International Orthodontics最新文献

{"title":"Efficacy of single versus double miniscrew-assisted maxillary anterior intrusion in subjects with gummy smile or deep bite: A systematic review and meta-analysis","authors":"Dhruv Ahuja ,&nbsp;Siddarth Shetty ,&nbsp;Rajaganesh Gautam ,&nbsp;Puneet Batra ,&nbsp;Toni Lego","doi":"10.1016/j.ortho.2025.100996","DOIUrl":"10.1016/j.ortho.2025.100996","url":null,"abstract":"<div><h3>Aim</h3><div>The focus of this review is to compare the efficacy and predictability of single versus double miniscrew placement for maxillary anterior intrusion.</div></div><div><h3>Material and methods</h3><div>Systematic search for relevant articles published between 2005 and January 2025 was conducted across electronic databases including Scopus, PubMed, WoS, EBSCOhost and Cochrane Library. Studies meeting pre-defined eligibility criteria were included and assessed for methodological quality. Data on intrusion of maxillary anteriors using MS was extracted from included studies. Meta-analysis was conducted to evaluate the effectiveness of single versus double MS in relation to anterior intrusion.</div></div><div><h3>Results</h3><div>The analysis showed that bilateral miniscrews (MS), placed between the maxillary lateral incisors and canines, resulted in significantly greater maxillary anterior intrusion compared to a single MS placed between the central incisors. Bilateral MS also provided better control over incisor inclination and stability with minimal side effects. The forest plot further confirmed significant intrusion with bilateral MS, with a mean difference of −0.25 and an overall effect (Z) of 1.98. The comparison between single and double MS demonstrated a significant effect of double MS on maxillary anterior intrusion (<em>P</em> <!-->&lt;<!--> <!-->0.00001).</div></div><div><h3>Conclusion</h3><div>Bilateral MS configurations offer a reliable and effective treatment approach in maxillary anterior intrusion, particularly when considering individual variations in anatomical and clinical factors.</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 3","pages":"Article 100996"},"PeriodicalIF":1.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative assessment of the BioBiteCorrector® and Herbst appliances combined with fixed appliances in class II patients: A retrospective cohort study on PAR and IOTN indices","authors":"Nick Schröder ,&nbsp;Eleni K. Alexopoulou ,&nbsp;Tim Schröder ,&nbsp;Alexandra K. Papadopoulou ,&nbsp;Vasiliki Koretsi","doi":"10.1016/j.ortho.2025.100994","DOIUrl":"10.1016/j.ortho.2025.100994","url":null,"abstract":"<div><h3>Purpose</h3><div>The BioBiteCorrector® (BBC) appliance was introduced as a further development of the Herbst appliance; however, there is no research comparing their treatment outcomes.</div></div><div><h3>Materials and methods</h3><div>Caucasian healthy patients with at least 5<!--> <!-->mm overjet were included and treated with either Herbst or BBC, both combined with fixed appliances, by one experienced orthodontist at a private practice in Switzerland. Treatment effectiveness was evaluated in terms of occlusal outcomes via the Peer Assessment Rating (PAR) and Index of Orthodontic Treatment Need (IOTN) indices, for which groups were matched at baseline. Data collection took place before bonding and after debonding and data was statistically analyzed with linear/logistic regressions at 5%.</div></div><div><h3>Results</h3><div>Each group was comprised of 58 patients. Patient and treatment related characteristics did not demonstrate any clinically relevant differences at baseline. The overall treatment duration was 19.3<!--> <!-->±<!--> <!-->5.3 and 22.9<!--> <!-->±<!--> <!-->5.7 months for the Herbst and BBC respectively (<em>P</em> <!-->&lt;<!--> <!-->0.001). The main outcomes of absolute PAR reduction, % PAR reduction, PAR improvement, or great PAR improvement were not statistically significant between groups (<em>P</em> <!-->&gt;<!--> <!-->0.05 in all instances); however, patients treated with Herbst had slightly worse overall IOTN scores (<em>P</em> <!-->&lt;<!--> <!-->0.03). The findings did not significantly change after controlling for confounders.</div></div><div><h3>Conclusion</h3><div>Both Herbst and BBC appeared to be equally effective in improving class II malocclusion, yet the BBC appliance led to slightly longer overall treatment duration.</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 2","pages":"Article 100994"},"PeriodicalIF":1.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occlusal cant correction using anterior unilateral bite turbo: A case series","authors":"Nguyen Viet Anh DDS, MDS ,&nbsp;Nguyen Thi Trang DDS, Ph.D ,&nbsp;Doan Thi Bich Ngoc","doi":"10.1016/j.ortho.2025.100991","DOIUrl":"10.1016/j.ortho.2025.100991","url":null,"abstract":"<div><div>Occlusal cant is often perceived by both patients and dental practitioners as an aesthetic concern. While occlusal cant due to skeletal discrepancies or severe cases may necessitate surgical intervention, dental occlusal cant can be corrected through orthodontic treatment. This case series demonstrates the successful management of occlusal cant with asymmetric overbite using a novel approach: unilateral bite turbo attached to the lingual surface of a lateral incisor, canine, or both. The results, applicable to both labial and lingual orthodontic mechanics, suggest that dental occlusal cant can be effectively addressed using this simple and minimally invasive bite turbo technique.</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 3","pages":"Article 100991"},"PeriodicalIF":1.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance assessment of artificial intelligence chatbots (ChatGPT-4 and Copilot) for sharing insights on 3D-printed orthodontic appliances: A cross-sectional study","authors":"Asma Muhammad Yousuf,&nbsp;Fizzah Ikram,&nbsp;Munnal Gulzar,&nbsp;Rashna Hoshang Sukhia,&nbsp;Mubassar Fida","doi":"10.1016/j.ortho.2025.100992","DOIUrl":"10.1016/j.ortho.2025.100992","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate and compare the performance of OpenAI's ChatGPT-4 and Microsoft Copilot in providing information on 3D-printed orthodontic appliances, with a focus on the accuracy, completeness of the content, and response generation time.</div></div><div><h3>Methods</h3><div>This cross-sectional study proceeded in five stages. Initially, three orthodontists created a total of 125 questions concerning 3D printed orthodontic appliances of which 105 questions were finalized to be incorporated into the study by a panel of senior orthodontists. These questions were subsequently organized into 15 distinct domains. Both chatbots were presented with the questions under consistent conditions, using the same laptop and internet setup. A stopwatch was used to record response times. The responses were anonymized and evaluated by seven orthodontists with extensive experience, who scored accuracy and completeness based on standardized tools. Through discussion, evaluators reached a consensus on each score, ensuring reliability.</div></div><div><h3>Results</h3><div>Spearman's correlation revealed a moderate to strong negative correlation between accuracy and completeness for both chatbots (<em>p<!--> </em>≤<!--> <!-->0.001). The negative correlation observed between accuracy and completeness scores, particularly prominent in Copilot, indicates a trade-off between these qualities in some responses. Mann-Whitney U tests confirmed significant differences in accuracy and completeness between the chatbots (<em>p<!--> </em>≤<!--> <!-->0.001), though response time differences were not statistically significant (<em>p</em> <em>=</em> <em>0.204</em>). Cohen's Kappa results implied little to no consistency between the two models on the assessed parameters (<em>p<!--> <!-->&gt;</em> <!-->0.05).</div></div><div><h3>Conclusion</h3><div>ChatGPT-4 outperformed Microsoft Copilot in accuracy and completeness, providing more precise and comprehensive information on 3D-printed orthodontic appliances demonstrating a greater ability to handle complex, and detailed requests in this area.</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 3","pages":"Article 100992"},"PeriodicalIF":1.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of cephalometric landmark identification by artificial intelligence platform versus expert orthodontist in unilateral cleft palate patients: A retrospective study","authors":"Mostafa A. Tageldin,&nbsp;Yomna Mohamed Yacout,&nbsp;Farah Y. Eid,&nbsp;Sherief H. Abdelhafiz","doi":"10.1016/j.ortho.2025.100990","DOIUrl":"10.1016/j.ortho.2025.100990","url":null,"abstract":"<div><h3>Objective</h3><div>The primary aim of the study was to evaluate the accuracy of automated artificial intelligence (AI) cephalometric landmark identification in cleft patients and compare it to landmarks identified by an expert orthodontist. The secondary objective was to compare cephalometric measurements obtained by both methods.</div></div><div><h3>Material and methods</h3><div>A total of 112 pre-treatment lateral cephalometric radiographs of unilateral cleft palate patients were collected from the archives of the Department of Orthodontics, Faculty of Dentistry, Alexandria University following screening of all the records of patients treated in the period January 2019–December 2022 for eligibility. For each of the acquired radiographs, cephalometric tracing was performed by fully automated WebCeph™ landmark detection process and by manual identification of the landmarks by an expert orthodontist using OnyxCeph™ software. The traced radiographs were then imported into Photoshop software for evaluation of the (x,y) coordinates, in mm, for each of the identified landmarks (Primary outcome). Moreover, linear and angular measurements generated using WebCeph™ and OnyxCeph™ software were compared (secondary outcomes).</div></div><div><h3>Results</h3><div>The coordinates of A-point, ANS, and Or showed statistically significant differences between both identification methods, with a mean difference between the two methods ranging between –0.86<!--> <!-->mm<!--> <!-->±<!--> <!-->2.15 and 3.15<!--> <!-->mm<!--> <!-->±<!--> <!-->6.07. None of the dental landmarks showed statistically significant differences between the two methods. None of the soft tissue landmarks showed statistically significant differences, except Ns y-coordinate. Several points showed clinically significant differences between both methods. The greatest mean differences in cephalometric measurements between the two methods were reported in nasolabial angle CotgSnLs (18.3<!--> <!-->±<!--> <!-->22.77<!--> <!-->̊) followed by Max1-NA (–8.86<!--> <!-->±<!--> <!-->17.46<!--> <!-->̊) and Max1-SN (–8.43<!--> <!-->±<!--> <!-->12.51<!--> <!-->̊).</div></div><div><h3>Conclusions</h3><div>The identification of cephalometric landmarks in cleft palate patients using the web-based AI platform is not as accurate as manual identification. Manual adjustment of landmarks following AI identification is advised.</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 2","pages":"Article 100990"},"PeriodicalIF":1.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe anterior open bite in a Class II hyperdivergent adult patient: A case report of clear aligner orthodontic camouflage treatment","authors":"Francesca Cremonini,&nbsp;Virginia Falconi,&nbsp;Lisa Carazzato,&nbsp;Mario Palone,&nbsp;Luca Lombardo","doi":"10.1016/j.ortho.2025.100989","DOIUrl":"10.1016/j.ortho.2025.100989","url":null,"abstract":"<div><div>The aim of this study was to describe the successful treatment of an anterior open bite in an adult Class II hyperdivergent patient. A 31-year-old female presented for orthodontic treatment, seeking an aesthetic solution to correct her anterior open bite and lower crowding to enhance her smile. As an initial step, all third molars were extracted to facilitate the forward rotation of the mandible and the initial closure of the open bite. Subsequently, clear aligner therapy (F22 aligners, Due Carrare, Italy) was initiated, with aligners changed every 15 days in combination with Class II elastics. Bite closure was achieved through programmed interproximal reduction (IPR) and the retroclination of anterior teeth. At the end of treatment, the open bite was successfully closed, a Class I relationship was obtained on the right side, and an edge-to-edge Class II relationship persisted on the left due to underlying skeletal asymmetry. Additionally, incisor exposure during smiling was improved. This clinical case demonstrates that clear aligners can effectively compensate a functional anterior open bite by promoting mandibular forward rotation and incisor retroclination.</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 3","pages":"Article 100989"},"PeriodicalIF":1.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of post-curing parameters and material thickness on the color stability of 3D-printed dental resins: An in vitro study","authors":"Kübra Gülnur Topsakal ,&nbsp;Merve Aksoy ,&nbsp;Yağızalp Sükut ,&nbsp;Gökhan Serhat Duran","doi":"10.1016/j.ortho.2025.100985","DOIUrl":"10.1016/j.ortho.2025.100985","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the effect of variations in post-curing temperatures and times on the colour stability of 3D-printed resins used in orthodontics and paediatric dentistry applications and the effect of material thickness on colour properties was also examined.</div></div><div><h3>Methods</h3><div>The two different disk samples (15.00<!--> <!-->×<!--> <!-->1.0<!--> <!-->mm, <em>n</em> <!-->=<!--> <!-->90; 15.00<!--> <!-->×<!--> <!-->2.00, <em>n</em> <!-->=<!--> <!-->90; diameter and height, respectively) were designed and printed from biocompatible resin with SLA technology. These samples were subjected to various post-curing temperatures and times (60<!--> <!-->̊C and 30<!--> <!-->min, 60<!--> <!-->̊C and 90<!--> <!-->min, 60<!--> <!-->̊C and 120<!--> <!-->min, 60<!--> <!-->̊C and 60<!--> <!-->min, 40<!--> <!-->̊C and 60<!--> <!-->min, 80<!--> <!-->̊C and 60<!--> <!-->min). The values of L*, a*, and b* of the 3D-printed resin samples were evaluated under D65 illumination conditions in the centre of the samples using a spectrophotometer. The same researcher recorded the average values after the measurements were performed three times for each sample.</div></div><div><h3>Results</h3><div>The results indicated significant differences in colour stability (L*, a*, b* values) among samples subjected to different post-curing conditions. Variations in post-curing time and temperature significantly affected the colour of the resins. The study found that certain post-curing conditions could lead to acceptable colour values that are similar to natural teeth.</div></div><div><h3>Conclusions</h3><div>The study concluded that the time and temperature of post-curing significantly affected the colour properties of 3D-printed clear resins used in orthodontic applications. It suggests that a 30-minute post-curing time can yield acceptable colour values, highlighting the importance of selecting appropriate post-curing conditions based on clinical requirements. Additionally, an increase in material thickness was found to correlate with increased yellowness in the samples.</div></div><div><h3>Clinical significance</h3><div>The changes in post-curing temperature and time may impact colour properties. Clinicians should consider this situation when manufacturing with 3D printing.</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 2","pages":"Article 100985"},"PeriodicalIF":1.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgement to our Reviewers","authors":"","doi":"10.1016/S1761-7227(25)00021-X","DOIUrl":"10.1016/S1761-7227(25)00021-X","url":null,"abstract":"","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 1","pages":"Article 100986"},"PeriodicalIF":1.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multipurpose miniscrew-anchored palatal appliance combined with a fixed multibracket appliance to correct a Class II Division 2 malocclusion with maxillary constriction and impacted upper canine in a 13-year-old girl: A case report","authors":"Mario Palone ,&nbsp;Ilaria Gasperoni ,&nbsp;Francesca Cremonini ,&nbsp;Giuliano B Maino ,&nbsp;Emanuele Paoletto ,&nbsp;Mattia Pramstraller ,&nbsp;Luca Lombardo","doi":"10.1016/j.ortho.2025.100984","DOIUrl":"10.1016/j.ortho.2025.100984","url":null,"abstract":"<div><div>This case report describes the successful non-extraction orthodontic treatment of a 13-year-old female patient affected by a Class II Division 2 malocclusion, maxillary constriction and a unilateral impacted maxillary canine. The miniscrew-assisted palatal expansion (MAPA) system was used for precise palatal miniscrew placement, achieving bicortical engagement. A hybrid T-Rex rapid palatal expander was then employed to achieve both skeletal expansion and molar distalization without requiring patient compliance. After that, tooth 2.3 was surgically exposed and orthodontically repositioned with a miniscrew-supported extrusion cantilever on a fixed vestibular appliance and piggyback mechanics. The orthodontic treatment was completed in a total of 31 months, yielding satisfactory intraoral results. Precise digital planning for palatal miniscrew insertion was instrumental in achieving bicortical anchorage, enabling the efficient use of a single multipurpose, miniscrew-supported palatal appliance.</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 2","pages":"Article 100984"},"PeriodicalIF":1.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143347999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro comparison of the effects of direct attachment shape and location on forces and moments generated by thermoplastic aligners during simulated torque movement","authors":"Janine Magura ,&nbsp;Amin Akbari ,&nbsp;Megann Lear ,&nbsp;Alexandra Bojrab ,&nbsp;George Eckert ,&nbsp;Jie Chen ,&nbsp;R. Scott Conley ,&nbsp;Hakan Turkkahraman","doi":"10.1016/j.ortho.2025.100982","DOIUrl":"10.1016/j.ortho.2025.100982","url":null,"abstract":"<div><h3>Introduction</h3><div>The aim of this study was to investigate the effects of direct attachment shape and location on the forces and moments generated by thermoplastic aligners during simulated maxillary central incisor torque.</div></div><div><h3>Materials and methods</h3><div>A total of 7 typodonts were digitally printed with different attachment design and locations. Five clear aligners were fabricated for each typodont and placed on an orthodontic force tester (OFT) with the maxillary central incisor rotated palatally 1° around the incisal edge. Forces and moments were measured 2 times by the load cells. Analysis of variance (Anova) was used to determine the effects of group, tooth, and the group-by-tooth interaction on the outcomes; A two-sided 5% significance level was used for all tests. Analyses were performed using SAS version 9.4 (SAS Institute Inc., Cary, NC, USA).</div></div><div><h3>Results</h3><div>The two-way interactions between group and tooth were significant (<em>P</em> <!-->&lt;<!--> <!-->0.001) for all outcomes except facial/palatal moment around the X axis (M_x) (<em>P</em> <!-->&gt;<!--> <!-->0.05). The horizontal ellipsoid attachment at the middle third generated the highest M_x (−25.74<!--> <!-->±<!--> <!-->8.93<!--> <!-->Nmm) with facial crown/palatal root, while the rectangular attachment at the middle third yielded the lowest Mx (3.31<!--> <!-->±<!--> <!-->12.92<!--> <!-->Nmm).</div></div><div><h3>Conclusions</h3><div>Changing attachment shape and location had a significant effect on the forces and moments generated during simulated maxillary incisor torque. The best design for the incisor torque movement was found to be the horizontal ellipsoid attachment at the middle third. Besides the desired torque moment, all attachment shape and location combinations produced a vertical extrusive force as a side effect.</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 2","pages":"Article 100982"},"PeriodicalIF":1.8,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143101120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}