Turkish Journal of Pathology最新文献_第8页

Placental Chorangiocarcinoma: Case Report with Literature Review of a Rare Entity. 胎盘绒毛管癌：一例罕见实体的病例报告及文献复习。

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Turkish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5146/tjpath.2021.01548

Nishant Sagar, Parul Tanwar, Nita Khurana, Poonam Kashyap

引用次数: 1

Multifocal Pseudomyogenic Hemangioendothelioma Involving the Scalp and Nose, Misdiagnosed as A Sarcoma: A Rare Case Report. 多灶性假性血管内皮瘤累及头皮及鼻子，误诊为肉瘤1例。

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Turkish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5146/tjpath.2021.01539

Neha Mittal, Bharat Rekhi, Priyamvada Singhal, Munita Bal, Swapnil Rane, Asawari Patil, Shivakumar Thiagarajan

{"title":"Multifocal Pseudomyogenic Hemangioendothelioma Involving the Scalp and Nose, Misdiagnosed as A Sarcoma: A Rare Case Report.","authors":"Neha Mittal, Bharat Rekhi, Priyamvada Singhal, Munita Bal, Swapnil Rane, Asawari Patil, Shivakumar Thiagarajan","doi":"10.5146/tjpath.2021.01539","DOIUrl":"https://doi.org/10.5146/tjpath.2021.01539","url":null,"abstract":"This case report aims to present clinicopathological features of an extremely rare case of multifocal pseudomyogenic hemangioendothelioma (PMHE) in the scalp. A 21-year-old male developed multiple, focally ulcerated, nodules over the root of his nose and scalp. One of the skin lesions was sampled at another dermatology clinic, where this was diagnosed as a sarcoma. A review of biopsy sections showed well-circumscribed dermal lesions, comprising plump spindle and epithelioid cells, mimicking rhabdomyoblasts. Immunohistochemically, tumor cells were positive for AE1/AE3, CD31, FLI-1 and ERG. INI-1 was retained. A diagnosis of PMHE was offered. Subsequently, the patient underwent wide excision and has been asymptomatic for 8 months, post-surgery. PMHE is rarely reported in the head and neck region, where it can constitute a diagnostic pitfall. Awareness of this tumor and appropriate immunohistochemical stains are necessary for its timely diagnosis, in order to avoid radical treatments. A review of similar, previously documented cases is presented.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9331565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atrophic Kidney-Like Lesion - Case Report of A Provisional Entity with Brief Review of Literature. 萎缩性肾样病变1例报告并文献复习。

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Turkish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5146/tjpath.2021.01541

Balamurugan Thirunavukkarasu, Saket Singh, Aditya Prakash Sharma, Amanjit Bal

引用次数: 2

HHV-8 and EBV Positive Lymphoproliferative Disease: A Challenging Case. HHV-8和EBV阳性淋巴增生性疾病:一个具有挑战性的病例。

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Turkish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5146/tjpath.2021.01540

Göksenil Bülbül, Gülen Gül, Mehmet Ali Özcan, Sermin Özkal

{"title":"HHV-8 and EBV Positive Lymphoproliferative Disease: A Challenging Case.","authors":"Göksenil Bülbül, Gülen Gül, Mehmet Ali Özcan, Sermin Özkal","doi":"10.5146/tjpath.2021.01540","DOIUrl":"https://doi.org/10.5146/tjpath.2021.01540","url":null,"abstract":"Human herpes virus-8 (HHV-8) is linked to four lymphoproliferative diseases: primary effusion lymphoma, HHV-8 positive multicentric Castleman disease (MCD), HHV-8 positive diffuse large B cell lymphoma and HHV-8 positive germinotropic lymphoproliferative disorder (GLPD). The diagnosis of HHV-8 associated lymphoproliferative diseases is quite challenging because each entity is rare and has a wide morphological spectrum. Our aim is to emphasize the overlapping histopathological features of MCD and GLPD as well as to underline the importance of clinicopathological correlation in case these two entities cannot be distinguished by pathological examination. We present here a case of an 82-year-old male patient who was examined for weight loss and multiple lymphadenopathy. Histopathological examination of the axillary lymph node revealed lymphoid follicle structures of varying shapes and sizes, including some atrophic germinal centers. Plasmablast-like cells were notable in some of these areas. HHV-8 and Epstein Barr Virus (EBV) positivity were noted in some of these cells and in a small number of cells in the mantle zone. Based on these findings; a diagnosis of \"HHV-8 and EBV positive lymphoproliferative disease\" was established. Since HHV-8 positive MCD and GLPD have similar histopathological features, it may not be possible to distinguish these two entities by histopathological examination only. At this point, the importance of clinicopathological correlation becomes more evident, especially in the determination of the treatment protocol to be applied to the patient.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9325319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Evidence for Diverse Prognosis in High-Grade Serous Ovarian Carcinoma: Solid, Pseudoendometrioid, and Transitional-Like; So-Called "SET Morphology" and Progesterone Receptor Status. 高级别浆液性卵巢癌不同预后的证据：实体癌、假子宫内膜样癌和移行样癌；所谓的“SET形态学”和孕酮受体状态。

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Turkish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5146/tjpath.2022.01571

Halit Uner, Metin Demir, Dincer Goksuluk, Ayse Kars, Meral Uner, Alp Usubutun

{"title":"Evidence for Diverse Prognosis in High-Grade Serous Ovarian Carcinoma: Solid, Pseudoendometrioid, and Transitional-Like; So-Called \"SET Morphology\" and Progesterone Receptor Status.","authors":"Halit Uner, Metin Demir, Dincer Goksuluk, Ayse Kars, Meral Uner, Alp Usubutun","doi":"10.5146/tjpath.2022.01571","DOIUrl":"10.5146/tjpath.2022.01571","url":null,"abstract":"Objective: High-grade serous ovarian carcinoma (HGSC) is one of the major tumors of the gynecological system with a poor survival rate and variable microscopic appearance. It was suggested that SET (solid, pseudo-endometrioid and transitional-like) morphology in ovarian HGSC is predictably associated with BRCA deficiencies. In this study, we investigated the microscopic patterns and some immunohistochemical markers predicting the prognosis of serous carcinoma.Material and method: We re-evaluated 305 HGSC ovarian resections morphologically and calculated the SET morphology percentages for each case. Morphological and immunohistochemical data correlated with the survival and post-treatment disease progression data.Results: The median age at diagnosis was 57 years and the median follow-up period was 3.1 years. The median overall survival (OS) of ovarian carcinoma in SET-predominant tumors (n=60) was 81 months, while for tumors with SET non-dominant morphology (n=63) and non-SET morphology (n=182) it was 59.7 and 44.7 months, respectively.Conclusion: Predominant (more than 50%) SET morphology was significantly associated with increased survival rates of HGSC. Immunohistochemically, p53, ERCC1, ER, and PR antibodies were applied and only PR antibody positivity was found to be associated with borderline statistical significance for increased survival rates. Our results suggest that SET morphology may be a potential predictive and prognostic marker in managing the treatment strategies of HGSC.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39910214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Eosinophilic Solid and Cystic Renal Cell Carcinoma: From Unclassified to Classified, A Case Report. 嗜酸性实性和囊性肾细胞癌:从未分类到分类1例报告。

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Turkish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5146/tjpath.2021.01531

Rashim Sharma, Balamurugan Thirunavukkarasu, Poonam Elhence, Mahaveer Singh Rodha, Binit Sureka

引用次数: 1

Low-Grade Oncocytic Tumor: Report of Two Cases of An Emerging Entity in the Spectrum of Oncocytic Renal Neoplasms. 低级别嗜酸细胞肿瘤:肾嗜酸细胞肿瘤谱中一个新出现的实体的两例报告。

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Turkish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5146/tjpath.2021.01549

Divakar Sharma, Trupti Pai, Gagan Prakash, Sangeeta Desai, Santosh Menon

引用次数: 4

Clinico-Histological Features of Thrombotic Microangiopathy in Renal Biopsies: A Retrospective Study. 肾活检中血栓性微血管病变的临床组织学特征:回顾性研究。

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Turkish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5146/tjpath.2021.01536

Niraimathi Manickam, Vinita Agrawal, Pallavi Prasad, Manoj Jain, Narayan Prasad

{"title":"Clinico-Histological Features of Thrombotic Microangiopathy in Renal Biopsies: A Retrospective Study.","authors":"Niraimathi Manickam, Vinita Agrawal, Pallavi Prasad, Manoj Jain, Narayan Prasad","doi":"10.5146/tjpath.2021.01536","DOIUrl":"https://doi.org/10.5146/tjpath.2021.01536","url":null,"abstract":"Objective: Thrombotic microangiopathy (TMA) is often first detected on a renal biopsy performed for renal manifestations. Apart from hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura, there are various secondary conditions associated with TMA. This study analyzes the clinico-pathological spectrum, etiological factors and renal outcome of TMA diagnosed on renal biopsy.Material and method: A retrospective evaluation of renal biopsies for TMA over 5.5 years was performed. Clinical and laboratory data was collected from patient records.Results: A total of 40 biopsies from 39 patients showed TMA comprising 33 native and 7 transplant biopsies. Malignant hypertension (n=13) was the most common etiology in native biopsies followed by postpartum TMA (n=7), atypical HUS (aHUS) (n=7), and lupus nephritis (n=6). TMA in transplant biopsies was due to acute rejection (n=4) and CNI toxicity (n=3). Serum creatinine was high in most patients (mean 5.6 + 2.5 mg/ dl). aHUS showed the highest mean LDH levels and the lowest average platelet counts. Renal biopsies in malignant hypertension and postpartum TMA showed isolated arterial changes while aHUS and lupus nephritis showed both glomerular and arterial involvement. Postpartum TMA and aHUS had poor renal outcome requiring renal replacement therapy.Conclusion: Most postpartum TMA and aHUS had systemic features of TMA while malignant hypertension and lupus nephritis showed 'isolated renal TMA'. This emphasizes the importance of careful evaluation of renal biopsies even in the absence of systemic features of TMA.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9332266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Mesenchymal Tumors Involving the Pancreas: A Clinicopathologic Analysis and Review of the Literature. 累及胰腺的间充质肿瘤:临床病理分析及文献回顾。

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Turkish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5146/tjpath.2022.01567

Gokce Askan, Olca Basturk

{"title":"Mesenchymal Tumors Involving the Pancreas: A Clinicopathologic Analysis and Review of the Literature.","authors":"Gokce Askan, Olca Basturk","doi":"10.5146/tjpath.2022.01567","DOIUrl":"https://doi.org/10.5146/tjpath.2022.01567","url":null,"abstract":"Objective: Most pancreatic tumors are epithelial, and, among these, more than 90% are of ductal origin. However, a variety of mesenchymal tumors may involve the pancreas and may manifest different clinicopathological characteristics. The literature on mesenchymal tumors in the pancreas is largely limited to individual case reports or analyses of small series, predominantly focusing on radiologic features.Material and method: Authors' institutional and consultation databases were reviewed to identify the mesenchymal tumors involving the pancreas.Results: Forty cases were identified; twenty-five (63%) tumors were benign/borderline, and the remaining fifteen (37%) were malignant. Of the benign/borderline tumors; 9 were solitary fibrous tumors, 6 gastrointestinal stromal tumors (GISTs), 4 schwannomas, 2 desmoid type fibromatosis, 1 lymphangioma, 1 ganglioneuroma, 1 inflammatory myofibroblastic tumor, and 1 low grade mesenchymal neoplasm. Malignant tumors included 6 cases of leiomyosarcomas, 4 liposarcomas, 2 rhabdomyosarcomas, 1 epithelioid angiosarcoma, 1 malignant peripheral nerve sheet tumor, and 1 undifferentiated pleomorphic sarcoma. Four cases (multicystic schwannoma, desmoid fibromatosis, lymphangioma and inflammatory myofibroblastic tumor) were preoperatively misdiagnosed as a primary epithelial tumor of the pancreas.Conclusion: Mesenchymal tumors rarely involve the pancreas. They are usually benign/borderline neoplasms but may be diagnostically challenging, especially clinically/radiologically, as they may form cystic and/or large lesions in the pancreas. Mesenchymal tumors should be considered in both the clinical/radiological and pathological differential diagnosis of pancreatic lesions.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9349530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Significance of Histopathologic Assessment in Bone Marrow Disease in Neuroblastoma. 神经母细胞瘤骨髓疾病组织病理学评估的意义。

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Turkish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5146/tjpath.2021.01556

Sumeyye Ekmekci, Dilek Ince, Nur Olgun, Erdener Ozer

{"title":"The Significance of Histopathologic Assessment in Bone Marrow Disease in Neuroblastoma.","authors":"Sumeyye Ekmekci, Dilek Ince, Nur Olgun, Erdener Ozer","doi":"10.5146/tjpath.2021.01556","DOIUrl":"https://doi.org/10.5146/tjpath.2021.01556","url":null,"abstract":"Objective: Neuroblastoma (NB) is the most common extracranial solid tumor in children and is responsible for 12% of cancer-related deaths. The status of metastatic disease in the bone marrow (BM) is a predictor of poor outcome. The purpose of this study was to investigate the predictive significance of histopathological examination of BM in NB.Material and method: The study included 61 cases with archival bone marrow biopsy tissues. The cases were evaluated regarding the percentage of metastatic tissue and its differentiation. Primary tumor slides were also reviewed to perform the Shimada classification based on the differentiation status and mitosis-karyorrhexis index. The patients' age, gender, NMYC amplification, clinical risk group, and disease outcome were also noted.Results: Of the 61 cases, 17 had BM involvement. Of those, eight cases (47.1%) were refractory NB showing disease relapse. Based on BM examination, five cases (29.4%) were categorized as complete response, seven (41.2%) as progressive disease, three (17.6%) as minimal disease, and two (11.8%) as stable disease. The progressive disease category was significantly related with refractory disease and NMYC amplification along with the high-risk category (p =0.002 and p= 0.003 respectively). Undifferentiated histology and presence of more than 20% of tumor tissue in the BM biopsy at diagnosis were significantly associated with the progressive disease category (p=0.01 and p < 0.001, respectively).Conclusion: We conclude that evaluating the percentage of metastatic tumor tissue and tumor differentiation in BM biopsies is of clinical importance in the management of neuroblastoma patients.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9687416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0