TOX Outperforms FOXP3, CD4 and GATA3 in Histopathological Diagnosis of Early Mycosis Fungoides.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-01-01 DOI:10.5146/tjpath.2022.01578

Mona Mostafa Ahmed, Abdelmonem Awad Hegazy, Ahmed Embaby, Esraa Mohammad Nawwar, Salwan Abdelmonem Hegazy, Hanaa M Ibrahim, Mai Ahmed Gobran

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引用次数: 0

Abstract

Objective: Mycosis fungoides (MF) is the most common type of cutaneous lymphoma. The early stage of MF is a difficult diagnostic case, as it is often confused with many benign inflammatory dermatoses (BID). The study aimed to evaluate the diagnostic utility of TOX, FOXP3, CDD4 and GATA3 in differentiating early stages of MF from histologically overlapping BID lesions.

Material and method: A retrospective cross-sectional study was performed, in which immunohistochemistry (IHC) was used to evaluate the expression of TOX, FOXP3, CD4 and GATA3 in formalin-fixed paraffin-embedded (FFPE) sections of skin lesions from 30 cases with BID and 30 patients with early-stage MF.

Results: The association between TOX expression and early-stage MF was statistically significant (P < 0.001). TOX had the highest sensitivity of 96.77% and accuracy of 85.71% in diagnosis of MF; followed by CD4 with sensitivity of 85.71% and accuracy of 78.95%; and then, GATA3 with sensitivity of 76.7% and finally FOXP3 with sensitivity of 70.0%.

Conclusion: TOX is suggested to be of higher diagnostic value in the early stages of MF than the conventionally used CD4 and other markers examined.

Abstract Image

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TOX在早期蕈样肉芽肿的组织病理学诊断中优于FOXP3、CD4和GATA3。

目的：蕈样肉芽肿（MF）是最常见的皮肤淋巴瘤类型。MF的早期诊断是一个困难的病例，因为它经常与许多良性炎症性皮肤病（BID）混淆。本研究旨在评估TOX、FOXP3、CDD4和GATA3在区分早期MF和组织学重叠BID病变中的诊断效用。材料和方法：采用回顾性横断面研究，结果：TOX表达与早期MF的相关性有统计学意义（P＜0.001），TOX诊断MF的敏感性最高，为96.77%，准确率为85.71%；CD4的敏感性为85.71%，准确率为78.95%；结论：TOX在MF早期的诊断价值高于常规检测的CD4等标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.