International Journal of Burns and Trauma最新文献

{"title":"Tuberculous compound palmar ganglion: unravelling a rare diagnosis.","authors":"Latif Zafar Jilani, Mohammad Istiyak, Akash Sudarshan","doi":"10.62347/ZYHQ5711","DOIUrl":"10.62347/ZYHQ5711","url":null,"abstract":"<p><strong>Background: </strong>Tuberculous tenosynovitis is a rare manifestation of musculoskeletal tuberculosis, often misdiagnosed due to its indolent course and nonspecific presentation. Compound palmar ganglion, a chronic form of tuberculous tenosynovitis, can mimic benign conditions like ganglion cysts, leading to diagnostic delays, especially in immunocompromised individuals.</p><p><strong>Case report: </strong>We report a case of a 35-year-old HIV-positive female who presented with a painless swelling on the volar aspect of the wrist for six months. MRI revealed flexor tendon thickening and synovial proliferation, raising suspicion of infectious tenosynovitis. Surgical excision was performed, and histopathological examination confirmed tuberculous tenosynovitis with caseous granulomas. Ziehl-Neelsen staining identified acid-fast bacilli, confirming the diagnosis. The patient was started on standard anti-tubercular therapy (ATT) and showed complete resolution of symptoms at six months.</p><p><strong>Conclusion: </strong>Tuberculous compound palmar ganglion should be considered in chronic wrist swellings, particularly in endemic regions and immunocompromised patients. Early diagnosis using imaging and histopathology is crucial for timely management. A combination of surgical excision and ATT ensures favorable outcomes.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"15 2","pages":"77-82"},"PeriodicalIF":1.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the effect aerials part of <i>Stachys Lavandulifolia ointment</i> on 2nd degree burns compared to silver sulfadiazine on male rat.","authors":"Esmaeel Panahi Kokhdan, Reza Bagherizadeh, Hosein Sadeghi, Mehrzad Jafari Barmak","doi":"10.62347/AQQT7267","DOIUrl":"10.62347/AQQT7267","url":null,"abstract":"<p><strong>Objective: </strong>Skin burns can occur due to exposure to heat, chemicals, electricity, or sunlight, and can cause significant damage to the skin. Burns are classified based on their severity. Research has indicated that herbal extracts may help treat burns. This study aimed to assess the effectiveness of Stachys Lavandulifolia extract ointment in healing burn wounds in rats.</p><p><strong>Methods: </strong>In this study, the efficacy of Stachys Lavandulifolia ointment was evaluated in treating second-degree burns by comparing it with silver sulfadiazine ointment. The study involved preparing Stachys Lavandulifolia extract in 2% and 4% concentrations. Thirty Wistar rats were divided into six groups, including a negative control group, a positive control group, and groups treated with silver sulfadiazine ointment, Stachys Lavandulifolia extract at 2% and 4% concentrations, and Eucerin ointment.</p><p><strong>Results: </strong>The study found that applying 2% Stachys Lavandulifolia ointment is effective in treating second-degree burns. Biochemical analysis revealed significant differences in tissue FRAPS levels between the normal control group and the groups treated with 2% Stachys Lavandulifolia, 4% Stachys Lavandulifolia, and 1% silver sulfadiazine ointment. Statistical analysis indicated that on day 21, the burn area in the 2% and 4% Stachys Lavandulifolia ointment groups was significantly smaller than in the positive control and Eucerin groups.</p><p><strong>Conclusion: </strong>The Stachys Lavandulifolia ointment, with its antioxidant ingredients, can potentially prevent oxidative damage, lower inflammatory factors, and speed up the healing process for burns.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"15 2","pages":"53-63"},"PeriodicalIF":1.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered lipid metabolism and ferroptosis in sodium hydroxide-induced skin burns: a comprehensive rat model-based analysis.","authors":"Chi Zhong, Guangyi Wang, Jianda Zhou, Yang Liu, Zhelin Li, Jianfei Zhang, Ke Shi, Peiting Li, Xiaohui Qiu, Xianrui Wu, Shuyue Chen, Fuying Li, Zitong Zhao, Geao Liang, Hui Xu, Dan Xu","doi":"10.62347/IQTK3162","DOIUrl":"10.62347/IQTK3162","url":null,"abstract":"<p><strong>Objectives: </strong>Sodium hydroxide (NaOH) is known to cause severe injuries through lipid saponification; however, the mechanisms underlying NaOH-induced skin injuries, particularly their effects on lipid metabolism and ferroptosis, are unclear. Here, we aimed to elucidate these mechanisms based on lipid profile evaluations and ferroptosis occurrence.</p><p><strong>Methods: </strong>We used experimental rat models of NaOH-induced skin burns (skin exposed to 0.05% NaOH for 90 or 180 s) alongside a sham-treated control group. Skin morphology and integrity were assessed. Differentially expressed lipid profiles were monitored via untargeted lipidomics. Oxidative stress, lipid peroxidation, and iron metabolism were also assessed. The expression of ferroptosis-associated genes, including acyl-CoA synthetase long-chain family member 4 (<i>ACSL4</i>), lysophosphatidylcholine acyltransferase 3 (<i>LPCAT3</i>), and glutathione peroxidase 4 (<i>GPX4</i>), was analysed using immunohistochemical and quantitative reverse transcription-polymerase chain reaction analyses.</p><p><strong>Results: </strong>NaOH exposure for 90 and 180 s caused second- and third-degree burns, respectively, leading to elevated and reduced levels of polyunsaturated and monosaturated fatty acid phospholipids, respectively. Both groups showed significant increases in reactive oxygen species, ferrous iron, and malondialdehyde levels and significant decreases in glutathione levels. <i>ACSL4</i> and <i>LPCAT3</i> expression increased, and <i>GPX4</i> expression decreased.</p><p><strong>Conclusion: </strong>NaOH-induced skin burns disrupt skin appendages, resulting in lipid metabolism alterations and ferroptosis induction. These findings could provide valuable insights for elucidating the precise mechanisms underlying ferroptosis in the context of NaOH burns and for identifying potential therapeutic strategies.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"15 2","pages":"64-76"},"PeriodicalIF":1.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review and meta-analysis of treatment modalities and their impact on the healing progression of diabetic foot ulcers.","authors":"Yanbiao Zhang, Bo Huang, Ting Wang, Hongfei Dong, Xi Huang, Xianhui Li","doi":"10.62347/WVEM7973","DOIUrl":"10.62347/WVEM7973","url":null,"abstract":"<p><strong>Background: </strong>The diabetic foot ulcer (DFU) is a common and serious complication of diabetes mellitus, which occurs in 15-25% of diabetic patients at some point in their lives. However, most of the Diabetic foot ulcers (DFUs) do not heal with conventional methods of wound care and progress to become chronic, non-healing ulcers with high morbidity, mortality, and economic stakes. Some of the recent techniques in the management of ulcers include Systemic Hyperbaric Oxygen Therapy (s-HBOT), Platelet-Rich Plasma (PRP), Vacuum-Assisted Closure (VAC) Therapy, and Negative Pressure Wound Therapy (NPWT) that aim at improving the ulcer healing rate and minimize the risks of amputation.</p><p><strong>Objective: </strong>This work intends to conduct a comprehensive meta-analysis of the effectiveness, healing time and effect on amputation of these advanced treatment modalities on management of DFUs.</p><p><strong>Methods: </strong>The present study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for the reporting of systematic reviews and meta-analysis of randomized controlled trials. Information was obtained from 10 researches that considered different types of DFU treatment. The major end-points studied were rates of ulcer healing, time to heal and frequency of lower extremity amputations. The meta-analysis was conducted using R statistical software and the synthesis of results was done using forest and funnel plots.</p><p><strong>Results: </strong>The pooled analysis showed that NPWT significantly improved ulcer healing rates (OR = 2.07, 95% CI: 1.09-3.05) and reduced time to healing (Mean Diff = -22 days, 95% CI: -41.60 to -2.40). HBOT, particularly s-HBOT, demonstrated a substantial reduction in amputation rates (OR = 0.08, 95% CI: -0.11-0.28). PRP also showed promise, especially in reducing healing time (Mean Diff = -25 days, 95% CI: -34.80 to -15.20), though with more variability across studies.</p><p><strong>Conclusion: </strong>The results of NPWT were found to be significantly superior for ulcer closure and reduced healing time making it the treatment of choice for DFUs. Compared to controls, both HBOT and s-HBOT were strikingly effective in averting amputations. PRP had the possibility of being used as supplementary treatment especially in treatment with regard to the aspect of promotion of healing. Collectively, these results suggest that it is possible to use such advanced therapies to enhance the treatment of DFU; however, more effort is required to refine the protocols of such therapies and determine the sources of a differential response.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"15 2","pages":"41-52"},"PeriodicalIF":1.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of pregabalin combined with different methods for treating postherpetic neuralgia.","authors":"Yi Yi","doi":"10.62347/DBMD3610","DOIUrl":"10.62347/DBMD3610","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To conduct a meta-analysis of the literature on the treatment of postherpetic neuralgia (PHN) with pregabalin combined with different methods.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Search for relevant literature on the treatment of postherpetic neuralgia with pregabalin combined with different methods in both Chinese and English databases, including PubMed, Web of science, Cochrane Library, Wanfang Data, and China National Knowledge Infrastructure (CNKI).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The final inclusion consisted of 29 articles published between 2009 and 2023, with a total of 2,738 patients. Among them, 22 articles were RCTs, and 7 were non-RCTs. Seven articles reported on NRS, and the meta-analysis of continuous variable showed that the NRS scores in the study group were significantly lower than in the control group (OR = -1.05, 95% CI: -1.37 to -0.73, Z = -6.47, P &lt; 0.01). Seven articles reported on breakthrough pain, and the meta-analysis of continuous variable showed that the frequency of breakthrough pain in the study group was significantly lower than in the control group (OR = -1.23, 95% CI: -1.52 to -0.94, Z = -8.31, P &lt; 0.01). Five articles reported on SF-MPQ, and the meta-analysis of continuous variable showed that the SF-MPQ in the study group was significantly lower than in the control group (OR = -1.47, 95% CI: -2.14 to -0.81, Z = -4.33, P &lt; 0.01). Ten articles reported on sleep quality, and the meta-analysis of continuous variable showed that the sleep quality scores in the study group were significantly lower than in the control group (OR = -2.16, 95% CI: -3.46 to -0.86, Z = -3.26, P &lt; 0.01). Twenty articles reported on VAS, and the meta-analysis of continuous variable showed that the VAS scores in the study group were significantly lower than in the control group (OR = -1.17, 95% CI: -1.49 to -0.85, Z = -7.15, P &lt; 0.01). Seven articles reported on efficacy, and the meta-analysis of dichotomous variable showed that the efficacy in the study group was significantly higher than in the control group (OR = 1.45, 95% CI: 0.94 to 1.95, Z = 5.65, P &lt; 0.01). Thirteen articles reported on adverse reactions, and the meta-analysis of dichotomous variable showed no statistically significant difference in adverse reactions between the study and control groups (OR = 0.31, 95% CI: -0.01 to 0.62, Z = 1.92, P = 0.06). Ten articles reported on quality of life, and the meta-analysis of continuous variable showed that the quality of life scores in the study group were significantly higher than in the control group (OR = 1.00, 95% CI: 0.73 to 1.27, Z = 7.20, P &lt; 0.01). Eleven articles reported on pregabalin dosage, and the meta-analysis of continuous variable showed that the dosage of pregabalin in the study group was significantly lower than in the control group (OR = -2.55, 95% CI: -3.15 to -1.95, Z = -8.30, P &lt; 0.01). Funnel plot analysis indicated publication bias in VAS and pregabalin dosage but no publication bias in a","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"15 2","pages":"21-40"},"PeriodicalIF":1.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Titanium elastic nail system in compound tibial fractures in children and adolescents.","authors":"Abdul Qayyum Khan, Latif Zafar Jilani, Mohammad Istiyak","doi":"10.62347/WMXS7935","DOIUrl":"10.62347/WMXS7935","url":null,"abstract":"<p><p><i>Background:</i> Closed reduction and casting remain the gold standard treatment for tibial shaft fractures in children and adolescents. However, surgical intervention is indicated in cases of unstable fractures, open fractures, polytrauma, compartment syndrome, and fractures with severe soft tissue injury. The present study aimed to evaluate the safety and efficacy of Titanium Elastic Nailing System (TENS) in the management of compound tibial shaft fractures in children and adolescents. <i>Methods:</i> This retrospective study reviewed 18 cases of tibial shaft fractures treated with TENS from 2018 to 2021. Clinical outcomes were assessed based on fracture alignment, delayed union, non-union, infection, range of motion (ROM) of the knee and ankle, limb length discrepancy, and time to fracture union during follow-up visits. Outcomes were classified according to Flynn's criteria. <i>Results:</i> All patients achieved fracture union at a mean duration of 11.6 weeks, with full weight-bearing permitted at an average of 10 weeks. Limb shortening was observed in 4 patients. There were no cases of delayed union or non-union. At the final follow-up, 10 patients demonstrated excellent outcomes, while 8 had satisfactory outcomes. The most common complication was infection at the fracture site, observed in 6 patients. <i>Conclusion:</i> TENS is a safe, reliable, and effective treatment modality for compound tibial shaft fractures in children and adolescents. It facilitates rapid fracture healing with an acceptable complication rate.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"15 1","pages":"11-20"},"PeriodicalIF":1.4,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of hemodynamic changes with ultrasound cardiac output monitoring during burn wound excision and skin grafting in severely burned patients: a prospective observational study.","authors":"Hien Van Vo, Quynh Van Nguyen, Anh Ngoc Le, Tri Thi Bui","doi":"10.62347/JNWH4046","DOIUrl":"10.62347/JNWH4046","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate changes in hemodynamic parameters using the Ultrasound Cardiac Output Monitoring (USCOM) method during general anesthesia for burn wound excision and skin grafting surgery in patients with severe burns.</p><p><strong>Methods: </strong>This prospective observational study included 40 severe burn patients, aged 18-60 years, treated at the Intensive Care Unit (ICU) of Le Huu Trac National Burn Hospital (Hanoi, Vietnam). All patients underwent burn wound excision and skin grafting between June 2023 and March 2024.</p><p><strong>Results: </strong>The average heart rate (HR) at the study time points ranged from 116.8 to 124.3 beats/min. The differences in HR at T₁, T₂, T₃, T₅, and T₆ compared to T₀ were statistically significant (P < 0.05). Mean arterial pressure (MAP) at the study time points ranged from 73.8 mmHg to 95.68 mmHg. The differences in MAP at T₁, T₂, T₃, T₄, and T₅ compared to T₀ were statistically significant (P < 0.05). Cardiac Output (CO) and Cardiac Index (CI) values at all study time points were within normal ranges (6-7.04 l/min and 3.66-4.33 l/min/m², respectively). CO and CI were highest at T₀ (7.04 l/min; 4.33 l/min/m²) and lowest at T₁ (6 l/min; 3.66 l/min/m²). The differences in CO and CI at T₁, T₂, T₄, T₅, and T₆ compared to T₀ were statistically significant (P < 0.05). Stroke Volume (SV) and Stroke Volume Index (SVI) values at all time points were within normal ranges (51.2-56.75 ml and 30.93-34.53 ml/m²). The differences in SV and SVI at T₁, T₄, and T₅ compared to T₀ were statistically significant (P < 0.05). Systemic Vascular Resistance (SVR) and Systemic Vascular Resistance Index (SVRI) values at all time points were within normal ranges (1006.03-1240.45 d.s.cm^-5 and 1681.98-2060.4 d.s.cm^-5.m²). SVR and SVRI were highest at T₆ (1240.45 d.s.cm^-5 and 2060.4 d.s.cm^-5.m²) and lowest at T₁ (1006.03 d.s.cm^-5 and 1681.98 d.s.cm^-5.m²). The differences in SVR and SVRI at T₁ compared to T₀ were statistically significant (P < 0.05).</p><p><strong>Conclusion: </strong>The study demonstrated that hemodynamic parameters, including CO, CI, SV, SVI, SVR, and SVRI, remained within normal ranges throughout the anesthesia process. However, heart rate and blood pressure tended to be elevated, reflecting the hemodynamic characteristics of burn patients. This underscores the importance of close monitoring and adaptive management during anesthesia and resuscitation to ensure hemodynamic stability tailored to the characteristics of severe burn patients.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"15 1","pages":"1-10"},"PeriodicalIF":1.4,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical treatment of mammalian bites----experience in the management of facial wounds by dog and cat bite in China.","authors":"Jianwei Wang, Hongmei Liu, Zhizhou Yang, Huili Wang","doi":"10.62347/GOFZ6734","DOIUrl":"10.62347/GOFZ6734","url":null,"abstract":"<p><p>Mammalian bites to the face challenges not only related to wound healing but also to aesthetic outcomes. This study aims to summarize 7 years of experience in treating mammalian bite wounds and propose a surgical approach for managing these wounds. From July 2016 to August 2023, 185 cases were treated and retrospectively evaluated. Variables collected included age, gender, anatomical location, wound features, and treatment management. The postoperative results were reviewed and analyzed. Of the 185 patients, 27.57% were under 18 years of age; with dog bites accounting for approximately 89.19% of cases. Notably, 59.46% of the injuries occurred in females. The most common injury sites were the forehead, chin, and cheek. Primary closure was utilized for 96.22% of the wounds. The fatty areas, such as the cheek, parotid gland, and mandibular region, were identified as high-risk areas for bite infections. In contrast, the forehead, periocular, nose, ear, and lip were classified as low-risk areas, while other regions were considered moderate-risk zones. The infection rates post-primary closure for high, moderate and low-risk areas are 9.09%, 6.67%, and 2.56%, respectively. Complex mammalian bite wounds should receive prompt plastic and reconstructive surgical treatment at a tertiary center. Most wounds can be effectively repaired with primary closure and other plastic techniques. Special attention should be given to high-risk bite wounds to prevent infection. This paper provides essential considerations and recommendations for the medical and surgical management of patients presenting with bite injuries.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"14 6","pages":"115-124"},"PeriodicalIF":1.4,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chondromyxoid fibroma of distal phalanx of great toe: a rare case report with literature review.","authors":"Latif Zafar Jilani, Mohammad Istiyak, Nikhil Kumar Sharma","doi":"10.62347/MHUS7790","DOIUrl":"10.62347/MHUS7790","url":null,"abstract":"<p><p>Chondromyxoid fibroma (CMF) in the foot is a rare condition. We report a case of CMF in a 7-year-old girl, affecting the distal phalanx of the great toe. Radiographs revealed a lytic lesion involving the entire distal phalanx, with destruction of both the medial and lateral cortices, while the articular surfaces remained intact. The diagnosis was confirmed through histopathological examination. The patient underwent extensive curettage followed by bone grafting. After a six-month follow-up, no signs of recurrence were observed. This case report aims to present and underscore the uncommon occurrence of CMF in the distal phalanx of the toe in a paediatric patient, drawing attention to its atypical location and age of presentation.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"14 6","pages":"142-147"},"PeriodicalIF":1.4,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The <i>COL1A1</i> rs1800012 polymorphism is associated with osteoporosis or fracture risk: a meta-analysis of 30 studies.","authors":"Pengcheng Xu, Yuzhong Wang, Xing Wu, Wei Wang, Qingwen Wang, Wei Lin, Zhisheng Zhang, Ming Li","doi":"10.62347/KKAM3344","DOIUrl":"10.62347/KKAM3344","url":null,"abstract":"<p><strong>Objectives: </strong>Osteoporosis is a complex disease that is influenced by several genetic markers. Many studies have examined the link between the <i>COL1A1</i> gene rs1800012 polymorphism and osteoporosis risk. However, the findings of these studies are contradictory. Therefore, we performed a meta-analysis to aggregate additional information and obtain increased statistical power to more efficiently examine this correlation.</p><p><strong>Methods: </strong>A meta-analysis was conducted to evaluate the association between the <i>COL1A1</i> rs1800012 (G > T) polymorphism and the risk of osteoporosis or fracture. A total of 30 case-control studies were included that contained 2,943 patients and 4,724 control subjects. The Stata 11.0 statistical software package was used to evaluate the odds ratio (OR) and 95% confidence interval.</p><p><strong>Results: </strong>Overall, the recessive and homozygote models showed no heterogeneity, with a significant fixed effect pooled OR (<i>P</i> < 0.001). Moreover, the allelic (<i>P</i> < 0.001), dominant (<i>P</i> < 0.001), and heterozygote (<i>P</i> = 0.002) models were associated with a significantly increased risk of osteoporosis or fracture by random effect analysis. Sub-group analyses revealed that all the hereditary models showed an increased risk of osteoporosis or fracture in a European population. Additionally, we found a significant association in the dominant (<i>P</i> = 0.035) and heterozygote (<i>P</i> = 0.030) models in North Americans. In addition, we observed an association between <i>COL1A1</i> and osteoporosis and fracture risk.</p><p><strong>Conclusions: </strong>Combined with data from previous studies, this meta-analysis suggested that <i>COL1A1</i> is associated with osteoporosis or fracture risk.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"14 6","pages":"148-159"},"PeriodicalIF":1.4,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}