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[Cellular immunotherapies for malignancies - How do they work and what are the side effects?] 恶性肿瘤的细胞免疫疗法-它们是如何起作用的，有什么副作用?］
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2023-10-01
Heinz Läubli
{"title":"[Cellular immunotherapies for malignancies - How do they work and what are the side effects?]","authors":"Heinz Läubli","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The advent of immunotherapy has brought about a revolutionary shift in the treatment of cancer patients, significantly improving their outcomes. However, it is disheartening that not all patients can benefit from the currently available immunotherapies. Fortunately, cellular immunotherapies have emerged as a promising alternative. Among these approaches, the use of ex vivo activated and expanded tumor-infiltrating lymphocytes (TIL) has shown promise, particularly in patients with immunogenic cancers like melanoma. Moreover, advancements in genetic manipulation techniques have enabled the engineering of T cells with synthetic chimeric antigen receptors (CAR) capable of recognizing specific targets, such as CD19-positive cancers like B-cell leukemias and lymphomas. These cellular immunotherapies have made their way into clinical practice, although they may occasionally give rise to severe and previously unknown side effects. This review aims to provide an in-depth understanding of these therapies while discussing the associated side effects and their management strategies.</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"80 8","pages":"348-352"},"PeriodicalIF":0.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Tumour immunotherapy - mechanism and side effects]. 肿瘤免疫治疗-机制和副作用。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2023-10-01
Christian Diehl, Sacha Rothschild
{"title":"[Tumour immunotherapy - mechanism and side effects].","authors":"Christian Diehl, Sacha Rothschild","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Since the development of the first immune checkpoint inhibitor, a new era in tumour immunotherapy has been initiated and response and survival rates have improved in many tumour entities. Despite this encouraging progress, the number of patients who achieve a durable response is limited by resistance mechanisms, and immune-related adverse events (irAEs) complicate treatment. The mechanism of irAE is not understood in all details. In this review, we summarise the mechanisms of action of immune checkpoint inhibitors, the different forms of irAE and their possible mechanisms of development, and describe possible prevention strategies and treatment options. strategies for prevention and treatment options.</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"80 8","pages":"359-362"},"PeriodicalIF":0.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[New treatment options in systemic therapy for breast cancer and associated new side effects]. [乳腺癌系统治疗的新治疗方案及相关新副作用]。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2023-10-01
Julia Landin, Walter Paul Weber, Marcus Vetter
{"title":"[New treatment options in systemic therapy for breast cancer and associated new side effects].","authors":"Julia Landin, Walter Paul Weber, Marcus Vetter","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Breast cancer today has a significantly better prognosis than two to three decades ago. Treatment options have improved significantly. However, new systemic therapy has also resulted in side effects that clinicians must first become familiar with in order to be able to treat them optimally. This article gives an overview of the most important innovations in the last 10 years in the field of systemic therapy in breast cancer and also shows the most important side effects and their management.</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"80 8","pages":"353-358"},"PeriodicalIF":0.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Polymedication and oral antitumour therapies - which drug interactions should be considered?] 多种药物治疗和口服抗肿瘤治疗-应考虑哪些药物相互作用?］
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2023-10-01
Selina N Späni, Tarun Mehra, Kanchan Dongre, Anne B Leuppi-Taegtmeyer
{"title":"[Polymedication and oral antitumour therapies - which drug interactions should be considered?]","authors":"Selina N Späni, Tarun Mehra, Kanchan Dongre, Anne B Leuppi-Taegtmeyer","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Oral anticancer therapies offer various advantages but also entail risks due to their toxicity and narrow therapeutic ranges. Since these drugs are increasingly prescribed in patients with existing polypharmacy, identifying and assessing potential drug interactions is of great importance for safe and effective therapy. This article provides an overview of the most common pharmacokinetic and pharmacodynamic drug-drug interactions of targeted anticancer therapies, with focus on protein kinase inhibitors.</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"80 8","pages":"373-376"},"PeriodicalIF":0.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Gesundheitliche Chancengleichheit in der Geburtshilfe durch transkategoriale Kompetenz]. [通过跨学科能力实现产科健康平等]。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2023-09-01
Paola Origlia Ikhilor, Anina Haefliger
{"title":"[Gesundheitliche Chancengleichheit in der Geburtshilfe durch transkategoriale Kompetenz].","authors":"Paola Origlia Ikhilor,&nbsp;Anina Haefliger","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Not all mothers and newborns have equal opportunities for a healthy motherhood and a healthy start. Differences exist in various diversity characteristics such as low socioeconomic status, migration background, sexual orientation, gender identity, and disability. In addition to a range of increased health risks for mothers and newborns, barriers in the care process, such as lack of awareness of the specific needs and interaction problems between clients and professionals, hinder the utilization of obstetric and maternity services. The elimination of access barriers and mechanisms of discrimination can be achieved through transcategorial competence. In the context of obstetrics and maternity care, transcategorial competence means, for example, the appropriate involvement of relatives in migrant women's care, recognition, and support of different family forms in LGBTI*Q people, and awareness of discriminatory behavior. Continuity in care provided by gynecologists and midwives facilitates healthcare provision and minimizes misunderstandings. The establishment of transcategorial competence requires institutional awareness of forms of discrimination and disadvantage. Interdisciplinary collaboration and diversity-sensitive education and training are crucial for reducing uncertainties and avoiding stereotyping.</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"80 7","pages":"320-326"},"PeriodicalIF":0.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49683400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Kulturelle Kompetenz in der klinischen Ethik]. [临床伦理的文化能力]。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2023-09-01
Jan Schürmann, Susanne Martina Schmidt, Manuel Trachsel
{"title":"[Kulturelle Kompetenz in der klinischen Ethik].","authors":"Jan Schürmann,&nbsp;Susanne Martina Schmidt,&nbsp;Manuel Trachsel","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Language, cultural identity, values, or migration experiences of patients, relatives and medical professionals have a significant influence on health care. In individual cases, this can lead to the perceptions of moral problems and conflicts, and to requests for clinical ethics support service. What is the role of clinical ethicists in the face of such perceptions? How does a culturally competent clinical ethics support service look like? In the present contribution, this question will be examined on the basis of reflections on the relationship between culture and ethics as well as the discussion about culturally competent medical ethics. On that basis, recommendations for a culturally competent clinical ethics support are derived.</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"80 7","pages":"312-319"},"PeriodicalIF":0.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49683403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kulturelle Kompetenz. 文化能力。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2023-09-01
Manuel Trachsel
{"title":"Kulturelle Kompetenz.","authors":"Manuel Trachsel","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong></p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"80 7","pages":"297"},"PeriodicalIF":0.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49683406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Kulturelle Aspekte (in) der Seelsorge - ein Essay]. [田园关怀的文化层面：随笔]。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2023-09-01
Luzius Müller
{"title":"[Kulturelle Aspekte (in) der Seelsorge - ein Essay].","authors":"Luzius Müller","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Work in the field of intercultural communication initially assumed negotiations between 'culturally homogeneous' delegations. In the clinical field, it became apparent that 'cultural homogeneity' cannot be assumed, especially in the 'party' of patients or relatives. Thus, the approach of transculturality was developed for the clinical field. The service of (hospital) pastoral care, if it wants to be understood correctly, must subject itself to a transcultural analysis. It is characterized by a constantly changing, individually shaped 'culture'. This proves to be an opportunity in the clinical field.</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"80 7","pages":"343-346"},"PeriodicalIF":0.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49683402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Limitations of Trainings in Cross-Cultural Competence - The Practitioner Perspective. 跨文化能力培训的局限性——从业者视角。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2023-09-01
Theresa Steinhäuser, Steffen Schödwell, Anna Auckenthaler
{"title":"Limitations of Trainings in Cross-Cultural Competence - The Practitioner Perspective.","authors":"Theresa Steinhäuser,&nbsp;Steffen Schödwell,&nbsp;Anna Auckenthaler","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Objective: Trainings in cross-cultural competence1 are of increasing importance for psychotherapists in order to provide adequate mental health care for patients with a migration background. Yet, little is known about practitioners´ perspectives on working with migrants. Method: Problem-centered interviews with 30 practitioners offering psychotherapy within the German mental health care system have been analyzed using Grounded Theory Methodology to get an insight into practitioners´ experiences with cross-cultural work. Results: Practitioners have to deal with strong feelings of insecurity in their cross-cultural work. Feelings of insecurity were influenced by practitioners' underlying cultural concepts, how specific they perceived the cross-cultural contact to be and how they saw themselves in their professional role as psychotherapists. Interestingly, the analysis shows that trainings in cross-cultural competence which mainly convey \"culture specific\" knowledge on a rather theoretical level might even increase practitioners' feelings of insecurity. Conclusions: Conventional teaching formats in cross-cultural competence might not provide psychotherapists with sufficient space to reflect on their insecurities, their \"cultural concepts\", and their expectations of themselves in their professional role. Therefore, other settings are required. Dealing with practitioners' perceived lack of knowledge in the context of culture could be an effective starting point to deal with cross-cultural insecurities.</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"80 7","pages":"333-342"},"PeriodicalIF":0.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49683407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Interkulturelle Kompetenz: Eine Einführung]. [跨文化能力：简介]。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2023-09-01
Tatjana Weidmann-Hügle
{"title":"[Interkulturelle Kompetenz: Eine Einführung].","authors":"Tatjana Weidmann-Hügle","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Modern societies are multicultural and diverse in many ways. Among numerous other facets, they are characterised by linguistic and cultural diversity. In health care, encounters, exchange and understanding between people of different cultural backgrounds are part of everyday life and require intercultural competence. The aim of this article is to shed more light on this ability as well as on important concepts related to interculturality.</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"80 7","pages":"298-301"},"PeriodicalIF":0.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49683401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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