International Journal of Burns and Trauma最新文献

{"title":"Hip biomechanics, health-related quality of life and walking ability after intramedullary fixation in intertrochanteric fracture: a prospective cohort study.","authors":"Deepak Bandu Ghuge, Sujit Kumar Tripathy, Mantu Jain, Gurudip Das, Shahnawaz Khan, Narayan Prasad Mishra","doi":"10.62347/LHBC5417","DOIUrl":"10.62347/LHBC5417","url":null,"abstract":"<p><strong>Objectives: </strong>Altered hip biomechanics following intertrochanteric fracture fixation can result in impaired mobility, decreased functional outcomes, and a reduced quality of life. Despite achieving optimal reduction and fixation, patients often fail to regain their pre-injury activity levels. This study aims to evaluate how changes in hip biomechanics after intertrochanteric fracture fixation using a proximal femoral nail impact the quality of life.</p><p><strong>Methods: </strong>This prospective cohort study, conducted from July 1, 2020, to June 30, 2022, included individuals aged 18 years and older with isolated intertrochanteric fractures managed using the Proximal Femur Nail Antirotation 2 (PFNA2). Clinical assessments included range of motion, pain levels, abductor strength, the modified Harris Hip Score (HHS), and the Parker and Palmer Mobility Score (PPMS) at 6 weeks, 3 months, and 6 months' post-surgery. Hip biomechanics were evaluated radiographically through parameters such as telescoping, tip-apex distance (TAD), neck-shaft angle, and femoral offset. These findings were correlated with functional scores and health-related quality of life (EQ5D-EuroQol 5 Dimension) score.</p><p><strong>Results: </strong>Out of 47 eligible patients, only 30 could be followed up for six months due to the COVID-19 pandemic, and three patients died in the postoperative period. 25 of 33 patients were over 60 years old. Twenty-nine patients had unstable fractures. All patients had hypovitaminosis D, and 92% of patients had osteoporosis. Fracture union occurred in all cases, with a mean union time of 2.9 ± 0.8 months. Radiographic evaluation showed minimal changes in tip-apex distance and other hip biomechanical parameters (femoral offset, neck shaft angle, telescopy). Functional scores, including modified Harris Hip score and health-related quality of life (HRQOL) measures, improved significantly after surgery. However, at six months, these scores were lower than pre-injury levels. Walking ability varied considerably between age groups (< 60 years' vs > 60 years) at 6 weeks, but abductor strength did not differ significantly in subsequent follow-ups.</p><p><strong>Conclusion: </strong>Poor bone quality, characterized by osteomalacia and osteoporosis, is significantly associated with intertrochanteric fractures in Indian populations. The PFNA 2 nailing system effectively maintains reduction and prevents varus collapse. Functional outcomes and HRQOL improve over time with intramedullary fixation, yet patients seldom return to pre-injury levels, potentially influenced by recall bias.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"15 3","pages":"92-101"},"PeriodicalIF":1.4,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in inter observer variation of Schatzker and AO/OTA classification of tibial plateau fractures on addition of CT scan.","authors":"Harpreet Singh Narang, Amit Srivastava, Aditya Nath Aggarwal, Manish Chadha, Anupama Tandon, Sandeep B Rathod","doi":"10.62347/YNVJ5137","DOIUrl":"10.62347/YNVJ5137","url":null,"abstract":"<p><strong>Objective: </strong>Schatzker and AO/OTA classification are commonly used to classify tibial plateau fractures, but they are defined using plain radiographs and may not capture fully the complexity of these fractures. CT scan offers better visualization of occult fractures, joint depression and overall fracture morphology, but its impact on these classifications in term of interobserver variation is unclear. There is paucity of literature on this aspect, hence this study.</p><p><strong>Methods: </strong>A total of 38 cases of tibial plateau fractures were classified by five different observers (four senior residents and one consultant) on the basis of Schatzker and AO/OTA classification. Initially, the observers classified the cases using plain radiographs and then reclassified the cases after supplementing the radiographs with CT scan images. The interobserver reliability was calculated using kappa coefficient.</p><p><strong>Results: </strong>The interobserver agreement for Schatzker classification was found to be moderate on plain radiographs (mean κ_X-ray = 0.593) and substantial after addition of CT scan images (mean κ_{(X-ray + CT scan)} = 0.630). The interobserver agreement for AO/OTA classification was found to be fair on plain radiographs as well as after addition of CT scan images (mean κ_X-ray = 0.313 and mean κ_{(X-ray + CT scan)} = 0.320).</p><p><strong>Conclusion: </strong>After providing advanced imaging both the classification systems showed improvement in the interobserver reliability. However, the change was found to be non-significant. This highlights the weakness of the plain radiograph based classification systems and indicates adoption of classifications based on advanced imaging.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"15 3","pages":"125-132"},"PeriodicalIF":1.4,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the success rate of the semi-sitting position compared with the supine position in the emergency intubation of traumatic patients.","authors":"Mohammad Nasr-Esfahani, Amir Reza Hooshmand","doi":"10.62347/ECFH4339","DOIUrl":"10.62347/ECFH4339","url":null,"abstract":"<p><strong>Objectives: </strong>Tracheal intubation (TI) is an essential skill for various healthcare providers, including emergency medicine specialists and anesthesiologists. The ramped position has been hypothesized to facilitate TI. In this study, we assessed the success rate of the semi-sitting position compared with the supine position in emergency intubation.</p><p><strong>Methods: </strong>In this double-blind clinical trial, 162 traumatic patients admitted to the emergency department at Al-Zahra Hospital were randomly assigned to three groups. Patients in Group I underwent TI in the supine position. Patients in Group II underwent TI in a semi-sitting position at a 25-degree angle, while Group III underwent TI in a semi-sitting position at a 35-degree angle. The Cormack-Lehane (C-L) grade and the number of intubation attempts were compared among the groups.</p><p><strong>Results: </strong>Our findings showed a significant reduction in the number of intubation attempts in Groups II and III compared to Group I (P < 0.001). However, the semi-sitting positions (Groups II and III) were associated with a higher incidence of Grade III and IV C-L views, indicating poorer glottic visualization (P < 0.01).</p><p><strong>Conclusions: </strong>The semi-sitting (ramped) position improves the success rate of TI by reducing the number of intubation attempts. However, it significantly worsens glottic visualization, which may pose challenges during airway management. Further studies are needed to optimize patient positioning in emergency intubation.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"15 3","pages":"143-148"},"PeriodicalIF":1.4,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative risk of osteoporotic fractures with direct oral anticoagulants versus vitamin K antagonists in atrial fibrillation patients: a systematic review.","authors":"Azad Mojahedi, Abhijeet Singh, Amirhossein Sadeghian, On Chen","doi":"10.62347/JUAO3451","DOIUrl":"10.62347/JUAO3451","url":null,"abstract":"<p><p>Atrial fibrillation (AF) is increasingly prevalent in the elderly population and is associated with an elevated risk of osteoporotic fractures. This systematic review aimed to compare the risk of osteoporotic fractures between direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs), particularly warfarin, in patients with AF and to conduct head-to-head comparisons among different DOACs. We systematically searched literature published between January 2020 and October 2024 across multiple scientific databases. The included studies focused on adult patients with AF taking anticoagulants with fracture outcomes. We extracted and synthesized data on the fracture risk across different anticoagulant types. Our analysis revealed that DOACs, particularly rivaroxaban and apixaban, were associated with a lower fracture risk in AF patients than VKAs. Among the DOACs, apixaban appeared to have the most favorable profile for reducing hip fracture risk. Multiple studies have confirmed that DOACs are associated with decreased vertebral fracture risk compared to warfarin, with risk reductions ranging from 18-32% depending on the specific DOAC. DOACs appear to offer a safer alternative to VKAs in terms of fracture risk in patients with atrial fibrillation. This protective effect may be attributed to their lack of interference with vitamin K-dependent bone metabolism. Although evidence suggests that apixaban and rivaroxaban may have superior bone-protective profiles among DOACs, further research is needed to establish definitive comparisons between individual DOACs and elucidate their protective mechanisms.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"15 3","pages":"83-91"},"PeriodicalIF":1.4,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the efficacy of precise platelet-rich plasma injection in grade II meniscus tears.","authors":"Ramin Shayan, Seyyed-Reza Sharifzadeh, Amirhossein Sadeghian, Ehsan Fallah","doi":"10.62347/JZYC7897","DOIUrl":"10.62347/JZYC7897","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated the efficacy of precise platelet-rich plasma (PRP) injection, guided by arthroscopy, in patients with grade II meniscus tears.</p><p><strong>Methods: </strong>The study protocol was reviewed and approved by the Institutional Review Board (IRB) of AJA University of Medical Sciences (Code: IR.AJAUMS.REC.1399.258). This study has also been approved by Iranian Registry of Clinical Trials (IRCT) with the code of: IRCT20200217046523N18. In this study, 90 patients with grade II meniscus tears, randomly assigning them to either a PRP injection group (n=45) or a conservative treatment control group (n=45) were enrolled. All patients included in the study had anterior cruciate ligament (ACL) tears and underwent arthroscopic ACL reconstruction. PRP was prepared using a standardized protocol, and injection was performed under arthroscopic guidance using a specialized cannulated loop navigator. Outcomes were assessed using magnetic resonance imaging (MRI) evaluation at baseline, 6, and 12 months post-intervention, and clinical evaluations at the same time points.</p><p><strong>Results: </strong>While the PRP group showed a trend towards improved meniscus tear healing compared to the control group at 6 months (P=0.0552), this difference was not statistically significant at either 6 or 12 months. Similarly, clinical scores showed slight improvements in the PRP group over time, but these differences were not statistically significant compared to baseline or the control group.</p><p><strong>Conclusion: </strong>This study did not demonstrate statistically significant superior outcomes with precise arthroscopically-guided PRP injection as a standalone treatment for grade II meniscus tears compared to conservative management at 6 and 12-month follow-up. Further research with larger sample sizes and longer follow-up periods is needed to definitively assess the role of PRP in the management of grade II meniscus tears.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"15 3","pages":"133-142"},"PeriodicalIF":1.4,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of insulin treatment in the morphological alterations and oxidative damage to DNA in the liver of young rats subjected to skin scald burn injury.","authors":"Larissa Cristina Schiavoni, Vivianne Izabelle de Araújo Baptista, Hananiah Tardivo Quintana, Mariana Cruz Lazzarin, Flavia de Oliveira","doi":"10.62347/ANQA2365","DOIUrl":"10.62347/ANQA2365","url":null,"abstract":"<p><strong>Background: </strong>Burn injury (BI) represents a major epidemiologic problem worldwide, mostly in children. BIs greater than 40% of the total body surface, are considered severe, and entail a hepatic hypermetabolic response, which is associated with proteins depletions and prolonged hypermetabolism.</p><p><strong>Objective: </strong>This study aims to evaluated the effects of short- and long-term insulin treatment on liver morphology and the use of a biomarker related to oxidative damage to DNA (8-OHdG) to better understand the anabolic action of this hormone in the liver.</p><p><strong>Methods: </strong>Wistar rats aged 21 d were distributed into four groups: control (C), control with insulin (C+I), scald burn injury (SBI), and SBI with insulin (SBI+I). The SBI groups were subjected to a burn 45% total body surface area. The C+I and SBI+I groups received insulin (5 UI/Kg/d) for 4- or 14 d. The livers were analyzed for morphometric, histopathological, and immunohistochemical for 8-OHdG.</p><p><strong>Results: </strong>The main results showed that, in a short time, insulin increases the density of binucleated hepatocytes as an organ response to burn injury. In the long term, insulin increased the area of hepatocytes in the SBI+I group in relation to SBI, highlighting the similar values between the SBI+I and the control groups. Regarding sinusoidal cells, insulin was able to modulate this liver proliferative reaction. Insulin reduces 8-OHdG immunoexpression in short and long-term post-burn moments.</p><p><strong>Conclusion: </strong>The insulin modulation of 8-OHdG makes us infer that a study about the control of 8-OHdG as a potential biomarker in patients could be an efficient precursor of the level of oxidative stress associated with hepatic dysfunction associated to extensive burn injury.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"15 3","pages":"115-124"},"PeriodicalIF":1.4,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Augmentation of clavicular fractures by dual plating.","authors":"Intekhab Alam, Mohammad Baqar Abbas, Sohail Ahmad, Abdul Qayyum Khan, Asad Khan, Afaq Alam","doi":"10.62347/HWHH2373","DOIUrl":"10.62347/HWHH2373","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The clavicle displays significant motion across all three anatomical planes, which poses challenges for achieving rigid internal fixation. While adding a second plate can increase construct stability, concerns exist about the potential compromise of the periosteal blood supply. This study evaluated the union rate, complications, reoperation rates, and functional outcomes of using an extra periosteal dual-plate fixation as an alternative to the conventional single-plate fixation for acute clavicle fractures at 1-year follow-up.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;In this prospective study (May 2023-May 2024), 25 patients with acute clavicle fractures underwent open reduction and internal fixation within four weeks of injury. Dual orthogonal plating was performed in all cases meeting inclusion criteria (midshaft or lateral-third fractures) and also in patients requiring revision after failure of a primary single plate. All procedures were extraperiosteal to preserve blood supply. Patients were followed for a minimum of one year. Outcome measures included radiographic union (regular interval X-rays) and functional recovery assessed by the Constant-Murley shoulder score. Complications and any reoperations were recorded. Institutional ethical approval was obtained and informed consent was taken from all patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 25 patients (7 females, 18 males; mean age 39.7 ± 10.0 years) were treated and followed for an average of 11.3 ± 4.1 months. Of these, 23 patients (92%) underwent dual plating primarily (20 midshaft [80%] and 3 lateral-end [12%] fractures), and 2 patients (8%) had dual plating as a revision after failed single plating. By final follow-up, all 25 fractures achieved full bony union with no cases of nonunion or implant failure. The average time to union was ≤3 months in 15 patients and &gt;3 months in 10 patients; all delayed unions had healed by one year without additional intervention. Shoulder function improved steadily, with mean Constant-Murley scores of 76.2 ± 6.1 at 6 weeks, 83.5 ± 3.5 at 3 months, and 92.2 ± 3.0 at 6 months post-surgery. According to Constant score categories, 20 patients (80%) had \"very good\" shoulder function and 5 patients (20%) had \"good\" function at final follow-up. Complications were infrequent: 2 patients (8%) developed superficial wound infections (resolved with antibiotics), and 6 patients (24%) experienced implant prominence/irritation. No hardware breakage, loosening, or refracture occurred, and no patient required reoperation for hardware-related problems within the follow-up period.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Dual-plate augmentation of acute clavicle fractures proved to be a reliable fixation strategy in this series, yielding a 100% union rate and a low incidence of complications. The application of a second plate in complex or highly unstable clavicle fractures did not adversely affect fracture healing or increase complication rat","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"15 3","pages":"102-114"},"PeriodicalIF":1.4,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberculous compound palmar ganglion: unravelling a rare diagnosis.","authors":"Latif Zafar Jilani, Mohammad Istiyak, Akash Sudarshan","doi":"10.62347/ZYHQ5711","DOIUrl":"10.62347/ZYHQ5711","url":null,"abstract":"<p><strong>Background: </strong>Tuberculous tenosynovitis is a rare manifestation of musculoskeletal tuberculosis, often misdiagnosed due to its indolent course and nonspecific presentation. Compound palmar ganglion, a chronic form of tuberculous tenosynovitis, can mimic benign conditions like ganglion cysts, leading to diagnostic delays, especially in immunocompromised individuals.</p><p><strong>Case report: </strong>We report a case of a 35-year-old HIV-positive female who presented with a painless swelling on the volar aspect of the wrist for six months. MRI revealed flexor tendon thickening and synovial proliferation, raising suspicion of infectious tenosynovitis. Surgical excision was performed, and histopathological examination confirmed tuberculous tenosynovitis with caseous granulomas. Ziehl-Neelsen staining identified acid-fast bacilli, confirming the diagnosis. The patient was started on standard anti-tubercular therapy (ATT) and showed complete resolution of symptoms at six months.</p><p><strong>Conclusion: </strong>Tuberculous compound palmar ganglion should be considered in chronic wrist swellings, particularly in endemic regions and immunocompromised patients. Early diagnosis using imaging and histopathology is crucial for timely management. A combination of surgical excision and ATT ensures favorable outcomes.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"15 2","pages":"77-82"},"PeriodicalIF":1.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the effect aerials part of <i>Stachys Lavandulifolia ointment</i> on 2nd degree burns compared to silver sulfadiazine on male rat.","authors":"Esmaeel Panahi Kokhdan, Reza Bagherizadeh, Hosein Sadeghi, Mehrzad Jafari Barmak","doi":"10.62347/AQQT7267","DOIUrl":"10.62347/AQQT7267","url":null,"abstract":"<p><strong>Objective: </strong>Skin burns can occur due to exposure to heat, chemicals, electricity, or sunlight, and can cause significant damage to the skin. Burns are classified based on their severity. Research has indicated that herbal extracts may help treat burns. This study aimed to assess the effectiveness of Stachys Lavandulifolia extract ointment in healing burn wounds in rats.</p><p><strong>Methods: </strong>In this study, the efficacy of Stachys Lavandulifolia ointment was evaluated in treating second-degree burns by comparing it with silver sulfadiazine ointment. The study involved preparing Stachys Lavandulifolia extract in 2% and 4% concentrations. Thirty Wistar rats were divided into six groups, including a negative control group, a positive control group, and groups treated with silver sulfadiazine ointment, Stachys Lavandulifolia extract at 2% and 4% concentrations, and Eucerin ointment.</p><p><strong>Results: </strong>The study found that applying 2% Stachys Lavandulifolia ointment is effective in treating second-degree burns. Biochemical analysis revealed significant differences in tissue FRAPS levels between the normal control group and the groups treated with 2% Stachys Lavandulifolia, 4% Stachys Lavandulifolia, and 1% silver sulfadiazine ointment. Statistical analysis indicated that on day 21, the burn area in the 2% and 4% Stachys Lavandulifolia ointment groups was significantly smaller than in the positive control and Eucerin groups.</p><p><strong>Conclusion: </strong>The Stachys Lavandulifolia ointment, with its antioxidant ingredients, can potentially prevent oxidative damage, lower inflammatory factors, and speed up the healing process for burns.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"15 2","pages":"53-63"},"PeriodicalIF":1.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered lipid metabolism and ferroptosis in sodium hydroxide-induced skin burns: a comprehensive rat model-based analysis.","authors":"Chi Zhong, Guangyi Wang, Jianda Zhou, Yang Liu, Zhelin Li, Jianfei Zhang, Ke Shi, Peiting Li, Xiaohui Qiu, Xianrui Wu, Shuyue Chen, Fuying Li, Zitong Zhao, Geao Liang, Hui Xu, Dan Xu","doi":"10.62347/IQTK3162","DOIUrl":"10.62347/IQTK3162","url":null,"abstract":"<p><strong>Objectives: </strong>Sodium hydroxide (NaOH) is known to cause severe injuries through lipid saponification; however, the mechanisms underlying NaOH-induced skin injuries, particularly their effects on lipid metabolism and ferroptosis, are unclear. Here, we aimed to elucidate these mechanisms based on lipid profile evaluations and ferroptosis occurrence.</p><p><strong>Methods: </strong>We used experimental rat models of NaOH-induced skin burns (skin exposed to 0.05% NaOH for 90 or 180 s) alongside a sham-treated control group. Skin morphology and integrity were assessed. Differentially expressed lipid profiles were monitored via untargeted lipidomics. Oxidative stress, lipid peroxidation, and iron metabolism were also assessed. The expression of ferroptosis-associated genes, including acyl-CoA synthetase long-chain family member 4 (<i>ACSL4</i>), lysophosphatidylcholine acyltransferase 3 (<i>LPCAT3</i>), and glutathione peroxidase 4 (<i>GPX4</i>), was analysed using immunohistochemical and quantitative reverse transcription-polymerase chain reaction analyses.</p><p><strong>Results: </strong>NaOH exposure for 90 and 180 s caused second- and third-degree burns, respectively, leading to elevated and reduced levels of polyunsaturated and monosaturated fatty acid phospholipids, respectively. Both groups showed significant increases in reactive oxygen species, ferrous iron, and malondialdehyde levels and significant decreases in glutathione levels. <i>ACSL4</i> and <i>LPCAT3</i> expression increased, and <i>GPX4</i> expression decreased.</p><p><strong>Conclusion: </strong>NaOH-induced skin burns disrupt skin appendages, resulting in lipid metabolism alterations and ferroptosis induction. These findings could provide valuable insights for elucidating the precise mechanisms underlying ferroptosis in the context of NaOH burns and for identifying potential therapeutic strategies.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"15 2","pages":"64-76"},"PeriodicalIF":1.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}