Journal of Audiology and Otology最新文献

{"title":"A Case of Unilateral Otologic Symptoms as Initial Manifestations of Granulomatosis With Polyangiitis.","authors":"Franko Batinović,&nbsp;Marina Krnić Martinić,&nbsp;Merica Glavina Durdov,&nbsp;Davor Sunara","doi":"10.7874/jao.2022.00311","DOIUrl":"https://doi.org/10.7874/jao.2022.00311","url":null,"abstract":"<p><p>Granulomatosis with polyangiitis (GPA) is a chronic and systematic autoimmune condition characterized by granuloma formation and necrotizing vasculitis of small to medium-sized vessels. GPA initially presents itself as respiratory and renal symptoms. Although temporal bone involvement is not uncommon, an otologic disorder is rarely the initial symptom. We present a case of a 36-year-old man who presented with unilateral ear pain, hearing loss, and facial palsy. After a series of diagnostics and temporal bone and chest imaging, he was diagnosed with GPA with multiorgan involvement. Cyclophosphamide and methylprednisolone relieved the patient's ear pain and partially improved his hearing, facial palsy, and overall clinical condition. Although uncommon, systemic GPA may cause initial otologic symptoms and should not be dismissed as a possible cause of an otologic disease resistant to standard therapy.</p>","PeriodicalId":44886,"journal":{"name":"Journal of Audiology and Otology","volume":"27 3","pages":"161-167"},"PeriodicalIF":1.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9c/ce/jao-2022-00311.PMC10352694.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9833766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Management of Glomus Tympanicum Tumor: Report of Three Cases and Review of the Literature.","authors":"Athanasios Luca Fountarlis,&nbsp;Jiannis Hajiioannou,&nbsp;Vasileios Lachanas,&nbsp;Ioannis Tsitiridis,&nbsp;Athanasios Saratziotis,&nbsp;Aggeliki Alagianni,&nbsp;Charalampos Skoulakis","doi":"10.7874/jao.2022.00276","DOIUrl":"https://doi.org/10.7874/jao.2022.00276","url":null,"abstract":"<p><p>Glomus tympanicum are benign tumors of vascular origin, arising from the neural crest cells and located on promontory. The treatment of choice is surgical excision of the lesion. Traditionally, it is performed under microscopic observation. With the introduction of endoscopes in the field of ear surgeries, an endoscopic approach has also evolved. Herein, we present case reports of three patients diagnosed with glomus tympanicum tumors who were operated on using an endoscopic approach. A review of the literature is also performed. The mass was completely excised in all patients, and there were no signs of recurrence at the follow-up at least a year later. Endoscopic ear surgery is a safe and effective method of managing glomus tympanicum tumors. Its main limitation is the tumor size; however, in most cases, tumors of stages I to II as per the Glasscock-Jackson classification and types A1 to B1 according to the modified Fisch-Mattox classification can be completely removed endoscopically. Careful preoperative selection of patients warrants the best outcomes.</p>","PeriodicalId":44886,"journal":{"name":"Journal of Audiology and Otology","volume":"27 3","pages":"145-152"},"PeriodicalIF":1.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5e/2c/jao-2022-00276.PMC10352693.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9832991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of Speech Testing Using Wireless Connection in Single-Sided Cochlear Implant Users.","authors":"Seong Hoon Bae,&nbsp;Youngrak Jung,&nbsp;Ji Hye Hur,&nbsp;Jeong Ha Kim,&nbsp;Jae Young Choi","doi":"10.7874/jao.2023.00017","DOIUrl":"https://doi.org/10.7874/jao.2023.00017","url":null,"abstract":"<p><strong>Background and objectives: </strong>The speech tests used to evaluate language performance in patients with bilateral deafness (BiD) and cochlear implant (CI) are problematic if applied to patients with single-sided deafness (SSD) because normal ear hearing should be excluded. Thus, we investigated the feasibility of using wireless connection to evaluate speech intelligibility of the CI ear in patients with SSD. Subjects and.</p><p><strong>Methods: </strong>Patients with BiD and SSD were administered the word recognition scores (WRS) and speech intelligibility tests using an iPadbased wireless connection and conventional methods. To exclude normal side hearing in patients with SSD, masking noise and \"plugged and muffed\" method were used in the WRS and speech intelligibility tests, respectively.</p><p><strong>Results: </strong>In patients with BiD, the WRS and speech intelligibility tests results using wireless connection and conventional methods were similar. In patients with SSD, the WRS using masking noise in the normal hearing ear was similar to that of using wireless connection. However, 3 of 11 patients with SSD showed under-masked results if using the \"plugged and muffed\" method.</p><p><strong>Conclusions: </strong>Speech intelligibility testing using wireless connection is a convenient and reliable method for evaluating CI performance in patients with SSD. The \"plugged and muffed\" method is not recommended for evaluating CI performance in patients with SSD.</p>","PeriodicalId":44886,"journal":{"name":"Journal of Audiology and Otology","volume":"27 3","pages":"133-138"},"PeriodicalIF":1.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fe/81/jao-2023-00017.PMC10352690.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9835322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tone-Burst Auditory Brainstem Response and Cortical Potentials in Diagnosis of Syndromic Auditory Neuropathy Spectrum Disorder.","authors":"Wafaa A Kaf,&nbsp;Samantha Reiter,&nbsp;Amanda Brodeur,&nbsp;Letitia White-Minnis,&nbsp;William Deal","doi":"10.7874/jao.2022.00192","DOIUrl":"https://doi.org/10.7874/jao.2022.00192","url":null,"abstract":"<p><p>In this study, we report our findings of comprehensive evaluation in a man with syndromic craniofacial features, cognitive impairment, and hearing loss. The patient underwent psychological and genetic testing and screening for 133 genetic mutations associated with hearing loss, as well as extensive audiological evaluation to assess the auditory pathway between the middle ear and the auditory cortex. Psychological testing showed moderate cognitive impairment. Genetic testing did not reveal a genetic mutation for hearing loss. Audiological evaluation revealed mixed hearing loss and signs of auditory neuropathy spectrum disorder (ANSD) despite absence of otoacoustic emissions and an absent click-evoked auditory brainstem response (ABR) without recording of cochlear microphonics (CM). ANSD was characterized by abnormal speech discrimination, bilateral robust CM to 2,000 Hz tone-burst (TB) ABR, and abnormal left thalamocortical and cortical pathways diagnosed based on auditory middle latency and cortical N1-P2 responses. These behavioral and electrophysiological findings suggest post-synaptic ANSD at the brainstem level. An abnormal left thalamocortical auditory pathway may be attributable to the combined effect of lack of neural synchrony secondary to ANSD mainly on the left and/or brain injury. The findings in this study support the use of TB ABR and auditory cortical potentials in the ANSD test protocol and in patients with craniofacial anomalies.</p>","PeriodicalId":44886,"journal":{"name":"Journal of Audiology and Otology","volume":"27 3","pages":"153-160"},"PeriodicalIF":1.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2a/8d/jao-2022-00192.PMC10352689.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9832988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-Related Quality of Life in Children With Cochlear Implants From Parents' Perspective.","authors":"Sara Rochd,&nbsp;Othmane Benhoummad,&nbsp;Youssef Lakhdar,&nbsp;Salma Salhi,&nbsp;Mohamed Amine Ait Lhadj,&nbsp;Youssef Rochdi,&nbsp;Abdelaziz Raji","doi":"10.7874/jao.2022.00353","DOIUrl":"https://doi.org/10.7874/jao.2022.00353","url":null,"abstract":"<p><strong>Background and objectives: </strong>To evaluate the health-related quality of life (HRQoL) in parents of children with cochlear implants and assess influencing factors. These data can enable practitioners to support patients and their families in utilizing the cochlear implant and its benefits to the fullest extent. Subjects and.</p><p><strong>Methods: </strong>A retrospective descriptive and analytic study was conducted at the Implantation center Mohammed VI. Parents of cochlear implant patients were asked to fill out forms and answer a questionnaire. Participants included parents of children <15 years old who underwent unilateral cochlear implantation between January 2009 and December 2019, presenting with bilateral severe to profound neurosensory deafness. Participants completed the children with cochlear implantation: parent's perspective (CCIPP) HRQoL questionnaire.</p><p><strong>Results: </strong>The mean age of the children was 6.49±2.55 years. The mean time between implantation for each patient and this study was calculated as 4.33±2.05 years. There was a positive correlation between this variable and the following subscales: communication, well-being and happiness, and the process of implantation. For these subscales, the score was higher as the delay was greater. Parents of children who received speech therapy before implantation were more satisfied on the following subscales: communication, general functioning, well-being and happiness, implantation process, implantation effectiveness, and support for the child.</p><p><strong>Conclusions: </strong>The HRQoL is better in families of children who received their implant at an early age. This finding raises awareness of the importance of systemic screening in newborns.</p>","PeriodicalId":44886,"journal":{"name":"Journal of Audiology and Otology","volume":"27 3","pages":"115-122"},"PeriodicalIF":1.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ef/83/jao-2022-00353.PMC10352692.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9833770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Meningitis Due to Otitis Media With Cholesteatoma in a Five-Year-Old Child With a Cochlear Implant.","authors":"Hanneke D van Oorschot,&nbsp;Hiske W Helleman,&nbsp;Adriana L Smit","doi":"10.7874/jao.2022.00045","DOIUrl":"https://doi.org/10.7874/jao.2022.00045","url":null,"abstract":"<p><p>Cochlear implants (CIs) restore hearing in patients with severe-to-profound deafness. Post-CI meningitis is a rare but redoubted complication. We present the case of a five-year-old CI recipient who experienced an episode of chronic meningitis caused by chronic otitis media with cholesteatoma encasing the electrode lead. We hypothesize that the cholesteatoma led to an ascending infection to the cochlea, passing through the labyrinths, resulting in chronic meningitis. Although positive neural responses were initially noted on cochlear electrical stimulation, these responses resolved a few weeks after reimplantation. Our report highlights the importance of careful otoscopic examination and diagnostic work-up in patients presenting with otogenic meningitis to rule out cholesteatoma formation and to ensure prompt surgical exploration if warranted.</p>","PeriodicalId":44886,"journal":{"name":"Journal of Audiology and Otology","volume":"27 2","pages":"110-114"},"PeriodicalIF":1.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1b/87/jao-2022-00045.PMC10126582.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9350014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Auditory and Vestibular Findings Differentiate Vestibular Migraine and Meniere's Disease?","authors":"Handan Yaman,&nbsp;Burcu Polat,&nbsp;Mustafa Bülent Şerbetçioğlu","doi":"10.7874/jao.2022.00465","DOIUrl":"https://doi.org/10.7874/jao.2022.00465","url":null,"abstract":"<p><strong>Background and objectives: </strong>Besides evaluating the auditory and vestibular systems of patients with vestibular migraine (VM) and Meniere's disease (MD), this study aimed to examine the clinical overlaps between these two conditions by detailed evaluation of the patient's symptoms. Subjects and.</p><p><strong>Methods: </strong>The ears of the patients with VM and MD were evaluated and patients' vestibular and auditory complaints were questioned particularly. Pure tone audiometry, vestibular evoked myogenic potential (VEMP) responses, and caloric test results were evaluated for objective measurements.</p><p><strong>Results: </strong>The VM group had better air-conduction and boneconduction threshold and speech reception threshold and speech discrimination score test values (p<0.05). Regarding the interaural N1-P1 asymmetry ratio, the cervical VEMP between the groups had significant differences (p=0.019). The MD group had more unilateral tinnitus and ear fullness complaints and canal paresis results (p<0.01). The VM group had more motion sickness complaints (p<0.01).</p><p><strong>Conclusions: </strong>If only ears with hearing loss are evaluated; there was no significant difference between VM and MD, but regardless of hearing level or only the patients with normal hearing were evaluated, the VM group had better hearing levels. It should be considered that patients with VM may have VM-independent hearing loss, and patient complaints should be sufficiently detailed to make an accurate distinction from MD.</p>","PeriodicalId":44886,"journal":{"name":"Journal of Audiology and Otology","volume":"27 2","pages":"104-109"},"PeriodicalIF":1.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d5/eb/jao-2022-00465.PMC10126588.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9350864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Music Perception Abilities of the Hearing Amplification System Users.","authors":"Sungmin Jo,&nbsp;Jiyeong Yun,&nbsp;Jeong-Sug Kyong,&nbsp;Yerim Shin,&nbsp;Jinsook Kim","doi":"10.7874/jao.2022.00367","DOIUrl":"https://doi.org/10.7874/jao.2022.00367","url":null,"abstract":"<p><strong>Background and objectives: </strong>Recently, the improvement of music perception abilities for emotional stability and high quality of life has become important for the hearing loss group. This study aimed to examine and compare the music perception abilities of the normal hearing (NH) and hearing amplification system (HAS) groups to find the needs and methods of music rehabilitation. Subjects and.</p><p><strong>Methods: </strong>The data were collected from 15 NH adults (33.1±11.4 years) and 15 HAS adults (38.7±13.4 years), of whom eight wore cochlear implant [CI] systems and seven wore CI and hearing aid systems depending on pitch, melody, rhythm, timbre, emotional reaction, and harmony perception tests. A mismatch negativity test was also conducted, and attitudes toward and satisfaction with listening to music were measured.</p><p><strong>Results: </strong>The correction percentages for the NH and HAS groups were 94.0%±6.1% and 75.3%±23.2% in the pitch test; 94.0%±7.1% and 30.3%±25.9% in the melody test; 99.3%±1.8% and 94.0%± 7.6% in the rhythm test; 78.9%±41.8% and 64.4%±48.9% in the timbre test; 96.7%±10.4% and 81.7%±16.3% in the emotional reaction test; and 85.7%±14.1% and 58.4%±13.9% in the harmony test, respectively, showing statistical significance (p<0.05). For the mismatch negativity test, the area of the waveform was smaller in the HAS groups than in the NH groups, with 70 dB of stimulation showing no statistical significance. The response rates for satisfaction with listening to music were 80% and 93.3% for the NH and HAS groups, showing no statistical significance.</p><p><strong>Conclusions: </strong>Although the HAS group showed lower music perception ability than the NH group overall, they showed a strong desire for music listening. Also, the HAS group revealed a higher degree of satisfaction even when listening to unfamiliar music played with unusual instruments. It is suggested that systematic and constant musical rehabilitation based on musical elements and different listening experiences will improve music perception qualities and abilities for HAS users.</p>","PeriodicalId":44886,"journal":{"name":"Journal of Audiology and Otology","volume":"27 2","pages":"78-87"},"PeriodicalIF":1.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a2/14/jao-2022-00367.PMC10126585.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9720647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunohistochemical Analysis of the Expression of Cytokeratins in Acquired Cholesteatoma and Its Clinico-Radiological Correlation.","authors":"Anupam Kanodia,&nbsp;Aanchal Kakkar,&nbsp;Yash Verma,&nbsp;Diya Roy,&nbsp;Hitesh Verma,&nbsp;Chirom Amit Singh,&nbsp;Rabia Monga,&nbsp;Deepali Jain,&nbsp;Alok Thakar,&nbsp;Kapil Sikka","doi":"10.7874/jao.2022.00451","DOIUrl":"https://doi.org/10.7874/jao.2022.00451","url":null,"abstract":"<p><strong>Background and objectives: </strong>Cholesteatomatous chronic otitis media acquires epithelial proliferation and differentiation characteristics, which render it able to erode the underlying bone and cause complications. We attempt to characterize the cholesteatoma epithelium by observing the expression of cytokeratins (such as 34ße12, CK17, and CK13) and Ki67 among patients with cholesteatoma with different aggressiveness as compared to disease-free controls. Subjects and.</p><p><strong>Methods: </strong>In this prospective study (2017-2021), we enrolled all consenting consecutive patients with cholesteatomatous chronic otitis media. They were staged in accordance with the staging guidelines of the European Academy of Otology and Neurotology and the Japanese Otological Society. Bony external auditory canal (EAC) skin specimens of the patients undergoing tympanoplasty were chosen as controls. We did an immunohistochemical analysis of the cholesteatoma specimens and normal bony EAC controls by observing the expression of 34ße12, CK17, CK13, and Ki67 across the layers of the epithelium. Fisher's exact test and chi-square test were used to evaluate any statistical significance between the cases and the controls, and the subgroups were made based on the clinical stage.</p><p><strong>Results: </strong>An increased expression of CK17 (p<0.001), CK13 (p<0.03), and Ki67 (p<0.001) was observed in cholesteatoma specimens when compared to normal bony EAC controls. Also, there was a loss of expression of 34ße12 in a subset of cholesteatoma specimens, all of which showed full-thickness expression of CK13. There was no difference in the expression of cytokeratin among specimens from patients belonging to different subgroups based on clinical stage, age, sex, duration of ear symptoms, or type of hearing loss (conductive vs. sensorineural).</p><p><strong>Conclusions: </strong>The majority of cholesteatoma specimens significantly overexpressed CK17, CK13, and Ki67 when compared to normal bony EAC skin controls, while a subset showed loss of expression of 34ße12, which provides some insight into its pathogenesis.</p>","PeriodicalId":44886,"journal":{"name":"Journal of Audiology and Otology","volume":"27 2","pages":"97-103"},"PeriodicalIF":1.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3a/78/jao-2022-00451.PMC10126587.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9705984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Language Intervention Instead of Speech Intervention for Children With Cochlear Implants.","authors":"Ivana Šimić Šantić, Luka Bonetti","doi":"10.7874/jao.2022.00584","DOIUrl":"10.7874/jao.2022.00584","url":null,"abstract":"<p><p>Cochlear implants are a standard rehabilitation option for children with severe hearing loss or deafness, allowing access to speech sounds necessary for the development of spoken language. However, the speech-language outcomes of pediatric cochlear implant users vary widely and are not directly or exclusively linked to technology but to combinations of individual audiological, personal, technical, and habilitational factors. These combinations may not favor spoken language development, which may further be linked to the issue of prior insistence on spoken language learning and associated with a high risk of language deprivation. Here, we discuss the outcomes of cochlear implantation from a habilitative perspective and lay down the efforts and resources necessary for the development of communication competence after cochlear implantation rather than the achievement of specific hearing, language, or speech skills that have limited socioemotional and educational contributions and do not guarantee an independent or productive life.</p>","PeriodicalId":44886,"journal":{"name":"Journal of Audiology and Otology","volume":"27 2","pages":"55-62"},"PeriodicalIF":1.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/60/c1/jao-2022-00584.PMC10126584.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9440250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}