Case Reports in Pathology最新文献_第7页

Renal Replacement Lipomatosis Presenting in the Setting of Ureteral Stricture with Absence of Renal Calculus Disease. 无肾结石的输尿管狭窄患者的肾脏替代脂肪瘤病。

IF 0.6

Case Reports in Pathology Pub Date : 2021-10-23 eCollection Date: 2021-01-01 DOI: 10.1155/2021/3640167

Katrina Collins, Eric Brocken, Laura M Warmke, Temel Tirkes, Michael Hwang

{"title":"Renal Replacement Lipomatosis Presenting in the Setting of Ureteral Stricture with Absence of Renal Calculus Disease.","authors":"Katrina Collins, Eric Brocken, Laura M Warmke, Temel Tirkes, Michael Hwang","doi":"10.1155/2021/3640167","DOIUrl":"https://doi.org/10.1155/2021/3640167","url":null,"abstract":"Renal replacement lipomatosis of the kidney is a rare, benign entity in which extensive fibrofatty proliferation of the renal sinus is associated with marked atrophy of the renal parenchyma. It is often associated with calculi or long-standing inflammation. This entity may be confused with a fatty neoplasm of the kidney. A 51-year-old woman with a past medical history of pancreas transplant for type 1 diabetes subsequently developed ureteral stricture. This was initially managed by a nephrostomy tube and nephroureterostomy stenting with periodic exchanges to help restore urine flow; however, the renal function of the kidney progressively declined with recurrent and complicated urinary tract infections. She presented for kidney transplant with right native nephrectomy. Gross examination of the right kidney revealed a 12.8 cm renal sinus lipomatous mass replacing much of the kidney. Microscopically, the mass consisted of mature adipose tissue with fibrous septae and occasional thick-walled vessels with prominent smooth muscle bundles. A rare atypical stromal cell was present, otherwise no significant cytologic atypia or lipoblasts were identified. After excluding fat-predominant angiomyolipoma and well-differentiated liposarcoma, a diagnosis of renal replacement lipomatosis was made. Renal replacement lipomatosis is a benign condition typically associated with a nonfunctioning or poorly functioning kidney often linked to renal calculus disease or chronic renal infection. The presentation in our case was atypical given an absence of associated renal calculus disease. This case is intended to increase awareness of this less commonly encountered entity as it may be confused with a fatty neoplasm of the kidney, some with malignant potential.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2021 ","pages":"3640167"},"PeriodicalIF":0.6,"publicationDate":"2021-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39849161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Cause of Bowel Obstruction in a Patient with Long-Standing Crohn's Disease. 长期克罗恩病患者肠梗阻的新原因。

IF 0.6

Case Reports in Pathology Pub Date : 2021-10-18 eCollection Date: 2021-01-01 DOI: 10.1155/2021/3278392

Satya V Vedula, T Paul Nickerson, Douglas J Grider

{"title":"A Novel Cause of Bowel Obstruction in a Patient with Long-Standing Crohn's Disease.","authors":"Satya V Vedula, T Paul Nickerson, Douglas J Grider","doi":"10.1155/2021/3278392","DOIUrl":"10.1155/2021/3278392","url":null,"abstract":"Solitary fibrous tumors are rare tumors of mesenchymal origin. Although most often observed in the lung pleura, they have been reported in varied extrapleural sites. A 70-year-old male with complicated Crohn's disease presented with 3 days of nausea, emesis, constipation, and abdominal pain. Computed Tomography (CT) demonstrated mucosal thickening of the middescending colon, consistent with fibrosing stricture. Surgical excision revealed an unusual, 5 cm mass originating in the subserosa. Histopathology of the lesion was notable for a proliferation of cells with spindle and stellate-shaped nuclei and no appreciable mitotic figures, which extended into the muscularis and submucosa. Immunohistochemistry was STAT6 nuclear positive and cytoplasmic CD34 positive, diagnostic for solitary fibrous tumor (SFT). In this case, the SFT infiltrating into the muscularis propria and subserosa caused the stricture and bowel obstruction. This illustrates that while fibrosing strictures are usually the etiology of bowel obstruction in the setting of Crohn's disease, other rare possible causes should be considered.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2021 ","pages":"3278392"},"PeriodicalIF":0.6,"publicationDate":"2021-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39566084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Liver Transplant for Local Control in a Pediatric Patient with Metastatic TFE3-Associated Perivascular Epithelioid Cell Tumor (PEComa) to the Liver. 肝脏转移tfe3相关血管周围上皮样细胞瘤(PEComa)患儿的局部控制肝移植

IF 0.6

Case Reports in Pathology Pub Date : 2021-10-05 eCollection Date: 2021-01-01 DOI: 10.1155/2021/3924565

Whayoung Lee, Josephine HaDuong, Aaron Sassoon, Tuan Dao, Ali Nael

引用次数: 1

A Case of Endometrial Carcinosarcoma Containing Sertoliform Endometrioid Carcinoma Component. 子宫内膜癌肉瘤含梭状子宫内膜样癌成分1例。

IF 0.6

Case Reports in Pathology Pub Date : 2021-09-20 eCollection Date: 2021-01-01 DOI: 10.1155/2021/5868818

Satoru Munakata, Hanae Kushibiki, Taishi Akimoto, Tsuyoshi Yamashita, Norihiko Shimoyama

{"title":"A Case of Endometrial Carcinosarcoma Containing Sertoliform Endometrioid Carcinoma Component.","authors":"Satoru Munakata, Hanae Kushibiki, Taishi Akimoto, Tsuyoshi Yamashita, Norihiko Shimoyama","doi":"10.1155/2021/5868818","DOIUrl":"https://doi.org/10.1155/2021/5868818","url":null,"abstract":"Carcinosarcomas (CSs) of the endometrium have admixture of malignant epithelial and mesenchymal components. The carcinomatous component exhibit endometrioid, serous, or clear cell differentiation, or are undifferentiated. CSs are considered homologous or heterologous according to the type of sarcomatous component. Sertoliform endometrioid carcinomas (SECs) of the endometrium which comprise a rare subtype of endometrial cancer, typically occur in the ovary. SECs as a carcinomatous component of CS of the endometrium have not been reported. Here, we report an endometrial carcinosarcoma that contains an SEC component. An 88-year-old female presented to a clinic with atypical genital bleeding. She was referred to our hospital and underwent total hysterectomy, bilateral adnexectomy and partial omentectomy due to endometrial carcinoma. Gross examination revealed a polypoid mass in the uterine cavity with massive myometrial invasion. Histologically, the tumor was a high-grade endometrioid carcinoma. In addition to an ordinary conventional endometrioid carcinoma, approximately 30% of the area exhibited sex cord-like pattern and contained small hollow tubules, anastomosing cords and trabeculae, and tightly packed nests. Immunohistochemically, the SEC component showed diffuse p53 staining. Sex cord-like area, especially the solid area, showed positive staining for EMA, vimentin, α-inhibin, CD99, calretinin, p53, CD56, synaptophysin, and chromogranin A, which is a staining pattern similar to that previously reported SEC of the endometrium. Diminished membranous and positive cytoplasmic staining for β-catenin was observed. This is the first case report of an endometrial carcinosarcoma containing an SEC component. SECs of the endometrium might exhibit sex cord-like differentiation in contrast to SECs of the ovary, which do not exhibit sex cord differentiation.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2021 ","pages":"5868818"},"PeriodicalIF":0.6,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39474888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progressive Nodular Histiocytosis: Report of a Case and Review of the Literature. 进行性结节性组织细胞增多症1例报告及文献复习。

IF 0.6

Case Reports in Pathology Pub Date : 2021-09-17 eCollection Date: 2021-01-01 DOI: 10.1155/2021/5531820

Numbereye Numbere, Tatsiana Pukhalskaya, Blythe Bowman, Katelynn Campbell, Bruce Smoller

{"title":"Progressive Nodular Histiocytosis: Report of a Case and Review of the Literature.","authors":"Numbereye Numbere, Tatsiana Pukhalskaya, Blythe Bowman, Katelynn Campbell, Bruce Smoller","doi":"10.1155/2021/5531820","DOIUrl":"https://doi.org/10.1155/2021/5531820","url":null,"abstract":"Progressive nodular histiocytosis (PNH) is a rare condition characterized by progressive eruption of multiple yellowish-brown papules and nodules on the skin and mucous membranes. We present the case of a 37-year-old Caucasian man with gradually increased appearance of nodular lesions on the forehead and right temple. These lesions were initially diagnosed as xanthomas and did not respond to intralesional injections of triamcinolone. Additional biopsy revealed an intense dermal infiltrate of foamy mononuclear epithelioid cells with a minor admixture of plasma cells, lymphocytes, and scattered multinucleated giant cells. On immunohistochemical staining, the lesional cells were positive for CD163 and CD68 and negative for CD1a, thus confirming a mononuclear-macrophage lineage. The clinical presentation and the histological impression lead to the diagnosis of PNH. This condition could be challenging, mimicking microscopically similar lesions of the non-Langerhans cell histiocytosis group. Although uncommon, PNH stands out due to its clinical and microscopic features and should be taken into consideration in the differential diagnosis of cutaneous histiocytoses.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2021 ","pages":"5531820"},"PeriodicalIF":0.6,"publicationDate":"2021-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39453968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Multiple Primary Angiosarcomas of the Colon. 结肠多发原发性血管肉瘤。

IF 0.6

Case Reports in Pathology Pub Date : 2021-09-09 eCollection Date: 2021-01-01 DOI: 10.1155/2021/7237379

Sonja Radić, Mario Zovak, Anita Galović Marić, Stjepan Baturina, Monica Stephany Kirigin, Božo Krušlin

{"title":"Multiple Primary Angiosarcomas of the Colon.","authors":"Sonja Radić, Mario Zovak, Anita Galović Marić, Stjepan Baturina, Monica Stephany Kirigin, Božo Krušlin","doi":"10.1155/2021/7237379","DOIUrl":"https://doi.org/10.1155/2021/7237379","url":null,"abstract":"Introduction: Gastrointestinal angiosarcomas are rare and represent less than 1% of all gastrointestinal tract malignancies, with most occurring in the stomach and small intestine. Occurrence in the colorectal segments is considered extremely rare. Case Report. We describe the case of a 61-year-old male with multiple primary angiosarcomas of the colon who presented with fever and abdominal pain. The patient was initially hospitalized and treated as having an infectious disease. A multislice computed tomography (MSCT) scan revealed multiple soft tissue tumors in the region of the left iliopsoas and gluteus medius muscles. After developing hematochezia, a colonoscopy was performed which found an ulcerated tumor in the sigmoid colon. The small tissue biopsy taken during the procedure presented diagnostic difficulties and was given a preliminary diagnosis of gastrointestinal stromal tumor (GIST). Examination of the resected colon segment and surrounding fat tissue revealed four separate tumors. Microscopically, the tumors were composed of solid sheets of spindle and epithelioid neoplastic cells with prominent nucleoli and numerous mitotic figures and immunohistochemically positive for ERG, CD31, CD34, vimentin, and CD117, while negative for CK7, CK20, CD20, CD3, CD45, TTF-1, PAN-CK, ALK, Mpox, S-100, and DOG1, leading to the final diagnosis of multiple colonic angiosarcomas. The patient's condition declined rapidly and he passed away from multiple organ failures 60 days after initial hospitalization.Conclusion: Both clinical and pathological diagnoses of colorectal angiosarcoma are challenging. Patients are present with nonspecific symptoms leading to mismanagement and late diagnosis. A definitive pathological diagnosis relies on immunohistochemical staining for endothelial markers. Misdiagnosis as poorly differentiated adenocarcinoma or GIST is possible in limited tissue biopsies.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2021 ","pages":"7237379"},"PeriodicalIF":0.6,"publicationDate":"2021-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39434602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Primary Dural Lymphoma Mimicking En Plaque Cerebellopontine Angle Meningioma. 原发性硬脑膜淋巴瘤模拟En斑块脑桥小脑角脑膜瘤。

IF 0.6

Case Reports in Pathology Pub Date : 2021-07-23 eCollection Date: 2021-01-01 DOI: 10.1155/2021/2845995

Mei Xu, Ashish Bains, Yuan Rong

{"title":"Primary Dural Lymphoma Mimicking En Plaque Cerebellopontine Angle Meningioma.","authors":"Mei Xu, Ashish Bains, Yuan Rong","doi":"10.1155/2021/2845995","DOIUrl":"https://doi.org/10.1155/2021/2845995","url":null,"abstract":"Primary dural lymphoma (PDL) usually arises from the calvarial dura without the brain parenchyma or systemic involvement and thus may not be considered as a typical form of primary CNS lymphoma (PCNSL). It is exceedingly rare. When it occurs, it might not be suspected as a primary diagnosis on clinical and radiologic findings. We present a PDL case that occurs at the cerebellopontine (CP) angle mimicking en plaque meningioma. The tumor histopathology showed a lymphoproliferative disorder immunophenotypically consistent with a low-grade marginal zone lymphoma. Bone marrow and systemic involvements were not identified, and a diagnosis of PDL was established. As a residual tumor at the CP angle was inaccessible to surgery, postoperative radiation therapy was performed. No recurrence was found at 15-month follow-up. PDLs are mostly indolent and have a good prognosis. There is no doubt that the most important differential diagnosis is meningioma. Furthermore, the present case emphasizes the necessity of an intraoperative consultation and knowledge of this rare yet essential form of PCNSL so that appropriate studies can be ordered.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2021 ","pages":"2845995"},"PeriodicalIF":0.6,"publicationDate":"2021-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39269473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Metastatic Seminoma with Positive Staining of Cytokeratin and MOC31: A Diagnostic Pitfall. 细胞角蛋白和MOC31染色阳性的转移性精原细胞瘤:一个诊断缺陷。

IF 0.6

Case Reports in Pathology Pub Date : 2021-06-29 eCollection Date: 2021-01-01 DOI: 10.1155/2021/9992978

Jiaming Fan, Ren Yuan, David Stefanelli, Gang Wang

引用次数: 1

Corrigendum to "Localized Biphasic Malignant Peritoneal Mesothelioma with Rhabdoid Features Involving the Liver: Case Report and Review of the Literature". “局部双期恶性腹膜间皮瘤伴横纹肌样特征累及肝脏:病例报告及文献回顾”的更正。

IF 0.6

Case Reports in Pathology Pub Date : 2021-06-15 eCollection Date: 2021-01-01 DOI: 10.1155/2021/9867879

Dalal Hassan, Saverio Ligato

引用次数: 0

A Rare Case of a Solitary Fibrous Tumor of the Spermatic Cord. 精索单发纤维性肿瘤1例。