Konstantina Papangelopoulou, Tatiana Kuznetsova, Marta Orlowska, Nicholas Cauwenberghs, Jens-Uwe Voigt, Jan D'hooge
{"title":"Strain rate during isovolumic relaxation as a prognostic biomarker for long-term cardiovascular morbidity and mortality: an exploratory study on a general population.","authors":"Konstantina Papangelopoulou, Tatiana Kuznetsova, Marta Orlowska, Nicholas Cauwenberghs, Jens-Uwe Voigt, Jan D'hooge","doi":"10.1007/s12574-024-00662-y","DOIUrl":"10.1007/s12574-024-00662-y","url":null,"abstract":"<p><strong>Aims: </strong>Left ventricular (LV) strain rate (SR) during early relaxation correlates with LV filling pressures and has been assessed as a prognostic biomarker in several cardiac diseases. Conversely, even though LV SR during isovolumic relaxation (SR<sub>IVR</sub>) is more strongly related to invasive measurements of LV diastolic function, to date, studies on the role of SR<sub>IVR</sub> in the long-term prognosis assessment are lacking. Thus, the goal of this study was to assess the potential additive prognostic value of SR<sub>IVR</sub> on top of conventional cardiovascular risk factors in a general population.</p><p><strong>Methods: </strong>657 subjects (mean age 51.6y; 47.6% males) were included in this study and, besides clinical and standard echocardiographic assessment, tissue Doppler imaging (TDI)-based SR was measured during IVR (SR<sub>IVR</sub>), early diastole (SR<sub>e</sub>), and atrial contraction (SR<sub>a</sub>) in the mid-segment of the inferior, inferolateral, lateral, and septal wall of the LV.</p><p><strong>Results: </strong>During the follow-up period (median 12.1 years), the total number of major adverse cardiac events was 85 (13.4%). Overall, after adjustment for known cardiovascular risk factors and important echocardiographic indices in a multivariable-adjusted Cox regression model, SR<sub>IVR</sub> of the inferolateral wall (SR<sub>IVRinflat</sub>) remained an independent predictor of fatal and nonfatal cardiac events (HR: 1.49, p = 0.016), along with GLS (HR: 1.35, p = 0.027), age (HR: 1.09, p < 0.001), and male sex (HR: 2.06, p = 0.037). None of SR<sub>IVR</sub> measured in the other myocardial walls were associated with cardiac outcome.</p><p><strong>Conclusion: </strong>SR<sub>IVRinflat</sub> predicted adverse outcome in the general population, on top of conventional cardiovascular factors. However, its incremental value as a prognosticator remained limited.</p>","PeriodicalId":44837,"journal":{"name":"Journal of Echocardiography","volume":" ","pages":"86-98"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142477170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reproducibility of the systolic and diastolic energy loss of the left ventricle in vector flow mapping.","authors":"Yuya Fukudome, Michinari Hieda, Nobuyuki Ohte, Shutaro Futami, Emi Kaneko, Akihiro Koike, Saki Kurokawa, Yuya Kunisaki, Akira Shiose, Koichi Akashi","doi":"10.1007/s12574-025-00688-w","DOIUrl":"https://doi.org/10.1007/s12574-025-00688-w","url":null,"abstract":"<p><strong>Background: </strong>Vector Flow Mapping (VFM) is a novel technique for visualizing intracardiac blood flow. A few reports have been made regarding the reproducibility of energy loss (EL) measurements using VFM. This study aims to elucidate the intra-class and inter-class correlation coefficient (intra-ICC and inter-ICC) in the EL measurements.</p><p><strong>Methods: </strong>Seven healthy participants were enrolled, and echocardiographic data were obtained by two cardiac sonographers (14 images). Three independent analysts analyzed all images in three different cardiac cycles three times: 378 data points (14 images × analysts × 3 cardiac cycles × 3 times). The intra-ICC (1, 1) and inter-ICC (2, 1) were calculated. Furthermore, the intra-ICC (1, k) and inter-ICC (2, k) were applied using the averaged EL value in three cardiac cycles. An ICC value greater than 0.75 was defined as acceptable reproducibility.</p><p><strong>Results: </strong>In diastole, the intra-ICC (1, 1) by the three analysts was 0.890, 0.830, and 0.802; the intra-ICC (1, k), using the average EL value was 0.986, 0.978, and 0.973. In systole, the intra-ICC (1, 1) was 0.729, 0.698, and 0.733; the intra-ICC (1, k) was 0.960, 0.954, and 0.961. In diastole, the inter-ICC (2, 1) was 0.950, and the inter-ICC (2, k) was 0.958. In contrast, in systole, the inter-ICC (2, 1) was 0.772, and the inter-ICC (2, k) was 0.774; these values were lower than those in diastole.</p><p><strong>Conclusions: </strong>These findings indicate that the intra- and inter-measurer reproducibility of diastolic and systolic EL is favorable for clinical use.</p>","PeriodicalId":44837,"journal":{"name":"Journal of Echocardiography","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ankit Agrawal, Aro Daniela Arockiam, Elio Haroun, Tiffany Dong, Joseph El Dahdah, Muhammad Majid, Mohammad Alamer, Sharmeen Sorathia, Richard A Grimm, Patrick Collier, Leonardo L Rodriguez, Zoran B Popovic, Brian P Griffin, Tom Kai Ming Wang
{"title":"Normal ranges of right atrial strain by contemporary echocardiography software: a prospective comparative cohort study.","authors":"Ankit Agrawal, Aro Daniela Arockiam, Elio Haroun, Tiffany Dong, Joseph El Dahdah, Muhammad Majid, Mohammad Alamer, Sharmeen Sorathia, Richard A Grimm, Patrick Collier, Leonardo L Rodriguez, Zoran B Popovic, Brian P Griffin, Tom Kai Ming Wang","doi":"10.1007/s12574-025-00689-9","DOIUrl":"https://doi.org/10.1007/s12574-025-00689-9","url":null,"abstract":"<p><strong>Background: </strong>Right atrial (RA) strains (RASr, RAScd, and RASct) are increasingly used in clinical and research settings, such as heart failure and pulmonary hypertension, but their feasibility and reference ranges across different strain software vendors are not well established. We aim to evaluate and compare two-dimensional RA strain values, reference ranges, and related factors across four strain software vendors in healthy subjects.</p><p><strong>Methods: </strong>Healthy subjects (n = 100) undergoing echocardiography during January-April 2023 were prospectively studied, with equal numbers by age groups, gender, and GE versus Philips scans. RA strains were quantified using TomTec version 51.02 (Autostrain LA), EchoPAC version 206 (AFI-LA), Velocity-Vector Imaging (VVI) version 2.00, and Epsilon software (5.0.2.11295) for statistical analyses.</p><p><strong>Results: </strong>Overall means and lower limits of normal (LLNs) of each type of RA strain by strain vendor, age group, sex, and scanner vendor were reported. For example, RASr (%) means and LLNs (95% confidence intervals) were 41.2 (38.5, 43.0) and 29.6 (26.5, 32.7) for TomTec, 35.9 (34.4, 37.3) and 27.0 (24.5, 29.5) for EchoPAC, 44.8 (42.3, 47.3) and 27.6 (23.3, 31.9) for VVI, and 38.9 (36.7, 41.0) and 25.5 (21.7, 29.3) for Epsilon, respectively. Linear mixed model regression showed EchoPAC and VVI had significantly lower RASr and higher RAScd magnitude than TomTec, with older age linked to lower RASr and RAScd magnitudes.</p><p><strong>Conclusion: </strong>TomTec and VVI were vendor-neutral for measuring RA strains, while EchoPAC worked only on GE scans. Normal values, lower limits of normal, and related factors for RA strain measurements by vendor were established for clinical use.</p>","PeriodicalId":44837,"journal":{"name":"Journal of Echocardiography","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Contrast echocardiography proved useful in detecting abnormal flow following ASD closure during minimally invasive cardiac surgery: a case report.","authors":"Natsumi Morisako, Tsukasa Iwasaki, Yasuyuki Kato, Tadanobu Irie","doi":"10.1007/s12574-025-00686-y","DOIUrl":"https://doi.org/10.1007/s12574-025-00686-y","url":null,"abstract":"","PeriodicalId":44837,"journal":{"name":"Journal of Echocardiography","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carmelo J Panetta, Les B Forgosh, Elizabeth Bisinov, Haitham Hussein, David Benditt, Benjamin Miller, Marat Yanavitski, Marit Thorsgard, Beth Jorgenson, Ganesh Raveendran, Nadeem Iqbal
{"title":"Lower vs upper extremity injection of agitated saline for identification of patent foramen ovale (LOCATE).","authors":"Carmelo J Panetta, Les B Forgosh, Elizabeth Bisinov, Haitham Hussein, David Benditt, Benjamin Miller, Marat Yanavitski, Marit Thorsgard, Beth Jorgenson, Ganesh Raveendran, Nadeem Iqbal","doi":"10.1007/s12574-025-00685-z","DOIUrl":"https://doi.org/10.1007/s12574-025-00685-z","url":null,"abstract":"<p><strong>Aims: </strong>Upper extremity injection of agitated saline using echocardiography is standard for locating patent foramen ovale (PFO), but several studies found the lower extremity to be more sensitive.</p><p><strong>Methods: </strong>In this prospective study, patients were selected who had a prior embolic stroke of undetermined source by history and no PFO identified with transthoracic echocardiography. We placed intravenous access in the upper extremity and used ultrasound-guided access in the superficial greater saphenous vein in the lower extremity, evaluating best view and presence and size of PFO if found.</p><p><strong>Results: </strong>On review of 910 subjects, twenty subjects completed the study. The average greater saphenous vein measured 0.49 ± 0.16 cm in diameter, and depth of 1.07 ± 0.66 cm. The apical four chamber view to visualize the atrial septum was considered superior (p < 0.005) to the subcostal and parasternal short axis views. A PFO was found in five of the twenty subjects with concordance among all readers via lower extremity injection, compared to four subjects via upper extremity injection. Lower extremity injection of contrast identified significantly (p < 0.05) larger PFO compared to upper extremity injection. Complications from greater saphenous vein access included one superficial thrombus, one vasovagal syncope and four with ecchymosis (all < 3cm).</p><p><strong>Conclusions: </strong>PFO are found significantly larger when utilizing the greater saphenous vein of the lower extremity compared to the upper extremity for injection of agitated saline and best visualized with the apical four-chamber view.</p>","PeriodicalId":44837,"journal":{"name":"Journal of Echocardiography","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case of acute severe aortic regurgitation due to aortic valve commissure avulsion.","authors":"Koichiro Imai, Kyo Kamisaka, Tomoko Tamada, Yoshitaka Sasahira, Yoji Neishi, Yuji Kanaoka, Shiro Uemura","doi":"10.1007/s12574-025-00683-1","DOIUrl":"https://doi.org/10.1007/s12574-025-00683-1","url":null,"abstract":"","PeriodicalId":44837,"journal":{"name":"Journal of Echocardiography","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Severe mitral regurgitation with coexisting giant left atrium in a patient with Williams syndrome.","authors":"Takuya Sasaki, Shinichi Okuda, Hitoshi Nagai, Takeshi Ueyama, Yasuhiro Ikeda","doi":"10.1007/s12574-025-00682-2","DOIUrl":"https://doi.org/10.1007/s12574-025-00682-2","url":null,"abstract":"","PeriodicalId":44837,"journal":{"name":"Journal of Echocardiography","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}