Journal of Transplantation最新文献

{"title":"The Leading Transplantation Journals: A Trend Analysis, 2011-2021.","authors":"Badi Rawashdeh,&nbsp;Saif Aldeen Alryalat,&nbsp;Joohyun Kim,&nbsp;Calvin Eriksen,&nbsp;Mohammad Abu Assi,&nbsp;Raj Prasad,&nbsp;Matthew Cooper","doi":"10.1155/2023/8858320","DOIUrl":"10.1155/2023/8858320","url":null,"abstract":"<p><strong>Background: </strong>As the field of transplantation has expanded, so have the quantity and variety of articles published on the topic. Evaluation of publications and journals is crucial to the expansion of transplant research. This study investigated the research output and journal metrics of the leading solid organ transplant journals published between 2011 and 2021 based on estimations of the trends in the category CiteScore from the Scopus database.</p><p><strong>Materials and methods: </strong>We obtained data on the listed journals from the Scopus Source List. We then filtered the list for \"Transplantation\" journals. Only the top quartiles or quartile 1 (Q1) journals were placed in this category. This study focused specifically on transplantation journals and did not include other journals related to diseases of transplanted organs such as the kidney, liver, heart, and lungs.</p><p><strong>Results: </strong>The number of transplantation journals increased by 42.8% in the last ten years, from 28 in 2011 to 40 in 2021. Between 2011 and 2021, nine transplantation journals ranked in the highest quartile (Q1). The American Journal of Transplantation was the top journal in both years, with a 150% increase in citations and an 11.2% increase in articles published. Open access (OA) transplant journals rose from 3 in 2011 to 10 in 2021. In 2021, OA journals earned 8,555 citations, a 125% increase from 2011. Despite this increase, non-OA journals received more citations than OA in 2021 (<i>p</i> value 0.026).</p><p><strong>Conclusion: </strong>Solid organ transplantation advances lead to more publications and citations. Regular journals and publications evaluation benefits academics and policymakers by promoting the growth of research. This study examined solid organ transplantation journals and gave a global perspective on transplant journal rankings and compared their status in 2011 and 2021.</p>","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2023 ","pages":"8858320"},"PeriodicalIF":2.5,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41173686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty and Age-Associated Assessments Associated with Chronic Kidney Disease and Transplantation Outcomes.","authors":"Christian P Fulinara,&nbsp;Alina Huynh,&nbsp;Deena Goldwater,&nbsp;Basmah Abdalla,&nbsp;Joanna Schaenman","doi":"10.1155/2023/1510259","DOIUrl":"https://doi.org/10.1155/2023/1510259","url":null,"abstract":"<p><strong>Background: </strong>Frailty is often defined as a decrease in physiological reserve and has been shown to be correlated with adverse health outcomes and mortality in the general population. This condition is highly prevalent in the chronic kidney disease (CKD) patient population as well as in kidney transplant (KT) recipients. Other age-associated changes include sarcopenia, nutrition, cognition, and depression. In assessing the contributions of these components to patient outcomes and their prevalence in the CKD and KT patient population, it can be determined how such variables may be associated with frailty and the extent to which they may impact the adverse outcomes an individual may experience.</p><p><strong>Objectives: </strong>We sought to perform a systematic literature review to review published data on frailty and associated age-associated syndromes in CKD and KT patients.</p><p><strong>Results: </strong>Over 80 references pertinent to frailty, sarcopenia, nutrition, cognition, or depression in patients with CKD or KT were identified. Systematic review was performed to evaluate the data supporting the use of the following approaches: Fried Frailty, Short Physical Performance Battery, Frailty Index, Sarcopenia Index, CT scan quantification of muscle mass, health-related quality of life, and assessment tools for nutrition, cognition, and depression.</p><p><strong>Conclusion: </strong>This report represents a comprehensive review of previously published research articles on this topic. The intersectionality between all these components in contributing to the patient's clinical status suggests a need for a multifaceted approach to developing comprehensive care and treatment for the CKD and KT population to improve outcomes before and after transplantation.</p>","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2023 ","pages":"1510259"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9652638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved Medication Adherence with the Use of Extended-Release Tacrolimus in Liver Transplant Recipients: A Pilot Randomized Controlled Trial.","authors":"Manisha Verma,&nbsp;Radi Zaki,&nbsp;Johnathan Sadeh,&nbsp;John P Knorr,&nbsp;Mark Gallagher,&nbsp;Afshin Parsikia,&nbsp;Victor Navarro","doi":"10.1155/2023/7915781","DOIUrl":"https://doi.org/10.1155/2023/7915781","url":null,"abstract":"<p><strong>Background: </strong>Nonadherence to immunosuppression in liver transplant recipients (LTRs) leads to deterioration in health outcomes. Once-dailyextended-release tacrolimus (TAC-ER) may improve adherence when compared to twice-dailyimmediate-release tacrolimus (TAC-IR).</p><p><strong>Methods: </strong>We conducted a randomized controlled study to evaluate medication adherence, clinical efficacy, and safety of TAC-ER in stable LTR. All patients >18 years who underwent liver transplantation before 6 months were eligible. Patients were randomized 1 : 1 to continued TAC-IR or conversion to TAC-ER. The primary outcome was change in medication adherence from baseline to 9 months, assessed using BAASIS. Secondary outcomes were tacrolimus trough levels, safety, and quality of life.</p><p><strong>Results: </strong>Thirty-one patients were consented and randomized to either of the two groups: conversion to TAC-ER (<i>n</i> = 15) or continued TAC-IR (<i>n</i> = 16). Six patients in the TAC-ER group withdrew after randomization due to apprehension about switching medication (<i>n</i> = 2), unwillingness to travel (<i>n</i> = 2), and increased liver tests after conversion (<i>n</i> = 2, both were acute rejections despite therapeutic tacrolimus levels and were considered unrelated to TAC-ER). We compared the results of nine patients in the TAC-ER group that completed the study with those of sixteen in the TAC-IR group. At baseline, there was no difference in tacrolimus trough levels between groups. Improved adherence was observed in the TAC-ER group as 100% of patients reported at least one period of full adherence during the study period (100% vs. 62.6%, <i>p</i> = 0.035). Tacrolimus trough levels and liver tests were comparable between groups throughout the study. There were no differences in eGFR, HbA1c, or QoL between the groups.</p><p><strong>Conclusion: </strong>TAC-ER improved medication adherence while maintaining comparable trough levels, liver function, and QoL as TAC-IR in LTR.</p>","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2023 ","pages":"7915781"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10535388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Banff 2016 Global Assessment and Quantitative Scoring for T Cell-Mediated Liver Transplant Rejection are Interchangeable.","authors":"Maryam Eghtedari,&nbsp;Catriona McKenzie,&nbsp;Lauren C Y Tang,&nbsp;Avik Majumdar,&nbsp;James G Kench","doi":"10.1155/2023/3103335","DOIUrl":"https://doi.org/10.1155/2023/3103335","url":null,"abstract":"<p><strong>Introduction: </strong>Histopathological assessment of liver biopsies is the current \"gold standard\" for diagnosing graft dysfunction after liver transplantation (LT), as graft dysfunction can have nonspecific clinical presentations and inconsistent patterns of liver biochemical dysfunction. Most commonly, post-LT, graft dysfunction within the first year, is due to acute T-cell mediated rejection (TCMR) which is characterised histologically by the degree of portal inflammation (PI), bile duct damage (BDD), and venous endothelial inflammation (VEI). This study aimed to establish the relationship between global assessment, which is the global grading of rejection using a \"gestalt\" approach, and the rejection activity index (RAI) of each component of TCMR as described in revised Banff 2016 guidelines.</p><p><strong>Methods: </strong>Liver biopsies (<i>n</i> = 90) taken from patients who underwent LT in 2015 and 2016 at the Australian National Liver Transplant Unit were identified from the electronic medical records. All biopsy slides were microscopically graded by at least two assessors independently using the revised 2016 Banff criteria. Data were analysed using IBM SPSS v21. A Fisher-Freeman-Halton test was performed to assess the correlation between the global assessment and the RAI scores for each TCMR biopsy.</p><p><strong>Results: </strong>Within the cohort, 60 (37%, <i>n</i> = 164) patients underwent at least 1 biopsy within 12 months after LT. The most common biopsy outcome (total <i>n</i> = 90) was acute TCMR (64, 71.1%). Global assessment of TCMR slides strongly positively correlated with PI (<i>p</i> value <0.001), BDD (<i>p</i> value <0.001), VEI (<i>p</i> value <0.001), and total RAI (<i>p</i> value <0.001). Liver biochemistry of patients with TCMR significantly improved within 4 to 6 weeks post-biopsy compared to the day of the biopsy.</p><p><strong>Conclusion: </strong>In acute TCMR, global assessment and total RAI are strongly correlated and can be used interchangeably to describe the severity of TCMR.</p>","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2023 ","pages":"3103335"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9250926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Symptomatic Pericardial Effusions Posthematopoietic Stem Cell Transplant.","authors":"Kelly Lyons,&nbsp;Niti Dham,&nbsp;Bryanna Schwartz,&nbsp;Blachy J Dávila Saldaña","doi":"10.1155/2023/7455756","DOIUrl":"https://doi.org/10.1155/2023/7455756","url":null,"abstract":"<p><strong>Background: </strong>Pericardial effusions are a known complication posthematopoietic stem cell transplant (HSCT), causing significant morbidity. We aimed to evaluate the risk factors associated with the development of high-grade effusions requiring interventions. <i>Procedure</i>. A retrospective chart review of all HSCT patients over a period of 7 years (2013-2019) in a single institution in the Northeastern United States is conducted. All patients who developed an effusion requiring intervention were included. Patient's clinical characteristics were compared with all others transplanted during the same time period. Echocardiogram findings of the affected patients were compared to a case-control cohort of unaffected patients with similar age and diagnosis. Chi-square and paired <i>t</i>-tests were utilized to ascertain statistical differences between the groups.</p><p><strong>Results: </strong>A total of 15 patients out of 201 (7.5%) transplanted at our institution developed a moderate or large pericardial effusion requiring pericardiocentesis or a pericardial window. Of this cohort, 13 (87%) underwent a myeloablative preparative regimen, 13 (87%) had cyclophosphamide as part of their regimen, 13 (87%) had recent treatment for viral reactivation, 6 (40%) had an underlying hemoglobinopathy diagnosis, and only 4 (27%) had an active diagnosis of GVHD. A myeloablative preparative regimen had a higher rate of effusion requiring intervention, although it was not statistically significant, and concurrent GVHD was not predictive of effusion development. However, exposure to cyclophosphamide, recent treatment for viral reactivation, and a diagnosis of transplant-associated thrombotic microangiopathy (Ta-TMA) were highly associated with effusions. The latter was associated with increased mortality. The duration of pericardial effusion correlated with the pretransplant echocardiogram left ventricle end diastolic diameter z-score and apical 4-chamber left ventricular peak average strain measurement.</p><p><strong>Conclusions: </strong>Potential risk factors for pericardial effusions post-HSCT include a diagnosis of Ta-TMA, active viral infection, exposure to cyclophosphamide, and a higher left ventricle end diastolic diameter <i>z</i>-score. This information may help guide management for these patients, including identifying high-risk subjects, determining the frequency of echocardiograms, and determining specific echocardiogram measures to follow over time.</p>","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2023 ","pages":"7455756"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10772736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney Retransplantation after Graft Failure: Variables Influencing Long-Term Survival.","authors":"Jonas Ehrsam,&nbsp;Fabian Rössler,&nbsp;Karoline Horisberger,&nbsp;Kerstin Hübel,&nbsp;Jakob Nilsson,&nbsp;Olivier de Rougemont","doi":"10.1155/2022/3397751","DOIUrl":"https://doi.org/10.1155/2022/3397751","url":null,"abstract":"<p><strong>Background: </strong>There is an increasing demand for kidney retransplantation. Most studies report inferior outcomes compared to primary transplantation, consequently feeding an ethical dilemma in the context of chronic organ shortage.</p><p><strong>Objective: </strong>To assess variables influencing long-term graft survival after kidney retransplantation. <i>Material and Methods</i>. All patients transplanted at our center between 2000 and 2016 were analyzed retrospectively. Survival was estimated with the Kaplan-Meier method, and risk factors were identified using multiple Cox regression.</p><p><strong>Results: </strong>We performed 1,376 primary kidney transplantations and 222 retransplantations. The rate of retransplantation was 67.8% after the first graft loss, with a comparable 10-year graft survival compared to primary transplantation (67% vs. 64%, <i>p</i>=0.104) but an inferior graft survival thereafter (log-rank <i>p</i>=0.026). Independent risk factors for graft survival in retransplantation were age ≥ 50 years, time on dialysis ≥1 year, previous graft survival <2 years, ≥1 mild comorbidity in the Charlson-Deyo index, active smoking, and life-threatening complications (Clavien-Dindo grade IV) at first transplantation.</p><p><strong>Conclusion: </strong>Graft survival is comparable for first and second kidney transplantation within the first 10 years. Risk factors for poor outcomes after retransplantation are previous graft survival, dialysis time after graft failure, recipient age, comorbidities, and smoking. Patients with transplant failure should have access to retransplantation as early as possible.</p>","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":" ","pages":"3397751"},"PeriodicalIF":2.5,"publicationDate":"2022-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40556907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthostatic Hypotension and Concurrent Autonomic Dysfunction: A Novel Complication of Lung Transplantation","authors":"D. Razia, S. Tokman, Sharjeel Israr, H. Mohamed, H. Abdelrazek, B. Buddhdev, A. Arjuna, K. Mcanally, S. Hashimi, Michael A. Smith, R. Bremner, R. Walia, A. Omar","doi":"10.1155/2022/3308939","DOIUrl":"https://doi.org/10.1155/2022/3308939","url":null,"abstract":"Background Persistent orthostatic hypotension (OH) is a lesser-known complication of lung transplantation (LTx). In this retrospective case series, we describe the clinical manifestations, complications, and treatment of persistent OH in 13 LTx recipients. Methods We identified LTx recipients who underwent transplantation between March 1, 2018, and March 31, 2020, with persistent symptomatic OH and retrospectively queried the records for clinical information. Results Thirteen patients were included in the analysis, 9 (69%) had underlying pulmonary fibrosis, and 12 (92%) were male. The median age, height, and body mass index at LTx were 68 years, 70 inches, and 27 kg/m2, respectively. Six (46%) patients were deceased at the time of chart abstraction with a median (IQR) posttransplant survival of 12.6 months (6, 21); the 7 remaining living patients were a median of 19.6 months (18, 32) posttransplant. Signs and symptoms of OH developed a median of 60 (7, 75) days after transplant. Patients were treated with pharmacological agents and underwent extensive physical therapy. Most patients required inpatient rehabilitation (n = 10, 77%), and patients commonly developed comorbid conditions including weight loss, renal insufficiency with eGFR <50 (n = 13, 100%), gastroparesis (n = 7, 54%), and tachycardia-bradycardia syndrome (n = 2, 15%). Falls were common (n = 10, 77%). The incidence of OH in LTx recipients at our center during the study period was 5.6% (13/234). Conclusions Persistent OH is a lesser-known complication of LTx that impacts posttransplant rehabilitation and may lead to comorbidities and shortened survival. In addition, most LTx recipients with OH at our center were tall, thin men with underlying pulmonary fibrosis, which may offer an opportunity to instate pretransplant OH screening of at-risk patients.","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2022-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46574015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mammalian Target of Rapamycin Inhibitors and Wound Healing Complications in Kidney Transplantation: Old Myths and New Realities","authors":"Muhammad Abdul Mabood Khalil, S. Al-Ghamdi, U. Dawood, Said Sayed Ahmed Khamis, H. Ishida, V. Chong, Jackson Tan","doi":"10.1155/2022/6255339","DOIUrl":"https://doi.org/10.1155/2022/6255339","url":null,"abstract":"Mammalian target of rapamycin inhibitors (mTOR-I) lacks nephrotoxicity, has antineoplastic effects, and reduces viral infections in kidney transplant recipients. Earlier studies reported a significant incidence of wound healing complications and lymphocele. This resulted in the uncomfortable willingness of transplant clinicians to use these agents in the immediate posttransplant period. As evidence and experience evolved over time, much useful information became available about the optimal use of these agents. Understandably, mTOR-I effects wound healing through their antiproliferative properties. However, there are a lot of other immunological and nonimmunological factors which can also contribute to wound healing complications. These risk factors include obesity, uremia, increasing age, diabetes, smoking, alcoholism, and protein-energy malnutrition. Except for age, the rest of all these risk factors are modifiable. At the same time, mycophenolic acid derivatives, steroids, and antithymocyte globulin (ATG) have also been implicated in wound healing complications. A lot has been learnt about the optimal dose of mTOR-I and their trough levels, its combinations with other immunosuppressive medications, and patients' profile, enabling clinicians to use these agents appropriately for maximum benefits. Recent randomized control trials have further increased the confidence of clinicians to use these agents in immediate posttransplant periods.","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2022 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44259626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Living-Donor Liver Transplant in Oman: A Quantitative Cross-Sectional Study of Donors' Experiences and Challenges.","authors":"Mudhar Al Adawi,&nbsp;Hasina Al Harthi,&nbsp;Raja Al Hinai,&nbsp;Suad Al Haddabi,&nbsp;Iqbal Al Busaidi,&nbsp;Omar Al Siyabi,&nbsp;Salah Thabit Al Awaidy","doi":"10.1155/2021/4251814","DOIUrl":"https://doi.org/10.1155/2021/4251814","url":null,"abstract":"<p><strong>Background: </strong>In Oman, the first liver transplant was performed at the Royal Hospital (RH) in September 2017. Since then, thirteen cases have been operated on at the RH. All of these cases were living-donor liver transplants (LDLT), and the remaining cases were treated in India with a total of approximately 193 recipients. To provide an in-depth overview of donor experiences, challenges, and perceptions, a cross-sectional study was conducted.</p><p><strong>Methods: </strong>A cross-sectional study was conducted at one tertiary hospital in 2019. The survey was designed to collect data composed of closed and open-ended questions to reveal a thorough knowledge of the topic.</p><p><strong>Results: </strong>A total of 50 of 120 donors responded to the survey with male dominance in the sample (68%) and 64% were aged 28 to 38 years. 66% of the respondents came to know about the donation through hospital staff. Interestingly, respondents (<i>n</i> = 8/12) who reported that fear of operation is the cause that prevents people from donating are among the male gender, while more men believe that the main cause is lack of knowledge. 90% of the respondents felt satisfied after donation. More men reported ambiguous feelings before donation. Moreover, married donors reported ambiguous feelings before donation (<i>p</i> = 0.008). The younger age group reported anxiety and doubt as a challenge through their donation experience.</p><p><strong>Conclusion: </strong>This study revealed that donors have a positive feeling after donating as they have saved a life, as well as being empowered by family and community. The donors encourage individuals to donate a portion of their liver. Some crucial questions arose, such as anxiety before surgery, ambiguous feelings before surgery, and fatigue after surgery. These findings underscore the importance of a holistic approach that would enable donors to be well informed prior to surgery.</p>","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2021 ","pages":"4251814"},"PeriodicalIF":2.5,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39656637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Antibodies and Alloreactive T Cells Long after Kidney Transplantation.","authors":"Nicole M van Besouw,&nbsp;Aleixandra Mendoza Rojas,&nbsp;Sarah B See,&nbsp;Ronella de Kuiper,&nbsp;Marjolein Dieterich,&nbsp;Dave L Roelen,&nbsp;Marian C Clahsen-van Groningen,&nbsp;Dennis A Hesselink,&nbsp;Emmanuel Zorn,&nbsp;Carla C Baan","doi":"10.1155/2021/7005080","DOIUrl":"https://doi.org/10.1155/2021/7005080","url":null,"abstract":"<p><strong>Background: </strong>The relationship between circulating effector memory T and B cells long after transplantation and their susceptibility to immunosuppression are unknown. To investigate the impact of antirejection therapy on T cell-B cell coordinated immune responses, we assessed IFN-<i>γ</i>-producing memory cells and natural antibodies (nAbs) that potentially bind to autoantigens on the graft.</p><p><strong>Methods: </strong>Plasma levels of IgG nAbs to malondialdehyde (MDA) were measured in 145 kidney transplant recipients at 5-7 years after transplantation. In 54 of these patients, the number of donor-reactive IFN-<i>γ</i>-producing cells was determined. 35/145 patients experienced rejection, 18 of which occurred within 1 year after transplantation.</p><p><strong>Results: </strong>The number of donor-reactive IFN-<i>γ</i>-producing cells and the levels of nAbs were comparable between rejectors and nonrejectors. The nAbs levels were positively correlated with the number of donor-reactive IFN-<i>γ</i>-producing cells (<i>r</i> _s = 0.39, <i>p</i>=0.004). The positive correlation was only observed in rejectors (<i>r</i> _s = 0.53, <i>p</i>=0.003; nonrejectors: <i>r</i> _s = 0.24, <i>p</i>=0.23). Moreover, we observed that intravenous immune globulin treatment affected the level of nAbs and this effect was found in patients who experienced a late ca-ABMR compared to nonrejectors (<i>p</i>=0.008).</p><p><strong>Conclusion: </strong>The positive correlation found between alloreactive T cells and nAbs in rejectors suggests an intricate role for both components of the immune response in the rejection process. Treatment with intravenous immune globulin impacted nAbs.</p>","PeriodicalId":45795,"journal":{"name":"Journal of Transplantation","volume":"2021 ","pages":"7005080"},"PeriodicalIF":2.5,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39504549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}