Carlos Mirel Peñate, Amalia T Peix Gonzalez, Kenia María Padrón García, Aylen Perez Barreda, Sheila Hechavarría, Roxana Pazmino, Orlando Henriquez Italin, Andrew Dzebu, Fernando Barba, Ivan Figueroa Baez, Carlos Fonseca Marrero
{"title":"Myocardial contraction fraction and mortality in cardiac amyloidosis: a prospective single-center cohort study.","authors":"Carlos Mirel Peñate, Amalia T Peix Gonzalez, Kenia María Padrón García, Aylen Perez Barreda, Sheila Hechavarría, Roxana Pazmino, Orlando Henriquez Italin, Andrew Dzebu, Fernando Barba, Ivan Figueroa Baez, Carlos Fonseca Marrero","doi":"10.1007/s12574-026-00756-9","DOIUrl":"https://doi.org/10.1007/s12574-026-00756-9","url":null,"abstract":"<p><strong>Background: </strong>Left ventricular ejection fraction (LVEF) often remains normal in cardiac amyloidosis (CA) because declines in stroke volume (SV) parallel reductions in end-diastolic volume. The myocardial contraction fraction (MCF), the ratio of SV to myocardial volume, has been proposed as superior to LVEF in predicting mortality in CA.</p><p><strong>Methods: </strong>Thirty patients with confirmed CA underwent echocardiography and were followed for a mean of 18.2 ± 5.8 months. MCF was calculated from standard two-dimensional echocardiographic measurements. Cox proportional hazards modeling with Lasso-penalized selection was used to evaluate the association of MCF with all-cause mortality.</p><p><strong>Results: </strong>Mean age was 70.1 ± 8.6 years; 76.7% were male. Thirteen patients (43.3%) died. MCF was lower among those who died compared with survivors (21.9% vs 38.2%; p < 0.0001); 87.5% of patients with MCF ≤ 25% died, compared with 27.3% of those with MCF > 25%. MCF ≤ 25% was independently associated with mortality (HR: 5.456; 95% CI: 1.628-18.29; p = 0.006); modeled as a continuous variable, each 5-percentage-point increase in MCF was associated with lower mortality (HR: 0.57; p = 0.002), while MAPSE < 10 mm and grade 3 diastolic dysfunction were retained in the multivariable model but did not reach significance after penalization.</p><p><strong>Conclusions: </strong>MCF ≤ 25% demonstrated numerically greater discriminative ability for all-cause mortality compared with LVEF (C-statistic 0.83 vs 0.71) and was the only echocardiographic parameter to remain an independent predictor after Lasso-penalized multivariable adjustment. These hypothesis-generating findings, from a small single-centre cohort, require validation in larger, subtype-specific studies.</p>","PeriodicalId":44837,"journal":{"name":"Journal of Echocardiography","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149275336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anomalous papillary muscle insertion beyond hypertrophic cardiomyopathy: insights from reported cases.","authors":"Yuki Kudo, Shinichiro Takahashi","doi":"10.1007/s12574-026-00755-w","DOIUrl":"https://doi.org/10.1007/s12574-026-00755-w","url":null,"abstract":"<p><p>Anomalous insertion of the papillary muscle (APM) into the mitral valve leaflet is a rare congenital abnormality of the subvalvular apparatus. Most published reports describe direct papillary muscle insertion in association with obstructive physiology, particularly in hypertrophic cardiomyopathy (HCM), where it contributes to left ventricular outflow tract (LVOT) obstruction and systolic anterior motion (SAM)-related mitral regurgitation. However, similar papillary muscle-leaflet continuity may also serve as a primary mechanical determinant of valve dysfunction in patients without a clinical diagnosis of HCM. This review synthesizes published reports of APM insertion across different clinical contexts and interprets them within a mechanism-oriented framework based on LVOT dynamics and functional role of the papillary muscle rather than disease labels. Available reports indicate a heterogeneous clinical spectrum in which hemodynamic manifestations reflect interactions among papillary muscle anatomy, mitral valve mechanics, and ventricular geometry. Although LVOT obstruction remains an important presentation, many cases show predominant mitral regurgitation due to leaflet tethering or, less commonly, functional mitral stenosis from impaired diastolic leaflet opening. These phenotypes arise from subvalvular mechanical restriction rather than primary leaflet pathology. Echocardiography plays a central role in diagnosis, yet APM insertion may be overlooked if assessment focuses primarily on leaflet morphology or Doppler findings. Transesophageal echocardiography, cardiac computed tomography, and cardiac magnetic resonance imaging provide complementary anatomical detail for accurate characterization and surgical planning. Greater awareness of this geometry-based interaction and adoption of a structured imaging approach may reduce diagnostic oversight and improve decision-making in patients with atypical mitral valve dysfunction.</p>","PeriodicalId":44837,"journal":{"name":"Journal of Echocardiography","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149275380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Echocardiographic predictors of left ventricular ejection fraction improvement after transcatheter aortic valve replacement.","authors":"Shin Sato, Akiko Kumagai, Kai Ninomiya, Akiko Murofushi, Kaho Shimada, Michiko Yoshizawa, Ryo Ninomiya, Tetsuya Fusazaki, Yoshihiro Morino","doi":"10.1007/s12574-026-00753-y","DOIUrl":"https://doi.org/10.1007/s12574-026-00753-y","url":null,"abstract":"<p><strong>Background: </strong>Improvement in left ventricular ejection fraction (LVEF) after transcatheter aortic valve replacement (TAVR) has been associated with better clinical outcomes, but predictors of recovery remain poorly defined. This study aimed to identify echocardiographic parameters associated with post-TAVR LVEF improvement in patients with severe aortic stenosis (AS) and reduced LVEF.</p><p><strong>Methods: </strong>Among 1,133 consecutive patients who underwent TAVR between December 2013 and June 2024, 128 with baseline LVEF < 50% and follow-up echocardiography within 3 months were analyzed. LVEF improvement was defined as an absolute increase ≥ 10%. Independent predictors were identified using multivariable logistic regression. Post-procedural outcomes were assessed using Kaplan-Meier analysis.</p><p><strong>Results: </strong>LVEF improvement occurred in 64 patients (50%). Multivariable analysis identified higher left ventricular mass index (LVMI) (OR 1.02, 95% CI 1.00-1.03, P = 0.01) and higher E/e' (OR 1.10, 95% CI 1.03-1.18, P < 0.01) as independent predictors of improvement, whereas larger left ventricular end-diastolic volume (LVEDV) (OR 0.98, P = 0.01) and larger AVA (OR 0.67 per 0.1 cm², P < 0.01) were inversely associated. Patients with LVEF improvement had significantly lower 1-year all-cause mortality (98.2% vs. 87.0%, P = 0.01).</p><p><strong>Conclusions: </strong>Echocardiographic parameters reflecting pressure overload and diastolic dysfunction predict LVEF recovery after TAVR. Postoperative LVEF improvement was associated with better 1-year survival, underscoring its prognostic value.</p>","PeriodicalId":44837,"journal":{"name":"Journal of Echocardiography","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149240010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Go Hashimoto, Yutsuki Tsukagoshi, Sari Waga, Yusuke Samejima, Kenji Makino, Hiroki Niikura, Hidehiko Hara
{"title":"Periprocedural echocardiographic guidance for transcatheter paravalvular leak closure: from patient selection to follow-up.","authors":"Go Hashimoto, Yutsuki Tsukagoshi, Sari Waga, Yusuke Samejima, Kenji Makino, Hiroki Niikura, Hidehiko Hara","doi":"10.1007/s12574-026-00752-z","DOIUrl":"https://doi.org/10.1007/s12574-026-00752-z","url":null,"abstract":"<p><p>Paravalvular leak (PVL) after surgical valve replacement may cause heart failure, hemolytic anemia, or both. Transcatheter closure is an important therapeutic option for selected patients at high surgical risk. The irregular and often complex anatomy of PVL requires imaging assessment throughout patient selection, procedural planning, device deployment, and follow-up.Transthoracic echocardiography assesses prosthetic valve function and the hemodynamic consequences of PVL. Transesophageal echocardiography, particularly three-dimensional imaging with color Doppler, characterizes defect anatomy and guides wire crossing, device positioning, and release decisions. Assessment must address residual regurgitation, device stability, and potential interference with prosthetic valve function.Therapeutic goals depend on the dominant clinical phenotype. In heart failure-dominant PVL, sufficient reduction of regurgitant burden may improve symptoms and hemodynamics despite a small residual leak. In hemolysis-dominant PVL, residual high-velocity jets may sustain hemolysis and require additional closure. Mixed presentations require assessment of both hemodynamic and hematologic responses.Cardiac computed tomography complements echocardiography by defining channel geometry and fluoroscopic working projections, particularly when acoustic shadowing limits visualization. This review summarizes periprocedural echocardiographic assessment, emphasizing the integration of anatomical findings, clinical phenotype, and treatment response to guide procedural decisions and follow-up.</p>","PeriodicalId":44837,"journal":{"name":"Journal of Echocardiography","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149138616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Satoshi Asano, Kiyohiro Takigiku, Ryusuke Numata, Ai Kojima, Takeshi Konuma
{"title":"Anomalous origin of the left coronary artery from the left pulmonary artery diagnosed using intraoperative pericardial echocardiography in a neonate with single ventricle physiology.","authors":"Satoshi Asano, Kiyohiro Takigiku, Ryusuke Numata, Ai Kojima, Takeshi Konuma","doi":"10.1007/s12574-026-00750-1","DOIUrl":"https://doi.org/10.1007/s12574-026-00750-1","url":null,"abstract":"","PeriodicalId":44837,"journal":{"name":"Journal of Echocardiography","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149065028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Does statistical significance demonstrate a change in prognostic utility after TAVI?","authors":"Güney Sarıoğlu","doi":"10.1007/s12574-026-00751-0","DOIUrl":"https://doi.org/10.1007/s12574-026-00751-0","url":null,"abstract":"","PeriodicalId":44837,"journal":{"name":"Journal of Echocardiography","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148946027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Ahmed, Ashvin Kumar, F N U Ridham, Insiya Fatima Azad, Riya Rani Lohana, Zubaida Qadir, Muskan Kumari, Fatima Moosani, Sania Saleh, Aiman Salam Shaikh, Allah Dito, Mahboob Alam
{"title":"A history that matters: a systematic review and meta-analysis on prior heart failure hospitalization and outcomes after transcatheter aortic valve implantation.","authors":"Muhammad Ahmed, Ashvin Kumar, F N U Ridham, Insiya Fatima Azad, Riya Rani Lohana, Zubaida Qadir, Muskan Kumari, Fatima Moosani, Sania Saleh, Aiman Salam Shaikh, Allah Dito, Mahboob Alam","doi":"10.1007/s12574-026-00729-y","DOIUrl":"10.1007/s12574-026-00729-y","url":null,"abstract":"","PeriodicalId":44837,"journal":{"name":"Journal of Echocardiography","volume":" ","pages":"149-161"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Manfredonia, Gabriella Locorotondo, Monica Filice, Eleonora Ruscio, Emanuele Salvatore Ravenna, Francesca Graziani, Giovanna Liuzzo, Antonella Lombardo, Massimo Massetti, Francesco Burzotta, Gaetano Antonio Lanza
{"title":"Effect of adenosine stimulation on global longitudinal strain and mechanical dispersion in the sub-acute phase of ST-segment elevation myocardial infarction.","authors":"Laura Manfredonia, Gabriella Locorotondo, Monica Filice, Eleonora Ruscio, Emanuele Salvatore Ravenna, Francesca Graziani, Giovanna Liuzzo, Antonella Lombardo, Massimo Massetti, Francesco Burzotta, Gaetano Antonio Lanza","doi":"10.1007/s12574-025-00719-6","DOIUrl":"10.1007/s12574-025-00719-6","url":null,"abstract":"","PeriodicalId":44837,"journal":{"name":"Journal of Echocardiography","volume":" ","pages":"179-191"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luca Pascalis, Stefania Corda, Anna Piredda, Alessandro Marco Atzei, Cristiana Montaldo, Carlo Balloi
{"title":"Imaging-led management of posterior mitral annular pseudoaneurysm: rapid evolution to post-operative surveillance on 3D-TEE.","authors":"Luca Pascalis, Stefania Corda, Anna Piredda, Alessandro Marco Atzei, Cristiana Montaldo, Carlo Balloi","doi":"10.1007/s12574-025-00718-7","DOIUrl":"10.1007/s12574-025-00718-7","url":null,"abstract":"","PeriodicalId":44837,"journal":{"name":"Journal of Echocardiography","volume":" ","pages":"222-224"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145805821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}