Evaluation of Relative Frequency of Pulmonary Hypoplasia and Various Anomalies Associated with Pulmonary Hypoplasia in Fetal Autopsy Study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-01-01 DOI:10.5146/tjpath.2022.01594

Aparna Sajjan, Surekha U Arakeri, Subhashchandra Mudanur

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Abstract

Objective: Pulmonary hypoplasia (PH) is one of the commonest causes of neonatal morbidity and mortality. The suggested diagnostic criteria for PH are the Lung Weight:Body Weight (LW:BW) ratio ≤ 0.012 and/or Radial Alveolar Count (RAC) ≤ 4.1. The present study was done to determine the relative frequency of PH in fetal autopsy study by the LW:BW ratio and RAC along with evaluation of the defects/anomalies associated with PH.

Material and method: A prospective observational study was done on fetal autopsy specimens in the Department of Pathology. Examination and grossing were done as per the standard format of fetal autopsy study. Evaluation of PH was done using the LW:BW ratio and RAC. Diagnostic criteria for PH were taken as LW:BW ratio < 0.012 and/ or RAC < 4.1. Chi-square test, Student T test and Kruskal Wallis test were used in statistical analysis.

Results: A diagnosis of PH was made in 45 cases. Concordance between the LW:BW ratio and RAC was observed in 33 cases amounting to 73.33%. The mean LW:BW ratio was the lowest in oligohydramnios. The mean RAC was the lowest in congenital cystic adenomatoid malformation.

Conclusion: A diagnosis of PH was rendered in a greater number of cases when evaluation was done by considering both the LW:BW ratio and RAC. Hence, evaluation by both the LW:BW ratio and RAC provides a reliable index of lung growth and should be an essential part of fetal autopsy study.

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胎儿尸检研究中肺发育不良和与肺发育不良相关的各种异常的相对频率评估。

目的：肺发育不全（PH）是新生儿发病和死亡的最常见原因之一。PH的建议诊断标准是肺重量与体重（LW:BW）之比≤0.012和/或径向肺泡计数（RAC）≤4.1。本研究通过LW:BW比率和RAC以及与PH相关的缺陷/异常的评估来确定胎儿尸检研究中PH的相对频率。材料和方法：在病理学系对胎儿尸检标本进行了前瞻性观察研究。按照胎儿尸检研究的标准格式进行检查和大体检查。使用LW:BW比率和RAC对PH进行评估。PH的诊断标准为LW:BW比值<0.012和/或RAC<4.1。采用卡方检验、Student T检验和Kruskal-Wallis检验进行统计分析。结果：诊断PH 45例。LW:BW比值与RAC的符合率为73.33%，其中羊水过少组LW:BW平均比值最低。先天性囊性腺瘤样畸形的平均RAC最低。结论：当同时考虑LW:BW比率和RAC进行评估时，在更多的病例中可以诊断出PH。因此，LW:BW比率和RAC的评估提供了一个可靠的肺部生长指标，应该是胎儿尸检研究的重要组成部分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.