Current Clinical Microbiology Reports最新文献_第9页

Current Aspects of Diagnosis and Therapeutics of Histoplasmosis and Future Trends: Moving onto a New Immune (Diagnosis and Therapeutic) Era? 组织浆菌病的诊断和治疗的现状和未来趋势:进入一个新的免疫(诊断和治疗)时代?

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2019-07-03 DOI: 10.1007/s40588-019-00118-3

Fernando Almeida-Silva, D. S. Gonçalves, Marcos de Abreu Almeida, A. Guimarães

引用次数: 6

The complexity of interactions between female sex hormones and Chlamydia trachomatis infections. 女性性激素与沙眼衣原体感染之间相互作用的复杂性。

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2019-06-01 Epub Date: 2019-05-11 DOI: 10.1007/s40588-019-00116-5

Amy Berry, Jennifer V Hall

{"title":"The complexity of interactions between female sex hormones and Chlamydia trachomatis infections.","authors":"Amy Berry, Jennifer V Hall","doi":"10.1007/s40588-019-00116-5","DOIUrl":"10.1007/s40588-019-00116-5","url":null,"abstract":"Purpose of review: This review focuses specifically on the mechanisms by which female sex hormones, estrogen and progesterone, affect Chlamydia trachomatis infections in vivo and in vitro.Recent findings: Recent data support previous work indicating that estrogen enhances chlamydial development via multiple mechanisms. Progesterone negatively impacts Chlamydia infections also through multiple mechanisms, particularly by altering the immune response. Conflicting data exist regarding the effect of synthetic hormones, such as those found in hormonal contraceptives, on chlamydial infections.Summary: Numerous studies over the years have indicated that female sex hormones affect C. trachomatis infection. However, we still do not have a clear understanding of how these hormones alter Chlamydia disease transmission and progression. The studies reviewed here indicate that there are many variables that determine the outcome of Chlamydia/hormone interactions, including: 1) the specific hormone, 2) hormone concentration, 3) cell type or area of the genital tract, 4) hormone responsiveness of cell lines, and 5) animal models.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"6 2","pages":"67-75"},"PeriodicalIF":5.2,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40588-019-00116-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37502299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Respiratory epithelial cells as master communicators during viral infections. 病毒感染过程中呼吸道上皮细胞作为主要通讯器

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2019-03-01 Epub Date: 2019-02-13 DOI: 10.1007/s40588-019-0111-8

Tanya A Miura

{"title":"Respiratory epithelial cells as master communicators during viral infections.","authors":"Tanya A Miura","doi":"10.1007/s40588-019-0111-8","DOIUrl":"10.1007/s40588-019-0111-8","url":null,"abstract":"Purpose of review: Communication by epithelial cells during respiratory viral infections is critical in orchestrating effective anti-viral responses but also can lead to excessive inflammation. This review will evaluate studies that investigate how respiratory epithelial cells influence the behavior of immune cells and how epithelial cell/immune cell interactions contribute to antiviral responses and immunopathology outcomes.Recent findings: Previous studies have characterized cytokine responses of virus-infected epithelial cells. More recent studies have carefully demonstrated the effects of these cytokines on cellular behaviors within the infected lung. Infected epithelial cells release exosomes that specifically regulate responses of monocytes and neighboring epithelial cells without promoting spread of virus. In contrast, rhinovirus-infected cells induce monocytes to upregulate expression of the viral receptor, promoting spread of the virus to alternate cell types. The precise alteration of PDL expression on infected epithelial cells has been shown to switch between inhibition and activation of antiviral responses.Summary: These studies have more precisely defined the interactions between epithelial and immune cells during viral infections. This level of understanding is critical for the development of novel therapeutic strategies that promote effective antiviral responses or epithelial repair, or inhibit damaging inflammatory responses during severe respiratory viral infections.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"6 1","pages":"10-17"},"PeriodicalIF":5.2,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40588-019-0111-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42423445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Reovirus: Friend and Foe. 呼肠孤病毒:朋友和敌人。

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2019-01-01 Epub Date: 2019-07-04 DOI: 10.1007/s40588-019-00121-8

Michael R Eledge, Marcelle Dina Zita, Karl W Boehme

引用次数: 3

Pathogenesis of Human Gammaherpesviruses: Recent Advances. 人类γ疱疹病毒的发病机制：最新进展。

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2019-01-01 Epub Date: 2019-08-01 DOI: 10.1007/s40588-019-00127-2

Darin J Weed, Blossom Damania

引用次数: 0

Molecular Pathogenesis of Middle East Respiratory Syndrome (MERS) Coronavirus. 中东呼吸综合征(MERS)冠状病毒的分子发病机制

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2019-01-01 Epub Date: 2019-07-05 DOI: 10.1007/s40588-019-00122-7

Arinjay Banerjee, Kaushal Baid, Karen Mossman

{"title":"Molecular Pathogenesis of Middle East Respiratory Syndrome (MERS) Coronavirus.","authors":"Arinjay Banerjee, Kaushal Baid, Karen Mossman","doi":"10.1007/s40588-019-00122-7","DOIUrl":"10.1007/s40588-019-00122-7","url":null,"abstract":"Purpose of review: Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 and is listed in the World Health Organization's blueprint of priority diseases that need immediate research. Camels are reservoirs of this virus, and the virus spills over into humans through direct contact with camels. Human-to-human transmission and travel-associated cases have been identified as well. Limited studies have characterized the molecular pathogenesis of MERS-CoV. Most studies have used ectopic expression of viral proteins to characterize MERS-CoV and its ability to modulate antiviral responses in human cells. Studies with live virus are limited, largely due to the requirement of high containment laboratories. In this review, we have summarized current studies on MERS-CoV molecular pathogenesis and have mentioned some recent strategies that are being developed to control MERS-CoV infection.Recent findings: Multiple antiviral molecules with the potential to inhibit MERS-CoV infection by disrupting virus-receptor interactions are being developed and tested. Although human vaccine candidates are still being developed, a candidate camel vaccine is being tested for efficacy. Combination of supportive treatment with interferon and antivirals is also being explored.Summary: New antiviral molecules that inhibit MERS-CoV and host cell receptor interaction may become available in the future. Additional studies are required to identify and characterize the pathogenesis of MERS-CoV EMC/2012 and other circulating strains. An effective MERS-CoV vaccine, for humans and/or camels, along with an efficient combination antiviral therapy may help us prevent future MERS cases.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"6 3","pages":"139-147"},"PeriodicalIF":5.2,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40588-019-00122-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37784719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Tissue Destruction Caused by Entamoeba histolytica Parasite: Cell Death, Inflammation, Invasion, and the Gut Microbiome. 由溶组织内阿米巴原虫引起的组织破坏:细胞死亡、炎症、入侵和肠道微生物群。

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2019-01-01 Epub Date: 2019-01-21 DOI: 10.1007/s40588-019-0113-6

Swagata Ghosh, Jay Padalia, Shannon Moonah

{"title":"Tissue Destruction Caused by Entamoeba histolytica Parasite: Cell Death, Inflammation, Invasion, and the Gut Microbiome.","authors":"Swagata Ghosh, Jay Padalia, Shannon Moonah","doi":"10.1007/s40588-019-0113-6","DOIUrl":"https://doi.org/10.1007/s40588-019-0113-6","url":null,"abstract":"Purpose of review: Entamoeba histolytica is a protozoan parasite that causes amebiasis, which remains a significant cause of morbidity and mortality worldwide. E. histolytica causes tissue destruction which leads to clinical disease. This review outlines some of the recent advances that have furthered our understanding of the processes that lead to the tissue damage caused by E. histolytica.Recent findings: Recent studies have identified new mechanisms involved in E. histolytica-induced tissue damage. These include (i) new form of contact-dependent killing called trogocytosis; (ii) parasite-produced cytokine, macrophage migration inhibitory factor, that contributes to inflammation; (iii) exploitation of host immune response to promote invasion; and (iv) the contribution of the gut microbiome to clinical disease.Summary: Targeting these mechanisms that result in tissue injury should be a focus of future research for the development of improved preventive and therapeutic strategies for amebiasis.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"6 1","pages":"51-57"},"PeriodicalIF":5.2,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40588-019-0113-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37174042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41

Transcriptional and post-transcriptional regulation of viral gene expression in the gamma-herpesvirus Kaposi's sarcoma-associated herpesvirus. γ -疱疹病毒卡波西肉瘤相关疱疹病毒病毒基因表达的转录和转录后调控

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2018-12-01 Epub Date: 2018-08-03 DOI: 10.1007/s40588-018-0102-1

Matthew Butnaru, Marta M Gaglia

{"title":"Transcriptional and post-transcriptional regulation of viral gene expression in the gamma-herpesvirus Kaposi's sarcoma-associated herpesvirus.","authors":"Matthew Butnaru, Marta M Gaglia","doi":"10.1007/s40588-018-0102-1","DOIUrl":"https://doi.org/10.1007/s40588-018-0102-1","url":null,"abstract":"Purpose of review: Kaposi's sarcoma-associated herpesvirus (KSHV), the etiological agent of the AIDS-associated tumor Kaposi's sarcoma, is a complex virus that expresses ~90 proteins in a regulated temporal cascade during its replication cycle. Although KSHV relies on cellular machinery for gene expression, it also uses specialized regulators to control nearly every step of the process. In this review we discuss the current understanding of KSHV gene regulation.Recent findings: High-throughput sequencing and a new robust system to mutate KSHV have paved the way for comprehensive studies of KSHV gene expression, leading to the characterization of new viral factors that control late gene expression and post-transcriptional steps of gene regulation. They have also revealed key aspects of chromatin-based control of gene expression in the latent and lytic cycle.Summary: The combination of mutant analysis and high-throughput sequencing will continue to expand our model of KSHV gene regulation and point to potential new targets for anti-KSHV drugs.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"5 4","pages":"219-228"},"PeriodicalIF":5.2,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40588-018-0102-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37041543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Antiviral Protection by IFITM3 In Vivo. IFITM3体内抗病毒保护。

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2018-12-01 Epub Date: 2018-08-03 DOI: 10.1007/s40588-018-0103-0

Ashley Zani, Jacob S Yount

{"title":"Antiviral Protection by IFITM3 In Vivo.","authors":"Ashley Zani, Jacob S Yount","doi":"10.1007/s40588-018-0103-0","DOIUrl":"10.1007/s40588-018-0103-0","url":null,"abstract":"Purpose of review: Interferon-induced transmembrane protein 3 (IFITM3) is a cellular restriction factor that blocks fusion between virus and host membranes. Here, we provide an introduction to IFITM3 and the biochemical regulation underlying its antiviral activity. Further, we analyze and summarize the published literature examining phenotypes of IFITM3 knockout mice upon infections with viral pathogens and discuss the controversial association between single nucleotide polymorphisms (SNPs) in the human IFITM3 gene and severe virus infections.Recent findings: Recent publications show that IFITM3 knockout mice experience more severe pathologies than wild-type mice in diverse virus infections, including infections with influenza A virus, West Nile virus, Chikungunya virus, Venezuelan equine encephalitis virus, respiratory syncytial virus, and cytomegalovirus. Likewise, numerous studies of humans of Chinese ancestry have associated the IFITM3 SNP rs12252-C with severe influenza virus infections, though examinations of other populations, such as Europeans, in which this SNP is rare, have largely failed to identify an association with severe infections. A second SNP, rs34481144-A, found in the human IFITM3 promoter has also recently been reported to be a risk allele for severe influenza virus infections.Summary: There is significant evidence for a protective role of IFITM3 against virus infections in both mice and humans, though additional work is required to identify the range of pathogens restricted by IFITM3 and the mechanisms by which human SNPs affect IFITM3 levels or functionality.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"5 4","pages":"229-237"},"PeriodicalIF":5.2,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36870450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chlamydia psittaci in Ocular Adnexal MALT Lymphoma: a Possible Causative Agent in the Pathogenesis of This Disease 眼附件MALT淋巴瘤中的鹦鹉热衣原体:一种可能的致病因子

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2018-11-16 DOI: 10.1007/s40588-018-0108-8

Maximilian C. Köller, A. Aigelsreiter

引用次数: 3