NUCLEAR MEDICINE REVIEW最新文献

{"title":"99m Tc-Octreotide-Avid Brain Mass In A Patient With Poorly Differentiated Papillary Thyroid Carcinoma, Hope In Despair.","authors":"Sara Shakeri,&nbsp;Parinaz Jahanpanah,&nbsp;Ghasemali Divband,&nbsp;Toktam Massoudi,&nbsp;Kamran Aryana","doi":"10.5603/NMR.2020.0011","DOIUrl":"https://doi.org/10.5603/NMR.2020.0011","url":null,"abstract":"<p><p>Brain metastases of PTC are rare and occur in 0.1-5% of the patients, especially in the poorly differentiated types that usually fail to concentrate iodine. We present a rare case of PTC with probable brain metastasis in a 58-year-old woman with a history of poorly differentiated PTC that showed elevated Tg levels and no metastasis was detected in the whole-body iodine scan, despite the positive 99m Tc-octreotide scintigraphy. This imaging modality could be helpful as a diagnostic guide for radionuclide therapy with labeled somatostatin analogs in cases of thyroid carcinoma with elevated Tg levels and negative whole-body iodine scan.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 1","pages":"49-50"},"PeriodicalIF":0.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38250431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of protein-losing enteropathy by 99m Tc-UBI scintigraphy.","authors":"Farnaz Nesari Javan,&nbsp;Ramin Sadeghi,&nbsp;Behzad Alizadeh,&nbsp;Atena Aghaee,&nbsp;Sousan Shafiei Forumad","doi":"10.5603/NMR.2020.0007","DOIUrl":"https://doi.org/10.5603/NMR.2020.0007","url":null,"abstract":"<p><p>nd localizing site of protein loss.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 1","pages":"42-44"},"PeriodicalIF":0.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38250427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PET/CT in thyroid cancer - the importance of BRAF mutations.","authors":"Vincenzo Cuccurullo,&nbsp;Giuseppe Danilo Di Stasio,&nbsp;Giuseppe Lucio Cascini","doi":"10.5603/NMR.a2020.0016","DOIUrl":"https://doi.org/10.5603/NMR.a2020.0016","url":null,"abstract":"<p><p>Thyroid cancer (TC) represents less than 1% of all newly diagnosed malignancies. In some selected cases, with a high clinical suspicion for disease but negative I-131 scan, positron emission tomography/computed tomography (PET) with F-18-Fluorodeoxyglucose (FDG) could be helpful in the detection of disease and the definition of its extent. FDG PET/CT, better if performed after TSH stimulation analogously to patient preparation done for radioiodine scintigraphy, could be useful mainly in the detection of metastatic and recurrent disease since the uptake and diagnostic sensitivity of FDG are increased by TSH stimulation. Recently, the role of oncogenic mutations in the tumorigenesis of TCs has become clearer. Among such mutations, BRAFV600E represents the most common genetic alteration. Mutated BRAF may define a more aggressive papillary carcinoma with poorer prognosis and therefore its analysis has been extensively studied as a rule-in test for thyroid carcinoma. In this paper, we try to outline the possible role of FDG PET/CT in the management of patients with TC and positive BRAF mutations and the impact that it could have on their therapeutic algorithm, in terms of thyroidectomy and radioactive iodine (RAI) therapy.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 2","pages":"97-102"},"PeriodicalIF":0.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38445505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of depression and anxiety in prognosis of patients undergoing myocardial perfusion imaging with 99mTc tetrofosmin SPECT for evaluation of possible myocardial ischemia.","authors":"Andreas Fotopoulos,&nbsp;Petros Petrikis,&nbsp;Ioannis Iakovou,&nbsp;Athanasios Papadopoulos,&nbsp;Konstantinos Sakelariou,&nbsp;Evangelia Gkika,&nbsp;Lampros Lakkas,&nbsp;Christos Touzios,&nbsp;Konstantinos Pappas,&nbsp;Antonios Klaroudas,&nbsp;Argyrios Doumas,&nbsp;Chrissa Sioka","doi":"10.5603/NMR.a2020.0014","DOIUrl":"https://doi.org/10.5603/NMR.a2020.0014","url":null,"abstract":"<p><strong>Background: </strong>The goal of this study was to evaluate the prevalence of depression and anxiety in patients subjected to myocardial perfusion imaging (MPI) with 99mTc tetrofosmin stress-rest single-photon emission computer tomography (SPECT), and their impact on their cardiological events or disease.</p><p><strong>Material and methods: </strong>Patients referred to the Nuclear Medicine Department for 99mTc tetrofosmin myocardial MPI-SPECT were asked to fulfill the Zung Self-Rating Depression Scale (ZDS) and Hamilton anxiety questionnaire (HAQ). Among 213 patients who completed the ZDS and HAQ, 80 patients (59 males and 21 females) were selected for this study because they had no known psychological disease, other disease that could influence psychological status, or use of narcotic drugs. Collected data from MPI and psychological status were subsequently analyzed.</p><p><strong>Results: </strong>Among all 80 patients, 52 patients (65%) had abnormal MPI of whom 28/52 (53.8%) exhibited either depression, anxiety or both, and 28 (35%) patients had normal MPI of whom 10/28 (35.7%) had abnormal psychological status. The higher number of patients with abnormal psychological status in association with abnormal MPI was noted predominantly in patients with previously established coronary artery disease. A correlation was also noted between obesity, cardiac heredity and depression or anxiety in patients with abnormal MPI.</p><p><strong>Conclusions: </strong>Patients that exhibit depression, anxiety, or both, have high rates of myocardial ischemia, and thus are at risk for subsequent cardiological events.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 2","pages":"58-62"},"PeriodicalIF":0.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38542568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiolabelled PSMA PET/CT in breast cancer. A systematic review.","authors":"Francesco Bertagna,&nbsp;Domenico Albano,&nbsp;Elisabetta Cerudelli,&nbsp;Maria Gazzilli,&nbsp;Davide Tomasini,&nbsp;Marco Bonù,&nbsp;Raffaele Giubbini,&nbsp;Giorgio Treglia","doi":"10.5603/NMR.2020.0004","DOIUrl":"https://doi.org/10.5603/NMR.2020.0004","url":null,"abstract":"<p><strong>Background: </strong>Radiolabelled prostate-specific membrane antigen (PSMA)-based PET/CT is a whole-body imaging technique currently performed for the detection of prostate cancer lesions. PSMA has been also demonstrated to be expressed by the neovasculature of many other solid tumours. The aim of this review is to evaluate the possible diagnostic role of radiolabelled PSMA PET/CT in breast cancer.</p><p><strong>Material and methods: </strong>A comprehensive literature search of the PubMed/MEDLINE, Scopus, Embase and Cochrane Library databases was conducted to find relevant published articles about the diagnostic performance of radiolabelled PSMA PET/CT in breast cancer.</p><p><strong>Results: </strong>The comprehensive computer literature search revealed 652 articles. On reviewing the titles and abstracts, 640 articles were excluded because the reported data were not within the field of interest of this review. Twelve articles were selected and retrieved in full-text version; no additional study was found when screening the references of these articles. In total, 12 articles were included in the systematic review.</p><p><strong>Conclusions: </strong>Further studies enrolling a wider population are needed to clarify the.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 1","pages":"32-35"},"PeriodicalIF":0.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38250424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normal ranges of renal function parameters for 99mTc-EC renal scintigraphy.","authors":"Agata Danilczuk,&nbsp;Anna Nocun,&nbsp;Beata Chrapko","doi":"10.5603/NMR.a2020.0013","DOIUrl":"https://doi.org/10.5603/NMR.a2020.0013","url":null,"abstract":"<p><strong>Background: </strong>Dynamic renal scintigraphy remains the recognized method for evaluation of kidney function and perfusion. Although there is an extensive body of knowledge about the use of technetium-99m-mercaptoacetyltriglycine (99mTc-MAG3), much less has been written about renal technetium-99m-ethylenedicysteine (99mTc-EC) scintigraphy. The aim of this study was to determine the normal value of renal function parameters in 99mTc-EC dynamic renal scintigraphy: Tmax and T1/2. The effects of age, left or right side in the retroperitoneal space, and sex on those parameters were examined.</p><p><strong>Material and methods: </strong>The research was conducted on 123 patients (F/M: 70/53; aged 2-71; averaging 14.8 years of age) with at least one normal kidney. A total of 194 healthy kidneys were examined, including pediatric kidneys.</p><p><strong>Results: </strong>According to this study, the normal value of Tmax is 2.85 min (± 1.16) and T1/2 is 8.7 min (± 3.61). Values calculated for pediatric studies are Tmax is 2.81 (± 1.16) and T1/2 is 8.63 (± 3.71).</p><p><strong>Conclusions: </strong>The normal value of secretory and excretory renal function parameters was calculated. Although the value is slightly lower for children, this is not statistically significant, as globally there are no differences between the kidney-location sides and sexes for any parameter.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 2","pages":"53-57"},"PeriodicalIF":0.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38542567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The levels of oxidative and nitrosative stress in patients who had 99mTc-MIBI myocardial perfusion scintigraphy and 99mTc-DMSA, 99mTc-MAG-3 renal scintigraphy.","authors":"Ebru Salmanoglu,&nbsp;Ergul Belge Kurutas","doi":"10.5603/NMR.a2020.0019","DOIUrl":"https://doi.org/10.5603/NMR.a2020.0019","url":null,"abstract":"<p><strong>Background: </strong>Ionizing radiation is a strong stimulator of reactive oxygen specises (ROS) and reactive nitrogen species (RNS). These reactive species may cause oxidative and nitrosative stress. In this study, we aimed to evaluate possible effects of 99mTechnetium (99mTc)-methoxyisobuthylisonitrite (MIBI), 99mTc-dimercaptosuccinic acid (DMSA), 99mTc-mercaptoacetyltriglycine (MAG-3) on oxidative and nitrosative stress biomarkers in patients who were performed myocardial perfusion scintigraphy (MPS) and renal scintigraphy.</p><p><strong>Material and methods: </strong>Patients (n = 29) who were referred to nuclear medicine department were chosen as the patient group. They were divided into three subgroups according to the type of disease and 99mTc labelled agent. The first patient group had MPS (n = 9). The second patient group had 99mTc-DMSA renal scintigraphy (n = 12). The third patient group had 99mTc-MAG-3 renal scintigraphy (n = 8). The blood samples were taken from first, second and third patient groups 1 h, 3 h, 45 min after injection of the agent, respectively. The samples were taken from healthy volunteers (n = 25) as a control group. Alterations in catalase (CAT),superoxide dismutase (SOD), malondialdehyde (MDA) levels as oxidative stress biomarkers and nitric oxide (NO) and 3-Nitrotyrosine (3-NTx) levels as nitrosative stress biomarkers in all blood samples were evaluated.</p><p><strong>Results: </strong>Results of MPS and renal scintigraphy performed patients were compared with control group separately. CAT, SOD, MDA and 3-NTx levels were higher in the first group than the control group (p < 0.05). Although NO levels were higher in the first group than the control group, it was not statistically significant (p > 0.05). CAT and SOD levels were lower in second and third groups than the control group (p < 0.0 5). However, MDA, NO, 3-NTx levels were higher in second and third groups than the control group (p < 0.05).</p><p><strong>Conclusions: </strong>These results show that oxidative and nitrosative balance is impaired due to ionization radiation. These reactive species might stimulate an adaptive and protective cellular defense mechanism in irradiated cells soon after exposure to radiation. Thereby, this mechanism protect organism from the effects of low dose ionizing radiation.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 2","pages":"89-96"},"PeriodicalIF":0.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38445504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the relationship between carotid intima-media thickness, flow-mediated dilatation in brachial artery and nuclear heart scan in patients with rheumatoid arthritis for evaluation of asymptomatic cardiac ischemia and atherosclerotic changes.","authors":"Zahra Mardanshahi,&nbsp;Alireza Mardanshahi,&nbsp;Aref Hosseinian Amiri,&nbsp;Mohammad Khademloo,&nbsp;Mehdi Zolfagharkhani,&nbsp;Maryam Tayebi,&nbsp;Abdolmajid Gholi Nattaj,&nbsp;Hamideh Jamshidi","doi":"10.5603/NMR.2020.0010","DOIUrl":"https://doi.org/10.5603/NMR.2020.0010","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease is the most common cause of death worldwide. In order to prevent and treat heart diseases, we need to estimate the trend of non-cardiac diseases with the cardiovascular system. Arthritis Rheumatoid is a chronic immune/inflammatory process which leads to subclinical atherosclerosis and increases cardiovascular disease. We examined the patients who referred to our nuclear medicine center for MPI and correlated their findings with flow-mediated dilatation (FMD) of the brachial artery and carotid intima-media thickness (CIMT) in arthritis rheumatoid patients.</p><p><strong>Material and methods: </strong>A total 30 known cases with arthritis rheumatoid were referred to our department for MPI and the single-photon emission computed tomography (SPECT) imaging were visually and quantitatively evaluated by two nuclear medicine physicians and the correlation of the measured FMD and CIMT were evaluated and compared with ultrasonography data. Demographic information such as gender, age and sex and medical history (risk factors, cardiovascular sign and symptoms, lab findings, medication etc…) were recorded in questionnaire sheets and were analyzed by SPSS.20. Chi-square and student t-test were used for further analysis.</p><p><strong>Results: </strong>The mean CIMT (R = 0.452 ± 0.07, L = 0.447 ± 0.08) and %FMD (R = 7.22 ± 8.66, L = 6.42 ± 11.88) were measured for all subjects. Age was the only parameter correlated with both right and left CIMT (P = 0.033 and P = 0.024, respectively). Among the patients, 26.7% had mild ischemia (SSS < 8) and 3 of them suffered from active arthritis rheumatoid. All patients with RA showed normal ventricular ejection fraction and normal volumes and among them, 93.3% had normal functional performance (normal wall motion…). Moreover, the mean CIMT and %FMD were not significantly different in ischemic and non-ischemic patients. Among ischemic patients, just the course of the disease was associated with CIMT and none of the parameters was correlated with FMD.</p><p><strong>Conclusions: </strong>There is no significant statistical difference between ischemic and non-ischemic patients and also the functional performance with values of CIMT and FMD. Among all populations, the parameter of age, and in ischemic group, the course of disease were found as the only variable correlated with CIMT.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 1","pages":"25-31"},"PeriodicalIF":0.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38250011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiomics and artificial Intelligence for PET imaging analysis.","authors":"Andrea d'Amico,&nbsp;Damian Borys,&nbsp;Izabela Gorczewska","doi":"10.5603/NMR.2020.0005","DOIUrl":"https://doi.org/10.5603/NMR.2020.0005","url":null,"abstract":"<p><p>In recent years, processing of the imaging signal derived from CT, MR or positron emission has proven to be able to predict outcome parameters in cancer patients. The processing techniques of the signal constitute the discipline of radiomics. The quantitative analysis of medical images outperform the information that can be obtained through traditional visual analysis. The recognition of neoplasm molecular and genetic characteristics in a non-invasive way, based on routine radiological examinations, potentially allow complete tumor profiling and subsequent treatment customization at practically zero costs. This process is further boosted with the availability of increased computing power and development of artificial intelligence approaches.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 1","pages":"36-39"},"PeriodicalIF":0.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38250425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial.","authors":"Grzegorz Kamiński","doi":"10.5603/NMR.2020.0013","DOIUrl":"10.5603/NMR.2020.0013","url":null,"abstract":"","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38252137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}