Case Reports in Pathology最新文献_第5页

Colonic Adenocarcinoma with Plasmacytoid Feature: Histopathology and Molecular Characteristics of a Rare Neoplasm with an Unusual Presentation. 具有浆细胞样特征的结肠腺癌:一种不寻常表现的罕见肿瘤的组织病理学和分子特征。

IF 0.6

Case Reports in Pathology Pub Date : 2022-02-08 eCollection Date: 2022-01-01 DOI: 10.1155/2022/2640456

Noor Marji, Jasrerman Dhillon, Gregory Y Lauwers, Sebastian Feuerlein, Reza Nikfar, Monica Chatwal, Aram Vosoughi

{"title":"Colonic Adenocarcinoma with Plasmacytoid Feature: Histopathology and Molecular Characteristics of a Rare Neoplasm with an Unusual Presentation.","authors":"Noor Marji, Jasrerman Dhillon, Gregory Y Lauwers, Sebastian Feuerlein, Reza Nikfar, Monica Chatwal, Aram Vosoughi","doi":"10.1155/2022/2640456","DOIUrl":"https://doi.org/10.1155/2022/2640456","url":null,"abstract":"Colorectal carcinoma with noncohesive tumor cells has been described in tumors with signet ring cells (mucinous adenocarcinoma and signet ring cell adenocarcinoma) and rhabdoid feature (carcinoma with sarcomatoid component). Cases of carcinoma with plasmacytoid morphology are rare in the gastrointestinal tract, and a single case of plasmacytoid colorectal carcinoma has been reported. We report the case of a 37-year-old woman who presented with urinary symptoms, hematuria, and abdominal pain. Imaging studies showed segmental sigmoid wall thickening with pericolic infiltration and focal bladder wall thickening. The cystoscopy with transurethral resection of bladder tumor revealed muscle invasion, dis-cohesive carcinoma with plasmacytoid morphology, which was initially misdiagnosed as the plasmacytoid urothelial carcinoma. Immunohistochemical stains showed the tumor cells to be positive for CDX2, CK20, and SATB2 and negative for p63, GATA3, CK7, and Uroplakin II, indicating the colorectal origin of the tumor. The subsequent colonic wall biopsy showed the same tumor. Molecular studies identified BRAF V600E, SMAD4, and p53 mutations associated with aggressive colorectal adenocarcinoma with mucinous/signet ring cell features. Further whole-exome sequencing and whole transcriptome analysis confirmed the colorectal origin of the tumor. This rare colorectal adenocarcinoma with the plasmacytoid feature may represent the signet ring cell adenocarcinoma lacking extracellular mucin or intracellular vacuole. Diagnosis of this rare histological subtype of colorectal carcinoma is important, particularly in the unusual presentation of this aggressive tumor.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39641776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac Involvement by Human Herpesvirus 8-Positive Diffuse Large B-Cell Lymphoma: An Unusual Presentation in a Patient with Human Immunodeficiency Virus. 人类疱疹病毒8阳性弥漫性大b细胞淋巴瘤累及心脏:人类免疫缺陷病毒患者的不寻常表现

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Case Reports in Pathology Pub Date : 2022-01-17 eCollection Date: 2022-01-01 DOI: 10.1155/2022/1298121

Elena M Fenu, Michael W Beaty, Tiffany E O'Neill, Stacey S O'Neill

引用次数: 2

Mucinous Adenocarcinoma of the Colon with Clear Cell Component: A Case Report and Literature Review. 带有透明细胞成分的结肠粘液腺癌1例报告及文献复习。

IF 0.6

Case Reports in Pathology Pub Date : 2022-01-01 DOI: 10.1155/2022/7631686

Andrija Karačić, Gabrijela Stanić, Domagoj Štritof, Branko Bakula, Dubravka Jandrić, Inka Kekez

引用次数: 0

A Huge Mesenteric Lymphangioma Presenting as a Small Bowel Volvulus in a Paediatric Patient: A Case Report. 一个巨大的肠系膜淋巴管瘤表现为小肠扭转的儿科患者:1例报告。

IF 0.6

Case Reports in Pathology Pub Date : 2022-01-01 DOI: 10.1155/2022/3033705

Sushma Thapa, Abhinav Sharma, Dipesh Upreti, Om Bahadur Karki, Sudeep Regmi, Dilasma Ghartimagar, Arnab Ghosh

{"title":"A Huge Mesenteric Lymphangioma Presenting as a Small Bowel Volvulus in a Paediatric Patient: A Case Report.","authors":"Sushma Thapa, Abhinav Sharma, Dipesh Upreti, Om Bahadur Karki, Sudeep Regmi, Dilasma Ghartimagar, Arnab Ghosh","doi":"10.1155/2022/3033705","DOIUrl":"https://doi.org/10.1155/2022/3033705","url":null,"abstract":"Lymphangioma is a benign tumor characterized by proliferation of thin-walled lymphatic spaces. Lymphangioma of the small-bowel mesentery is rare, with an incidence of 1 : 250,000, representing less than 1% of all lymphangiomas. The predilection of the tumor is in the head and neck (70%), axillary (20%), and internal organs (10%). They are usually asymptomatic but can cause acute abdominal symptoms due to complications such as volvulus, bleeding, or lymphangioma rupture that require emergent surgery. Here, we report a case of mesenteric lymphangioma (ML) of a small bowel in a paediatric patient who presented with pain abdomen on and off which increased in severity and later had features of subacute intestinal obstruction. He underwent explorative laparotomy, and the mass was excised completely along with the part of small intestine. Pathological analysis of the surgical specimen confirmed the diagnosis of ML of the small intestine. The postoperative recovery was uneventful, and the patient was discharged after ten days of hospital stay. Though benign in nature, ML may cause acute abdominal symptoms that require emergent surgery. Therefore, it has to be kept in differential diagnosis of the acute abdominal condition.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10618429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benign Neurofibroma/Schwannoma Hybrid Peripheral Nerve Sheath Tumor of the Ulnar Nerve Harboring a Metastatic Papillary Thyroid Carcinoma Deposit: A Case Report of Tumor-to-Tumor Metastasis. 尺神经良性神经纤维瘤/神经鞘瘤混合型周围神经鞘瘤伴转移性甲状腺乳头状癌沉积:肿瘤到肿瘤转移1例报告。

IF 0.6

Case Reports in Pathology Pub Date : 2022-01-01 DOI: 10.1155/2022/9038222

Juan M Colazo, Alexander N Perez, Anthony D Judice, Julia Quirion, Carlos N Prieto-Granada, Ginger E Holt

{"title":"Benign Neurofibroma/Schwannoma Hybrid Peripheral Nerve Sheath Tumor of the Ulnar Nerve Harboring a Metastatic Papillary Thyroid Carcinoma Deposit: A Case Report of Tumor-to-Tumor Metastasis.","authors":"Juan M Colazo, Alexander N Perez, Anthony D Judice, Julia Quirion, Carlos N Prieto-Granada, Ginger E Holt","doi":"10.1155/2022/9038222","DOIUrl":"https://doi.org/10.1155/2022/9038222","url":null,"abstract":"A 74-year-old man with a medical history significant for papillary thyroid cancer (PTC) presented with a rapidly enlarging grape-sized mass in his right medial arm with paresthesia in the ulnar nerve distribution. Imaging was suspicious for a peripheral nerve sheath tumor (PNST), but an ultrasound-guided biopsy was equivocal. The mass was excised with final histopathology demonstrating a benign neurofibroma/schwannoma hybrid nerve sheath tumor (N/S HNST) harboring a metastatic PTC deposit, ultimately mimicking the rare glandular schwannoma subtype. Next-generation sequencing (NGS) of the lesion demonstrated somatic variants in BRAF and TERT (common in PTC) and NF2 (common in PNSTs). After excision, the patient's nerve symptoms improved. A postsurgical PET/CT scan also showed progression in the lungs/mediastinum. Due to the metastatic nature of his PTC, he was treated with 14 mg of Lenvima (lenvatinib) daily, and his PET/CT surveillance was performed at more frequent intervals. Tumor-to-tumor metastasis (TTM) is a rare occurrence. To our knowledge, this is the first case reported on PTC metastasizing into a benign (hybrid) PNST, which mimicked glandular schwannoma. Symptomatology, imaging characteristics, NGS, and histopathological characteristics that can decipher between different benign PNST subtypes (schwannoma, neurofibroma, glandular, hybrid, etc.), malignant PNSTs (MPNSTs), and TTM are described.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10787343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Microcystic Stromal Tumor with Predominant Bizarre Nuclei of Ovary in a Pregnant Woman. 孕妇卵巢微囊性间质瘤，以奇异核为主。

IF 0.6

Case Reports in Pathology Pub Date : 2022-01-01 DOI: 10.1155/2022/8457901

Tip Pongsuvareeyakul, Chalita Kingnate, Kornkanok Sukpan, Surapan Khunamornpong

引用次数: 0

Sarcina ventriculi in an Endoscopic Ultrasound-Guided Fine Needle Aspiration of a Perigastric Lymph Node with Metastatic Pancreatic Adenocarcinoma: A Carry-Through Contaminant Bacterial Microorganism from the Stomach. 超声内镜引导下细针穿刺胃周围淋巴结转移性胰腺腺癌的脑室肌瘤:一种来自胃的污染物细菌微生物。

IF 0.6

Case Reports in Pathology Pub Date : 2021-12-29 eCollection Date: 2021-01-01 DOI: 10.1155/2021/4933279

Bharat Nandakumar, Diva R Salomao, Nicholas A Boire, Audrey N Schuetz, Charles D Sturgis

{"title":"Sarcina ventriculi in an Endoscopic Ultrasound-Guided Fine Needle Aspiration of a Perigastric Lymph Node with Metastatic Pancreatic Adenocarcinoma: A Carry-Through Contaminant Bacterial Microorganism from the Stomach.","authors":"Bharat Nandakumar, Diva R Salomao, Nicholas A Boire, Audrey N Schuetz, Charles D Sturgis","doi":"10.1155/2021/4933279","DOIUrl":"https://doi.org/10.1155/2021/4933279","url":null,"abstract":"Sarcina ventriculi is a rare gram-positive coccus increasingly reported in patients with a history of delayed gastric emptying or gastric outlet obstruction and is sometimes seen in association with emphysematous gastritis and perforation. We report a case of a 67-year-old male who presented with epigastric pain. CT imaging and cholangiopancreatography were concerning for pancreatic neoplasia. Upper endoscopic ultrasound-guided fine needle aspiration cytology of a perigastric lymph node confirmed metastatic adenocarcinoma of pancreatic origin, and cocci arranged in a tetrad fashions characteristic of Sarcina ventriculi were noted. To our knowledge, this is the first reported case of Sarcina ventriculi in an FNA of metastatic pancreatic carcinoma in a perigastric lymph node. These organisms likely represent carry-through contaminants from the transgastric approach of the endoscopic FNA.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8731288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39662365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Tiger-Striped PASH: Recognition of a Unique Morphology Allows for a Zippered-Up Diagnosis of Pseudoangiomatous Stromal Hyperplasia of Breast. 虎纹PASH:识别一种独特的形态允许一个快速诊断乳腺假性血管瘤间质增生。

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Case Reports in Pathology Pub Date : 2021-12-26 eCollection Date: 2021-01-01 DOI: 10.1155/2021/7697987

Mohamad Sakibuzzaman, Ryan W Kendziora, Toshi Ghosh, Malvika H Solanki, Amy Lynn Conners, Lisa J Ahlberg, Charles D Sturgis

引用次数: 2

A Case of Untreated Myeloid Sarcoma of the Pancreas Head Region: Diagnostic Process of AML Subtyping in an Autoptic Case. 1例未经治疗的胰腺头区髓系肉瘤:一例自体病例的AML亚型诊断过程。

IF 0.6

Case Reports in Pathology Pub Date : 2021-12-21 eCollection Date: 2021-01-01 DOI: 10.1155/2021/7439148

Yuki Fukumura, Gentaro Taniguchi, Ai Koyanagi, Yuki Horiuchi, Tomonori Ochiai, Yoko Tabe, Katsuhiro Sano, Yifare Maimaitiaili, Naomi Otsuji, Karin Ashizawa, Takashi Yao

{"title":"A Case of Untreated Myeloid Sarcoma of the Pancreas Head Region: Diagnostic Process of AML Subtyping in an Autoptic Case.","authors":"Yuki Fukumura, Gentaro Taniguchi, Ai Koyanagi, Yuki Horiuchi, Tomonori Ochiai, Yoko Tabe, Katsuhiro Sano, Yifare Maimaitiaili, Naomi Otsuji, Karin Ashizawa, Takashi Yao","doi":"10.1155/2021/7439148","DOIUrl":"https://doi.org/10.1155/2021/7439148","url":null,"abstract":"This study describes an autopsy case of pancreatic/peripancreatic myeloid sarcoma in a 70-year-old man, initially presenting with obstructive jaundice. Pathologically, diffuse infiltration of round cells containing atypical nuclei with marked cleavage was observed mainly in the pancreas head, peripancreatic lymph nodes, spleen, bilateral lung, and bone marrow. Immunohistochemically, the tumor cells were negative for CD20, CD79a, CD3, CD5, c-kit, CD34, and TdT and positive for myeloperoxidase, CD33, CD68, and CD163. Flow cytometry of the peripheral blood showed underexpression of CD11c and aberrant expression of CD56 in the monocyte subset. The peripheral blood smear showed an increase in monocytes and atypia in neutrophils and monocytes, as well as enlarged platelets and polychromatic erythroblasts. Hence, it was suggested that the myeloid sarcoma was derived from the acute transformation of chronic myelomonocytic leukemia. Myeloid sarcoma is an extramedullary-mass-forming hematologic malignancy that is difficult to diagnose, especially when the initial presentation is a pancreatic mass. However, early diagnosis is important for appropriate therapy. Although bone marrow examination could not be performed because of the patients' severe condition, the pathological specimen obtained with autopsy helped subtype the patient's leukemia. The immunohistochemical features of this case merit attention.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39774710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Schwannoma of the Appendix Orifice. 阑尾孔神经鞘瘤。

IF 0.6

Case Reports in Pathology Pub Date : 2021-12-11 eCollection Date: 2021-01-01 DOI: 10.1155/2021/7250145

Maha Alkhattab, Amenah Dhannoon, Rishabh Sehgal, Conor Gormley, Margaret Sheehan, Ray Mclaughlin

{"title":"Schwannoma of the Appendix Orifice.","authors":"Maha Alkhattab, Amenah Dhannoon, Rishabh Sehgal, Conor Gormley, Margaret Sheehan, Ray Mclaughlin","doi":"10.1155/2021/7250145","DOIUrl":"https://doi.org/10.1155/2021/7250145","url":null,"abstract":"Schwannomas are rare mesenchymal tumors. They are usually diagnosed incidentally during endoscopic or diagnostic imaging for another reason. Malignant transformation is rare. In this case report, we present an incidental schwannoma protruding through the appendiceal orifice diagnosed during endoscopy. A healthy 56-year-old female underwent a surveillance colonoscopy for family history of colorectal cancer. A prominent and edematous appendiceal orifice was noted, and the area was aggressively biopsied. Histopathological assessment revealed a benign schwannoma. Computerized topography was unremarkable. Subsequently, the patient underwent a right hemicolectomy. Patient is scheduled to undergo routine surveillance in three years. Grossly, schwannomas are white, encapsulated, and well-circumscribed lesions that stain strongly positive for S100, GFAP, and CD57. Histologically, schwannomas demonstrate spindle cell proliferation. Several imaging modalities have been utilized in the diagnosis and management of mesenchymal neoplasms. Despite the benign nature of the diagnosis, complete surgical resection with clear margins remains the gold standard management strategy. Our case highlights the presence of a relatively uncommon tumor in an unusual anatomical location.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2021-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39620445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2