Angela de Salles Rezende, Teresa Cristina Ferreira Gutman, Marcus Vinicius Teixeira Calejon Stumpf, Karin Soares Gonçalves Cunha, Fabiana Resende Rodrigues, Vânia Gloria Silami Lopes
{"title":"Metastatic Melanoma Mimicking Primary Breast Cancer-A Diagnostic Challenge: A Case Report.","authors":"Angela de Salles Rezende, Teresa Cristina Ferreira Gutman, Marcus Vinicius Teixeira Calejon Stumpf, Karin Soares Gonçalves Cunha, Fabiana Resende Rodrigues, Vânia Gloria Silami Lopes","doi":"10.1155/crip/8820195","DOIUrl":"10.1155/crip/8820195","url":null,"abstract":"<p><strong>Introduction: </strong>Metastatic melanoma to the breast is rare and may be misdiagnosed as primary breast carcinoma. Histological, immunohistochemical, and clinical correlations, such as a history of previous melanoma, are essential for diagnosis.</p><p><strong>Patient presentation: </strong>A female patient presented with melanoma in the left gluteal region. Five years later, a palpable nodule was detected in the right breast on routine mammography. Microscopic and immunohistochemical examination confirmed the diagnosis of metastatic melanoma. The patient passed away 3 years later.</p><p><strong>Conclusion: </strong>The findings in this case indicate that metastatic melanoma can present in atypical ways and that specialists should pay attention to metastases in unusual locations in cases of melanoma.</p>","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2026 ","pages":"8820195"},"PeriodicalIF":0.4,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12930203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147291523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Raiane Machado Maia, Guilherme Alves Andrade, Heitor Lino Guimarães, Flávio Ricardo Manzi, Luís Cândido Pinto da Silva, Izabella Lucas de Abreu Lima
{"title":"Ask-Upmark Kidney Disease: Case Report of a Rare Congenital Malformation.","authors":"Raiane Machado Maia, Guilherme Alves Andrade, Heitor Lino Guimarães, Flávio Ricardo Manzi, Luís Cândido Pinto da Silva, Izabella Lucas de Abreu Lima","doi":"10.1155/crip/5533202","DOIUrl":"10.1155/crip/5533202","url":null,"abstract":"<p><p>Ask-Upmark kidney disease is a congenital renal malformation characterized by segmental hypoplasia, leading to progressive impairment of renal function and severe hypertension. It is a rare anomaly that presents with various complications. A 14-year-old boy diagnosed with Ask-Upmark kidney was referred for dental care. The patient presented with mouth breathing, unsatisfactory occlusion, and severe drug-induced gingival hyperplasia, which hindered speech, diet, and oral hygiene. Imaging revealed the presence of all permanent teeth, but with delayed eruption, oblique eruption pathways, and risk of impaction. Management included oral hygiene instructions, prophylaxis, and ulectomy to facilitate tooth eruption. This case highlights the oral manifestations associated with the management of Ask-Upmark kidney, specifically drug-induced gingival enlargement and eruption disturbances. It underscores the necessity of multidisciplinary treatment, including dentistry, to improve the quality of life for these patients.</p>","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2026 ","pages":"5533202"},"PeriodicalIF":0.4,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12921525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sena Zengin, Chaow Charoenkijkajorn, David Warner, T David Bourne, Daisy Alapat, Neriman Gokden, Murat Gokden, Stephen Nix
{"title":"Illuminating Blurry Vision: Visualization of Corneal Protein Deposition With Immunofluorescence in Two Illustrative Case Reports.","authors":"Sena Zengin, Chaow Charoenkijkajorn, David Warner, T David Bourne, Daisy Alapat, Neriman Gokden, Murat Gokden, Stephen Nix","doi":"10.1155/crip/2915592","DOIUrl":"10.1155/crip/2915592","url":null,"abstract":"<p><strong>Background: </strong>Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic, premalignant disease with a progression rate of 0.5%-1% per year to multiple myeloma. It can rarely present with significant ocular symptoms in the context of crystalline keratopathy, necessitating medical and surgical interventions. Lattice corneal dystrophy Type I (LCD-1), a rare inherited disorder caused by mutations of <i>TGFBI</i>, manifests with amyloid deposition within the corneal stroma and causes visual impairment. Here, we pictorially highlight protein deposition using immunofluorescence in two representative cases, both having undergone penetrating keratoplasty for blurry vision.</p><p><strong>Methods: </strong>Medical records were reviewed. Hematoxylin and eosin, special staining, immunohistochemistry, and immunofluorescent techniques were performed. A literature review was performed.</p><p><strong>Results: </strong>Case 1: Eosinophilic accumulations of the cornea were highlighted with PAS-D and IgG-kappa by immunohistochemistry, whereas immunofluorescence (IF) technique demonstrated IgG-kappa (2+) staining in the stroma with rare globules in the epithelium. Case 2: Amorphous, eosinophilic deposits within the corneal stroma were congophilic with apple-green birefringence on polarized light. Thioflavin T highlighted the amyloid through immunofluorescence. Mass spectrometry detected a peptide profile consistent with ATGFBI-type amyloid deposition.</p><p><strong>Conclusion: </strong>Immunofluorescence can be helpful in the workup of corneal protein deposition, such as MGUS-related crystalline keratopathy and LCD-1.</p>","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2026 ","pages":"2915592"},"PeriodicalIF":0.4,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12921536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pathological Study of Rare Malignant Cardiac Tumors: A Case Series of Five Patients.","authors":"Mahshid Hesami, Kambiz Mozaffari, Behnaz Jahanbin","doi":"10.1155/crip/8876442","DOIUrl":"10.1155/crip/8876442","url":null,"abstract":"<p><p>Malignant cardiac tumors are uncommon but highly aggressive growths that may develop within the heart or spread from other primary locations. Considering the significance of pathological studies and the dissemination of findings on malignant cardiac tumors in advancing medical knowledge and informing future research in this complex area, this study is aimed at presenting cases of malignant cardiac tumors identified in patients treated at the Rajaie Hospital, Tehran, Iran. In this study, we focused on five cases of malignant cardiac tumors documented in the hospital's surgical pathology archives spanning from 2020 to 2024. The identified tumors consisted of invasive thymoma, diffuse large B-cell lymphoma, primary cardiac synovial sarcoma, primary undifferentiated pleomorphic sarcoma, and metastatic renal cell carcinoma, all classified as rare cardiac neoplasms.</p>","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2026 ","pages":"8876442"},"PeriodicalIF":0.4,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12903990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case Report of Pigmented Purpuric Dermatosis With No Granuloma Formation: A 20-year Follow-Up Case Study.","authors":"Yasuhiro Horiuchi","doi":"10.1155/crip/5536378","DOIUrl":"10.1155/crip/5536378","url":null,"abstract":"<p><p>In a case of pigmented purpuric dermatosis with hyperlipidemia reported earlier to be persistent for over 20 years, the primary disease was cured by oral rinsing with ozone water; however, the remaining prominent pigmentation was not remarkably improved even with oral administration of vitamin C and laser treatment. A histological examination of the lesion was performed to resolve the difficulty in removing this pigmentation. No granuloma reaction, including giant cells, was observed in the lesion tissue, even after such a long course and significant pigmentation. Granuloma formation in this disease may be a functional problem of the patient's histiocytes and/or phagocytes rather than its chronic course or excessive hemosiderin deposition. Similarly, hyperlipidemia did not affect granuloma formation.</p>","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2026 ","pages":"5536378"},"PeriodicalIF":0.4,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12891435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146182916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"<i>MAML2</i>-Rearranged Hidradenoma of the Breast: Clinicopathologic and Molecular Analysis of Four Patients.","authors":"Naomi Gondo, Yasuyo Ohi, Tsubasa Hiraki, Akira I Hida, Shuichi Kanemitsu, Yasuaki Sagara, Shinji Ohno","doi":"10.1155/crip/3861274","DOIUrl":"10.1155/crip/3861274","url":null,"abstract":"<p><p>Hidradenoma (HA) is a rare, benign adnexal tumor typically arising in the skin, with only a few reported cases in the breast. Histologically, HA displays solid and cystic patterns with diverse cellular components. Although <i>MAML2</i> gene rearrangement is observed in some cutaneous HAs, its significance in breast HA remains unclear. We retrospectively analyzed four cases of breast HA at our institution, focusing on clinicopathologic and molecular characteristics. <i>MAML2</i> rearrangement was detected in all cases by FISH, suggesting it may be a defining feature of breast HA. Because breast HA frequently mimics malignancy and is often diagnosed only after excision, heightened awareness and recognition of its distinctive clinicopathologic and molecular features are essential to prevent overtreatment.</p>","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2026 ","pages":"3861274"},"PeriodicalIF":0.4,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12857466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146107815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nathan A Williams, Mark Colantonio, Anastasia Miller, Allen P Burke
{"title":"Noninfectious Necrotizing Aortitis With Predominantly Neutrophilic Infiltrate.","authors":"Nathan A Williams, Mark Colantonio, Anastasia Miller, Allen P Burke","doi":"10.1155/crip/5727208","DOIUrl":"10.1155/crip/5727208","url":null,"abstract":"<p><p>Aortitis can be either infectious or noninfectious, and cases of noninfectious aortitis are not well understood. Our study presents a case of noninfectious ascending aortitis in a relatively young, previously healthy man, characterized by a predominantly neutrophilic infiltrate on histopathological examination without an inciting microorganism. This case report highlights that a neutrophilic infiltrate does not necessarily indicate an infectious etiology in ascending aortic aneurysms.</p>","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2026 ","pages":"5727208"},"PeriodicalIF":0.4,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12780741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chronic Basal Ganglia Infarction With PCR-Identified <i>Paeniclostridium sordellii</i>: A Rare Neuropathological Case Report.","authors":"Cassandra Lamm, Angus Toland, Samuel Guzman","doi":"10.1155/crip/7304864","DOIUrl":"10.1155/crip/7304864","url":null,"abstract":"<p><strong>Background: </strong>Within 1 month of diagnosis, 40% of patients with positive blood cultures will develop CNS complications. Rare pathogens, that is, <i>Paeniclostridium sordellii</i>, pose diagnostic challenges due to atypical presentations and detection difficulties.</p><p><strong>Case presentation: </strong>A 67-year-old man presented with metabolic encephalopathy and diabetes insipidus. Imaging showed bilateral basal ganglia abnormalities and an enhancing lesion near the anterior commissure, suspicious for neoplasm. Postmortem findings included reactive gliosis, atypical lymphocytic inflammation, and polyclonal plasma cells. NGS performed at the University of Washington confirmed <i>P. sordellii</i> infection.</p><p><strong>Neuropathologic findings: </strong>The gross and histologic examination showed mild hydrocephalus, right hippocampal atrophy, and anterior commissure-centric inflammation. Vascular congestion, arteriosclerosis with microthrombi, and oligodendrocyte loss were present without hemorrhage.</p><p><strong>Differential diagnosis: </strong>Hemophagocytic lymphohistiocytosis and CNS lymphoma were considered but ruled out microscopically.</p><p><strong>Conclusion: </strong>This case highlights the importance of considering <i>P. sordellii</i> in CNS inflammatory lesions and demonstrates the utility of molecular diagnostics in negative cultures.</p>","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2026 ","pages":"7304864"},"PeriodicalIF":0.4,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12775830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145935118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case of Thyroid Storm With Fatal Outcome due to Liver Failure.","authors":"Kanako Suzuki, Satomi Makiuchi, Yukiko Kishida","doi":"10.1155/crip/1962799","DOIUrl":"10.1155/crip/1962799","url":null,"abstract":"<p><p>We conducted an autopsy on a patient who succumbed to thyroid storm complicated by liver failure. As autopsies of thyroid storm are rare, we present the findings of the autopsy. A 70-year-old female patient who developed rapid onset acute liver failure passed away on the 15th day of hospitalization due to a thyroid storm. As in previously reported cases, lobular central necrosis of the liver was a predominant feature, and fibrosis was also seen. In this case, acute cardiac failure seemed to play a significant role as a cause of the liver failure. It may be crucial to prevent heart failure (HF), leading to hepatic ischemia before liver fibrosis develops.</p>","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2025 ","pages":"1962799"},"PeriodicalIF":0.4,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12750098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145879141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intersection of Tyrosine Kinase Inhibition and Sepsis-Induced Cardiomyopathy.","authors":"Hiroshi Abe, Kiyoshi Takasu, Kei Yamamoto, Tomita Shigeki, Tetsuro Miyazaki, Takashi Tokano, Tohru Minamino","doi":"10.1155/crip/7134352","DOIUrl":"10.1155/crip/7134352","url":null,"abstract":"<p><p>This case details a 78-year-old male with a history of old myocardial infarction and chronic myeloid leukemia treated with tyrosine kinase inhibitors (TKIs). The patient presented with exertional dyspnea and was hospitalized for congestive heart failure. Following the development of a urinary tract infection, the patient exhibited signs of sepsis-induced cardiomyopathy (SIC), including myocardial injury and rapid hemodynamic deterioration, leading to death. Autopsy findings indicated SIC, characterized by neutrophil-dominant inflammatory cell infiltration and endothelial damage, which might have been exacerbated by the patient's preexisting conditions of old myocardial infarction and TKI therapy. This case underscores the multifactorial nature of SIC, suggesting that preexisting old myocardial infarction and TKI therapies can significantly impact the disease's pathogenesis and progression. It highlights the need for comprehensive management strategies in patients with complex medical histories and the importance of further research to elucidate the underlying mechanisms of SIC.</p>","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2025 ","pages":"7134352"},"PeriodicalIF":0.4,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12748528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145879171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}