The complexity of interactions between female sex hormones and Chlamydia trachomatis infections.

IF 3.1 Q2 MICROBIOLOGY

Current Clinical Microbiology Reports Pub Date : 2019-06-01 Epub Date: 2019-05-11 DOI:10.1007/s40588-019-00116-5

Amy Berry, Jennifer V Hall

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引用次数: 10

Abstract

Purpose of review: This review focuses specifically on the mechanisms by which female sex hormones, estrogen and progesterone, affect Chlamydia trachomatis infections in vivo and in vitro.

Recent findings: Recent data support previous work indicating that estrogen enhances chlamydial development via multiple mechanisms. Progesterone negatively impacts Chlamydia infections also through multiple mechanisms, particularly by altering the immune response. Conflicting data exist regarding the effect of synthetic hormones, such as those found in hormonal contraceptives, on chlamydial infections.

Summary: Numerous studies over the years have indicated that female sex hormones affect C. trachomatis infection. However, we still do not have a clear understanding of how these hormones alter Chlamydia disease transmission and progression. The studies reviewed here indicate that there are many variables that determine the outcome of Chlamydia/hormone interactions, including: 1) the specific hormone, 2) hormone concentration, 3) cell type or area of the genital tract, 4) hormone responsiveness of cell lines, and 5) animal models.

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女性性激素与沙眼衣原体感染之间相互作用的复杂性。

综述的目的：这篇综述特别关注女性性激素，雌激素和孕激素，在体内外影响沙眼衣原体感染的机制。最近的发现：最近的数据支持了先前的研究，表明雌激素通过多种机制促进衣原体的发育。孕酮也通过多种机制对衣原体感染产生负面影响，特别是通过改变免疫反应。关于合成激素（如激素避孕药中的合成激素）对衣原体感染的影响，存在着相互矛盾的数据。总结：多年来的大量研究表明，女性性激素会影响沙眼衣原体感染。然而，我们仍然不清楚这些激素是如何改变衣原体疾病的传播和进展的。本文综述的研究表明，有许多变量决定了衣原体/激素相互作用的结果，包括：1）特定激素，2）激素浓度，3）生殖道的细胞类型或面积，4）细胞系的激素反应性，以及5）动物模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Clinical Microbiology Reports MICROBIOLOGY-

CiteScore

7.50

自引率

1.90%

发文量

期刊介绍： Current Clinical Microbiology Reports commissions expert reviews from leading scientists at the forefront of research in microbiology. The journal covers this broad field by dividing it into four key main areas of study: virology, bacteriology, parasitology, and mycology. Within each of the four sections, experts from around the world address important aspects of clinical microbiology such as immunology, diagnostics, therapeutics, antibiotics and antibiotic resistance, and vaccines. Some of the world’s foremost authorities in the field of microbiology serve as section editors and editorial board members. Section editors select topics for which leading researchers are invited to contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, which are highlighted in annotated reference lists. These timely reviews of the literature examine the latest scientific discoveries and controversies as they emerge and are indispensable to both researchers and clinicians. The editorial board, composed of more than 20 internationally diverse members, reviews the annual table of contents, ensures that topics address all aspects of emerging research, and where applicable suggests topics of critical importance to various countries/regions.