵巢功能调节对生育年龄小鼠肌肉减少症有显著影响

IF 2.5

Journal of Transplantation Pub Date : 2016-09-22 DOI: 10.1155/2016/4570842

Rhett L. Peterson, Kate C Parkinson, J. Mason

{"title":"Manipulation of Ovarian Function Significantly Influenced Sarcopenia in Postreproductive-Age Mice","authors":"Rhett L. Peterson, Kate C Parkinson, J. Mason","doi":"10.1155/2016/4570842","DOIUrl":"https://doi.org/10.1155/2016/4570842","url":null,"abstract":"Previously, transplantation of ovaries from young cycling mice into old postreproductive-age mice increased life span. We anticipated that the same factors that increased life span could also influence health span. Female CBA/J mice received new (60 d) ovaries at 12 and 17 months of age and were evaluated at 16 and 25 months of age, respectively. There were no significant differences in body weight among any age or treatment group. The percentage of fat mass was significantly increased at 13 and 16 months of age but was reduced by ovarian transplantation in 16-month-old mice. The percentages of lean body mass and total body water were significantly reduced in 13-month-old control mice but were restored in 16- and 25-month-old recipient mice by ovarian transplantation to the levels found in six-month-old control mice. In summary, we have shown that skeletal muscle mass, which is negatively influenced by aging, can be positively influenced or restored by reestablishment of active ovarian function in aged female mice. These findings provide strong incentive for further investigation of the positive influence of young ovaries on restoration of health in postreproductive females.","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"27 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2016-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/4570842","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64387059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

C1Q Assay Results in Complement-Dependent Cytotoxicity Crossmatch Negative Renal Transplant Candidates with Donor-Specific Antibodies: High Specificity but Low Sensitivity When Predicting Flow Crossmatch 补体依赖性细胞毒性交叉配型阴性肾移植候选人供体特异性抗体的C1Q检测结果:在预测血流交叉配型时，高特异性但低敏感性

IF 2.5

Journal of Transplantation Pub Date : 2016-09-04 DOI: 10.1155/2016/2106028

J. M. Arreola-Guerra, N. Castelán, A. de Santiago, A. Arvizu, Norma González-Tableros, Mayra López, I. Salcedo, M. Vilatoba, J. Granados, L. Morales-Buenrostro, J. Alberú

{"title":"C1Q Assay Results in Complement-Dependent Cytotoxicity Crossmatch Negative Renal Transplant Candidates with Donor-Specific Antibodies: High Specificity but Low Sensitivity When Predicting Flow Crossmatch","authors":"J. M. Arreola-Guerra, N. Castelán, A. de Santiago, A. Arvizu, Norma González-Tableros, Mayra López, I. Salcedo, M. Vilatoba, J. Granados, L. Morales-Buenrostro, J. Alberú","doi":"10.1155/2016/2106028","DOIUrl":"https://doi.org/10.1155/2016/2106028","url":null,"abstract":"The aim of the present study was to describe the association of positive flow cross match (FXM) and C1q-SAB. Methods. In this observational, cross-sectional, and comparative study, patients included had negative AHG-CDC-XM and donor specific antibodies (DSA) and were tested with FXM. All pretransplant sera were tested with C1q-SAB assay. Results. A total of 50 donor/recipient evaluations were conducted; half of them had at least one C1q+ Ab (n = 26, 52%). Ten patients (20.0%) had DSA C1q+ Ab. Twenty-five (50%) FXMs were positive. Factors associated with a positive FXM were the presence of C1q+ Ab (DSA C1q+ Ab: OR 27, 2.80–259.56, P = 0.004, and no DSA C1q+ Ab: OR 5, 1.27–19.68, P = 0.021) and the DSA LABScreen-SAB MFI (OR 1.26, 95% CI 1.06–1.49, P = 0.007). The cutoff point of immunodominant LABScreen SAB DSA-MFI with the greatest sensitivity and specificity to predict FXM was 2,300 (sensitivity: 72% and specificity: 75%). For FXM prediction, DSA C1q+ Ab was the most specific (95.8%, 85–100) and the combination of DSA-MFI > 2,300 and C1q+ Ab was the most sensitive (92.0%, 79.3–100). Conclusions. C1q+ Ab and LABScreen SAB DSA-MFI were significantly associated with FXM. DSA C1q+ Ab was highly specific but with low sensitivity.","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2016 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2016-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/2106028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64261801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Impact of Recipient and Donor Obesity Match on the Outcomes of Liver Transplantation: All Matches Are Not Perfect 受体和供体肥胖匹配对肝移植结果的影响:并非所有匹配都是完美的

IF 2.5

Journal of Transplantation Pub Date : 2016-09-01 DOI: 10.1155/2016/9709430

E. Beal, D. Tumin, L. Conteh, A. Hanje, Anthony J. Michaels, D. Hayes, S. Black, K. Mumtaz

{"title":"Impact of Recipient and Donor Obesity Match on the Outcomes of Liver Transplantation: All Matches Are Not Perfect","authors":"E. Beal, D. Tumin, L. Conteh, A. Hanje, Anthony J. Michaels, D. Hayes, S. Black, K. Mumtaz","doi":"10.1155/2016/9709430","DOIUrl":"https://doi.org/10.1155/2016/9709430","url":null,"abstract":"There is a paucity of literature examining recipient-donor obesity matching on liver transplantation outcomes. The United Network for Organ Sharing database was queried for first-time recipients of liver transplant whose age was ≥18 between January 2003 and September 2013. Outcomes including patient and graft survival at 30 days, 1 year, and 5 years and overall, liver retransplantation, and length of stay were compared between nonobese recipients receiving a graft from nonobese donors and obese recipient-obese donor, obese recipient-nonobese donor, and nonobese recipient-obese donor pairs. 51,556 LT recipients were identified, including 34,217 (66%) nonobese and 17,339 (34%) obese recipients. The proportions of patients receiving an allograft from an obese donor were 24% and 29%, respectively, among nonobese and obese recipients. Graft loss (HR: 1.27; 95% CI: 1.09–1.46; p = 0.002) and mortality (HR: 1.38; 95% CI: 1.16–1.65; p < 0.001) at 30 days were increased in the obese recipient-obese donor pair. However, 1-year graft (HR: 0.83; 95% CI: 0.74–0.93; p = 0.002) and patient (HR: 0.84; 95% CI: 0.74–0.95; p = 0.007) survival and overall patient (HR: 0.93; 95% CI: 0.86–1.00; p = 0.042) survival were favorable. There is evidence of recipient and donor obesity disadvantage early, but survival curves demonstrate improved long-term outcomes. It is important to consider obesity in the donor-recipient match.","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2016 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/9709430","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64634597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Liver Transplantation for Hepatocellular Carcinoma: A Single Center Resume Overlooking Four Decades of Experience 肝细胞癌的肝移植:单中心简历忽视四十年的经验

IF 2.5

Journal of Transplantation Pub Date : 2016-01-10 DOI: 10.1155/2016/7895956

N. Emmanouilidis, Rickmer Peters, B. Ringe, Z. Güner, W. Ramackers, H. Bektas, F. Lehner, M. Manns, J. Klempnauer, H. Schrem

{"title":"Liver Transplantation for Hepatocellular Carcinoma: A Single Center Resume Overlooking Four Decades of Experience","authors":"N. Emmanouilidis, Rickmer Peters, B. Ringe, Z. Güner, W. Ramackers, H. Bektas, F. Lehner, M. Manns, J. Klempnauer, H. Schrem","doi":"10.1155/2016/7895956","DOIUrl":"https://doi.org/10.1155/2016/7895956","url":null,"abstract":"Background. This is a single center oncological resume overlooking four decades of experience with liver transplantation (LT) for hepatocellular carcinoma (HCC). Methods. All 319 LT for HCC that were performed between 1975 and 2011 were included. Predictors for HCC recurrence (HCCR) and survival were identified by Cox regression, Kaplan-Meier analysis, Log Rank, and χ 2-tests where appropriate. Results. HCCR was the single strongest hazard for survival (exp⁡(B) = 10.156). Hazards for HCCR were tumor staging beyond the histologic MILAN (exp⁡(B) = 3.645), bilateral tumor spreading (exp⁡(B) = 14.505), tumor grading beyond G2 (exp⁡(B) = 8.668), and vascular infiltration of small or large vessels (exp⁡(B) = 11.612, exp⁡(B) = 18.324, resp.). Grading beyond G2 (exp⁡(B) = 10.498) as well as small and large vascular infiltrations (exp⁡(B) = 13.337, exp⁡(B) = 16.737, resp.) was associated with higher hazard ratios for long-term survival as compared to liver transplantation beyond histological MILAN (exp⁡(B) = 4.533). Tumor dedifferentiation significantly correlated with vascular infiltration (χ 2 p = 0.006) and intrahepatic tumor spreading (χ 2 p = 0.016). Conclusion. LT enables survival from HCC. HCC dedifferentiation is associated with vascular infiltration and intrahepatic tumor spreading and is a strong hazard for HCCR and survival. Pretransplant tumor staging should include grading by biopsy, because grading is a reliable and easily accessible predictor of HCCR and survival. Detection of dedifferentiation should speed up the allocation process.","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2016 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2016-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/7895956","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64538407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The Kidney Transplant Evaluation Process in the Elderly: Reasons for Being Turned down and Opportunities to Improve Cost-Effectiveness in a Single Center. 老年人肾移植评估过程:在单一中心被拒绝的原因和提高成本效益的机会。

IF 2.5

Journal of Transplantation Pub Date : 2016-01-01 Epub Date: 2016-08-04 DOI: 10.1155/2016/7405930

Beatrice P Concepcion, Rachel C Forbes, Aihua Bian, Heidi M Schaefer

{"title":"The Kidney Transplant Evaluation Process in the Elderly: Reasons for Being Turned down and Opportunities to Improve Cost-Effectiveness in a Single Center.","authors":"Beatrice P Concepcion, Rachel C Forbes, Aihua Bian, Heidi M Schaefer","doi":"10.1155/2016/7405930","DOIUrl":"https://doi.org/10.1155/2016/7405930","url":null,"abstract":"Background. The kidney transplant evaluation process for older candidates is complex due to the presence of multiple comorbid conditions. Methods. We retrospectively reviewed patients ≥60 years referred to our center for kidney transplantation over a 3-year period. Variables were collected to identify reasons for patients being turned down and to determine the number of unnecessary tests performed. Statistical analysis was performed to estimate the association between clinical predictors and listing status. Results. 345 patients were included in the statistical analysis. 31.6% of patients were turned down: 44% due to coronary artery disease (CAD), peripheral vascular disease (PVD), or both. After adjustment for patient demographics and comorbid conditions, history of CAD, PVD, or both (OR = 1.75, 95% CI (1.20, 2.56), p = 0.004), chronic obstructive pulmonary disease (OR = 8.75, 95% CI (2.81, 27.20), p = 0.0002), and cancer (OR 2.59, 95% CI (1.18, 5.67), p = 0.02) were associated with a higher risk of being turned down. 14.8% of patients underwent unnecessary basic testing and 9.6% underwent unnecessary supplementary testing with the charges over a 3-year period estimated at $304,337. Conclusion. A significant number of older candidates are deemed unacceptable for kidney transplantation with primary reasons cited as CAD and PVD. The overall burden of unnecessary testing is substantial and potentially avoidable. ","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2016 ","pages":"7405930"},"PeriodicalIF":2.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/7405930","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34350884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Clinical Course and Outcomes of Late Kidney Allograft Dysfunction. 晚期同种异体肾移植功能障碍的临床过程和结果。

IF 2.5

Journal of Transplantation Pub Date : 2016-01-01 Epub Date: 2016-07-10 DOI: 10.1155/2016/7401808

Viktor Denisov, Vadym Zakharov, Anna Ksenofontova, Eugene Onishchenko, Tatyana Golubova, Sergey Kichatyi, Olga Zakharova

{"title":"Clinical Course and Outcomes of Late Kidney Allograft Dysfunction.","authors":"Viktor Denisov, Vadym Zakharov, Anna Ksenofontova, Eugene Onishchenko, Tatyana Golubova, Sergey Kichatyi, Olga Zakharova","doi":"10.1155/2016/7401808","DOIUrl":"https://doi.org/10.1155/2016/7401808","url":null,"abstract":"Background. This study is provided to increase the efficiency of the treatment of kidney transplant recipients by predicting the development of the late allotransplant dysfunction. Methods. 330 patients who have lived for more than one year with functioning kidney allograft were evaluated. To predict the subsequent duration of the well-functioning of allotransplant the prognostic significance of 15 baseline clinical and sociodemographic characteristics on the results of the survey one year after transplantation was investigated. The result was considered to be positive in constructing the regression prognostication model if recipient lived more than 3 years from the time of transplantation. Results. It was established that more late start of renal allograft dysfunction after transplantation correlates with the more time it takes till complete loss of allograft function. Creatinine and hemoglobin blood concentration and the level of proteinuria one year after transplantation within created mathematical model allow predicting the loss of kidney transplant function three years after the transplantation. Patients with kidney transplant dysfunction are advised to renew the program hemodialysis upon reaching plasma creatinine concentration 0.5-0.7 mmol/L. Conclusion. Values of creatinine, hemoglobin, and proteinuria one year after transplantation can be used for subsequent prognostication of kidney transplant function. ","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2016 ","pages":"7401808"},"PeriodicalIF":2.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/7401808","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34720600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The Utility of Routine Ultrasound Imaging after Elective Transplant Ureteric Stent Removal. 择期输尿管支架置换术后常规超声成像的应用。

IF 2.5

Journal of Transplantation Pub Date : 2016-01-01 Epub Date: 2016-07-14 DOI: 10.1155/2016/1231567

Bibek Das, Dorian Hobday, Jonathon Olsburgh, Chris Callaghan

{"title":"The Utility of Routine Ultrasound Imaging after Elective Transplant Ureteric Stent Removal.","authors":"Bibek Das, Dorian Hobday, Jonathon Olsburgh, Chris Callaghan","doi":"10.1155/2016/1231567","DOIUrl":"https://doi.org/10.1155/2016/1231567","url":null,"abstract":"Background. Ureteric stent insertion during kidney transplantation reduces the incidence of major urological complications (MUCs). We evaluated whether routine poststent removal graft ultrasonography (PSRGU) was useful in detecting MUCs before they became clinically or biochemically apparent. Methods. A retrospective analysis was undertaken of clinical outcomes following elective stent removals from adult single renal transplant recipients (sRTRs) at our centre between 1 January 2011 and 31 December 2013. Results. Elective stent removal was performed for 338 sRTRs. Of these patients, 222 had routine PSRGU (median (IQR) days after stent removal = 18 (11-31)), 79 had urgent PSRGU due to clinical or biochemical indications, 12 had CT imaging, and 25 had no further renal imaging. Of the 222 sRTRs who underwent routine PSRGU, 210 (94.6%) had no change of management, three (1.4%) required repeat imaging only, and eight patients (3.6%) had incidental (nonureteric) findings. One patient (0.5%) had nephrostomy insertion as a result of routine PSRGU findings, but no ureteric stenosis was identified. Of 79 patients having urgent PSRGU after elective stent removal, three patients required transplant ureteric reimplantation. Conclusions. This analysis found no evidence that routine PSRGU at two to three weeks after elective stent removal provides any added value beyond standard clinical and biochemical monitoring. ","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2016 ","pages":"1231567"},"PeriodicalIF":2.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/1231567","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34733846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

For and against Organ Donation and Transplantation: Intricate Facilitators and Barriers in Organ Donation Perceived by German Nurses and Doctors. 支持和反对器官捐献与移植：德国护士和医生眼中器官捐献中错综复杂的促进因素和障碍。

IF 2.5

Journal of Transplantation Pub Date : 2016-01-01 Epub Date: 2016-08-15 DOI: 10.1155/2016/3454601

Niels Christian Hvidt, Beate Mayr, Piret Paal, Eckhard Frick, Anna Forsberg, Arndt Büssing

{"title":"For and against Organ Donation and Transplantation: Intricate Facilitators and Barriers in Organ Donation Perceived by German Nurses and Doctors.","authors":"Niels Christian Hvidt, Beate Mayr, Piret Paal, Eckhard Frick, Anna Forsberg, Arndt Büssing","doi":"10.1155/2016/3454601","DOIUrl":"10.1155/2016/3454601","url":null,"abstract":"Background. Significant facilitators and barriers to organ donation and transplantation remain in the general public and even in health professionals. Negative attitudes of HPs have been identified as the most significant barrier to actual ODT. The purpose of this paper was hence to investigate to what extent HPs (physicians and nurses) experience such facilitators and barriers in ODT and to what extent they are intercorrelated. We thus combined single causes to circumscribed factors of respective barriers and facilitators and analyzed them for differences regarding profession, gender, spiritual/religious self-categorization, and self-estimated knowledge of ODT and their mutual interaction. Methods. By the use of questionnaires we investigated intricate facilitators and barriers to organ donation experienced by HPs (n = 175; 73% nurses, 27% physicians) in around ten wards at the University Hospital of Munich. Results. Our study confirms a general high agreement with the importance of ODT. Nevertheless, we identified both facilitators and barriers in the following fields: (1) knowledge of ODT and willingness to donate own organs, (2) ethical delicacies in ODT, (3) stressors to handle ODT in the hospital, and (4) individual beliefs and self-estimated religion/spirituality. Conclusion. Attention to the intricacy of stressors and barriers in HPs continues to be a high priority focus for the availability of donor organs. ","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2016 ","pages":"3454601"},"PeriodicalIF":2.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34710456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Treatment Approaches to HCC with a Special Consideration to Transplantation. 当前肝细胞癌的治疗方法，特别考虑移植。

IF 2.5

Journal of Transplantation Pub Date : 2016-01-01 Epub Date: 2016-06-20 DOI: 10.1155/2016/7926264

N Bhardwaj, M T P R Perera, M A Silva

{"title":"Current Treatment Approaches to HCC with a Special Consideration to Transplantation.","authors":"N Bhardwaj, M T P R Perera, M A Silva","doi":"10.1155/2016/7926264","DOIUrl":"https://doi.org/10.1155/2016/7926264","url":null,"abstract":"Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. The mainstay of treatment of HCC has been both resectional and transplantation surgery. It is well known that, in selected, optimized patients, hepatectomy for HCC may be an option, even in patients with underlying cirrhosis. Resectable patients with early HCC and underlying liver disease are however increasingly being considered for transplantation because of potential for better disease-free survival and resolution of underlying liver disease, although this approach is limited by the availability of donor livers, especially in resectable patients. Outcomes following liver transplantation improved dramatically for patients with HCC following the implementation of the Milan criteria in the late 1990s. Ever since, the rather restrictive nature of the Milan criteria has been challenged with good outcomes. There has also been an increase in the donor pool with marginal donors including organs retrieved following cardiac death being used. Even so, patients still continue to die while waiting for a liver transplant. In order to reduce this attrition, bridging techniques and methods for downstaging disease have evolved. Additionally new techniques for organ preservation have increased the prospect of this potentially curative procedure being available for a greater number of patients. ","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2016 ","pages":"7926264"},"PeriodicalIF":2.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/7926264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34731314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Incidence, Characteristics, and Prognosis of Incidentally Discovered Hepatocellular Carcinoma after Liver Transplantation. 肝移植术后偶然发现的肝细胞癌的发生率、特点及预后。

IF 2.5

Journal of Transplantation Pub Date : 2016-01-01 Epub Date: 2016-06-15 DOI: 10.1155/2016/1916387

Walid El Moghazy, Samy Kashkoush, Glenda Meeberg, Norman Kneteman

{"title":"Incidence, Characteristics, and Prognosis of Incidentally Discovered Hepatocellular Carcinoma after Liver Transplantation.","authors":"Walid El Moghazy, Samy Kashkoush, Glenda Meeberg, Norman Kneteman","doi":"10.1155/2016/1916387","DOIUrl":"https://doi.org/10.1155/2016/1916387","url":null,"abstract":"Background. We aimed to assess incidentally discovered hepatocellular carcinoma (iHCC) over time and to compare outcome to preoperatively diagnosed hepatocellular carcinoma (pdHCC) and nontumor liver transplants. Methods. We studied adults transplanted with a follow-up of at least one year. Patients were divided into 3 groups according to diagnosis of hepatocellular carcinoma. Results. Between 1990 and 2010, 887 adults were transplanted. Among them, 121 patients (13.6%) had pdHCC and 32 patients (3.6%) had iHCC; frequency of iHCC decreased markedly over years, in parallel with significant increase in pdHCC. Between 1990 and 1995, 120 patients had liver transplants, 4 (3.3%) of them had iHCC, and only 3 (2.5%) had pdHCC, while in the last 5 years, 263 patients were transplanted, 7 (0.03%) of them had iHCC, and 66 (25.1%) had pdHCC (P < 0.001). There was no significant difference between groups regarding patient survival; 5-year survival was 74%, 75.5%, and 77.3% in iHCC, pdHCC, and non-HCC groups, respectively (P = 0.702). Patients with iHCC had no recurrences after transplant, while pdHCC patients experienced 17 recurrences (15.3%) (P = 0.016). Conclusions. iHCC has significantly decreased despite steady increase in number of transplants for hepatocellular carcinoma. Patients with iHCC had excellent outcomes with no tumor recurrence and survival comparable to pdHCC. ","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2016 ","pages":"1916387"},"PeriodicalIF":2.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/1916387","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34659629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7