NUCLEAR MEDICINE REVIEW最新文献

{"title":"Primary nasal-ethmoid choriocarcinoma detected by 18F-FDG PET/CT: a rare tumor with complete remission.","authors":"Maria Gazzilli,&nbsp;Domenico Albano,&nbsp;Laura Ardighieri,&nbsp;Francesco Bertagna,&nbsp;Raffaele Giubbini","doi":"10.5603/NMR.a2020.0012","DOIUrl":"https://doi.org/10.5603/NMR.a2020.0012","url":null,"abstract":"<p><p>Choriocarcinoma is a highly malignant and rare tumor characterized by secretion of the beta-subunit-of-humanchoriogonadotropin (β-HCG). We report a case of primary nasal choriocarcinoma with good response to chemotherapy. A 36-years-old woman gravida 0 and with history of 4 spontaneous abortion, in December 2018 referred to Otorhinolaryngology Department for repeated episodes of epistaxis. Cervical Magnetic Resonance Imaging (MRI) revealed a tumor mass involving right nasal cavity, right ethmoid, sphenoidal and maxillary sinuses. For a differential diagnosis between metastatic gestational choriocarcinoma and primary choriocarcinoma in January 2019 she underwent 18Fluorine-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG-PET/CT) scan that demonstrated intense uptake only in the nasal-ethmoid tumor mass showed by MRI. This was suggestive of primary nasal-ethmoid choriocarcinoma she received 3 courses of BEP - regimen and after β-HCG was reduced to 500 mIU/mL and 18F-FDG-PET/CT scan showed a decreased uptake in tumor mass but the appearance of a new uptake in cervical lymph node which was analysed and reported as metastatic localization of choriocarcinoma. Therefore she was treated with 2 cycles of TIP-regimen. Subsequents 18F-FDG-PET/CT and MRI showed a complete tumor remission. This case proved the fundamental role of PET/CT to make diagnosis of primitive choriocarcinoma and to exclude the hypothesis of distant metastasis.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 2","pages":"105-107"},"PeriodicalIF":0.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38445507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual 18F-FDG PET-CT finding of paraneoplasic polymyositis in a patient with lung epidermoïd carcinoma.","authors":"Salah Nabih Oueriagli, Yassir Benameur, Omar Ait Sahel, Abdelhamid Biyi, Abderrahim Doudouh","doi":"10.5603/NMR.2020.0022","DOIUrl":"10.5603/NMR.2020.0022","url":null,"abstract":"","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 2","pages":"110-111"},"PeriodicalIF":0.6,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38445509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calendar of Events 2020 Overview.","authors":"","doi":"10.5603/NMR.2020.0012","DOIUrl":"https://doi.org/10.5603/NMR.2020.0012","url":null,"abstract":"","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 1","pages":"51"},"PeriodicalIF":0.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38250430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney efficiency index quantitative parameter of a dynamic renal scintigraphy. II. usefulness in the diagnosis of obstructive nephropathy.","authors":"Pawel Cichocki,&nbsp;Krzysztof Filipczak,&nbsp;Anna Plachcinska,&nbsp;Jacek Kusmierek","doi":"10.5603/NMR.2020.0018","DOIUrl":"https://doi.org/10.5603/NMR.2020.0018","url":null,"abstract":"<p><strong>Background: </strong>One of the main indications for DRS is a diagnosis of obstructive uro-/nephropathy. In standard practice, this study includes the assessment of sequential scintigraphic images, renographic curves and such quantitative parameters as TMAX, T1/2 and split function of each kidney (SF). Due to the relative nature of SF and limitations of diagnostic capabilities of TMAX and T1/2, DRS was expanded to include new quantitative parameters describing kidney function in absolute values. This study aims to evaluate the usefulness of kidney efficiency index (KEi) - new, in-house developed parameter proportional to the average clearance function of the kidney.</p><p><strong>Material and methods: </strong>The study included 156 people aged 18-84 (average 51) years. The first group, from which normative values of new parameters were determined, consisted of 20 healthy volunteers. The second group consisted of 136 patients selected retrospectively, based on archived scintigraphic data. \"Normalcy rate\" (percentage of normal results among selected 62 patients with a low likelihood of obstructive uro-/nephropathy) was used to evaluate the reliability of KEi. A comparative differential analysis of obstructive uro-/nephropathy, based on standard and new DRS parameters, was performed on selected 74 patients (92 kidneys) with single functioning kidney or bilateral obstructive uropathy, where SF is unreliable.</p><p><strong>Results: </strong>Normative values: KEi ≥ 8; Normalcy rate for KEi: 95%. In comparison with standard DRS evaluation, application of KEi changed the diagnosis in 1/3 of assessed kidneys (from uropathy to nephropathy in 27/92 kidneys and vice versa in 4 kidneys).</p><p><strong>Conclusions: </strong>KEi enables reproducible, quantitative assessment of absolute kidney function without any modifications of the standard DRS protocol. Its values can be compared between independent studies (e.g. follow-up examinations). KEi corrected the diagnosis of obstructive uro-/nephropathy in cases of single functioning kidney or bilateral obstructive uropathy.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 2","pages":"84-88"},"PeriodicalIF":0.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38445503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy of Sodium [99mTc] Pertechnetate from Low Specific Activity 99Mo/99mTc Autosolex Generator in Hospital Radiopharmacy Centre.","authors":"Arpit Mitra,&nbsp;Sankha Chattopadhyay,&nbsp;Ashok Chandak,&nbsp;Sangita Lad,&nbsp;Luna Barua,&nbsp;Anirban De,&nbsp;Umesh Kumar,&nbsp;Rajesh Chinagandham,&nbsp;Trupti Upadhye,&nbsp;Kamaldeep Koundal,&nbsp;Sharmila Banerjee,&nbsp;Ramakrishna Rajan","doi":"10.5603/NMR.a2020.0001","DOIUrl":"https://doi.org/10.5603/NMR.a2020.0001","url":null,"abstract":"<p><strong>Background: </strong>Few nuclear reactors in the world producing high specific activity (HSA) 99Mo using enriched 235U (HEU), are aging and are planned for shut down in the near future. Further, HEU will not be freely available, due to safeguards, and the technology for 99Mo from low-enriched 235U (LEU) is not yet widely accepted since 239Pu contamination in the product is an issue. Production of 99mTc from low specific activity (LSA) 99Mo obtained from 98Mo(n,)99Mo reaction in research reactor and 100Mo(,n)99Mo reaction in accelerator or directly from 100Mo(p,2n)99mTc nuclear reaction in cyclotron, has been explored [1]. The methyl ethyl ketone (MEK) based solvent extraction technique is n well known method for the separation of 99mTc from low specific activity 99Mo. The 99Mo/99mTc autosolex generator [2], a computer controlled automated module, utilizes the conventional MEK solvent extraction method for extraction of 99mTc. Herein, we have validated the usage of autosolex for preparation of pharmacopoeia grade 99mTcO4- from 7.40-27.5 GBq of LSA 99Mo-SodiumMolybdate (99MoO42-) solution and validated the quality of the 99mTcO4- by preparing wide range of 99mTc-radiopharmaceuticals (99mTc-RP).</p><p><strong>Materials and methods: </strong>The 99mTcO4- was extracted from the autosolex as described in [2] starting from 7.40-27.5 GBq of LSA 99MoO42- and subjected to the required physico-chemical and biological quality control (QC) tests. The eluted 99mTcO4- labeled various fourth generation 99mTc radiopharmaceuticals cold kits (99mTc-cold kits) apart from regular 99mTc-cold kits in our centre. Various 99mTc-RP extracted 99mTcO4- using standard procedures [3] were prepared and subjected to required QC as Indian Pharmacopeia monograph [4] and used in scintigraphic imaging in patients. The radiation exposure dose to the operator were compared between autosolex and manual MEK based solvent extraction generator.</p><p><strong>Results: </strong>The extracted 99mTcO4- from autosolex is a clear and colorless solution with pH between 5.0-6.5. The elemental molybdenum (Mo) and aluminum (Al) content <10µg/mL, MEK levels <0.1%, 99Mo breakthrough <0.030% and radiochemical purity (RCP) >98%. All the extracted 99mTcO4- batches complies sterility test, endotoxin limit (EL) <5EU/mL. The RCP of all the labeled 99mTc-RP >95%. The autosolex delivers much less radiation dose to the operator than the convention manually handled MEK based solvent extraction generator.</p><p><strong>Conclusions: </strong>Autosolex Generator was successfully used to obtain pharmaceutical grade 99mTcO4- from LSA 99MoO42- and generator is safe in radiological and pharmacological point of view. The suitability of the autosolex for use in hospital radiopharmacy was shown by using the 99mTcO4- to prepare various 99mTc-RP and using these 99mTc-RP for scintigraphic imaging in patients.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 1","pages":"1-14"},"PeriodicalIF":0.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38250008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of vascular graft infection in 18F-FDG PET/CT.","authors":"Beata E Chrapko,&nbsp;Marek Chrapko,&nbsp;Anna Nocuń,&nbsp;Tomasz Zubilewicz,&nbsp;Bogusław Stefaniak,&nbsp;Jakub Mitura,&nbsp;Andrzej Wolski,&nbsp;Piotr Terelecki","doi":"10.5603/NMR.a2020.0015","DOIUrl":"https://doi.org/10.5603/NMR.a2020.0015","url":null,"abstract":"<p><strong>Background: </strong>18F-FDG PET/CT has become an important tool in diagnosis of prosthetic vascular graft infections (PVGI). The aim of the study was to identify the patterns of vascular graft infection in 18F-FDG PET/CT.</p><p><strong>Material and methods: </strong>The study was performed in 24 patients with vascular graft infection, in 17 patients implanted in an open surgery mode and in 7 patients by endovascular aortic repair (EVAR). Vascular prostheses were evaluated by two visual scales and semi-quantitative analysis with maximum standardized uptake values (SUV max).</p><p><strong>Results: </strong>In the 3-point scale: 23 patients were in grade 1 and one patient was in grade 2. In the 5-point scale: 19 patients were in grade 5 with the highest activity in the focal area, 4 patients were in grade 4 and one patient in grade 3. The visual evaluation of 18F-FDG PET/CT study revealed that peri-graft high metabolic activity was associated with occurrence of morphological abnormalities (n = 21) like gas bubbles and peri-graft fluid retention or without abnormal CT findings (n = 3). The presence of the gas bubbles was linked to higher uptake of 18F-FDG (p < 0.01, SUVmax 11.81 ± 4.35 vs 7.36 ± 2.80, 15 vs 9 pts). In EVAR procedure, the highest metabolic activity was greater than in classical prosthesis (SUVmax 21.5 vs 13).</p><p><strong>Conclusions: </strong>18F-FDG PET/CT is a very useful tool for assessment of vascular graft infections. CT findings like gas bubbles, or peri-graft fluid retention were associated with significantly higher glucose metabolism; however, in some cases without anatomic alterations, increased metabolic activity was the only sign of infection.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 2","pages":"63-70"},"PeriodicalIF":0.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38542569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodality imaging of ectopic focus in Graves' Disease.","authors":"Egesta Lopci,&nbsp;Angelo Castello,&nbsp;Emanuela Mazziotti","doi":"10.5603/NMR.2020.0008","DOIUrl":"https://doi.org/10.5603/NMR.2020.0008","url":null,"abstract":"<p><p>Herein, we report imaging findings related to an ectopic focus of thyroid tissue in a young female with Graves' disease. The occurrence of ectopic thyroid tissue affects approximately 7% of adult population and represents commonly an occasional finding. Only rarely ectopic tissue can present with metastasis or develop a primary thyroid carcinoma. Multimodality imaging may be of help in this case to detect thyroid ectopia, although recent studies question its capability to differentiate benign from malignant tissue.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 1","pages":"45-46"},"PeriodicalIF":0.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38250428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial.","authors":"Grzegorz Kamiński","doi":"10.5603/NMR.2020.0024","DOIUrl":"10.5603/NMR.2020.0024","url":null,"abstract":"","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 2","pages":""},"PeriodicalIF":0.6,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38542566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A contribution of Józef Rotblat, a winner of the Nobel Peace Prize, to the development of nuclear medicine.","authors":"J. Kuśmierek, A. Płachcińska","doi":"10.5603/NMR.A2019.0011","DOIUrl":"https://doi.org/10.5603/NMR.A2019.0011","url":null,"abstract":"Józef Rotblat, a nuclear physicist born and educated in Poland, is the only laureate of the Nobel Peace Prize, who made a significant contribution to the development of nuclear medicine. In 1948 he went down in the annals of nuclear medicine by obtaining, with extarnal measurements, the first \"image \" of a function of an internal organ - thyroid gland, by registering gamma rays with a collimated Geiger counter at many points of the patient's neck and chest. He was awarded the Nobel Prize in Rotblat in 1995 for organizing, together with the a British philosopher Bertrand Russell, the international, peaceful movement of scholars for the eradication of weapons of mass destruction (Pugwash) and multi-annual activity in this movement.","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"32 1","pages":"96-97"},"PeriodicalIF":0.9,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90337872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Political Change and National Diversity","authors":"Ivo Banac","doi":"10.4324/9780429033865-6","DOIUrl":"https://doi.org/10.4324/9780429033865-6","url":null,"abstract":"","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"94 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2019-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85656359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}