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Current Clinical Microbiology Reports最新文献

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Picornavirus Cellular Remodeling: Doubling Down in Response to Viral-Induced Inflammation. 皮卡病毒细胞重塑：加倍努力应对病毒引发的炎症
IF 3.1
Current Clinical Microbiology Reports Pub Date : 2020-06-01 Epub Date: 2020-04-17 DOI: 10.1007/s40588-020-00138-4
Alexis Bouin, Bert L Semler
{"title":"Picornavirus Cellular Remodeling: Doubling Down in Response to Viral-Induced Inflammation.","authors":"Alexis Bouin, Bert L Semler","doi":"10.1007/s40588-020-00138-4","DOIUrl":"10.1007/s40588-020-00138-4","url":null,"abstract":"<p><strong>Purpose of review: </strong>To highlight recent findings on how picornavirus infections of the airways and cardiac tissues impact cellular inflammation and remodeling events.</p><p><strong>Recent findings: </strong>Recent published work has revealed that although many picornavirus infections appear to be initially asymptomatic, there are significant disease sequelae that result from chronic or persistent infections and the long-term, pathogenic effects on host tissues.</p><p><strong>Summary: </strong>Because many acute picornavirus infections are asymptomatic, it is difficult to diagnose these pathologies at the early stages of disease. As a result, we must rely on preventative measures (i.e., vaccination) or discover novel treatments to reverse tissue damage and remodeling in affected individuals. Both of these strategies will require a comprehensive knowledge of virus-and cell-specific replication determinants and how these processes induce pathogenic effects in infected cells and tissues.</p>","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38186840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fungal Infections of the Eye 眼部真菌感染
IF 5.2
Current Clinical Microbiology Reports Pub Date : 2020-05-22 DOI: 10.1007/s40588-020-00142-8
R. Rammohan, V. Suneetha, S. Sen, G. Rameshkumar, P. Lalitha
{"title":"Fungal Infections of the Eye","authors":"R. Rammohan, V. Suneetha, S. Sen, G. Rameshkumar, P. Lalitha","doi":"10.1007/s40588-020-00142-8","DOIUrl":"https://doi.org/10.1007/s40588-020-00142-8","url":null,"abstract":"","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2020-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141203521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fungal Infections of the Eye 眼部真菌感染
IF 5.2
Current Clinical Microbiology Reports Pub Date : 2020-05-22 DOI: 10.1007/s40588-020-00142-8
R. Rammohan, V. Suneetha, S. Sen, G. Rameshkumar, P. Lalitha
{"title":"Fungal Infections of the Eye","authors":"R. Rammohan, V. Suneetha, S. Sen, G. Rameshkumar, P. Lalitha","doi":"10.1007/s40588-020-00142-8","DOIUrl":"https://doi.org/10.1007/s40588-020-00142-8","url":null,"abstract":"","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2020-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141203645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunotherapy as an Antifungal Strategy in Immune Compromised Hosts 免疫疗法作为免疫受损宿主的抗真菌策略
IF 5.2
Current Clinical Microbiology Reports Pub Date : 2020-05-20 DOI: 10.1007/s40588-020-00141-9
W. Posch, D. Wilflingseder, C. Lass‐Flörl
{"title":"Immunotherapy as an Antifungal Strategy in Immune Compromised Hosts","authors":"W. Posch, D. Wilflingseder, C. Lass‐Flörl","doi":"10.1007/s40588-020-00141-9","DOIUrl":"https://doi.org/10.1007/s40588-020-00141-9","url":null,"abstract":"","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2020-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141203927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunotherapy as an Antifungal Strategy in Immune Compromised Hosts 免疫疗法作为免疫受损宿主的抗真菌策略
IF 5.2
Current Clinical Microbiology Reports Pub Date : 2020-05-20 DOI: 10.1007/s40588-020-00141-9
W. Posch, D. Wilflingseder, C. Lass‐Flörl
{"title":"Immunotherapy as an Antifungal Strategy in Immune Compromised Hosts","authors":"W. Posch, D. Wilflingseder, C. Lass‐Flörl","doi":"10.1007/s40588-020-00141-9","DOIUrl":"https://doi.org/10.1007/s40588-020-00141-9","url":null,"abstract":"","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2020-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141204055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polymicrobial Infections and Neurodegenerative Diseases 多微生物感染与神经退行性疾病
IF 5.2
Current Clinical Microbiology Reports Pub Date : 2020-05-13 DOI: 10.1007/s40588-020-00139-3
Luis Carrasco, D. Pisa, R. Alonso
{"title":"Polymicrobial Infections and Neurodegenerative Diseases","authors":"Luis Carrasco, D. Pisa, R. Alonso","doi":"10.1007/s40588-020-00139-3","DOIUrl":"https://doi.org/10.1007/s40588-020-00139-3","url":null,"abstract":"","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2020-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141205238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polymicrobial Infections and Neurodegenerative Diseases 多微生物感染与神经退行性疾病
IF 5.2
Current Clinical Microbiology Reports Pub Date : 2020-05-13 DOI: 10.1007/s40588-020-00139-3
Luis Carrasco, D. Pisa, R. Alonso
{"title":"Polymicrobial Infections and Neurodegenerative Diseases","authors":"Luis Carrasco, D. Pisa, R. Alonso","doi":"10.1007/s40588-020-00139-3","DOIUrl":"https://doi.org/10.1007/s40588-020-00139-3","url":null,"abstract":"","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2020-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141205239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biology and function of exo-polysaccharides from human fungal pathogens. 人真菌病原菌外多糖的生物学和功能。
IF 5.2
Current Clinical Microbiology Reports Pub Date : 2020-03-01 Epub Date: 2020-01-17 DOI: 10.1007/s40588-020-00137-5
Krystal Y Chung, Jessica C S Brown
{"title":"Biology and function of exo-polysaccharides from human fungal pathogens.","authors":"Krystal Y Chung,&nbsp;Jessica C S Brown","doi":"10.1007/s40588-020-00137-5","DOIUrl":"https://doi.org/10.1007/s40588-020-00137-5","url":null,"abstract":"<p><strong>Purpose of review: </strong>Environmental fungi such as <i>Cryptococcus neoformans</i> and <i>Aspergillus fumigatus</i> must survive many different and changing environments as they transition from their environmental niches to human lungs and other organs. Fungi alter their cell surfaces and secreted macromolecules to respond to and manipulate their surroundings.</p><p><strong>Recent findings: </strong>This review focuses on exo-polysaccharides, chains of sugars that transported out of the cell and spread to the local environment. Major exo-polysaccharides for <i>C. neoformans</i> and <i>A. fumigatus</i> are glucuronylxylomannan (GXM) and galactosaminogalactan (GAG), respectively, which accumulate at high concentrations in growth medium and infected patients.</p><p><strong>Summary: </strong>Here we discuss GXM and GAG synthesis and export, their immunomodulatory properties, and their roles in biofilm formation. We also propose areas of future research to address outstanding questions in the field that could facilitate development of new disease treatments.</p>","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40588-020-00137-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38479697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Correction to: Herpesvirus DNA Polymerase Mutants—How Important Is Faithful Genome Replication? 更正：疱疹病毒DNA聚合酶突变体——忠实的基因组复制有多重要？
IF 5.2
Current Clinical Microbiology Reports Pub Date : 2020-01-27 DOI: 10.1007/s40588-019-00136-1
J. Trimpert, N. Osterrieder
{"title":"Correction to: Herpesvirus DNA Polymerase Mutants—How Important Is Faithful Genome Replication?","authors":"J. Trimpert, N. Osterrieder","doi":"10.1007/s40588-019-00136-1","DOIUrl":"https://doi.org/10.1007/s40588-019-00136-1","url":null,"abstract":"","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2020-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40588-019-00136-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48529481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reactive Arthritis: Update. 反应性关节炎:更新。
IF 5.2
Current Clinical Microbiology Reports Pub Date : 2020-01-01 Epub Date: 2020-09-26 DOI: 10.1007/s40588-020-00152-6
Ibtissam Bentaleb, Kawther Ben Abdelghani, Samira Rostom, Bouchra Amine, Ahmed Laatar, Rachid Bahiri
{"title":"Reactive Arthritis: Update.","authors":"Ibtissam Bentaleb,&nbsp;Kawther Ben Abdelghani,&nbsp;Samira Rostom,&nbsp;Bouchra Amine,&nbsp;Ahmed Laatar,&nbsp;Rachid Bahiri","doi":"10.1007/s40588-020-00152-6","DOIUrl":"https://doi.org/10.1007/s40588-020-00152-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>The aim of this paper is to provide an overview about reactive arthritis, with an update regarding pathophysiology and therapeutic approach of the disease, outlining the clinical features and diagnostic approach, based on recent literature review.</p><p><strong>Recent findings: </strong>Reactive arthritis is considered to be part of the spectrum of the spondyloarthritis. Its epidemiology is changing worldwide due to several reasons, among them are as follows: different diagnosis approach and clinical presentations, different grades of infection, microbiome changes, etc. The understanding of pathophysiological models is challenging, but recent studies contribute to elucidate the major factors involved in the development of the disease. The management of ReA depends on the triggering agent and the phase of disease, whether it is acute or chronic.</p><p><strong>Summary: </strong>The association between the microbiome changes and spondyloarthropathies (ReA) is becoming increasingly evident. The results regarding the biologic treatment on refectory ReA are promising.</p>","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40588-020-00152-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38453057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
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