Turkish Journal of Pathology最新文献_第7页

Apple Peel Deformity and Malrotation of Gut: Autopsy Findings of a Rare Cause of Mortality in Utero. 苹果皮畸形和肠道旋转不良:一种罕见的子宫死亡原因的尸检结果。

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Turkish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5146/tjpath.2021.01533

Deepti Mutreja, Sharanjit Singh

引用次数: 0

Alveolar Adenoma: A Rare Benign Tumour of the Lung with A Challenging Diagnosis. 肺泡腺瘤:一种罕见的肺良性肿瘤，诊断具有挑战性。

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Turkish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5146/tjpath.2021.01547

Soumaya Graja, Saadia Makni, Abdessalem Hentati, Chiraz Chaari, Tahya Sellami-Boudawara, Rim Kallel

引用次数: 2

GLUT-1 Expression in Breast Cancer. GLUT-1在乳腺癌中的表达。

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Turkish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5146/tjpath.2021.01557

Oguzhan Okcu, Bayram Sen, Cigdem Ozturk, Gulname Findik Guvendi, Recep Bedir

{"title":"GLUT-1 Expression in Breast Cancer.","authors":"Oguzhan Okcu, Bayram Sen, Cigdem Ozturk, Gulname Findik Guvendi, Recep Bedir","doi":"10.5146/tjpath.2021.01557","DOIUrl":"https://doi.org/10.5146/tjpath.2021.01557","url":null,"abstract":"Objective: Numerous studies have been conducted to predict the prognosis of breast cancers. The effect of glucose transporter protein 1 (GLUT-1), the main carrier protein responsible for glucose transport, was investigated in breast cancer patients.Material and method: 170 patients operated for breast carcinoma were included in this study. We analysed the prognostic significance of GLUT-1 immune-expression in 149 patients without neoadjuvant therapy, and in 21 patients with neoadjuvant therapy.Results: GLUT-1 expression was correlated with poor prognostic factors such as estrogen receptor and progesterone receptor negativity, high Ki-67 proliferation index, and high histological and nuclear grade (p < 0.001). GLUT-1 was expressed at a statistically higher rate in invasive ductal carcinomas, compared to invasive lobular carcinomas (p < 0.001), and was expressed at a higher rate in luminal B, human epidermal growth factor receptor 2 and triple-negative molecular subtypes compared to luminal A subtype tumors (p < 0.001). There was no statistically significant difference between GLUT-1 expression and presence of neoadjuvant therapy. Univariate survival analysis showed high GLUT1 expression was associated with low disease-free survival.Conclusion: GLUT-1 expression was found to be associated with poor pathological prognostic factors in breast carcinoma patients. The results suggest that GLUT-1 expression can be considered as a prognostic marker in breast cancers, and it may be used as a target molecule in personalized treatment approaches.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"38 2","pages":"114-121"},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9687415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Clinical Significance of Endometrial Cells in Pap Smear of Women Aged 40 Years and Older. 子宫内膜细胞在40岁及以上妇女巴氏涂片中的临床意义。

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Turkish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5146/tjpath.2022.01570

Esra Keleş, Uğur Kemal Öztürk, Cihat Murat Alinca, Serkan Akiş, Canan Kabaca, Handan Çetiner

{"title":"Clinical Significance of Endometrial Cells in Pap Smear of Women Aged 40 Years and Older.","authors":"Esra Keleş, Uğur Kemal Öztürk, Cihat Murat Alinca, Serkan Akiş, Canan Kabaca, Handan Çetiner","doi":"10.5146/tjpath.2022.01570","DOIUrl":"10.5146/tjpath.2022.01570","url":null,"abstract":"Objective: To investigate the histopathological follow-up results in women diagnosed with endometrial cells in the Papanicolaou (Pap) test.Material and method: Between January 2013 to December 2018, women with endometrial cells on the Pap test were searched from the hospital electronic database. The patients with endometrial cells on the Pap test who underwent further histopathological evaluation and who were followed-up for at least 1 year were enrolled in the study, while those who had a Pap test result other than endometrial cells, were lost during follow-up, or had missing data were excluded.Results: Out of 91,142 Pap smears, 121 (0.1%) cytologically had endometrial cells, and of those 65 cases were eligible for final analysis. The mean age of patients with premalignant/malignant lesions (57.7 ± 2.9) was higher than those with benign lesions (50.1 ± 0.7), with 77% of them in the postmenopausal period. Gynecologic premalignant/malignant lesions were detected in 9 (17.7%) patients including 2 (3.1%) endometrial hyperplasias and 7 (10.8%) endometrial cancers. The menopausal status (p=0.010) and being 50 years and older (p=0.002) were significantly associated with pre-neoplastic or neoplastic changes in patients with endometrial cells.Conclusion: The presence of endometrial cells in Pap tests may be a harbinger of endometrial pathologies, especially at the age of 50 years and over. The menopausal status is another possible determinant in detecting endometrial carcinoma. Further investigation may be suggested in women aged ≥50 years and postmenopausal in the event of endometrial cell detection.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"38 3","pages":"235-239"},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39910213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Histopathologic Examination of a Second Muscle Biopsy Specimen at a Later Date may Sometimes be the Best Approach to Make a Differential Diagnosis in Neuromuscular Disorders. 在以后的日期进行第二次肌肉活检标本的组织病理学检查有时可能是鉴别诊断神经肌肉疾病的最佳方法。

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Turkish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5146/tjpath.2019.01512

Gulden Diniz, Berk Ozyilmaz, Sarenur Gokben

引用次数: 0

Secondary Localized Cutaneous Amyloidosis is not Rare in Bowen's Disease and Bowenoid Papulosis. 继发性局部皮肤淀粉样变性在鲍文氏病和鲍文氏样丘疹病中并不罕见。

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Turkish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5146/tjpath.2021.01530

Can Baykal, Ozge Hurdogan, Goncagul Babuna Kobaner, Algun Polat Ekinci, Nesimi Buyukbabani

{"title":"Secondary Localized Cutaneous Amyloidosis is not Rare in Bowen's Disease and Bowenoid Papulosis.","authors":"Can Baykal, Ozge Hurdogan, Goncagul Babuna Kobaner, Algun Polat Ekinci, Nesimi Buyukbabani","doi":"10.5146/tjpath.2021.01530","DOIUrl":"https://doi.org/10.5146/tjpath.2021.01530","url":null,"abstract":"Secondary localized cutaneous amyloidosis is a histopathological finding seen in the dermis, in various benign, premalignant, and malignant skin conditions, without clinical significance. The real incidence is not known. We aimed to investigate the phenomenon of secondary localized cutaneous amyloidosis in Bowen's disease and Bowenoid papulosis. We retrospectively evaluated the data of all cases with histopathological confirmation of Bowen's disease and Bowenoid papulosis between 2006 and 2017 in our Dermatovenereology and/or Pathology departments. Secondary localized cutaneous amyloidosis was observed in three patients with Bowen's disease (3/52; 5.8%) and in three patients with Bowenoid papulosis (3/18; 16.7%). Herein, we present the demographic, clinical and histopathological features of these six cases of secondary localized cutaneous amyloidosis in detail. Although the occurrence of secondary localized cutaneous amyloidosis in epithelial tumors is a well-known phenomenon, its incidence has not been previously reported in Bowen's disease and Bowenoid papulosis. Therefore, our results indicating a high incidence may be particularly important for Bowenoid papulosis, as its association with secondary localized cutaneous amyloidosis has only been shown in one case before. Moreover, in three of six cases, we histologically observed areas of regression with a marked prominence of amyloid deposition. Remarkably, two of these patients had a history of topical application of destructive agents which reveals a possible etiologic relationship between secondary localized cutaneous amyloidosis and cellular apoptosis/necrosis induced by these external agents.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"38 1","pages":"54-59"},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9332265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Placental Chorangiocarcinoma: Case Report with Literature Review of a Rare Entity. 胎盘绒毛管癌：一例罕见实体的病例报告及文献复习。

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Turkish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5146/tjpath.2021.01548

Nishant Sagar, Parul Tanwar, Nita Khurana, Poonam Kashyap

引用次数: 1

HHV-8 and EBV Positive Lymphoproliferative Disease: A Challenging Case. HHV-8和EBV阳性淋巴增生性疾病:一个具有挑战性的病例。

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Turkish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5146/tjpath.2021.01540

Göksenil Bülbül, Gülen Gül, Mehmet Ali Özcan, Sermin Özkal

{"title":"HHV-8 and EBV Positive Lymphoproliferative Disease: A Challenging Case.","authors":"Göksenil Bülbül, Gülen Gül, Mehmet Ali Özcan, Sermin Özkal","doi":"10.5146/tjpath.2021.01540","DOIUrl":"https://doi.org/10.5146/tjpath.2021.01540","url":null,"abstract":"Human herpes virus-8 (HHV-8) is linked to four lymphoproliferative diseases: primary effusion lymphoma, HHV-8 positive multicentric Castleman disease (MCD), HHV-8 positive diffuse large B cell lymphoma and HHV-8 positive germinotropic lymphoproliferative disorder (GLPD). The diagnosis of HHV-8 associated lymphoproliferative diseases is quite challenging because each entity is rare and has a wide morphological spectrum. Our aim is to emphasize the overlapping histopathological features of MCD and GLPD as well as to underline the importance of clinicopathological correlation in case these two entities cannot be distinguished by pathological examination. We present here a case of an 82-year-old male patient who was examined for weight loss and multiple lymphadenopathy. Histopathological examination of the axillary lymph node revealed lymphoid follicle structures of varying shapes and sizes, including some atrophic germinal centers. Plasmablast-like cells were notable in some of these areas. HHV-8 and Epstein Barr Virus (EBV) positivity were noted in some of these cells and in a small number of cells in the mantle zone. Based on these findings; a diagnosis of \"HHV-8 and EBV positive lymphoproliferative disease\" was established. Since HHV-8 positive MCD and GLPD have similar histopathological features, it may not be possible to distinguish these two entities by histopathological examination only. At this point, the importance of clinicopathological correlation becomes more evident, especially in the determination of the treatment protocol to be applied to the patient.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"38 2","pages":"142-147"},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9325319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Multifocal Pseudomyogenic Hemangioendothelioma Involving the Scalp and Nose, Misdiagnosed as A Sarcoma: A Rare Case Report. 多灶性假性血管内皮瘤累及头皮及鼻子，误诊为肉瘤1例。

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Turkish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5146/tjpath.2021.01539

Neha Mittal, Bharat Rekhi, Priyamvada Singhal, Munita Bal, Swapnil Rane, Asawari Patil, Shivakumar Thiagarajan

{"title":"Multifocal Pseudomyogenic Hemangioendothelioma Involving the Scalp and Nose, Misdiagnosed as A Sarcoma: A Rare Case Report.","authors":"Neha Mittal, Bharat Rekhi, Priyamvada Singhal, Munita Bal, Swapnil Rane, Asawari Patil, Shivakumar Thiagarajan","doi":"10.5146/tjpath.2021.01539","DOIUrl":"https://doi.org/10.5146/tjpath.2021.01539","url":null,"abstract":"This case report aims to present clinicopathological features of an extremely rare case of multifocal pseudomyogenic hemangioendothelioma (PMHE) in the scalp. A 21-year-old male developed multiple, focally ulcerated, nodules over the root of his nose and scalp. One of the skin lesions was sampled at another dermatology clinic, where this was diagnosed as a sarcoma. A review of biopsy sections showed well-circumscribed dermal lesions, comprising plump spindle and epithelioid cells, mimicking rhabdomyoblasts. Immunohistochemically, tumor cells were positive for AE1/AE3, CD31, FLI-1 and ERG. INI-1 was retained. A diagnosis of PMHE was offered. Subsequently, the patient underwent wide excision and has been asymptomatic for 8 months, post-surgery. PMHE is rarely reported in the head and neck region, where it can constitute a diagnostic pitfall. Awareness of this tumor and appropriate immunohistochemical stains are necessary for its timely diagnosis, in order to avoid radical treatments. A review of similar, previously documented cases is presented.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"38 1","pages":"73-78"},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9331565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atrophic Kidney-Like Lesion - Case Report of A Provisional Entity with Brief Review of Literature. 萎缩性肾样病变1例报告并文献复习。

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Turkish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5146/tjpath.2021.01541

Balamurugan Thirunavukkarasu, Saket Singh, Aditya Prakash Sharma, Amanjit Bal

引用次数: 2