International Orthodontics最新文献

{"title":"Protraction of a second molar and a mesially-impacted third molar into the adjacent first-molar extraction site through mini-implant anchored Albert protraction loop with the aid of alveolar ridge augmentation.","authors":"Xuechun Yuan, Hong Zhou, Lingling Pu, Qi Fan, Shangyou Wen, Wenli Lai, Hu Long","doi":"10.1016/j.ortho.2025.100966","DOIUrl":"https://doi.org/10.1016/j.ortho.2025.100966","url":null,"abstract":"<p><p>Protraction of a mandibular second molar to substitute the adjacent missing first molar is challenging in clinical practice. In this case report, we demonstrated a 21-year-old patient with an untreatable periapical lesion of the mandibular right first molar. The adjacent mandibular second molar had normal root length and the third molar was mesially-impacted. Two treatment alternatives were available: implant restoration of the first molar with poor prognosis or mesialization of the second and third molars to substitute the first and second molars. The patient finally chose the second treatment option. Ridge augmentation with bone grafting was performed to deal with alveolar atrophy at the first-molar extraction site. Molar protraction was accomplished with a novel protraction loop appliance (Albert loop) that was anchored onto an interradicular mini-implant. At the end of the treatment, excellent buccal interdigitations and good root parallelism were achieved. Molar protraction into the atrophic alveolar site can be efficiently accomplished through Albert protraction loop anchored on a mini-implant and ridge augmentation.</p>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 2","pages":"100966"},"PeriodicalIF":1.8,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the most effective method for reducing pain during debonding procedures? A systematic review.","authors":"Bahaa Aldeen Jeha, Rania Haddad","doi":"10.1016/j.ortho.2025.100969","DOIUrl":"https://doi.org/10.1016/j.ortho.2025.100969","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the most effective methods in controlling pain during debonding procedures.</p><p><strong>Material and methods: </strong>Electronic searches in published and unpublished studies were performed. Restricted to the English language and publication date up to 23/3/2024, the searches in published literature covered the following databases: MEDLINE, PubMed, EMBASE, Tripe, Web of Science, Scopus and PubMed Central. However, unpublished literature was searched at ClinicalTrials.gov, National Research Register, and ProQuest Dissertations and Theses. Lists of all eligible studies were checked for further scrutiny. Risk of bias for randomized and non-randomized control trials was assessed using ROB2 and ROBINS Cochrane tools.</p><p><strong>Results: </strong>Thirteen RCTs and two non-RCTs were included. All the reviewed articles studied the pain during debonding events and included 886 patients aged between 12-65. They used different scales such as VAS, NRS, Wong-Baker faces, and others scales. Two studies have shown that the lift-off plier causes less pain than other pliers when comparing different types of dental instruments. However, when comparing different adjunctive techniques, two studies have found that using a wafer causes less pain, while two studies have reported no significant difference between methods and one study has found that using finger pressure causes less pain. In addition, three separate studies have found that utilizing an ultrasonic device, as well as a thermal device and laser radiation, can lead to lower pain scores. Furthermore, two studies have demonstrated that using medication has a positive impact on reducing pain.</p><p><strong>Conclusions: </strong>According to reported evidence, applying finger pressure is more effective in relieving pain in the anterior teeth, while wafer biting is more effective in the posterior teeth. Pain-relieving medications like paracetamol or ibuprofen can also effectively reduce debonding pain. Promising procedures, such as using diode or Er-YAG lasers, and thermal devices, may also be effective, but further studies are needed to confirm their efficacy. The protocol of this systematic review was registered with the PROSPERO International Database under ID number CRD42024529190. This review follows the guidelines established by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and the instructions provided in the Cochrane Handbook.</p>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 2","pages":"100969"},"PeriodicalIF":1.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CBCT-based assessment of apical root resorption and alveolar bone height following orthodontic treatment of Class I moderate crowding with labial vs. lingual fixed appliances in young adults: A randomized controlled trial.","authors":"Jehad M Kara-Boulad, Ahmad S Burhan, Mohammad Y Hajeer, Fehmieh R Nawaya, Samer T Jaber","doi":"10.1016/j.ortho.2025.100968","DOIUrl":"https://doi.org/10.1016/j.ortho.2025.100968","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;Apical root resorption and alveolar bone loss are potential complications associated with orthodontic treatment. This study aimed to assess apical root resorption and alveolar bone height following orthodontic treatment of moderate crowding with labial vs. lingual fixed appliances using CBCT imaging.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Subjects and methods: &lt;/strong&gt;All patients meeting the eligibility criteria were included from March 2022 to June 2022 at the University of Damascus Faculty of Dentistry, Department of Orthodontics. The study involved patients diagnosed with Class I malocclusion and moderate crowding in both arches that could be treated on a non-extraction basis. Participants were randomly divided into two groups. One group was treated using lingual appliances (DTC® IN-Tendo JK-SL, DTC Medical Apparatus Co., Hangzhou, China) with a 0.018-inch slot. The sequence of archwires used included 0.012″, 0.014 0.016″ nickel-titanium, 0.016″×0.022″ TMA, 0.016″×0.022″ stainless steel, and 0.017″×0.025″ stainless steel. The other group received treatment with labial straight-wire appliances (AO Mini Master® - MBT System, metal brackets, Sheboygan, WI, USA) also featuring a 0.018-inch slot. The sequence of archwires used was 0.012″, 0.014″, 0.016″ nickel-titanium, 0.016″×0.022″ nickel-titanium, 0.016 and 0.017″×0.025″ stainless steel. The CBCT images were taken before the commencement of treatment (T0) and one day following the end of treatment (T1). The apical root resorption and alveolar bone height of the upper and lower teeth were assessed at these assessment times. Paired-sample t-test used to analyse the intergroup differences, while a two-sample t-test was employed to assess intragroup changes. The significance level was set at P&lt;0.004 after adjustment using Bonferroni's correction.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Out of forty patients, nineteen patients in each group were included in the statistical analysis (16 men and 24 women; mean age: 21.3years). In both groups, there was a significant decrease in the lengths of all studied teeth at T1 (P&lt;0.004). The apical resorption was significantly greater in the lingual appliance group for lower central and lateral incisors compared to the labial appliance group (0.64mm, 0.7, respectively). The mean lingual bone loss in the lingual appliances was statistically greater than that in the labial appliances for lower central incisors (0.53mm), while the mean buccal bone loss in the labial appliance group was statistically greater than that in the lingual appliance group for the lower lateral incisors (0.52mm).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The use of DTC® lingual or AO Mini Master® labial brackets with archwire sequences is associated with clinically acceptable mild to moderate root resorption and clinically insignificant alveolar bone loss when treating moderate crowding. The record resorption in both cases is less than 1.34mm. The lingual appliances cause greater resorption of lo","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 2","pages":"100968"},"PeriodicalIF":1.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the mesiodistal angulation of maxillary canines based on their impaction sector in panoramic radiographs: A cross-sectional study.","authors":"Victoria Diaz Celis, María Cecilia Fernández Canedo, Luis Ernesto Arriola-Guillén","doi":"10.1016/j.ortho.2025.100967","DOIUrl":"https://doi.org/10.1016/j.ortho.2025.100967","url":null,"abstract":"<p><strong>Introduction: </strong>The complexity of treating impacted maxillary canines varies based on their angulation and position within the dental arch. The aim of this research was to compare the mesiodistal angulation of maxillary canines according to their impaction sector.</p><p><strong>Methods: </strong>This cross-sectional study evaluated 229 impacted maxillary canines in 171 panoramic radiographs from two private radiology centres in Uruguay and Chile of individuals of both sexes aged 11 years and older with impacted maxillary canines. The radiographs were taken with two panoramic radiography equipment. All the images were evaluated using Planmeca Romexis® software. Two investigators were trained and calibrated to perform all the measurements at two measurement times. The Ericson and Kurol method was used to classify the impaction sector into five sectors and the Wardorf method was used to measure the mesiodistal impaction angle and, finally, the level of impaction was measured with respect to the root of the lateral incisor. Student t-test, Anova and multiple linear regression were used. P<0.05.</p><p><strong>Results: </strong>The impaction angle of sectors 1 and 2 was (70.03°±9.65°) and of sectors 3, 4 and 5 it was 52.21°±16.60° (P<0.001) while at the cervical level of the lateral incisor root it was 74.15°, 68.04° at mid-level and 57.39° at the apical level (P<0.001). The impaction angle decreases 13.02° in sectors 3, 4 and 5 (P<0.001), for each year the impaction angle decreases 0.30° (P=0.001), and as the level of impaction becomes more apical the impaction angle decreases 7.46°.</p><p><strong>Conclusions: </strong>Impacted maxillary canines are more horizontal the closer they are to the midline or the higher the level of impaction. Likewise, this horizontality tends to increase over time. All these considerations should be taken into account by orthodontists when planning their treatments.</p>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 2","pages":"100967"},"PeriodicalIF":1.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-surgical correction of an adult Class II high-angle with occlusal plane cant by four compromised permanent first molars extraction, preadjusted lingual appliance and miniscrews: A case report.","authors":"Enrico Albertini, Anna Colonna, Paolo Albertini, Luca Lombardo, Ryuzo Fukawa","doi":"10.1016/j.ortho.2024.100965","DOIUrl":"https://doi.org/10.1016/j.ortho.2024.100965","url":null,"abstract":"<p><p>This case report describes a complex full-step asymmetrical Class II division 1 high-angle in an adult patient treated by extraction of compromised first molars with a preadjusted lingual appliance. Since the patient presented severe sagittal and vertical discrepancies combined with an Izard orthofrontal profile with upper lip protrusion, an extraction camouflage was performed with the twofold aim of obtaining ideal occlusal relationship and profile improvement, correcting occlusal plane cant by selective intrusion with interradicular miniscrews. Appropriate biomechanical strategies, including extraction choice and anchorage control during space closure, were needed to achieve the planned results. This case report demonstrates the possibility of solving successfully severe sagittal and vertical discrepancies with significant asymmetric component in adult patient without surgical treatment by means of a completely invisible technique, with the extraction of the most compromised teeth in both arches. This report also underlines the need for careful planning during both diagnostic and treatment phases, with appropriate skeletal anchorage management, in order to obtain the best results.</p>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 2","pages":"100965"},"PeriodicalIF":1.8,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthodontic treatment of deep bite in mixed dentition and/or early permanent dentition: What about stability? - A systematic review.","authors":"Boutaina El Guennouni, Afaf Houb-Dine, Hajar Ben Mohimd, Fatima Zaoui","doi":"10.1016/j.ortho.2024.100956","DOIUrl":"https://doi.org/10.1016/j.ortho.2024.100956","url":null,"abstract":"<p><strong>Introduction: </strong>Deepbite is a vertical malocclusion found alone or in association with other types of sagittal and transverse disorders. With a high relapse tendency, deepbite is considered one of the most challenging malocclusions to treat. It is commonly found in mixed dentition with increased prevalence of 21.3% compared to 14.1% in temporary dentition, thus resulting on unfavourable consequences, preventing the mandible from its full growth potential. Therefore, this systematic review aims to investigate the efficiency of conducting an early correction of deepbite malocclusion in mixed and early permanent dentition on the long-term postretention outcomes.</p><p><strong>Material and methods: </strong>An electronic search extending from 2000 to July 2024, was performed on the following databases Medline via PubMed, Web of Science, Science Direct and Embase. The search was established on a well-defined research question following PICO principle: population, intervention, comparator and outcome. Search evaluation and the assessment of risk of bias were undertaken in each study following its type and design.</p><p><strong>Results: </strong>Six studies were included for qualitative analysis, with overall moderate RoB. Two studies treated deepbite in a single phase orthopaedic treatment with eruption guidance appliance in early mixed dentition; two studies orthodontically corrected deepbite at early permanent dentition using fixed multibracket appliance and two studies used a combination of orthopaedic treatment followed by orthodontic treatment targeting both subjects in early mixed and early permanent dentition.</p><p><strong>Conclusion: </strong>Patients treated in late mixed to early permanent dentition presented better efficacy and greater stability of outcomes than patients treated in the early mixed phase of dentition. More studies must be conducted to support and confirm the results of the included studies.</p><p><strong>Prospero under the registration id: </strong>CRD42023408820.</p>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 2","pages":"100956"},"PeriodicalIF":1.8,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of self-perception in relation to the normative need for orthodontic treatment in a population of dental students in Brazil: A cross-sectional study.","authors":"Luciana Rougemont Squeff, Flavio Copello, Guido Artemio Marañón-Vásquez, Ronir Raggio Luiz, Lincoln Nojima, Matilde da Cunha Gonçalves Nojima","doi":"10.1016/j.ortho.2024.100963","DOIUrl":"https://doi.org/10.1016/j.ortho.2024.100963","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to identify predictive factors of having a positive or negatively divergent self-perception from the normative orthodontic treatment need (N-OTN).</p><p><strong>Methods: </strong>All eligible undergraduate students from the School of Dentistry of the XXX were recruited through convenience sampling. They were clinically evaluated to determine their N-OTN using the IOTN and were asked about their self-perceived orthodontic treatment need (S-OTN) using the same scale for both evaluations. The subjects were classified according to the orientation of their perception as: coincident (S-OTN=N-OTN), positive (S-OTN<N-OTN), or negative (S-OTN>N-OTN). Multinomial logistic regression models were implemented to evaluate the contribution of the N-OTN, Angle's malocclusion, oral health-related quality of life (OHRQoL), self-esteem, sex, undergraduate year and age.</p><p><strong>Results: </strong>Two hundred first- and third-year undergraduate dentistry students were evaluated. It was evidenced that a higher N-OTN increases the probability that S-OTN is positively oriented and decreases the probability that it is negative. A worse OHRQoL score increases the chance that the S-OTN orientation is negative and decreases the chance that it is positive. Moreover, the probability of divergent self-perception in either direction is expected to be lower for women.</p><p><strong>Conclusions: </strong>Students with a more severe malocclusion tend to have a more positive view of their normative condition. A greater impact on OHRQoL favours having a more negative self-perception of the N-OTN. Women have a less divergent self-perception of the N-OTN.</p>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 2","pages":"100963"},"PeriodicalIF":1.8,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The quality of orthognathic surgery information on social media: A scoping review.","authors":"Mimi Ngo, Emilija Jensen, Maurice Meade","doi":"10.1016/j.ortho.2024.100959","DOIUrl":"https://doi.org/10.1016/j.ortho.2024.100959","url":null,"abstract":"<p><strong>Introduction: </strong>Orthognathic surgery combined with orthodontic treatment is commonly undertaken to address facial and dental disharmony. Content uploaded onto social media platforms can be an important source of healthcare information. This scoping review aimed to collate and synthesize data from studies that investigated the quality of information communicated through these platforms.</p><p><strong>Methods: </strong>Five databases and grey literature were searched, with no restrictions on location and year published. The PCC (Population, Concept, Context) framework was adopted to select eligible studies. Inclusion criteria included literature that assessed the quality of information on orthognathic surgery in relation to orthodontic treatment in the context of social media.</p><p><strong>Results: </strong>A total of 12 cross-sectional studies satisfied the selection criteria. The most investigated social media platform was YouTube. The quality of information on all platforms examined was found to be poor to moderate. The most popular content featured patients sharing their treatment experiences, but these often lacked clinically relevant information, focusing mainly on satisfaction with treatment, outcomes and their supervising healthcare professionals. In contrast, healthcare professionals provided content that contained better quality information but had lower views and engagement. The least frequently mentioned topics were found to be complications and their duration, costs, and postoperative expectations. Certain search terms such as \"#jawsurgery\", \"#surgeryfirst\" and \"#genioplasty\" appeared to resonate more with the public. There was heterogeneity across the methodologies and quality of information instruments used.</p><p><strong>Conclusions: </strong>Information communicated through social media platforms regarding orthognathic surgery was of poor to moderate quality. Orthodontic professionals should be aware of the limitations of health information on these online platforms and guide individuals to more accurate sources.</p>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 1","pages":"100959"},"PeriodicalIF":1.8,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of facial asymmetry assisted with digitally designed surgical guide for 3-dimensional maxillary repositioning: A case report.","authors":"Sanjeev Verma, Vinay Kumar, Raj Kumar Verma, Naveen K Subbaiah, Chaman Lal, Satinder Pal Singh, Shagun Sharma","doi":"10.1016/j.ortho.2024.100953","DOIUrl":"https://doi.org/10.1016/j.ortho.2024.100953","url":null,"abstract":"<p><p>Orthodontists play a pivotal role in diagnosing, planning, and preparing patients for orthognathic surgeries. Digital technologies like cephalometry, intraoral scans, CBCT scans, CAD-CAM-assisted 3-D planning, and printed surgical splints, have largely replaced conventional techniques. The automated software produces surgical splints with a design similar to conventional which may not address complex scenarios, involving symmetric and asymmetric maxillary impaction. To address this, a surgical splint designed using 3D dolphin software was modified with 3-matic software for precise guidance. This article gives insight into the digitally designed surgical splint for the correction of facial asymmetry on skeletal Class III bases and occlusal canting in an 18-year-old woman. The precise relocation of the maxilla was achieved as planned pre-surgically leading to significant improvement in the facial aesthetics. In conclusion, modified splint design fabrication offers more predictable outcomes, reduces laborious laboratory procedures, and acts as a reliable guide for precise surgical results.</p>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 1","pages":"100953"},"PeriodicalIF":1.8,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can fluoxetine influence orthodontic tooth movement? A systematic review and meta-analysis of studies on animal models.","authors":"Fawad Javed, Zain Uddin Ahmed, P Emile Rossouw, Georgios E Romanos","doi":"10.1016/j.ortho.2024.100960","DOIUrl":"https://doi.org/10.1016/j.ortho.2024.100960","url":null,"abstract":"<p><strong>Introduction: </strong>Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine adversely affect bone mineral density (BMD) and turnover, thereby increasing the risk of fractures. The objective of the present systematic review and meta-analysis was to evaluate studies on animal models that assessed whether fluoxetine can influence orthodontic tooth movement (OTM).</p><p><strong>Material and methods: </strong>Indexed databases (PubMed/Medline, EMBASE, Cochrane Library, Scopus and ISI Web of Knowledge) and Google Scholar were searched without time and language barriers up to and including June 2024. Original studies that assessed the influence of fluoxetine on OTM were included. Letters to the Editor, reviews, commentaries, perspectives and, in-vitro/ex-vivo studies were excluded. Study selection, and risk of bias (RoB) and quality assessments were assessed. Quantitative assessment (meta-analysis) was also performed using fixed-effects and random effects models.</p><p><strong>Results: </strong>Four studies performed on male rats were included. Rats in the experimental group underwent OTM with adjunct fluoxetine injections at concentrations ranging between 10-20mg/kg. Orthodontic forces applied ranged between 25-60grams. Three studies reported that fluoxetine does not influence OTM. All studies had a high RoB. Three studies demonstrated low certainty (weak) and two showed very low certainty of evidence. In the meta-analysis, the pooled SMD using a random effects model was 0.05 (95% CI: -0.42 to 0.52), indicating no significant overall effect of fluoxetine on OTM. The analysis revealed substantial heterogeneity across the included studies.</p><p><strong>Conclusion: </strong>Further well-designed and power-adjusted prospective studies are needed to elucidate the role of SSRIs on OTM.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024563793.</p>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 2","pages":"100960"},"PeriodicalIF":1.8,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}