Pediatric Reports最新文献

筛选
英文 中文
Hospitalizations of Adolescents with Psychiatric Disorders in a Pediatric Unit: A 10-Year Retrospective Study. 儿科青少年精神疾病住院:一项10年回顾性研究
IF 1.9
Pediatric Reports Pub Date : 2026-08-10 DOI: 10.3390/pediatric18040111
Francesco Accomando, Melodie O Aricò, Enrico Valletta
{"title":"Hospitalizations of Adolescents with Psychiatric Disorders in a Pediatric Unit: A 10-Year Retrospective Study.","authors":"Francesco Accomando, Melodie O Aricò, Enrico Valletta","doi":"10.3390/pediatric18040111","DOIUrl":"10.3390/pediatric18040111","url":null,"abstract":"<p><p><b>Background:</b> To assess temporal trends in psychiatric hospitalizations among adolescents admitted to a general pediatric ward in Forlì, Italy, between 2016 and 2025 and to examine diagnostic patterns and their association with sex and age, using the individual patient as the primary unit of analysis. <b>Methods:</b> Single-center retrospective study including all hospitalizations for psychiatric disorders in patients aged 10-17 years over a 10-year period. Each discharge episode was assigned to a single dominant diagnostic category. The primary analyses were conducted at the level of the individual patient (first admission), while episode-level analyses were retained as a pre-specified sensitivity analysis reflecting inpatient burden. <b>Results:</b> A total of 165 adolescents (210 hospitalization episodes) were included; mean (SD) age was 14.47 (1.73) years, and females were 77% of patients (80.5% of episodes). Admissions increased significantly over time (patients: IRR 1.20 per year, 95% CI 1.13-1.27; <i>p</i> < 0.001), with 124/165 (75.2%) patients first admitted in 2021-2025. Suicidal ideation/attempt (27.3%) and eating disorders (15.2%) were the most frequent diagnoses, and both showed a significant upward trend. Overall, diagnosis was associated with sex (<i>p</i> = 0.004): most diagnoses, including the two most frequent, were female-predominant, whereas psychomotor agitation was over-represented in males. Age at admission increased modestly over time and was higher in 2021-2025. Twenty-seven patients accounted for 45 readmissions, concentrated in the most severe diagnoses. <b>Conclusions:</b> Psychiatric hospitalizations of adolescents in a general pediatric ward rose substantially over the decade, especially from 2021, driven mainly by suicidal ideation/attempt and eating disorders. Findings were robust to analysis at the patient level and support the role of the general pediatric ward as a sentinel setting for severe adolescent mental distress.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"18 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13516791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148832894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibiotic Prescribing in Hospitalized Pediatric Patients Before Implementation of a Syndromic Antibiogram at Maputo Central Hospital, Mozambique. 莫桑比克马普托中心医院实施综合征抗生素谱前住院儿科患者的抗生素处方
IF 1.9
Pediatric Reports Pub Date : 2026-08-10 DOI: 10.3390/pediatric18040110
Darlenne B Kenga, Jahit Sacarlal, Mohsin Sidat, Valéria Chicamba, Andrea Ntanga Kenga, Yara Manjate, Manuel D Naiene, Raquel I Langa, Ramígio Pololo, Troy D Moon
{"title":"Antibiotic Prescribing in Hospitalized Pediatric Patients Before Implementation of a Syndromic Antibiogram at Maputo Central Hospital, Mozambique.","authors":"Darlenne B Kenga, Jahit Sacarlal, Mohsin Sidat, Valéria Chicamba, Andrea Ntanga Kenga, Yara Manjate, Manuel D Naiene, Raquel I Langa, Ramígio Pololo, Troy D Moon","doi":"10.3390/pediatric18040110","DOIUrl":"10.3390/pediatric18040110","url":null,"abstract":"<p><p><b>Background:</b> Empiric antibiotic prescribing is frequently used in low- and middle-income countries because microbiological diagnostic capacity is often limited, highlighting the need for locally generated microbiological data to support evidence-informed empiric antibiotic selection. However, data on pediatric antibiotic prescribing practices in Mozambique remain scarce. This study aimed to characterize empiric antibiotic prescribing among hospitalized pediatric patients at Maputo Central Hospital prior to the implementation of a syndromic antibiogram intervention. <b>Methods:</b> An exploratory, retrospective, descriptive baseline analysis was conducted among pediatric patients aged 1 month to 14 years admitted with suspected bacterial infections between January and December 2023, prior to the implementation of a syndromic antibiogram intervention. Sociodemographic, clinical, microbiological, and antibiotic prescribing data were extracted from clinical records. Antibiotics were classified according to the WHO AWaRe framework, and associations between patient characteristics, treatment strategies, and outcomes were analyzed using R software version 4.6.0. <b>Results:</b> A total of 358 pediatric patients were included, with a median age of 14 months (IQR: 6-48), and 57% were male. Lower respiratory tract infections were the most frequent diagnosis. Empiric treatment predominated, accounting for 89% of cases, whereas microbiologically guided therapy was observed in only 11%. Urinary tract infections showed significantly higher proportions of microbiologically guided treatment compared with respiratory infections (<i>p</i> < 0.001). Monotherapy predominated, while Watch antibiotics accounted for 64.7% of prescriptions. Prolonged hospitalization was associated with respiratory distress, decreased skin turgor, referral status, infection type, and anemia. <b>Conclusions:</b> Pediatric antibiotic prescribing was characterized by extensive empiric therapy and high Watch antibiotic use, highlighting important antimicrobial stewardship challenges in Mozambique.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"18 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13516340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148833446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reading and Screen Time: Associations with Behavioral and Sleep Difficulties in Children and Adolescents. 阅读和屏幕时间:与儿童和青少年行为和睡眠困难的关系。
IF 1.9
Pediatric Reports Pub Date : 2026-08-06 DOI: 10.3390/pediatric18040107
Henrike Waterstrat, Nico Grafe, Wieland Kiess, Andreas Merkenschlager, Tanja Poulain
{"title":"Reading and Screen Time: Associations with Behavioral and Sleep Difficulties in Children and Adolescents.","authors":"Henrike Waterstrat, Nico Grafe, Wieland Kiess, Andreas Merkenschlager, Tanja Poulain","doi":"10.3390/pediatric18040107","DOIUrl":"10.3390/pediatric18040107","url":null,"abstract":"<p><strong>Objective: </strong>This study examined reading behavior and screen time in children and adolescents and their associations with sleep behavior and behavioral difficulties.</p><p><strong>Methods: </strong>This study was conducted as part of the LIFE Child study (Germany). Participants were 579 6- to 10.5-year-old children (younger age group) and 972 10.5- to 18-year-old children and adolescents (older age group). Information on reading (duration of reading, on paper or electronically), screen time, sleep difficulties, and behavioral difficulties was assessed via parental (younger sample) or self-reported (older sample) questionnaires. Associations of reading behavior and screen time with child age, sex, maternal education, behavioral difficulties, and sleep difficulties were assessed using linear regression analyses.</p><p><strong>Results: </strong>Girls reported longer reading times than boys, whereas boys reported longer daily screen time. In the younger age group, reading time increased with age. Daily screen time increased with age in both age groups. Higher screen time was significantly associated with more sleep difficulties in both age groups and with more behavioral difficulties in the older age group. In the younger age group, reading time was not associated with screen time, sleep difficulties, or behavioral difficulties. In the older age group, however, longer reading times were significantly associated with longer screen time, more behavioral difficulties, and more problematic sleep.</p><p><strong>Conclusions: </strong>These results indicate that both the use of electronic media and reading behavior are relevant for understanding child health and development. The findings suggest that guidance for families of older children should address not only screen use but also balance and context of reading activities.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"18 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13516216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148833030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe Methylmalonic Acidemia Precipitated by Dietary B12 Deficiency in Vegan Toddler. 严重甲基丙二酸血症由饮食B12缺乏引起的素食幼儿。
IF 1.9
Pediatric Reports Pub Date : 2026-08-06 DOI: 10.3390/pediatric18040108
April Edwell, Susan Bessler, Shannon Burke
{"title":"Severe Methylmalonic Acidemia Precipitated by Dietary B12 Deficiency in Vegan Toddler.","authors":"April Edwell, Susan Bessler, Shannon Burke","doi":"10.3390/pediatric18040108","DOIUrl":"10.3390/pediatric18040108","url":null,"abstract":"<p><p>A previously healthy 19-month-old female presented after her family found her upon awakening to be sleepy, uninterested in eating, and lethargic. On arrival, blood gas showed profound metabolic acidosis with normal lactate that did not improve with normalization of glucose and sodium. Her acidosis continued to worsen, so a broad workup was initiated, considering ingestions, DKA, and inborn errors of metabolism. In collecting further history, the patient's nutrition history included a combination of breastfeeding and a vegan diet followed by her family. Her B12 level returned undetectably low. She improved dramatically over the next several hours after receiving an injection of cyanocobalamin. Ultimately, she was confirmed to have methylmalonic acidemia secondary to severe Vitamin B12 deficiency.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"18 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13516533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148832956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Designing and Implementing a Simulation-Based Pediatric Trauma Training Program in a Resource-Limited Setting: The PRACTICE Study. 在资源有限的环境下设计和实施基于模拟的儿科创伤训练计划:实践研究。
IF 1.9
Pediatric Reports Pub Date : 2026-08-06 DOI: 10.3390/pediatric18040109
Jakob Olbrich, Alexander Hönning, Icaro Luan Tavares Latado, Andrea Laufer, Janna Schwab, Erik Haucke, Alexander Jünemann, Uwe Weibrecht, José de Ribamar Bandeira Filho, Kristina Zappel, Sinan Bakir
{"title":"Designing and Implementing a Simulation-Based Pediatric Trauma Training Program in a Resource-Limited Setting: The PRACTICE Study.","authors":"Jakob Olbrich, Alexander Hönning, Icaro Luan Tavares Latado, Andrea Laufer, Janna Schwab, Erik Haucke, Alexander Jünemann, Uwe Weibrecht, José de Ribamar Bandeira Filho, Kristina Zappel, Sinan Bakir","doi":"10.3390/pediatric18040109","DOIUrl":"10.3390/pediatric18040109","url":null,"abstract":"<p><strong>Background/objectives: </strong>Road traffic accidents represent the leading cause of death in children and adolescents in Brazil. In the state of Piauí, non-specialized facilities frequently manage critically injured pediatric patients. Targeted training programs are considered a key strategy for improving outcomes. This study assessed the feasibility of adapting a pediatric trauma course developed in a high-income setting for medical first responders in both pre-hospital and in-hospital settings in a resource-limited environment in northeastern Brazil.</p><p><strong>Methods: </strong>This prospective non-randomized mixed-methods feasibility-oriented implementation and educational evaluation study involved the design of a simulation-based course based on a literature review by a German interprofessional and interdisciplinary team. Local adaptation was achieved through a needs assessment, field visits, and stakeholder collaboration. Implementation included the training of Brazilian instructor candidates, who subsequently delivered the course under supervision. Data were collected using study-specific, non-validated questionnaires at two timepoints and analyzed descriptively and exploratively.</p><p><strong>Results: </strong>A total of 98 healthcare professionals participated in the needs assessment (mean experience 9.7 ± 6.3 years; 62.2% nursing staff); 66 completed the pediatric trauma management section. Although familiarity with the ABCDE approach was high (86%), confidence in pediatric trauma management was significantly lower than management in adults (47% vs. 68%, <i>p</i> = 0.0018), particularly for invasive procedures. During implementation, 38 participants completed the course, with a 100% recommendation rate; approximately 80% felt prepared to teach independently. However, participants and instructors highlighted the need for more practical training, longer course duration, and follow-up instructor training.</p><p><strong>Conclusions: </strong>A context-adapted, simulation-based pediatric trauma training program was feasibly implemented and well accepted in a resource-limited region of Brazil. The train-the-trainer approach shows promise for strengthening local pediatric trauma capacity, but sustained implementation requires continued instructor development, supervised teaching, and long-term evaluation of educational and clinical outcomes.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"18 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13516510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148832532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Diagnostic Journey from Rhabdomyolysis to Myopathy with Tubular Aggregates: A Family-Based Case Report and Review of the Literature. 从横纹肌溶解到小管聚集性肌病的诊断历程:一个基于家庭的病例报告和文献回顾。
IF 1.9
Pediatric Reports Pub Date : 2026-08-05 DOI: 10.3390/pediatric18040106
Slavica Ostojić, Sanja Milenković, Sonja Pavlović, Gordana Kovačević, Gordana Petrović, Aleksandra Paripović, Adrijan Sarajlija, Marina Anđelković, Vladimir Gašić, Danijela Radivojević
{"title":"The Diagnostic Journey from Rhabdomyolysis to Myopathy with Tubular Aggregates: A Family-Based Case Report and Review of the Literature.","authors":"Slavica Ostojić, Sanja Milenković, Sonja Pavlović, Gordana Kovačević, Gordana Petrović, Aleksandra Paripović, Adrijan Sarajlija, Marina Anđelković, Vladimir Gašić, Danijela Radivojević","doi":"10.3390/pediatric18040106","DOIUrl":"10.3390/pediatric18040106","url":null,"abstract":"<p><p><b>Introduction/Aims:</b> Myopathies with Tubular Aggregates (TAM) are rare, chronic neuromuscular disorders that may be inherited or acquired. The aim of this report is to present the diagnostic pathway and the challenges encountered in a family with three members affected by TAM caused by a rare <i>ORAI1</i> variant. <b>Case report</b>: Two siblings (15 and 11 years old) developed severe rhabdomyolysis triggered by a viral respiratory infection. Histopathological analysis demonstrated numerous tubular aggregates with mild focal secondary inflammatory changes and no immunophenotypic evidence of autoimmune inflammatory myopathy. Whole-exome sequencing identified a likely pathogenic heterozygous missense variant, NM_032790.3(ORAI1):c.319G>A (p.Val107Met), in the <i>ORAI1</i> gene, in both children and their asymptomatic mother. <b>Conclusions:</b> The identification of a rare <i>ORAI1</i> variant in this family supports the association with TAM, broadens the spectrum of phenotypic presentation, and illustrates the phenotypic variability that may exist even among affected members of the same family. Careful interpretation of inflammatory changes in muscle biopsy, together with immunohistochemical and genetic findings, is essential to avoid misclassification of hereditary tubular aggregate myopathy as autoimmune inflammatory myopathy.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"18 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13516330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148833015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RETRACTED: Frolli et al. Executive Functions and Foreign Language Learning. Pediatr. Rep. 2022, 14, 450-456. 撤稿:Frolli et al。执行功能与外语学习。Pediatr。众议员2022,14,450-456。
IF 1.9
Pediatric Reports Pub Date : 2026-08-05 DOI: 10.3390/pediatric18040105
Alessandro Frolli, Francesco Cerciello, Clara Esposito, Sonia Ciotola, Gaia De Candia, Maria Carla Ricci, Maria Grazia Russo
{"title":"RETRACTED: Frolli et al. Executive Functions and Foreign Language Learning. <i>Pediatr. Rep.</i> 2022, <i>14</i>, 450-456.","authors":"Alessandro Frolli, Francesco Cerciello, Clara Esposito, Sonia Ciotola, Gaia De Candia, Maria Carla Ricci, Maria Grazia Russo","doi":"10.3390/pediatric18040105","DOIUrl":"10.3390/pediatric18040105","url":null,"abstract":"<p><p>The journal retracts the article \"<i>Executive functions and foreign language learning</i>\" [...].</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"18 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13470958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Social, Emotional, and Physical Consequences of Hidradenitis Suppurativa in Pediatric Patients: A Scoping Review. 探讨儿童化脓性汗腺炎的社会、情感和生理后果:一项范围综述。
IF 1.9
Pediatric Reports Pub Date : 2026-08-04 DOI: 10.3390/pediatric18040103
Kathryn Lotharius, Kendell Lewis, Clarissa Portocarrero, Megha Srivastav, Silvia Zervos, Rebecca Urbonas, Michelle Knecht, Lea Sacca
{"title":"Exploring the Social, Emotional, and Physical Consequences of Hidradenitis Suppurativa in Pediatric Patients: A Scoping Review.","authors":"Kathryn Lotharius, Kendell Lewis, Clarissa Portocarrero, Megha Srivastav, Silvia Zervos, Rebecca Urbonas, Michelle Knecht, Lea Sacca","doi":"10.3390/pediatric18040103","DOIUrl":"10.3390/pediatric18040103","url":null,"abstract":"<p><p>There remains a widespread lack of knowledge regarding hidradenitis suppurativa (HS) among physicians in the United States, impeding timely diagnosis and implementation of comprehensive treatment interventions. Despite the presence of supporting communities for affected adolescents and their caretakers, the overall awareness of HS remains low, and a greater consensus on the treatment of HS is needed. Current research highlights the lack of standardized pediatric guidelines for treatment of HS largely due to the varied nature of the disease and limited efficacy of current therapies. Our study aims to explore the relationship between the chronic skin condition HS and social-emotional concerns, mental health, and physical health issues in US children and adolescents. Using the Arksey and O'Malley framework and PRISMA-ScR reporting, we searched PubMed/MEDLINE, Scopus, Web of Science, Cochrane Library, and Embase for U.S. studies (2015-2025) on pediatric HS (<18 years) and social-emotional, mental health, or quality-of-life outcomes. Recommendations were synthesized, and study quality was appraised with CASP checklist methods and rigor. Ten studies (2020-2025) met inclusion criteria. Pediatric HS was associated with depression, anxiety, social withdrawal, shame, low self-esteem, and reduced quality of life. Physical comorbidities increased psychosocial burden. Socioeconomic and racial disparities worsened outcomes and access to care. Studies emphasized early diagnosis, routine screening, multidisciplinary management, and disparity-focused interventions. Findings may inform clinical practice and guide research initiatives aimed at improving outcomes for children and adolescents with HS.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"18 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13516647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148832898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing Respiratory Support Modalities in Pediatric Asthma Exacerbation-A Systematic Review and Meta-Analysis. 比较呼吸支持方式对儿童哮喘加重的影响:系统综述和荟萃分析。
IF 1.9
Pediatric Reports Pub Date : 2026-08-04 DOI: 10.3390/pediatric18040104
Maha A Odeh, Garam Kiswani, Alex Gileles-Hillel
{"title":"Comparing Respiratory Support Modalities in Pediatric Asthma Exacerbation-A Systematic Review and Meta-Analysis.","authors":"Maha A Odeh, Garam Kiswani, Alex Gileles-Hillel","doi":"10.3390/pediatric18040104","DOIUrl":"10.3390/pediatric18040104","url":null,"abstract":"<p><p><b>Objectives:</b> To compare clinical outcomes and racial disparities of children hospitalized for acute asthma exacerbation who required any respiratory support: invasive mechanical ventilation (IMV), non-invasive modalities (non-invasive ventilation (NIV) and high-flow nasal cannula (HFNC)). <b>Methods:</b> We searched PubMed, Embase, Cochrane, and Scopus for randomized controlled trials (RCTs) and observational studies published between 2010 and 2025 that involved pediatric asthma patients (0-18 years) who received HFNC, NIV, or IMV. Network meta-analyses (NMA) were conducted separately for RCTs (change in asthma score) and observational studies (PICU length of stay). Subgroup analyses compared respiratory support modalities and failure rates. Racial and ethnic disparities were analyzed narratively. <b>Results:</b> In five RCTs (<i>n</i> = 233), compared to oxygen, HFNC showed no significant benefit (MD = 0.24; <i>p</i> = 0.58), whereas NIV showed the greatest improvement in asthma scores (mean difference [MD] = 1.24; <i>p</i> = 0.07), reaching significance in sensitivity analysis (MD = 2.5; <i>p</i> < 0.001). Observational NMA found no differences in PICU stay between respiratory support modalities, but HFNC was associated with 2-fold increase in PICU stay in a subgroup analysis compared to standard oxygen (<i>p</i> = 0.04) and with a higher failure rate compared to NIV (12.6% vs. 2.6%; OR = 5.3, <i>p</i> < 0.001). Black children had higher odds of intubation. <b>Conclusions:</b> Available evidence suggests that NIV may confer greater short-term clinical benefit in children with severe acute asthma requiring respiratory support, although findings should be interpreted cautiously given the limited and heterogeneous data. Further high-quality studies with standardized outcomes are needed to inform respiratory support selection.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"18 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13516637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148833501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatricians' Practice Patterns on the Revised 2022 Neonatal Hyperbilirubinemia Guidelines. 儿科医生对修订的2022年新生儿高胆红素血症指南的实践模式。
IF 1.9
Pediatric Reports Pub Date : 2026-08-03 DOI: 10.3390/pediatric18040101
Estherline J Thoby, Aimee Lariviere, Katherine Briski, Anna Petrova
{"title":"Pediatricians' Practice Patterns on the Revised 2022 Neonatal Hyperbilirubinemia Guidelines.","authors":"Estherline J Thoby, Aimee Lariviere, Katherine Briski, Anna Petrova","doi":"10.3390/pediatric18040101","DOIUrl":"10.3390/pediatric18040101","url":null,"abstract":"<p><p><b>Background/Objective:</b> In 2022, the American Academy of Pediatrics (AAP) revised the guidelines used to manage neonatal hyperbilirubinemia with a focus on reducing unnecessary testing and phototherapy. However, pediatricians' knowledge and compliance with the current guidelines have not been assessed. We conducted a survey to evaluate New Jersey pediatricians' current knowledge and practice patterns with the newly proposed guidelines. <b>Patients and Methods:</b> A questionnaire consisting of 28 closed-ended Likert-scale questions, along with demographic data, was distributed twice in 2024 to all members of the New Jersey AAP Chapter. Of 128 respondents, 120 who defined their involvement in the care of neonates with hyperbilirubinemia were analyzed. <b>Results:</b> The majority of survey respondents were general pediatricians (71.7%). Up to 70% recognized the risk factors for developing severe hyperbilirubinemia, except for Down Syndrome. Up to 60% of respondents utilized transcutaneous bilirubin in low-risk hyperbilirubinemia neonates and serum bilirubin after phototherapy initiation in high-risk neonates as recommended by the AAP. Almost all of the respondents followed the AAP recommended post-discharge follow-up and/or bilirubin measurement. The majority reported phototherapy initiation at the recommended thresholds; however, only 12.5% of surveyed pediatricians followed the recommended threshold for phototherapy discontinuation. <b>Conclusions:</b> Surveyed pediatricians in our study were most likely to comply with the 2022 AAP guidelines; however, opportunities remain for improving pediatricians' awareness of specific risk factors, reducing unnecessary laboratory testing and discontinuation of phototherapy at the recommended level.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"18 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13516341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148832909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书